• Title/Summary/Keyword: Effect Modification

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Semiparametric and Nonparametric Modeling for Matched Studies

  • Kim, In-Young;Cohen, Noah
    • Proceedings of the Korean Statistical Society Conference
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    • 2003.10a
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    • pp.179-182
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    • 2003
  • This study describes a new graphical method for assessing and characterizing effect modification by a matching covariate in matched case-control studies. This method to understand effect modification is based on a semiparametric model using a varying coefficient model. The method allows for nonparametric relationships between effect modification and other covariates, or can be useful in suggesting parametric models. This method can be applied to examining effect modification by any ordered categorical or continuous covariates for which cases have been matched with controls. The method applies to effect modification when causality might be reasonably assumed. An example from veterinary medicine is used to demonstrate our approach. The simulation results show that this method, when based on linear, quadratic and nonparametric effect modification, can be more powerful than both a parametric multiplicative model fit and a fully nonparametric generalized additive model fit.

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Effect of Divergent Trailing Edge Modification of Supercritical Airfoil in Transonic Flow (천음속유동에서 초임계익형 후연확대수정의 영향)

  • Yoo, Neung-Soo
    • Journal of Industrial Technology
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    • v.17
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    • pp.183-189
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    • 1997
  • The computation of the flow around a supercritical airfoil with a divergent trailing edge(DTE) modification(DLBA 243) is compared to that of original supercritical airfoil(DLBA 186). For this computation, Reynolds-Averaged Navier-Stokes equations are solved with a linearized block implicit ADI method and a mixing length turbulence model. Results show the effects of the shock and separated flow regions on drag reduction due to DTE modification. Results also show that DTE modification accelerates the boundary layer flow near the trailing edges which has an effect similar to a chordwise extension that increases circulation and is consistent with the calculated increase in the recirculation region in the wake. Airfoil with DTE modification achieves the same lift coefficient at a lower incidence and thus at a lower drag coefficient, so that lift-to-drag ratio is increased in transonic cruise conditions compared to the original airfoil. The reduction in drag due to DTE modification is associated with weakening of shock strength and delay of shock which is greater than the increase in base drag.

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The Effect of Addendum Modification Coefficient on Gear Strength to Planetary Gear Reducer (유성기어 감속기에서 전위계수가 기어 강도에 미치는 영향)

  • Kwak, Ki-Suk;Han, Dong-Seop
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.10 no.4
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    • pp.38-43
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    • 2011
  • Industrial reducer is in general use to Deck Crane. High-precision and high-efficient reducer is minimized the power-loss and energy-loss of a machine. So it contribute the price reduction and life extension. Reducer is usually using the Planetary gear reducer. Planetary gear reducer is composed the sun gear, planet gear, internal gear and casing. Industrial reducer's wear and breakage have a short-life. To solve this problem, it is using the profile-shifted-gear or tooth modification. This study was carried out the effect of addendum modification coefficient on tooth fillet bending strength to planetary reducer. Tooth fillet bending stress is calculate. And all parameter were expressed the function of addendum modification coefficient. And then stress concentration factor of tooth fillet curve was express the function of addendum modification coefficient using comparison between theory and finite element analysis.

Modification of Turnip yellow mosaic virus coat protein and its effect on virion assembly

  • Shin, Hyun-Il;Chae, Kwang-Hee;Cho, Tae-Ju
    • BMB Reports
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    • v.46 no.10
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    • pp.495-500
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    • 2013
  • Turnip yellow mosaic virus (TYMV) is a positive strand RNA virus. We have modified TYMV coat protein (CP) by inserting a c-Myc epitope peptide at the N- or C-terminus of the CP, and have examined its effect on assembly. We introduced the recombinant CP constructs into Nicotiana benthamiana leaves by agroinfiltration. Examination of the leaf extracts by agarose gel electrophoresis and Western blot analysis showed that the CP modified at the N-terminus produced a band co-migrating with wild-type virions. With C-terminal modification, however, the detected bands moved faster than the wild-type virions. To further examine the effect, TYMV constructs producing the modified CPs were prepared. With N-terminal modification, viral RNAs were protected from RNase A. In contrast, the viral RNAs were not protected with C-terminal modification. Overall, the results suggest that virion assembly and RNA packaging occur properly when the N-terminus of CP is modified, but not when the C-terminus is modified.

Effect of Mixing Shear on Flocculation of Anionic PAM and Cationic Starch Adsorbed PCC and Its Effect on Paper Properties (교반 속도가 음이온성 PAM과 양이온성 전분으로 도포된 경질탄산칼슘의 응집과 종이 물성에 미치는 영향)

  • Choi, Do-Chim;Won, Jong Myoung;Cho, Byoung-Uk
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.47 no.2
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    • pp.53-60
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    • 2015
  • The effects of stirring speed during filler modification by dual polymers on flocculation and reflocculation of PCC (precipitated calcium carbonate) particles and its effect on handsheet properties were elucidated. PCC surface was modified by adsorbing A-PAM (anionic polyacrylamide) and C-starch (cationic starch) in series at various stirring speeds. It was found that increasing stirring speed during filler modification decreased the initial floc size of PCC. Continuous stirring with the same speed for filler modification resulted in the decrease of a floc size, eventually reached a steady state. The variations in a floc size was influenced by the stirring speed during filler modification: the lower the stirring speed during filler modification, the larger the floc size variations. Conclusively, the stability of PCC floc could be improved by increasing the stirring speed. In addition, the stirring speed influenced the handsheet properties. The smaller the PCC floc, the lower the strength of handseet. However, too much larger floc size also deteriorated paper strength. There exists an optimum floc size in term of paper strength which shall be controlled by stirring speed during filler modification.

Aerodynamic Performance Improvement by Divergent Trailing Edge Modification to a Supercritical Airfoil

  • Yoo, Neung-Soo
    • Journal of Mechanical Science and Technology
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    • v.15 no.10
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    • pp.1434-1441
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    • 2001
  • A computational study has been performed to determine the effects of divergent trailing edge (DTE) modification to a supercritical airfoil in transonic flow field. For this, the computational result with the original DLBA 186 supercritical airfoil was compared to that of the modified DLBA 283. A wavier-Stokes code, Fluent 5. 1, was used with Spalart-Allmaras's one-equation turbulence model. Results in this study showed that the reduction in drag due to the DTE modification is associated with weakened shock and delayed shock appearance. The decrease in drag due to the DTE modification is greater than the increase in base drag. The effect of the recirculating flow region on lift increase was also observed. An airfoil with DTE modification achieved the same lift coefficient at a lower angle of attack while giving a lower drag coefficient. Thus, the lift-to-drag ratio increases in transonic flow conditions compared to the original airfoil. The lift coefficient increases considerably whereas the lift slope increases just a little due to DTE modification.

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Determination of Damping Modification Factor in RC Structures Due to Energy Absorption Efficiency (에너지 흡수효율에 의한 철근콘크리트 구조물의 감쇠비 수정계수 결정)

  • 김장훈;좌동훈
    • Proceedings of the Korea Concrete Institute Conference
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    • 2002.10a
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    • pp.161-166
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    • 2002
  • The modification factor( k-factor) of equivalent damping ratio utilized in the current state-of-the-practice to account for the imperfection of reinforced concrete structures in hysteresis loop is investigated. From this, it is found that the current modification factor does not include the effect of cyclic loading, one of the important characteristic properties of earthquake loading. This could be taken into account by considering the energy absorption efficiency based on the cummulative plastic deformation. From the study, it is suggested that the current approach for the modification factor for the equivalent damping ratio should be reformed.

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Surface Modification Method of Stainless Steel using Electrochemical Etching (전기화학적 에칭을 이용한 스테인리스 스틸의 표면 개질)

  • Lee, Chan;Kim, Joonwon
    • Journal of the Korean Society for Precision Engineering
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    • v.31 no.4
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    • pp.353-358
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    • 2014
  • This paper reports a simple, yet effective 1-step surface modification method for stainless steel. Electrochemical etching in dilute Aqua Regia forms hierarchical micro and nanoscale structure on the surface. The surface becomes highly hydrophobic (${\sim}150^{\circ}$) as a result of the etching in terms of static contact angle (CA). However the liquid drops easily pinned on the surface because of high contact angle hysteresis (CAH), which is called a "petal effect": The petal effect occur because of gap between surface microstructures, despite of intrinsic hydrophobicity of the base material. The pore size and period of surface structure can be controlled by applied voltage during the etching. This method can be applied to wide variety of industrial demand for surface modification, while maintaining the advantageous anti-corrosion property of stainless steel.

Inhibitory effects of dl-Puerol A in the root of Sophora japonica on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro

  • Toda, Shizuo;Shirataki, Yoshiaki
    • Advances in Traditional Medicine
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    • v.4 no.3
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    • pp.211-214
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    • 2004
  • The inhibitory effect of dl-puerol A as but-2-enolide isolated from Sophora japonica was investigated on copper ion-induced protein oxidative modification in vitro. It inhibited copper-induced protein oxidative modification. However, its inhibitory effect was a little weaker than that of $dl-{\alpha}-tocopherol$ as an antioxidant. The results demonstrated that dl-puerol A, one of but-2-enolides, might be of use in the oxidative stress.

Effect of Surface Modification of Waste Glass for Fine Aggregate on the Mechanical Properties and Alkali Silica Reaction of Mortar (잔골재용 폐유리의 표면개질이 모르타르의 역학적 특성 및 알칼리 실리카 반응에 미치는 영향)

  • Son, Min-Jae;Kim, Gyu-Yong;Lee, Sang-Kyu;Sasui, Sasui;Eu, Ha-Min;Nam, Jeong-Soo
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2020.11a
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    • pp.23-24
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    • 2020
  • In this study, effect of surface modification of waste glass for fine aggregates on the mechanical properties and alkali silica reaction of mortar was analyzed. As a result, it was confirmed that the incorporation of waste glass fine aggregate decreases the mechanical properties of the mortar and increase the alkali silica reaction expansion. On the other hand, the surface modification of the waste glass fine aggregate is effective in improving this problem. However, unlike green and brown waste glass, it is judged that an additional experiment to determine the cause is necessary for white waste glass where alkali silica reactive expansion occurs extremely.

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