Browse > Article
http://dx.doi.org/10.6116/kjh.2011.26.1.119

Effects of Hair Tonic and Food including Korean Medicinal Herbs on Hair Growth in an Alopecia Model of C57BL/6 Mice  

Choi, Hye-Min (R&D Team for the New Drug of Oriental Medicine (BK 21))
Hwang, Su-Jung (R&D Team for the New Drug of Oriental Medicine (BK 21))
Lee, Jin-Sang (Oriental Medicine Industry Support Center)
Do, Eun-Ju (Oriental Medicine Industry Support Center)
Kim, Mu-Young (Jeuncell Co. Ltd)
Kim, Mi-Ryeo (R&D Team for the New Drug of Oriental Medicine (BK 21))
Publication Information
The Korea Journal of Herbology / v.26, no.1, 2011 , pp. 119-124 More about this Journal
Abstract
Objective : This study was carried out to investigate effect of korean medicinal herbs-included hair tonic (MHT) and food (MF) on hair growth in an alopecia model of C57BL/6 mice. Methods : Six-weeks old mice were given laboratory rodent chow diet for 1 week. Then, we used a depilatory for hair removal on mice. The next day, mice were randomized and separated in 3 groups of 6 mice; normal group (N, vehicle epidermal application+normal diet-treated group), positive control group (C, 3% minoxidil sulfate epidermal application+normal diet-treated group), and the treatment group (T, HT epidermal application+ MF diet-treated group). The hair regrowth was determined by photograph, which was taken at 7, 14 and 21 days. And scoring indices, hair density and hair thickness, were evaluated by Folliscope at same day. In addition, the hair regrowth was analyzed insulin-like growth factor (IGF-1) in the dorsal skin of mice. Results : As a result, not only external appearance but also hair density and hair thickness on dorsal skin were increased more in C, T groups than in N group at 21 days with mixed treatment. Therefore, distinct regrowth pattern is appeared by treatment of herbal tonic and natural food for 21 days. Also, the expressions of IGF-1 on dorsal skin were higher in C, T groups than in N group. Conclusion : These results suggested that this herbal hair tonic and natural food has hair growth promoting activities and may be useful for treatment of bald or alopecia.
Keywords
Herbal hair tonic and natural food; alopecia; hair density; hair thickness; IGF-1;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Uno Hm Allegra F, Adachi K, Montagna W. Studies of common baldness of the stumptailed macaque. I. Distribution of the hair follicles, J Invest Dermatol. 1967 ; 49 : 288-296.   DOI
2 Uno H, Adachi K, Allergra F, Montagna W. Studies of common baldness of the stumptailed macaque. II. Enzyme activities if carbohydrate metabolism in the hair follicles, J Invest Dermatol. 1968 ; 51 : 11-18.   DOI
3 Allegra F, Giacometti L, Uno H, Adachi K. Stydies of common baldness in the stumptailed macaque, III, DNA synthesis in regrowing hair, Acta Derm-Venereol. 1970 ; 50 : 169-175.
4 Takashima I, Adachi K, Montagna W, Studies of common baldness of the stumptailed macaque. IV. In vitro metabolism of testosterone in the hair fillicles, J Invest Dermatol. 1970 ; 55 : 329-334.   DOI   ScienceOn
5 Suuki M, Akamtsu H, Matsungaga K. Allergic contact dermatitis from minoxidil : Study of the cross reaction to minoxidil. Am J Contact Dermatitis. 2002 ; 13 : 45-46.
6 Mackay A, Isles C, Henderson I, Fife R, Kennedy AC. Minoxidil in the management of intractable hypertension. Quart J Med. 1981 ; 52 : 175-190.
7 전국한의과대학 공동교재편찬위원회. 본초학. 서울 : 영림사. 2007 : 81-182, 437-438, 654-655.
8 Tobin DJ, Hagen E, Botchkarev VA. Paus R.. Do hair bulb melanocytes undergo apoptosis during hair follicle regression (catagen). J Invest Dermatol. 1998 ; 111 : 941-947.   DOI   ScienceOn
9 Wester RC, Maibach HI, Guy RH. Novac E.. Minoxidiil stimulates cutaneous blood flow in human balding scalp : Pharmacodynanics measured by laser doppler velocimetry and photopulse plethysmography. J Invest Dermatol. 1984 ; 82 : 515-517.   DOI   ScienceOn
10 이상인, 안덕균, 신민수, 편역. 한약임상응용. 서울 : 성보사. 1982 : 399-401.
11 Mori O, Uno H. The effect of topical minoxidil on hair follicular cycles of rats. J Dermatol. 1990 ; 17 : 276-281.   DOI
12 Buhl AE, Waldon DJ, Baker CA, Johnson GA. Minoxidil sulfate is the active metabolite that stimulates hair follicles. J Invest Dermatol. 1990 ; 195 : 553-557.
13 이윤경, 김정기, 한약추출물의 발모효과에 관한 연구 : 하수오, 당귀 및 구기자 혼합물의 발모효과. 대한본초학회지. 2004 ; 19(2) : 83-90.
14 Stem KS. The molecular and structural biology of hair : introduction. Ann NY Acad Sci. 1991 ; 642 : xi-xiii.
15 김용준, 정헌철, 정헌택, 채규윤, 윤용갑, 장선일. 側柏추출물에 따른 발모 효능에 대한 연구. 동의생리병리학회지. 2004 ; 18(5) : 1471-1475.
16 최원준. 발모제, 육모제, 탈모방지 특허동향에 관한 연구. 한국두피모발미용학회지. 2007 ; 3(1) : 27-38.
17 Uno H. Quantitative models for the study of hair growth in vivo. Ann NY Acad Sci. 1991 ; 642 : 107-124.
18 Messenger AG. The control of hair growth and pigmentation. In : Olsen EA. ed. Disorders of hair growth : diagnosis and treatment. NY McGraw-Hill. 1994 : 39-58.
19 Messenger AG, Rundegren J. Minoxidil : Mechanisms of action on hair growth. Br J Dermatol. 2004 ; 150 : 186-194.   DOI   ScienceOn
20 Kim JD, Hue JJ, Kang BS, Kim JH, Nam SY, Yun YW, Kim JS, Jeong JH, Kim YC, L BJ. Effects of Herbal Extracts on Hair Growth in an Animal Model of C3H/HeJ Mice. Lab Anim Res. 2009 ; 25(3) : 225-232.
21 Inui S, Fukuzato Y, Nakajima T, Yoshikawa K, Itami S. Androgen-inducible TGF-beta 1 from dermal papoilla cells inhibits epithelial cell growt h : A clue to understand paradoxical effects of androgen on human hair growth. FASEB J. 2002 ; 16 : 1967-1969.
22 Shapiro J, Price VH. Hair regrowth therapeutic agents. Dermatol. Clinics. 1998 ; 16 : 341-356.   DOI   ScienceOn
23 Philpott MP, Sanders DA, Kealey T. Effects of insulin and insulin like growth factors on cultured human hair follicles : IGF-1 at physiologic concentrations is an important regulator of hair follicle growth in vitro. J Invest Dermatol. 1994 ; 102 : 857-861.   DOI   ScienceOn
24 Tang L, Bernado O, Bolduc C, Lui H, Shapiro J. The expression of insulin-like growth factor 1 in follicular dermal papilae correlates with therapeutic efficacy of finasteride in androgenetic alopecia. J Am Acad Dermatol. 2003 ; 49(2) : 229-233.   DOI   ScienceOn
25 박영철. 골드바이오셀의 랫드를 이용한 2주 반복 투여에 의한 간기능 및 신기능 독성에 대한 영향. 연구결과보고서. 대구가톨릭대학교 바이오안전성센터. 2009.
26 Passchier J. Quality of life issues in male pattern hair loss. Dermatol. 1998 ; 197 : 217-218.   DOI   ScienceOn
27 Rumsfield JA, West DP, Fiedler-Weiss VC. Topical minoxidil therapy for hair regrowth, Clin Pharm. 1987 ; 6 : 54-67.
28 Kang H, Kang TW, Lee SD, Park YM, Kim HO, Kim SY, The changing patterns of hair density and thickness in South Korean women with hair loss : clinical office-based phototrichogram analysis. J International Dermatol. 2009 ; 48 : 14-21.   DOI   ScienceOn
29 Takashima I, Montagna W. Studies of common baldness of the stumptailed macaque (Macacaspeciosa). VI The effect of testosterone on common baldness, Arch Dermatol. 1971 ; 103 : 527-534.   DOI   ScienceOn
30 Takashima I. Studies of common baldness of the stumptailed macaque. V. Regional difference of testosterone metabolites in the hair follicles, J Invest Dermatol. 1974 ; 1 : 14-21.   DOI
31 Mitsui S, Ohuchi A, Hotta M, Tsuboi R, Ogawa H. Gene for a range of growth factor and cyclin dependent kinase inhibitors are expressed by isolated human hair follicle. Br J Dermatol. 1997 ; 137 : 693-698.   DOI   ScienceOn