• Clinical and Experimental Pediatrics
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• v.52 no.8
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• pp.938-943
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• 2009

Purpose : We performed this study in order to investigate the effect of direct renin inhibition on an experimental animal model with nephrotoxic serum nephritis and tried to give useful information for clinical research and renin inhibitor treatment. Methods : Thirty BALB/c 6-week-old male mice were divided into 4 groups: control group (CO, n=5), control-treatment group with aliskiren (CT, n=5), disease group (DO, n=10), and disease treatment group with aliskiren (DT, n=10). Nephritis was induced by an intravenous injection of 0.25 mg/g weight of rabbit anti-GBM immunoglobulin G. Model 2002 Alzet mini-osmotic pumps (Durect Corp.) for aliskiren infusion were implanted into CT and DT. Each group strain was sacrificed serially one at a time on day 14. We estimated the protein-creatinine ratio in 12-hour-collected urine (UP/Cr) and measured the mesangial matrix score in the PAS-stained kidney of each strain. Results : One strain at CT and DT died on day 6 and 7, respectively. Each group strain was sacrificed serially at a time on day 10 because DO were seriously ill. The UP/Cr of each group is as follows: CO, $31.24{\pm}6.54mg/mg$, CT, $23.38{\pm}13.60mg/mg$, DO, $112.72{\pm}10.97mg/mg$, DT $114.07{\pm}32.30mg/mg$. There was no significant difference between DO and DT. The mesangial matrix score of each group was CO, $0.23{\pm}0.10$; CT, $0.13{\pm}0.03$; DO, $1.90{\pm}0.48$; and DT, $1.28{\pm}0.41$, respectively, and there was a significant difference between DO and DT in the extent of mesangial matrix expansion (P=0.008). Conclusion : We found that renin inhibition was able to suppress the mesangial matrix expansion in experimental mice with acute nephritis, although there were no significant differences in UP/Cr.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.1063-1064
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• 2006

Mechanical properties of 7xxx series Al metal matrix composite (MMC) powders containing different amounts of ceramic were investigated. The ceramic contents of the starting powders were 5 wt.% or 10 wt.%. The powders were uniaxially cold compacted using a cylindrical die with a compacting pressure of 250 MPa and were sintered at $620^{\circ}C$ in a dry $N_2$ atmosphere for 60 min. For the heat treatment, sintered parts were solution treated at $475^{\circ}C$ and aged at $175^{\circ}C$. Compression tests were conducted to reveal the effect of $Al_2O_3$ particle content on the mechanical properties of the composites. Fractography was examined using a scanning electron microscope.

• The Korea Journal of Herbology
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• v.26 no.1
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• pp.119-124
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• 2011

Objective : This study was carried out to investigate effect of korean medicinal herbs-included hair tonic (MHT) and food (MF) on hair growth in an alopecia model of C57BL/6 mice. Methods : Six-weeks old mice were given laboratory rodent chow diet for 1 week. Then, we used a depilatory for hair removal on mice. The next day, mice were randomized and separated in 3 groups of 6 mice; normal group (N, vehicle epidermal application+normal diet-treated group), positive control group (C, 3% minoxidil sulfate epidermal application+normal diet-treated group), and the treatment group (T, HT epidermal application+ MF diet-treated group). The hair regrowth was determined by photograph, which was taken at 7, 14 and 21 days. And scoring indices, hair density and hair thickness, were evaluated by Folliscope at same day. In addition, the hair regrowth was analyzed insulin-like growth factor (IGF-1) in the dorsal skin of mice. Results : As a result, not only external appearance but also hair density and hair thickness on dorsal skin were increased more in C, T groups than in N group at 21 days with mixed treatment. Therefore, distinct regrowth pattern is appeared by treatment of herbal tonic and natural food for 21 days. Also, the expressions of IGF-1 on dorsal skin were higher in C, T groups than in N group. Conclusion : These results suggested that this herbal hair tonic and natural food has hair growth promoting activities and may be useful for treatment of bald or alopecia.

• Journal of environmental and Sanitary engineering
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• v.13 no.2
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• pp.128-138
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• 1998

This study was focused to find how each factors effect on the biological nitrification in wastewater treatment under high ammonia nitrogen concentration. Batch reactors in aerobic conditions were used to test the treatment efficiency of mixed liquor, nightsoil and piggery wastewater. The results are summeried as follows; Initial ammonia nitrogen concentration and pH were the direct influencing factors of nitrite build-up. More than 250 mg NH$_{4}$$^{+}$ - N/L in initial concentration built up nitrite and then the inhibition rate to Nitrobacter was above 70 percentage. And maximum nitritation rate was showed at pH 8.3 and nitrification could be completely achieved by pH control. Temperature and dissolved oxygen were the indirect influencing factors of nitrite build-up. These were a great effect on the activity of nitrifying microbes and ammonia nitrogen removal. Maximum nitritation rate was showed at 30 $\circ $C. The effect of DO concentration was negligible at more than 3 mg/L.

• The Journal of the Korea Contents Association
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• v.10 no.11
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• pp.243-250
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• 2010

The bonding strength and color reproducibility of titanium-ceramic prosthesis were analyzed the effect according to the surface treatments of titanium and the glazing temperatures of the low fused porcelain. The result of bonding strength compared with respect to the surface treatments was observed that the STB1 group coated by TiN had strongest boding strength and then came the SB1 group used special bonding agent, the SGB1 group coated by gold in that order. The bonding strength by the glazing temperature was indicated that the group with $770^{\circ}C$ of glazing temperature was observed increasing the bonding strength as compared with it of the other group, and the group with $810^{\circ}C$ of glazing temperature was observed to be decreased the bonding strength. Glazing temperature increases, the color by the surface treatment of titanium influenced the color of titanium-ceramic on account of getting higher brightness(${\Delta}L$). As a this result, the SB1 and SGB3 groups was evaluated to has the best color reproducibility.

• Journal of the Korean Chemical Society
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• v.22 no.3
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• pp.150-157
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• 1978

The rate constants for the hydrolysis of the derivatives of N-(p-nitrophenyl)-benzohydrazonyl azide (p-$CH_3,\;p-CH_3O,\;p-NO_2$, p-Cl, p-Br) have been determined by UV spectrophotometry in 50% dioxane-water at $25^{\cicr}C$ and a rate equation which can be applied over wide pH range was obtained. Below pH 5, the rate of hydrolysis of hydrazonyl azides is accelerated by electron-donating group ($\rho$ = -0.47), whereas at the pH values greater than 7, the $\rho$-value is 0.68. The effect of salt, solvent, substituent and azide ion on the rate of hydrolysis are rationalized in terms of $S_N1$ and $S_N2$ mechanism; below pH 5, the hydrolysis proceed through $S_N1$, however, above pH 7, the hydrolysis is started by the attack of hydroxide ion and in the range of pH 5∼7, these two reactions occur competitively.

• Journal of Digital Convergence
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• v.17 no.5
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• pp.399-405
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• 2019

This study was investigated the effect of aerobic exercise and chrysin supplementation on macrophage infiltration and lipolysis in high-fat diet mice. To accomplish the purpose of this study, C57BL/6 mice were fed high fat diet(60% fat diet) during experimental period. The animals were divided into 4 groups; NC (normal diet control, n=5), HC (high fat diet control, n=5), Hch(high fat diet with chrysin, n=5), and HME (high fat diet with aerobic exercise training, n=5). Exercise training was performed for 16 weeks on a treadmill running. As a result, macrophage marker, F480 and CD11c were significantly decreased in HME comparison with HD and Hch. Also, M2 macrophage marker CD11c, and lipolysis marker PRDM were significantly increased in HME compared with HC and Hch These findings suggest that regular aerobic exercise has beneficial effects to inhibit macrophage infiltration in high fat diet mice.

• Elastomers and Composites
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• v.39 no.4
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• pp.318-323
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• 2004

Cloud-point and bubble-point curves for poly(ethylene-co-13.8 mol% octene) ($PEO_{13.8}$) and Poly(ethylene-co-15.3 mol% octene) ($PEO_{15.3}$) were determined up to $150^{\circ}C$ and 450 bar in hydrocarbons which have different molecular size and structure. Whereas ($PEO_{15.3}$+ n-pentane) system has cloud-point and bubble-point type transitions, ($PEO_{15.3}$+ n-propane) and ($PEO_{15.3}$+ n-butane) systems do only cloud-point type transition. In cyclo-pentane, -hexane, -heptane, and -octane, $PEO_{15.3}$ has a bubble-point transition. ($PEO_{13.8}$+ n-butane) mixture has a critical mixture concentration at 5 wt% PEO. (PEO + hydrocarbon) mixtures exhibit LCST type behavior. Solubility of PEO increases with hydrocarbon size due to increasing dispersion interaction which is favorable to dissolve PEO.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.335-339
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• 2005

Enterobacteria, named ${\lambda}-bacteria$ isolated from fusiform fish bearing higher antioxidative capacity with ORP values, ${\lambda}-28$ strain bore higher anti-angiogenesis effect than other ${\lambda}-species$. Optimum growth condition of ${\lambda}-28$ bacterium was $25^{\circ}C$, neutral pH, Glc as a C-source, ammonium chloride as a N-source, and not effected with organic N-source.

• Applied Biological Chemistry
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• v.7
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• pp.45-52
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• 1966

This study was carried out to determine how the water soluble, the available $P_2O_5$ and urea-N would change in the course of time, when the mixtures of calcium superphosphate and urea with lime for fertilizer which occurred in Korea and largely contained calcium carbonate were made. Three kinds of materials, i. e., calcium superphosphate, urea and lime for fertilizer were used in this study. Three kinds of mixed fertilizer, i. e., A, B and C were made up by mixing these materials to satisfy the following formula. $$1)\;Ca(H_2PO_4)_2+CaCO_3+CO(NH_2)_2{\rightarrow}$$$$Ca_2H_2(PO_4)+H_2CO_3+NH_3$$ $$2)\;Ca(H_2PO_4)_2+CaCO_3+CO(NH_2)_2{\rightarrow}$$$$Ca_3(PO_4)_2+H_2CO_3+NH_3$$ $$3)\;Ca(H_2PO_4)_2+CaCO_3+CO(NH_2)_2{\rightarrow}$$$$Ca_3(PO_4)_2+H_2CO_3+CaCO_3+NH_3$$ A,B and C were placed in desiccators respectively a six month period. During the time of storage, the water soluble, the available phosphoric acid and urea-N were measured once a month, seven times with the control measurement. The results may be summarized as follows. 1. None of A, B and C showed any change in the urea-N with the lapse of time. This fact indicated that the combination of calcium superphosphate and urea with lime for fertilizer was not unfavourable. 2. A, B and C decreased in the amount of water soluble $P_2O_5$ with the passage of time. This fact indicated that the mixing of calcium superphosphate and urea with lime for fertilizer was unfeasible. 3. The available $P_2O_5$ in any of A,B and C did not undergo a change as time went by. This fact suggested that the combination of calcium superphate and urea with lime for fertilizer was favourable.