• 대기
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• 제28권1호
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• pp.37-51
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• 2018

In this study, we investigate the performance of Global Seasonal Forecasting System version 5 (GloSea5) in Korea Meteorological Administration on the relationship between El $Ni{\tilde{n}}o$ and East Asian climate for the period of 1991~2010. It is found that the GloSea5 has a great prediction skill of El $Ni{\tilde{n}}o$ whose anomaly correlation coefficients of $Ni{\tilde{n}}o$ indices are over 0.96 during winter. The eastern Pacific (EP) El $Ni{\tilde{n}}o$ and the central Pacific (CP) El $Ni{\tilde{n}}o$ are considered and we analyze for EP El $Ni{\tilde{n}}o$, which is well simulated in GloSea5. The analysis period is divided into the developing phase of El $Ni{\tilde{n}}o$ summer (JJA(0)), mature phase of El $Ni{\tilde{n}}o$ winter (D(0)JF(1)), and decaying phase of El $Ni{\tilde{n}}o$ summer (JJA(1)). The GloSea5 simulates the relationship between precipitation and temperature in East Asia and the prediction skill for the East Asian precipitation and temperature varies depending on the El $Ni{\tilde{n}}o$ phase. While the precipitation and temperature are simulated well over the equatorial western Pacific region, there are biases in mid-latitude region during the JJA(0) and JJA(1). Because the low level pressure, wind, and vertical stream function are simulated weakly toward mid-latitude region, though they are similar with observation in low-latitude region. During the D(0)JF(1), the precipitation and temperature patterns analogize with observation in most regions, but there is temperature bias in inland over East Asia. The reason is that the GloSea5 poorly predicts the weakening of Siberian high, even though the shift of Aleutian low is predicted. Overall, the predictability of precipitation and temperature related to El $Ni{\tilde{n}}o$ in the GloSea5 is considered to be better in D(0)JF(1) than JJA(0) and JJA(1) and better in ocean than in inland region.

• East Asian Economic Review
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• 제23권3호
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• pp.285-309
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• 2019

Unlike the popular belief, digital transformation mainly gets stymied by legal and regulatory issues related with legacy institutions in Asia rather than technical difficulties. The real challenges triggered by the PSD2 (Payment Services Directive 2) are how the region would overcome the overly fragmented, centralized, and hierarchical legacy framework to allow necessary changes to respond to the digital single market initiatives as promulgated by the European counterpart. The PSD2 is expected to bring about substantial changes in the payment ecosystem by allowing payment service providers to access customers' accounts and transactions information via API that have been traditionally controlled by banks. This paper suggests an incentive-compatible mechanism design for open collaboration among legacy institutions in the region to help them adapt to the PSD2. As evidenced by case studies in Korea, the Asian equivalent of PSD2 can be implemented and further expanded to create region-wide PCS (payment-clearing-settlement) network by reconnecting the dots of legacy infrastructures. These decentralized, diverse, small payment networks can be further combined with the expanded RTGS-CDS platform to evolve into the next phase of Asian Financial Network.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9955-9960
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• 2014

Background: Promoter hypermethylation is a common event in human cancer. O6-methylguanine-DNA methyltransferase (MGMT) is a gene involved in DNA repair, which is methylated in a variety of cancers. We aimed to explore the methylation status of MGMT gene among the North Eastern population where esophageal cancer incidence and exposure to carcinogens like nitrosamines is high. Materials and Methods: A total of 100 newly diagnosed esophageal cancer cases along with equal number of age, sex and ethnicity matched controls were included in this study. Methylation specific PCR was used to determine the MGMT methylation status in serum samples. Results: Aberrant promoter methylation of the MGMT gene was detected in 70% of esophageal cancer cases. Hypermethylation of MGMT gene was found to be influenced by environmental factors like betel quid and tobacco which contain potent carcinogens like nitrosamines. Tobacco chewing and tobacco smoking habit synergistically with MGMT methylation elevated the risk for esophageal cancer development [adjusted OR=5.02, 95% CI=1.35-18.74; p=0.010 for tobacco chewing and Adjusted OR=3.00, 95% CI=1.22-7.36; p=0.014 for tobacco smoking]. Conclusions: Results suggest that the DNA hypermethylation of MGMT is an important mechanism for MGMT gene silencing resulting in esophageal cancer development and is influenced by the environmental factors. Thus MGMT hypermethylation can be used as a biomarker for esophageal cancer in high incidence region of North East India.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10653-10658
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• 2015

Background: A very high incidence of lung cancer is observed in Mizoram and Manipur, North East India. We conducted a population based case control study to establish associations of p53 codon 72 polymorphisms and interactions with environmental factors for this high incidence. Material and Methods: A total of 272 lung cancer cases and 544 controls matched for age (${\pm}5years$), sex and ethnicity were collected and p53 codon 72 polymorphism genotypes were analyzed using a polymerase chain based restriction fragment length polymorphism assay. We used conditional multiple logistic regression analysis to calculate adjusted odds ratios and 95% confidence intervals after adjusting for confounding factors. Results: p53 Pro/Pro genotype was significantly associated with increased risk of lung cancer in the study population (adjusted OR=2.14, CI=1.35-3.38, p=0.001). Interactions of the p53 Pro/Pro genotype with exposure to wood smoke (adjusted OR=3.60, CI=1.85-6.98, p<0.001) and cooking oil fumes (adjusted OR=3.27, CI=1.55-6.87, p=0.002), betel quid chewing (adjusted OR=3.85, CI=1.96-7.55, p<0.001), tobacco smoking (adjusted OR=4.42, CI=2.27-8.63, p<0.001) and alcohol consumption (adjusted OR=3.31, CI=1.10-10.03, p=0.034) were significant regarding the increased risk of lung cancer in the study population. Conclusions: The present study provided preliminary evidence that a p53 codon 72 polymorphism may effect lung cancer risk in the study population, interacting synergistically with environmental factors.

• 한국군사과학기술학회지
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• 제12권4호
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• pp.415-423
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• 2009

To investigate low frequency acoustic transmissions in the Sub-Polar Front(SPF) of the East Sea, numerical experiments are conducted with Range dependent Acoustic Model(RAM) using Circulation Research of the East Asian Marginal Seas(CREAMS) data and Autonomous Profiling Explorer(APEX)) data. Significant seasonal variations of sea water properties are existed across the Sub-Polar Front(SPF) region from the north and the south. The model results show that Transmission Loss(TL) decrease(about 20dB) with ideal front in the warm region whereas TL increase(about 25dB) with ideal front in the cold region. Regardless of season(both in summer and winter), when the sound source is located in the cold region of the SPF, the model results show weak TL, compared to the case of the source in the warm region(Maximum difference of TL reaches 28dB). This difference between the cases when the source is located in the cold region and the warm region, is accounted for from the different vertical profiles of sound speed in both regions.

• East Asian Economic Review
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• 제22권1호
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• pp.55-73
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• 2018

The substantial slowdown of economic growth since the global financial crisis of 2008-2009 is rekindling debate on whether developing Asia should use fiscal expansion to boost aggregate demand. A key factor in the debate is the effectiveness of countercyclical fiscal policy in the region. The global crisis, as well as the fiscal stimulus packages implemented by developing Asian countries at that time, give some clues to this important issue. The region weathered the global crisis well and experienced a robust V-shaped recovery. According to conventional wisdom, the fiscal stimulus packages put in place by Asian governments played a key role in the region's recovery. The central objective of this paper is to empirically test this wisdom by using cross-country panel data. Our main finding is that the stimulus has had a limited but positive impact on developing Asia's output during the global crisis. This lends some support to the notion that countercyclical fiscal policy can help the region cope with severe external shocks. The broader, more fundamental implication for regional policymakers is that the region's long-standing commitment to fiscal discipline can yield significant benefits beyond macroeconomic stability. An important consequence of this commitment - relatively healthy fiscal balance sheets - enabled the region's governments to quickly and decisively embark upon fiscal stimulus programs.

• 한국지구과학회지
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• 제40권1호
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• pp.1-8
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• 2019

Although recent reports suggest that the negative correlation between the Arctic Oscillation (AO) and the East Asian winter monsoon (EAWM) has been strengthened, it is not clear whether this intermittent relationship is an intrinsic oscillation in the climate system. We investigate the oscillating behavior of the AO-EAWM relationship at decadal time scales using the long-term (500-yr) climate model simulation. The results show that ice cover over the East Siberian Seas is responsible for the change in the coupling strength between AO and EAWM. We found that increased ice cover over these seas strengthens the AO-EAWM linkage, subsequently enhancing cold advection over the East Asia due to anomalous northerly flow via a weakened jet stream. Thus, this strengthened relationship favors more frequent occurrences of cold surges in the EAWM region. Results also indicate that the oscillating relationship between AO and EAWM is a natural variability without anthropogenic drivers, which may help us understand the AO-EAWM linkage under climate change.

• 동아시아식생활학회지
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• 제4권1호
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• pp.19-29
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• 1994

In this paper a review of literature on Nuruk(yeast) between 1907 and 1945 was made, which showed that barley, rice bran, oat, rye, and other ingredients were originally used according to region and production quantity. Yeast can be classified into rough (Chokuk) and powder (Bunkuk) types depending on the degree of grinding. Yeast also had seasonal names, being called " Choonkuk", Hakuk", Jeolkuk", and "Dongkuk" in the spring, summer, autumn and wither respectively. The form of yeast in terms of quantity, size, and shape varied greatly by region, Production facilities were composed of plant structures to suit each process, enabling continuous output. The production process included shaping, placement in the fermenting chamber, piling by turns, risk-sifting and final output. Testing procudures were divided into visual inspection, physical testing, and chemical analyses.

• Journal of East-Asian Urban History
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• 제2권2호
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• pp.309-339
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• 2020

Obviously the speed of dissemination of new, modern ideas in Jiangnan was closely related to the development of transportation. Looking back at the history, the backwardness of transportation in the early modern Jiangnan restrict the dissemination of new ideas in this region and then the situation changed a lot since the 1890s, when the spatial distance between Shanghai and Jiangnan was remarkably shortened, the dissemination of new ideas was accelerated, and the new ideas in return significantly influenced the Jiangnan society. It was the constantly improved transportation that facilitated the diversification of channels disseminating information and made the dissemination itself faster. As a consequence, the new ideas, knowledge, and things were rapidly disseminated and popularized in Jiangnan, thereby giving impetus to the social changes in this region.

• 생명과학회지
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• 제15권6호
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• pp.904-908
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• 2005

최근에 발표된 연구 결과에 의하면 pylori CagA내에 존재하는 SHP-2 binding site의 아미노산 서열을 분석한 후, 특정 서열이 위선암의 발병과 연관되어 있다고 보고하였다. 그러나 한국인을 대상으로 CagA 내 에 존재하는 SHP-2 binding site아미노산 서열의 특성을 밝힌 연구는 없다. 따라서 본 연구는 한국인에서 획득한 H. pylori의 CagA SHP-2 binding site에 대해 아미노산 서열을 분석하여 그 특성을 알아보고자 하였다. 총 62 균주의 H. pylori 를 분석한 결과 환자의 질환과 관계없이 모든 H. pylori 균주에서 East Asian (A-B상 혹은 A-B-B-D)을 보여주었다. 일본과 더불어 한국은 위선암 유병률이 높은 나라이므로, 연구 대상의 모든 한국인에서 East Asian type CagA를 가진 H. pylori가 발견된 것이 위선암 유병률과 연관될 가능이 높아 보인다. 그러나 H. pylori의 발병 기전을 보다 더 명확히 이해하기 위해서는 보다 많은 국가와 지역을 대상으로 이러한 유전형 조사가 필요할 것 같다.