• 셀메드
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• 제13권6호
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• pp.4.1-4.10
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• 2023

Background and objective: Cervicitis are an inflammatory condition of the cervix. This may be acute, chronic, active & specific or non-specific, which may cause various sign & symptoms. Abnormal vaginal discharge, lower abdominal pain, lower backache, post coital bleeding. If not treated timely it causes various complications viz PID, infertility, endometritis, ectopic pregnancy etc. Hence it has been decided to conduct a clinical trial for its management. Method: This study was an open observational study. The entire patients were allocated by considering the criteria of inclusion & exclusion. Marhame dakhilyun with roghane sausan is given 10 mg as ḥamūl at bed time, after menses for 21 days. All the patients were assessed by primary outcome of abnormal vaginal discharge, lower abdominal pain, lower backache, post coital bleeding & secondary outcomes of vaginal symptoms scale score (VSS) which score the vaginal discharge with QOL in cervicitis patients and vaginal analogue scale (VAS) for pain. Result: In this present study, marked improvement is observed in cervicitis. The mean ± SD of vaginal discharge before & after treatment is 2.57±0.050, 0.33±0.48 respectively which is highly significant with p value of<0.0001^**. VSS score before & after treatment is 21.27±6.12, 7.47±2.48 respectively with p<0.0001^** which is highly significant. VAS score used for LAB & LPA before & after treatment is 6.63±1.09, 1.90±1.29 respectively with p<0.0001^** which is highly significant. Interpretation & Conclusion: The study revealed that the formulation has been found effective in healing congestion, hypertrophied of the cervix and discharge and relieving the others associated symptoms of cervicitis. It is useful and provided immediate and effective treatment for cervicitis. Hence, the trial drug can be recommended for its management.

• Molecules and Cells
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• 제45권3호
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• pp.148-157
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• 2022

Hepatitis C virus (HCV) is a major cause of chronic liver disease and is highly dependent on cellular proteins for viral propagation. Using protein microarray analysis, we identified 90 cellular proteins as HCV nonstructural 5A (NS5A) interacting partners, and selected telomere length regulation protein (TEN1) for further study. TEN1 forms a heterotrimeric complex with CTC and STN1, which is essential for telomere protection and maintenance. Telomere length decreases in patients with active HCV, chronic liver disease, and hepatocellular carcinoma. However, the molecular mechanism of telomere length shortening in HCV-associated disease is largely unknown. In the present study, protein interactions between NS5A and TEN1 were confirmed by immunoprecipitation assays. Silencing of TEN1 reduced both viral RNA and protein expression levels of HCV, while ectopic expression of the siRNA-resistant TEN1 recovered the viral protein level, suggesting that TEN1 was specifically required for HCV propagation. Importantly, we found that TEN1 is re-localized from the nucleus to the cytoplasm in HCV-infected cells. These data suggest that HCV exploits TEN1 to promote viral propagation and that telomere protection is compromised in HCV-infected cells. Overall, our findings provide mechanistic insight into the telomere shortening in HCV-infected cells.

• Journal of Yeungnam Medical Science
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• 제40권2호
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• pp.202-206
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• 2023

Cesarean scar pregnancy (CSP) is a rare complication that occurs in less than 1% of ectopic pregnancies, and uterine didelphys is one of the rarest uterine forms. We report a successful laparoscopic excision and repair of CSP in a woman with uterine didelphys and a double vagina. A 34-year-old gravida one, para one woman with a history of low transverse cesarean section presented to our hospital with a suspected CSP. She was confirmed to have uterine didelphys with a double vagina during an infertility examination 7 years earlier. Magnetic resonance imaging showed a 2.5-cm gestational sac-like cystic lesion in the lower segment of the right uterus at the cesarean scar. We decided to perform a laparoscopic approach after informing the patient of the surgical procedure. The lower segment of the previous cesarean site was excised with monopolar diathermy to minimize bleeding. We identified the gestational sac in the lower segment of the right uterus, which was evacuated using spoon forceps. The myometrium and serosa of the uterus were sutured layer-by-layer using synthetic absorbable sutures. No remnant gestational tissue was visible on follow-up ultrasonography one month after the surgery. This laparoscopic approach to CSP in a woman with uterine didelphys is an effective and safe method of treatment. In women with uterine anomalies, it is important to confirm the exact location of the gestational sac by preoperative imaging for successful surgery.

• 대한영상의학회지
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• 제82권2호
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• pp.481-486
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• 2021

내난관종은 이소성 난관 상피의 비종양적 증식으로 발생한다. 비전형적인 형태로 종괴 형태를 보여 종양성 병변과 감별을 필요로 하는 개화성 낭성 내난관종이 매우 드물게 보고되어 있다. 저자들은 복막 외 골반강과 후복막강에서 다발성으로 발생한 개화성 낭성 내난관종 증례의 영상의학적 소견을 보고하고자 한다.

• 대한소아치과학회지
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• 제50권4호
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• pp.469-482
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• 2023

This study aimed to investigate the treatment options for the delayed eruption of mandibular premolars and identify the predictors of spontaneous eruption using panoramic radiography. The prevalence of delayed mandibular premolar eruption in this retrospective analysis, comprising 254 patients (aged 9 - 15 years), was 5.19%, with no significant difference based on gender. The mandibular second premolars were most affected (4.39%) compared to the first premolars (0.76%). No significant difference in prevalence was observed between the left and right sides. Among the treated mandibular premolars, primary molar-related lesions were identified as the leading cause (7.85%) of delayed tooth eruption. The treatment duration varied based on the Nolla stage, eruption stage, and treatment method. Teeth with Nolla stage 7 or lower had a treatment duration of 22.89 ± 11.96 months, whereas those with stage 8 or higher had a 15.02 ± 6.34 month duration. The deeper the tooth was located in the bone, the longer the treatment period became. The treatment duration varied depending on the treatment method, and statistically, there was no significant difference. The treatment durations for affected mandibular premolars increased with the depth of impaction angle of inclination. In this study, the treatment duration for delayed eruptions varied depending on the Nolla stage, eruption stage, and treatment method. Variations in the impaction depth and inclination angle across various treatment approaches, as explored in this study, might offer valuable insights into the selection of the most suitable management options for delayed tooth eruptions.

• Molecules and Cells
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• 제46권12호
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• pp.746-756
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• 2023

A recent study revealed that the loss of Deup1 expression does not affect either centriole amplification or multicilia formation. Therefore, the deuterosome per se is not a platform for amplification of centrioles. In this study, we examine whether gain-of-function of Deup1 affects the development of multiciliated ependymal cells. Our time-lapse study reveals that deuterosomes with an average diameter of 300 nm have two different fates during ependymal differentiation. In the first instance, deuterosomes are scattered and gradually disappear as cells become multiciliated. In the second instance, deuterosomes self-organize into a larger aggregate, called a deuterosome cluster (DC). Unlike scattered deuterosomes, DCs possess centriole components primarily within their large structure. A characteristic of DC-containing cells is that they tend to become primary ciliated rather than multiciliated. Our in utero electroporation study shows that DCs in ependymal tissue are mostly observed at early postnatal stages, but are scarce at late postnatal stages, suggesting the presence of DC antagonists within the differentiating cells. Importantly, from our bead flow assay, ectopic expression of Deup1 significantly impairs cerebrospinal fluid flow. Furthermore, we show that expression of mouse Deup1 in Xenopus embryos has an inhibitory effect on differentiation of multiciliated cells in the epidermis. Taken together, we conclude that the DC formation of Deup1 in multiciliated cells inhibits production of multiple centrioles.

• Clinical and Experimental Pediatrics
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• 제45권4호
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• pp.466-472
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• 2002

목 적 : Meckel 게실은 장출혈, 장폐색, 감염, 천공등의 합병증에 의한 증상이 나타날 수 있으며 급성 복증을 일으키는 다른 질환과 감별진단이 어렵고 진단이 지연되기 쉽다. 저자들은 Meckel 게실 환자에서 임상증상과 조직학적 소견을 비교하여 신속히 진단하고 치료하는데 도움이 되고자 하였다. 방 법 : 1993년 10월부터 2001년 8월까지 이화의료원에서 진단한 Meckel 게실 10례의 의무기록을 후향적으로 조사하여 임상증상과 조직학적 소견 등을 분석하였다. 결 과 : 1) 환자의 연령은 7일-14세의 분포를 보였고, 6세 이전(60%)이 많았다. 남녀비는 2.3 : 1로 남아에서 많았다. 2) 주요증상은 무통성 하부 장출혈, 복통, 복부 팽만, 구토 순이었고 나이가 많을수록 증상이 심하였다. 3) 수술 전에 Meckel 게실로 진단되거나 의심되어 수술 한 경우 5례, 초음파 유도하 수압으로 정복되지 않은 장중첩증(3례)과 장폐색(2례)으로 수술하여 발견된 경우 5례이었다. 4) Meckel 스캔($^{99m}Tc-pertechnetate$)은 cimetidine을 투여한 후 6례에서 시행되었으며, 이소성 위점막이 있었던 5례 중 4례에서 양성, 1례 위음성, 이소성 위점막이 없었던 1례에서 음성이었다. 5) Meckel 게실은 회맹판으로부터 35-70 cm 상부에 있었고, 길이는 4-12 cm이었으며 이중 80%가 5cm 미만이었다. 6) 하부 장출혈이 있었던 5례 모두에서 이소성 위점막이 발견되었고, 그 외의 조직학적 소견은 염증 3례, 궤양 3례, 천공 1례, 출혈 3례, 경색 1례이었다. 결 론 : Meckel 게실은 출혈량이 적거나 증상이 경미한 환자에서 신속히 진단하게 되면 출혈이나 수혈의 빈도를 줄일 수 있으며 회복도 빠르므로, Meckel 게실을 염두에 두고 조영술이나 내시경에 우선하여 Meckel 스캔을 시행하는 것이 좋다. 이소성 위점막이 없는 Meckel 게실에서는 Meckel 스캔이 음성이므로 임상적으로 의심될 때에는 복강경, 컴퓨터 단층촬영, 고해상도 초음파촬영 등의 다양한 진단법이 시도되어야 할 것이다.

• 대한소아치과학회지
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• 제37권1호
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• pp.117-123
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• 2010

치아 맹출이란 치아가 치조골 내의 발생 장소에서부터 교합면쪽으로 이동하여 구강 내로 출현한 후 치아의 기능적 위치까지 이동하는 것을 말한다. 유치의 치근부에서 발육하는 영구치배는 천천히 유치의 치근과 지지하는 치조골 부위를 흡수하면서 맹출하고, 이와 동시에 영구 치배의 치근과 치조골 및 기저골을 성장시킴으로써 영구치의 지지부위가 확립된다. 대개 영구전치의 치배는 유전치의 치근단 설측에 위치하는데 잘 발달된 도대삭(gubernacular cord)을 따라서 교합면상으로 맹출하게 된다. 이소 맹출이란 일반적으로 치배가 본래 발생 위치에서부터 예상되는 정상 맹출경로에 이상이 있는 것을 말한다. 즉, 치아가 치조골 내 발생 위치에서 예측되는 정상맹출 경로를 벗어나 맹출하는 것이다. 그 중 하악 측절치의 이소 맹출의 경우 치아의 위치를 바로잡는데 있어서, 그 치료 시기가 중요한 요소로 여겨지는데 일반적으로 혼합치열기 초기가 바람직한 치료시기이다. 하악전치가 이소 맹출한 경우 적절한 시기에 치료를 시행함으로써 공간 소실의 문제나 하악 전치부의 설측경사 등의 문제가 발생하는 것을 예방할 수 있다. 본 증례는 만 8세 여아에서 혀 아래쪽의 구강저 부근에 수평방향으로 이소 맹출하는 하악 우측 측절치를 주소로 연세대학교 치과대학병원 소아치과에 내원하였다. 컴퓨터 단층촬영(CT)을 이용하여 문제 치아의 치근 만곡 정도를 확인한 후, 혼합 치열기 초기에 lip bumper와 buccal arch를 이용하여 26주간 적극적인 견인적 처치를 시행하였다. 결과적으로 이소 맹출한 측절치를 본래 위치로 이동시켰으며 나머지 영구치의 맹출에 대한 관찰 및 평가 후 전반적인 교정치료를 진행하기로 계획하였다.

• Clinical and Experimental Reproductive Medicine
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• 제27권4호
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• pp.353-357
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• 2000

Objective: Extrauterine formation of decidua of stromal cells has been well described, particularly in the cervix and ovary. The apparent hormonal mechanisn of this phenomenon suggestes a relationship to endometriosis. Whether formation of ectopic decidua represents a marked progestational response of endometriosis or an independent peritoneal-stromal reaction to pregnancy is unclear. This study was designed to determine the prevalence of deciduosis in the patients whose fertility were proven. Design: Prospective study of patients who had undergone cesarean delivery without history of endometriosis. Materials and Methods: The study was performed in 179 full tenn pregnant women. During the cesarean section, the pelvic organs were thoroughly investigated and the biopsies were collected at the lesions suspicious endometriosis. And then microscopic examination of removed tissues were done. Results: Of the 179 patients who underwent cesarean delivery, 48 women (26.8%) had the lesions suspicious endometriosis such as adhesion, pigmented spots. The ovary was the most frequently ocurred site (79.2%). Microscopically, decidual cells were observed in 34 cases (70.8%) of 48 biopsed patients. Conclusion: Endometriosis has been known to be associated with subfertility. Our observations found the prevalence of deciduosis was 19.0% (34/179) in tenn pregnant women whose fertilites were proven. We suggests that the deciduosis maya manifestation of endometriosis during pregnancy. However, further follow up study should be done to confirm this clinicopathologic process.

• Clinical and Experimental Reproductive Medicine
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• 제12권1호
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• pp.47-70
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• 1985

This study was presented of the 1,872 cases of infertile couples who visited and examined at the sterility clinic of Department of Obstetrics & Gynecology, Seoul National University Hospital from Sept., 1980 to Dec., 1983. Age, duration of infertility, past medical history, and other general factors were analyzed, and the factors responsible for infertility were classified and discussed. Mode of treatment, outcome of pregnancy, pregnancy rate responsible for each factor were also presented. The results were as follows: 1) The infertility was primary in 1,128, or 60.3% and secondary in 744, or 39.7%. 2) The age between 26 and 30 years of age comprised about one half of the total patients. 3) The duration of infertility between 1 and 4 years comprised about three quarters of the total patients, and the mean duration was 3.8 years. 4) The most common medical history in primary infertility was tuberculous disease, and that in secondary infertility was history of previous laparotomy. 5) About two thirds of antecedent pregnancies were abortion. 6) The major etiologic factor of infertility were male factor in 12.3%, tubal factor in 38.8%, ovulatory failure in 25.4%, uterine factor in 8.8%, cervical factor in 5.2%, peritoneal factor in 9.5%, and no demonstrable cause in 11.3%. 7) The types of male factor were azoospermia in 61.6%, oligospermia in 25.8%, low motility in 11.6%, and other abnormality in 1.0%. 8) The types of ovulatory failure were ovarian failure in 7.4%, hypothalamo-pituitary failure in 8.1 %, hypothalamo-pituitary dysfunction (including Polycystic ovarian syndrome) in 30.2%, and hyperprolactinemia in 22.4%. 9) The types of uterine factor were endometrial tuberculosis in 27.5%, uterine synechia in 33.8%, uterine anomaly in 19.7%, myoma and polyp in 9.1 %, and luteal phase defect in 9.9%. 10) The types of peritoneal factor were pelvic adhesion in 80.9% and endometriosis in 19.6%. 11) Surgeries were done in 408 patients, and they were salpingolysis, lysis of extraadnexal adhesion, salpingostomy, fimbrioplasty, ovarian wedge resection for polycystic ovarian disease, tubo-tubal anastomosis, and tubo-uterine implantation in orders. 12) 243 pregnancies were achieved during the infertility work-up, of which livebirth was 46.5%, ectopic pregnancy was 7.4%, spontaneous abortion was 7.8%, and on-going pregnancy or lost to follow-up was 36.2%. 13) Pregnancy rates in various factors were male factor in 18.7%, ovulatory factor in 31.7%, tubal factor in 24.2%, uterine factor in 34.6%, cervical factor in 19.0%, peritoneal factor in 29.0%, combined factors in 10.5%, and unexplained infertility in 37.1%. Pregnancy rate in whole patients was 25.2%.