• BMB Reports
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• v.42 no.1
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• pp.6-15
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• 2009

The most common genetic disorder Down syndrome (DS) displays various developmental defects including mental retardation, learning and memory deficit, the early onset of Alzheimer's disease (AD), congenital heart disease, and craniofacial abnormalities. Those characteristics result from the extra-genes located in the specific region called 'Down syndrome critical region (DSCR)' in human chromosome 21. In this review, we summarized the recent findings of the DYRK1A and RCAN1 genes, which are located on DSCR and thought to be closely associated with the typical features of DS patients, and their implication to the pathogenesis of neural defects in DS. DYRK1A phosphorylates several transcriptional factors, such as CREB and NFAT, endocytic complex proteins, and AD-linked gene products. Meanwhile, RCAN1 is an endogenous inhibitor of calcineurin A, and its unbalanced activity is thought to cause major neuronal and/or non-neuronal malfunction in DS and AD. Interestingly, they both contribute to the learning and memory deficit, altered synaptic plasticity, impaired cell cycle regulation, and AD-like neuropathology in DS. By understanding their biochemical, functional and physiological roles, we hope to get important molecular basis of DS pathology, which would consequently lead to the basis to develop the possible therapeutic tools for the neural defects in DS.

• BMB Reports
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• v.49 no.8
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• pp.431-436
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• 2016

Human papillomavirus (HPV) is the major cause of cervical cancer, a deadly threat to millions of females. The early oncogene product (E7) of the high-risk HPV16 is the primary agent associated with HPV-related cervical cancers. In order to understand how E7 contributes to the transforming activity, we investigated the structural features of the flexible N-terminal region (46 residues) of E7 by carrying out N-15 heteronuclear NMR experiments and replica exchange molecular dynamics simulations. Several NMR parameters as well as simulation ensemble structures indicate that this intrinsically disordered region of E7 contains two transient (10-20% populated) helical pre-structured motifs that overlap with important target binding moieties such as an E2F-mimic motif and a pRb-binding LXCXE segment. Presence of such target-binding motifs in HPV16 E7 provides a reasonable explanation for its promiscuous target-binding behavior associated with its transforming activity.

• Parasites, Hosts and Diseases
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• v.56 no.4
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• pp.313-324
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• 2018

This article reviews Leptotrombidium deliense, including its discovery and nomenclature, morphological features and identification, life cycle, ecology, relationship with diseases, chromosomes and artificial cultivation. The first record of L. deliense was early in 1922 by Walch. Under the genus Leptotrombidium, there are many sibling species similar to L. deliense, which makes it difficult to differentiate L. deliense from another sibling chigger mites, for example, L. rubellum. The life cycle of the mite (L. deliense) includes 7 stages: egg, deutovum (or prelarva), larva, nymphochrysalis, nymph, imagochrysalis and adult. The mite has a wide geographical distribution with low host specificity, and it often appears in different regions and habitats and on many species of hosts. As a vector species of chigger mite, L. deliense is of great importance in transmitting scrub typhus (tsutsugamushi disease) in many parts of the world, especially in tropical regions of Southeast Asia. The seasonal fluctuation of the mite population varies in different geographical regions. The mite has been successfully cultured in the laboratory, facilitating research on its chromosomes, biochemistry and molecular biology.

• Fire Science and Engineering
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• v.22 no.4
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• pp.27-32
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• 2008

In this paper, a flame and smoke detection algorithm is proposed to recognize a fire. Flame and smoke have specific color distribution and continuously change shapes of them. In the proposed flame detection algorithm, specific regions are candidated as flame by color distributions and variations of frames of video. Some of candidated regions are decided as flame by the magnitude of motion vector. To determine smoke in the field of view of camera, edge is important because high frequency component is decreased by it. Candidated region of smoke is assigned by color distributions, inter-frame differences and the value of edge. The candidated region is settled as smoke region with magnitude of motion vector. As results of simulations, it is shown that the proposed algorithm is useful for flame and smoke detection.

• Proceedings of the Korea Contents Association Conference
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• 2005.11a
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• pp.257-263
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• 2005

If baby disease not treats at early, case that cause problem in health hereafter much exists. Specially, because baby expresses own inexpedience by crying, parents or practitioner's is not apt to grasp. Therefore, In this paper, I wish to develop system for analyze if disease is in some region to analyze face and baby cry that organism signal appears intensive for baby disease diagnosis. In this paper, I wish to propose methodology that analyze organism signal that appear in face of whole baby organism signal analysis system. For this, I necessary region binary input baby face picture and to draw necessary five sensory organ and Myungdang region in baby disease diagnosis. Finally, the usefulness of this paper is verified by several experiments.

• Journal of The Korean Astronomical Society
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• v.34 no.2
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• pp.59-66
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• 2001

In this paper, we investigate the correlation between the radial ultraviolet color distribution and the shapes of the ultraviolet isophote for elliptical galaxies (M32, NGC 1399) and spiral bulges (of M31, M81) by using their archival UIT images. For M31, M81, and NGC 1399, the radial ultraviolet color distributions show a two-component trend; as the distance from the galactic center increase the color becomes redder in the inner region while it becomes bluer in the outer region. On the other hand, the color of M32 continues to become bluer with the increasing galactocentric distance. We also find, unlike the optical/IR images, significant variations of the position angle and the ellipticity in the ultraviolet isophotes of M31, M81, and NGC 1399 through the inner regions. For M32, the variation is significant in the outer region. Since these variation implies the triaxiality of their intrinsic shapes, we suggest that the early-type galaxies and spiral bulges with a radial color gradient in ultraviolet tend to have a triaxiality. On the other hand, the shape parameter characterized by the fourth order cosine Fourier coefficient of the isophote, a(4)/a, indicates that the systematic deviations of the ultraviolet isophotes of the four galaxies are smaller than $\~0.2\%$ in units of the semi-major axis. The latter result implies that the ultraviolet isophotes of the galaxies have a pure elliptical shape rather than the boxy or disky shapes. Therefore, there is no clear evidence of correlation between the radial ultra-violet color gradient and the boxy/disky shapes of isophotes.

• Journal of The Korean Astronomical Society
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• v.14 no.1
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• pp.13-17
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• 1981

The observed radial UBV colour variations (both B-V and U-B) of some globular clusters are examined for correlations with radial variations in the integrated spectra. The results show that the presence of a radial colour gradient is correlated with the presence of a gradient of the CN (and possibly the G-band) line strength, in the sense that the CN (and possibly the G-band) is stronger in the centre (where the cluster is redder) and becomes weaker in the outer region of the cluster (where the cluster is bluer). This may suggest that a primordial abundance, possibly nitrogen and carbon gradient was set up in the early stage of cluster formation.

• Proceedings of the Korean Society of Crop Science Conference
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• 1989.02a
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• pp.32-33
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• 1989

• Fisheries and Aquatic Sciences
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• v.4 no.3
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• pp.101-111
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• 2001

In an attempt to demonstrate the seasonal variation of the Ulleung Warm Eddy (UWE), in which the UWE changes its shape from a warm core ring in early spring to a warm lens in late summer under the effect of surrounding East Korean Warm Current (EKWC) Water, a simple geostrophic adjustment model is considered. Model results indicate that the buoyancy increase of the EKWC Water and the strengthening of the EKWC towards summer, both of which are typical of this region, are the major factors governing the seasonal variation of the UWE.

• Journal of the Korean housing association
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• v.6 no.2
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• pp.171-180
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• 1995

This paper tries to define the characteristics of windows frame built in the end of Koryu dynasty to the early period of Chosun dynasty. The windows frame is found both in temples and in Maeng's house. It is thus proved that the frame was a general one prevailed in that time without regard to function and region. And it proves to be the original form of windows frame of temples and houses in the middle or the end of Chosun dynasty.