• Journal of Acupuncture Research
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• 제37권1호
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• pp.64-67
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• 2020

The aim of this study was to investigate the efficacy of thread-embedding therapy for the treatment of knee osteoarthritis. There were 20 patients treated with thread-embedding therapy at various acupoints on the muscles around the knee. Gender, age, location, morbidity period, numeric rating scale (NRS), Western Ontario and McMaster Universities (WOMAC) index, improvement result, side effects, and patient's satisfaction were investigated. After the treatment, the NRS score (z = -4.07, p < 0.001) and WOMAC (p < 0.001) indices decreased in most patients. The NRS score decreased by more than 2 points in 95% of the patients. The WOMAC index decreased by 6-12 points. There were no serious side effects, although bruising, pain, and edema were observed. Overall, 85% of the patients felt satisfied with the thread-embedding therapy. These findings suggested that thread-embedding therapy was effective and may be used widely for knee osteoarthritis.

• 동의생리병리학회지
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• 제25권6호
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• pp.1000-1007
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• 2011

This study was conducted to determine the analgesic effect of onion and acanthopanax senticosus mixture extract using the rheumatoid arthritis rat model. Rheumatoid arthritis model was made by the intradermal injection of type II collagen emulsified. Rats were divided into four groups: (1) Sham group(n=5), (2) Control group(administered DW 3 $m{\ell}$/1 day after RA induced, n=7), (3) Experimental group I(administered Onion extractor 600 mg/3 $m{\ell}$/1 day after RA induced, n=7). (4) Experimental group III(administered Onion and Acanthopanax senticosus mixture extractor 600 mg/3 $m{\ell}$/1 day after RA induced, n=7). After that, we examined the arthritic index, paw edema, pain threshold at 1st, 14th, 28th days. And also we examined histopathologic study(safranin-O green), immunohistochamical stain(COX-2) of knee joint at 28th days. Arthritic index, paw edema and pain threshold test were decrease in experimental group I, II than control group. Especially group II was most significantly inhibit effect than the other groups at 28th days. On the histopathologic view, all experimental groups were relieved and reproduced the erosion of arthritic site compared with control group. All experimental groups were COX-2 positive cells in the immunohistological stain of the knee joint were significantly decreased compared with control group. Especially group II was most significantly decreased than the other groups at 28th days. Onion and Acanthopanax senticosus mixture extractor can be used for curing rheumatoid arthritis. Anti-inflammatory effects may be somewhat better in combination of Onion and Acanthopanax senticosus.

• 대한물리의학회지
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• 제11권2호
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• pp.131-139
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• 2016

PURPOSE: The purpose of this study was to confirm the effect of exercise combined with scapular stabilizing on resting scapular position (RSP) in breast cancer-related lymphedema patients. METHODS: A total of 20 patients with lymphedema after mastectomy participated in the study. All assessments of the patients edema sides (ES) and non-edema sides (NES) were evaluated. The assessment tools used wad RSP. RSP are; 1) scapular index, 2) 8th thoracic spines process (T8S) to inferior angle of scapular (IA) distance, 3) standing pectoralis minor (PM) distance, and 4) PM index (PMI). All patients carried out a scapular stabilizing exercise seven times a week for 8 weeks. The collected data were analyzed with PASW 18.0. The statistical significance (${\alpha}$) was 0.05. RESULTS: According to the results, all the variable between the ES and NES for RSP were statistically significant (p<0.05) in the pre-test. After the exercise, the differences in T8S to IA distance and the PMI between the ES and NES weren't statistically significant. The results of the RSP showed a significant improvement in T8S to IA distance, standing PM distance, and PMI. CONCLUSION: The results of this study showed that, performing the scapular stabilizing exercise had a significant effect on improving RPS in breast cancer-related lymphedema patients.

• 한국환경과학회지
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• 제26권2호
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• pp.249-256
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• 2017

In this study, we evaluated the potential of 70% ethanol extract from Persicaria nepalensis (PNE) as a cosmetic ingredient by primary skin irritation, ocular irritation, and maximization tests for delayed hypersensitivity in New Zealand white rabbits and Hartley guinea pig. Skin safety study was performed to evaluate the potential toxicity of PNE using the primary irritation test. In the primary irritation test, 50% PNE was applied to the skin, and no adverse reactions such as erythema and edema were observed at the intact skin sites. Therefore, PNE was classified as a practically non-irritating material based on a primary irritation index of "0.0.". In the ocular irritation test, the 50% PNE applied did not show any adverse reactions in the different parts of rabbit eyes, including the cornea, iris, and conjunctiva. Thus, PNE was classified as a practically non-irritating material based on an acute ocular irritation index of "0.0.". Skin sensitization was tested by the Guinea Pig Maximization Test (GPMT) and Freund's Complete Adjuvant (FCA) using an intradermal injection of 10% PNE. Edema and erythema were not observed 24 and 48 h after the topical application of PNE in skin sensitization test, which exhibited a sensitization score of "0.0.". Therefore, it can be suggested that P. nepalensis could be used as potential candidates for cosmoceutical ingredients, without any major side effects.

• 대한후두음성언어의학회지
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• 제13권1호
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• pp.5-17
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• 2002

Objectives : Videostrobokymography(VSK) has been recently developed and reported by Sung et at. We aimed to analyze vibratory patterns and objective parameters in various benign vocal fold lesions using VSK, and examine the efficacy of VSK in clinical application. Materials and Methods : Using VSK, we analyzed the vibration pattern of normal vocal fold and various benign lesions, such as nodules, polyps, cysts, Reinke's edema and unilateral vocal fold paralysis. We also calculated objective parameters, open quotient and asymmetric index, and compared them with mean values of parameters in normal controls. Results : In nodules, polyps, and cysts, the open quotient on the site of the lesion was similar to the mean value in normal controls, however, on the other part of the vocal folds it was much larger than normal mean value. In Reinke's edema, irregular and asymmetric vibration was observed. The posterior portion of the vocal folds showed larger open quotients than the anterior portion. In the unilateral vocal fold paralysis, irregular vocal folds vibration and incomplete closure of the vocal folds were documented. Much larger asymmetric indices were calculated in the unilateral vocal fold paralysis than in normal controls and other lesions. The asymmetric index could be a good quantitative parameter of vibration from a patient with vocal fold paralysis. Conclusion : This study demonstrated that VSK could generate clear quantitative documentations of fine vibrations of vocal folds in many different benign lesions. VSK has a potential as an effective tool for quantitative analysis of vibratory patterns of the vocal folds iii clinical settings.

• Archives of Pharmacal Research
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• 제21권5호
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• pp.531-536
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• 1998

We had previously reported that the protective effect of taurine against indomethacin-induced gastric mucosal injury was due to its antioxidant effects, which inhibited lipid peroxidation and neutrophil activation. In this study, we examined the effect of taurine on reducing the inflammatory parameters of trintrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease (IBD) in rats. In order to induce IBD, ethanolic TNBS was given to rats intracolonically. Then they received 500 mg/kg.day of taurine orally and were sacrificed one week after IBD induction. While ulceration and inflammation of distal colon with formation of granuloma in the vehicle-treated IBD rats two days after administration of TNBS were observed, treatment with taurine ameliorated colonic damage and decreased the incidence of diarrhea and adhesion. also, colon weight as an index of tissue edema, which was mardedly increased in the IBD rats, became significantly lower after administration of TNBS were observed, treatment with taurine ameliorated colonic damage and decreased the incidence of diarrhea and adhesion. Also colon weitht as an index of tissue edema, which was markedly increased in the IBD rats, became significantly lower after taruine treatment. Myeloperoxidase (MPO) activity in the vehicle-treated IBD rats was substantially increased, compared with that of normal control. the taurine-treated animals significantly reduced MPO activity (35% lower) when compared with that of the vehicle-treated animals. Taurine treatment decreased both basal and formyl-methionyl leucyl phenylalanine-stimulated reactive oxygen generation from colonic tissue in the IBD rats. These results suggest that the administration of taurine reduce the inflammatory parameters in this IBD rat model by increasing defending capacity against oxidative damage.

• 한국전문물리치료학회지
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• 제14권3호
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• pp.1-8
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• 2007

The purpose of this study was to determine whether aromatherapy massages with manual lymph drainage (MLD) are significantly more effective than sham massages with MLD in reducing edematous limb volume in lymphedema. This study was performed on 46 patients who had developed unilateral upper or lower lymphedema. Twenty-three patients served as the experimental group and were treated with complex decongestive physiotherapy (CDP) applications including aroma massages with MLD, multi layered compression bandages, remedial exercises and skin care. Twenty-three patients in the control group were treated with CDP applications including sham massages with MLD, bandages, exercises and skin care. Patients undergo a therapy program once a day; 5 days a week for 2 weeks. Percentage excess volume (PEV) and body mass index (BMI) were recorded before and after treatment. PEV and BMI were significantly decreased before and after treatment in the experimental as well as in the control groups (p<.05). However, the percentage excess volume and BMI were not significantly improved after treatment between the two groups (p>.05). This study there suggests that aroma massages is not effective in the edema of patients with lymphedema.

• 한방안이비인후피부과학회지
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• 제27권1호
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• pp.17-36
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• 2014

Objectives : The purpose of this study is to investigate the efficacy of external preparation containing herbal extract(Sophorae Radix, Aurantii Immaturus Fructus, Schizonepetae Spica, Forsythia fructus and Portulacea Herba) on atopic dermatitis patients. Methods : A total of 33 patients who visited the Dept. of Ophthalmology, Otolaryngology & Dermatology of Korean Medicine of Korean Medical hospital of Daejeon university from February 2012 to February 2013 were engaged in this study. Patients who corresponded the requirements were enrolled in the study. This study shows symptom comparisons before and after the use of this product. Effectiveness was evaluated through SCORAD(SCORing Atopic Dermatitis) Index, and the quality of life scale was conducted through Skindex-29. Results : 1. Comparison of the general changes through SCORAD Index indicated that the experimental group showed more statistically significant declines than the placebo group after the two-week use. 2. Comparison of changes in intensity criteria(Erythema, Edema, Oozing, Excoriation) through SCORAD Index indicated that the experimental group showed more statistically significant declines than the placebo group after the two-week use. 3. Comparison of changes in subjective symptoms through SCORAD Index indicated that the experimental group showed no statistically remarkable changes. 4. Comparison of changes in the body parts(Upperlimb) through SCORAD Index indicated the experimental group showed statistically significant changes after the two-week use. 5. Comparison of the general changes in quality of life through Skindex-29 indicated that the total score from experimental group showed statistically significant changes after the four-week use. Conclusions: This study, evaluated through SCORAD Index, indicated that the treatment with the external preparation containing herbal extract has a statistically marginal significance of efficacy on atopic dermatitis patients in the short term.

• Clinical and Experimental Pediatrics
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• 제49권12호
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• pp.1275-1281
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• 2006

목 적 : 뇌수막염은 뇌와 척수를 둘러싸는 막의 염증으로 여름과 가을에 소아들에 호발하여 합병증이 발생하면 신경학적 후유증을 야기할 수 있는 질환이다. 뇌수막염의 합병증으로 뇌부종이 발생한 경우 증상치료로서 mannitol과 고장성 식염수가 삼투성 이뇨치료로 이용되어진다. 고장성 식염수는 다양한 농도와 투여방법이 있을 수 있는데 본 연구는 고장성 식염수의 가장 효과적이고 안전한 투여 형태에 대해 고찰하였다. 방 법 : 2002년 1월부터 2005년 10월까지 부산의료원 소아과에 입원하였던 뇌수막염환아 283명중 뇌부종이 발생했던 42명의 환아를 대상으로 하였다. 20% mannitol과 4가지 형태의 고장성 식염수로 치료하였던 5가지 투여군을 분석하였다. 증상과 징후의 호전유무, 뇌압측정치, 뇌혈류속도 측정치, 검사소견으로 효과적인 투여형태에 대해 통계적 분석을 하였다. 결 과 : 1) 환아의 평균연령은 5.34세이었으며 남녀 비율은 남아가 22명이고 여아는 20명이었다. 주된 임상양상은 발열(97%), 두통(92%), 구토(71%), 경련(47%), 기면(35%), 경부강직(35%), 복통(35%), 기침(35%), 유두부종(35%), 보챔(28%), 수두증(11%) 순으로 나타났다. 2) 증상 및 징후의 호전유무는 치료 4일째 24명이 상기증상 및 징후의 50%이상의 호전을 나타내었다. 3% 고장성 식염수 농축괴와 3% 고장성 식염수 연속적 농축괴 그리고 7.5% 고장성 식염수 연속적 농축괴의 방법이 효과적인 것으로 분석되었다(P<0.05). 3) 뇌압측정치는 5가지 방법모두 뇌압하강효과가 있는 것으로 나타났다. 3% 고장성 식염수 연속적 농축괴 주입이 뇌압하강치가 1.86 kPa로서 가장 좋은 기록이었지만 통계학적 의미는 없었다(P=0.31). 4) Transcranial doppler에 의한 MFV와 PI 측정에서는 5가지 방법 모두 MFV도의 상승과 PI 하강을 보여주었다. PI와 MFV 상에서는 5가지 방법에서 치료효과의 차이가 없는 것으로 분석할 수 있었다(P=0.59, P=0.99). 5) 치료기간동안 다양한 검사소견을 비교할 수 있는데 나트륨, 염소, 수소이온농도, 젖산, 몰삼투압농도, 칼슘은 차이가 날 수 있는 것으로 관찰되었고(P<0.05), 칼륨, 혈색소, 중탄산염, 염기 과다는 차이가 없는 것으로 분석되었다. 나트륨, 염소, 몰 삼투압농도는 약간 상승되었고 수소이온농도, 젖산, 칼슘은 약간 하강하였으나 큰 변화는 없었다. 결 론 : 뇌수막염에서 뇌압상승, 뇌부종이 발생한 환아의 증상치료로서 고장성 식염수가 다양한 농도와 투입방법이 고려되어 질 수 있다. 본 연구의 결과로는 3% 고장성 식염수 연속적 농축괴의 투여방법이 가장 우수해 보이나 무작위 추출이 아니며 여러 가지 결과를 종합할 때 가장 우수하다고 하기에는 무리가 있었다. 향후 보다 더 많은 집단을 대상으로 한 무작위 추출의 다양하고 종합적인 연구가 필요할 것으로 사료된다.

• 한방재활의학과학회지
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• 제21권1호
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• pp.79-95
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• 2011

Objectives : This study was to investigate the antiarthritic effect of Hwallak-dan(Huoluo-dan) on the complete freund's adjuvant(CFA)-induced arthritis in Lewis rats. Methods : Arthritis was induced by intradermal injection of CFA into base of tail. Experimental groups divided into normal(n=10), control(n=10) and treated(n=10) group. Animals of control group received normal saline for twenty days, treated group received extracts Hwallak-dan(Huoluo-dan) for same duration, light mineral oil only injected non-arthritic rats were served as normal group. The incidence of arthritis and arthritic index were observed after treatment. Body weight, paw edema volume and thickness of ankle joint were measured at 0, 11, 14, 17, 20 days after treatment. White blood cell(WBC) counts in blood were analysed at 20 days after treatment and tumor necrosis $factor-{\alpha}(TNF-{\alpha})$, $interleukin-1{\beta}(IL-1{\beta}$), IL-6 contents in paw exudate were analysed by ELISA at 20 days after treatment. Histopathology on the ankle joint were performed at 20 days after treatment. Results : 1. Incidence of arthritis of treated group was 60% and control group was 100% at 20 days after treatment. 2. Arthritic index of treated group was significantly decreased compared with control group at 20 days after treatment. 3. Paw edema volume and thickness of ankle joint of treated group was significantly decreased compared with control group at 20 days after treatment. 4. Total WBC of treated group was significantly decreased compared with control group at 20 days after treatment. 5. Neutrophils of treated group was significantly decreased compared with control group at 20 days after treatment. 6. $TNF-{\alpha}$ content in paw exudate of treated group was significantly decreased compared with control group at 20 days after treatment. 7. $IL-1{\beta}$ content content in paw exudate of treated group was significantly decreased compared with control group at 20 days after treatment. 8. IL-6 content content in paw exudate of treated group was significantly decreased compared with control group at 20 days after treatment. 9. Histopathological arthritic index of treated group was significantly decreased compared with control group at 20 days after treatment. Conclusions : These results indicate that Hwallak-dan(Huoluo-dan) has inhibitory effect on the development and progression of CFA-induced arthritis in rats.