• Journal of Korean Foot and Ankle Society
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• v.22 no.2
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• pp.78-81
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• 2018

This paper presents a case of an early malignant transformation of untreated ulcers in a patient with diabetes. This case shows that Marjolin's ulcer can occur not only after chronic injury, but can also develop in the early stages after the onset. Hence, an early biopsy for diabetic foot ulcers that fail to heal with acute treatment can enable an earlier diagnosis and treatment without amputation, resulting in a better quality of life for the patient.

• Journal of the Korean Professional Engineers Association
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• v.44 no.2
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• pp.43-45
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• 2011

Somalian pirates with the onset of civil war in the early 1990s have caused a threat to international transportation. Various international organizations including the International Maritime Organization and the World Food Program are concerned about this problem. The cost of shipping is increasing and food-aid shipment is hindered by these ships are needed military escort. Since 2008, international society has deployed multinational naval vessel in the nearby Somalian sea and strengthen multinational naval operations to minimize damages from piracy.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.17 no.2
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• pp.89-97
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• 2006

The stop consonants in Korean are classified into three types according to the manner of articulation as unaspirated (UA), slightly aspirated (SA) and heavily aspirated (HA) stops. Both the UA and the HA types are always voiceless in any environment. Generally, the voice onset time (VOT) could be measured spectrographically from release of consonant burst to onset of following vowel. The VOT of the UA type is within 20 msec of the burst, and about 40-50 msec in the SA and 50-70 msec in the HA. There have been many efforts to clarify properties that differentiate these manner categories. Umeda, et $al^{1)}$ studied that the fundamental frequency at voice onset after both the UA and HA consonants was higher than that for the SA consonants, and the voice onset times were longest in the HA followed by the SA and UA. Han, et $al^{2)}$ reported in their speech synthesis and perception studies that the SA and UA stops differed primarily in terms of a gradual versus a relatively rapid intensity build-up of the following vowel after the stop release. Lee, et $al^{3)}$ measured both the intraoral and subglottal air pressure that the subglottal pressure was higher for the HA stop than for the other two stops. They also compared the dynamic pattern of the subglottal pressure slope for the three categories and found that the HA stop showed the most rapid increase in subglottal pressure in the time period immediately before the stop release. $Kagaya^{4)}$ reported fiberscopic and acoustic studies of the Korean stops. He mentioned that the UA type may be characterized by a completely adducted state of the vocal folds, stiffened vocal folds and the abrupt decreasing of the stiffness near the voice onset, while the HA type may be characterized by an extensively abducted state of the vocal folds and a heightened subglottal pressure. On the other hand, none of these positive gestures are observed for the SA type. Hong, et $al^{5)}$ studied electromyographic activity of the thyroarytenoid and posterior cricoarytenoid (PCA) muscles during stop production. He reported a marked and early activation of the PCA muscle associated with a steep reactivation of the thyroarytenoid muscle before voice onset in the production of the HA consonants. For the production of the UA consonants, little or no activation of the PCA muscle and earliest and most marked reactivation of the thyroarytenoid muscle were characteristic. For the SA consonants, he reported a more moderate activation of the PCA muscle than for the UA consonant, and the least and the latest reactivation of the thyroarytenoid muscle. Hong, et $al^{6)}$ studied the observation of the vibratory movements of vocal fold edges in terms of laryngeal gestures according to the different types of stop consonants. The movements of vocal fold edges were evaluated using high speed digital images. EGG signals and acoustic waveforms were also evaluated and related to the vibratory movements of vocal fold edges during stop production.

• Development and Reproduction
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• v.13 no.3
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• pp.183-190
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• 2009

In mammals, puberty is a dynamic transition process from infertile immature state to fertile adult state. The neuroendocrine aspect of puberty is started with functional activation of hypothalamus-pituitary-gonadal hormone axis. The timing of puberty can be altered by many factors including hormones and/or hormone-like materials, social cues and metabolic signals. For a long time, attainment of a particular body weight or percentage of body fat has been thought as crucial determinant of puberty onset. However, the precise effect of high-fat (HF) diet on the regulation of hypothalamic GnRH neuron during prepubertal period has not been fully elucidated yet. The present study was undertaken to test the effect of a HF diet on the puberty onset and hypothalamic gene expressions in immature female rats. The HF diet (45% energy from fat, HF group) was applied to female rats from weaning to around puberty onset (postnatal days, PND 22-40). Body weight and vaginal opening (VO) were checked daily during the entire feeding period. In the second experiment, all animals were sacrificed on PND 36 to measure the weights of reproductive tissues. Histological studies were performed to assess the effect of HF diet feeding on the structural alterations in the reproductive tissues. To determine the transcriptional changes of reproductive hormone-related genes in hypothalamus, total RNAs were extracted and applied to the semi-quantitative reverse transcription polymerase chain reaction (RT-PCR). Body weights of HF group animals tend to be higher than those of control animals between PND 22 and PND 31, and significant differences were observed PND 32, PND 34, PND 35 and PND 36 (p<0.05). Advanced VO was shown in the HF group (PND $32.8{\pm}0.37$ p<0.001) compared to the control (PND $38.25{\pm}0.25$). The weight of ovaries (p<0.01) and uteri (p<0.05) from HF group animals significantly increased when compared to those from control animals. Corpora lutea were observed in the ovaries from the HF group animals but not in control ovaries. Similarly, hypertrophy of luminal and glandular uterine epithelia was found only in the HF group animals. In the semi-quantitative RT-PCR studies, the transcriptional activities of KiSS-1 in HF group animals were significantly higher than those from the control animals (p<0.001). Likewise, the mRNA levels of GnRH (p<0.05) were significantly elevated in HF group animals. The present study indicated that the feeding HF diet during the post-weaning period activates the upstream modulators of gonadotropin such as GnRH and KiSS-1 in hypothalamus, resulting early onset of puberty in immature female rats.

• Journal of the Korean Geographical Society
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• v.41 no.4 s.115
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• pp.435-456
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• 2006

This study examines the long-term spatial patterns and recent trends of seasonal onsets and durations defined by daily temperatures in South Korea for the period 1973-2004. Spatially, spring and winter onset dates show approximately 44 day and 63 day maximum difference respectively between south and north (Seongsanpo to Daegwallryeong) attributable to the impacts of latitudes and altitudes. In contrast, summer onset, which is more affected by proximity to oceans and altitudes than by latitudes, begins earlier in interior low elevated areas than in the coastal areas but earliest at higher latitudes than Jeiu Island. Five climatic types regarding the seasonal cycles in South Korea are spatially clustered according to the combination of longer seasonal durations. As a reflection of recent climate changes on seasonal cycles in South Korea, winter duration was shortened by 10 days during the post-1988 period due to a late winter onset of 4 days and an early spring onset of 6 days. The winter reduction began in the southern regions of the Korean Peninsula in the mid-1980s and spread northward during the 1990s period, ultimately appearing everywhere. In urbanized cities, where much of the surface is covered with asphalt or concrete, the winter reduction was intensified and summer duration was locally incremented. The reduced winter duration in recent decades shows significant teleconnections with variations of geopotential height (925hPa) in the eastern Arctic region ($0-90^{\circ}E$, $65-85^{\circ}N$) during the cold season. The reduction in winter duration in South Korea agrees with results in overall global warming trends as a climate change signal.

• Journal of the Korean Geographical Society
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• v.28 no.2
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• pp.112-122
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• 1993

Since more than 50${\%}$ of annual precipitation in Korea falls during Changma, the rainy season of early summer, and Late Changma, the rainy season of late summer, forcasting the onset days Changmas, and the amount related rainfalls would be necessary not only for agriculture but also for flood-control. In this study the authors attempted to build a prediction model for the forecast of the onset date of Changmas. The onset data of each Changma was derived out of daily rainfall data of 47 stations for 30 years(1961~1990) and weather maps over East Asia. Each station represent any of the 47 districts of local forecast under the Korea Meteorological Administration. The average onset dates of Changma during the period was from 21 through 26 June. The dates show a tendency to be delayed in El Ni${\~{n}}o years while they come earlier than the average in La Nina years. In 1982, the year of El Ni${\~{n}}o, the date was 9 Julu, two weeks late compared with the average. The relation of sea surface temperature(SST) over Pacific and Northern hemispheric 500mb height to the Changma onset dates was analyzed for the prediction model by polynomial regression. The onset date of Changma over Korea was correlated with SST in May(SST${_(5)}{^\circ}$C) of the district (8${^\circ}$~12${^\circ}S, 136${^\circ}~148${^\circ}W)of equatirial middle Pacific and the 500mb height in March (MB${_(3)}$"\;"m)over the district of the notrhern Hudson Bay. The relation between this two elements can be expressed by the regression: Onset=5.888SST${_5}"\;"+"\;"0.047MB${_(3)}$"\;"-251.241. This equation explains 77${\%}$ of variances at the 0.01${\%}$ singificance level. The onset dates of Late Changma come in accordance with the degeneration of the Subtro-pical High over northern Pacific. They were 18 August in average for the period showing positive correlation(r=0.71) with SST in May(SST)${_(i5)}{^\circ}$C) over district of IndiaN Ocean near west coast of Australia (24${^\circ}$~32${^\circ}$S, 104${^\circ}$~112${^\circ}$E), but negativ e with SST in May(SST${_(p5)}{^\circ}$ over district (12${^\circ}$~20${^\circ}$S,"\;"136${^\circ}$~148${^\circ}$W)of equatorial mid Pacific (r=-0.70) and with the 500mb height over district of northwestern Siberia (r=-0.62). The prediction model for Late Changma can be expressed by the regression: Onset=706.314-0.080 MB-3.972SST${_(p5)}+3.896 SST${_(i5)}, which explains 64${\%}$ of variances at the 0.01${\%}$ singificance level.

• Journal of Trauma and Injury
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• v.29 no.4
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• pp.176-179
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• 2016

Delayed posttraumatic spinal epidural hematoma is an extremely rare disease, and it remains a challenge for surgical teams of trauma centers. Magnetic resonance imaging is an essential tool for early diagnosis, and emergent evacuation of the hematoma is the best choice of treatment. We report the case of a 33-year old man with posttraumatic epidural hematoma in the thoracic spine (T10 and T11 levels), who developed an abrupt-onset paraplegia 5 days after the trauma.

• Journal of Chest Surgery
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• v.27 no.9
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• pp.759-763
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• 1994

Between November 1990 and December 1993, 9 patients underwent surgical intervention for acute active endocarditis at Gyeongsang National University Hospital. All the patients were operated on within the first six weeks after onset of symptoms for various reasons. Surgical indications for early surgery were heart failure, systemic septic emboli, new murmur and growing vegetation. Most common infecting organism was Staphylococcus[55 %], and the others were Streptococcus, anaerobes, Candida and unknown in 1 case. The infection was in the mitral valve in 5 patients, the aortic valve in 2, the aortic and mitral in 1, and the aortic and pulmonary in 1. There was one operative death[11 %] and no late death. Preoperative Functional Class were II in 4 patients, III in 5 and after surgery all the patients improved to Class I. We conclude that early surgical intervention in acute active endocarditis is effective in most instances.

• Journal of Environmental Health Sciences
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• v.33 no.5
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• pp.434-440
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• 2007

The livestocks are sometimes infected with pathogenic microorganisms such as bird influenza, brucellosis, pig cholerae, and salmonella. However, it is difficult to predict the outcome of these diseases because the livestocks are mostly raised in the rural areas. Efficient systems for detecting and alerting the onset of livestock diseases are urgently required. In these studies, the fluorescent analysis method, luminescent analysis method, and frequently used gene amplification method (polymerase chain reaction) have been developed in order to detect the pathogenic microbes in the early stages of disease progression. By using these developed systems, damages due to the livestock diseases induced by microbes can be minimized. If we can detect livestock diseases in the early stage, the costs for diagnosis and treatment will be reduced, and the livestock can be quickly recovered.

• Journal of Genetic Medicine
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• v.10 no.1
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• pp.7-12
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• 2013

Familial Juvenile hyperuricemic nephropathy (FJHN) is a rare autosomal dominant disorder, characterized by early onset of hyperuricemia, gout and progressive kidney disease. Hyperuricemia prior to renal impairment and decreased fractional excretion of uric acid are hallmarks of FJHN. Renal dysfunction gradually appears early in life and results in end-stage renal disease usually between the ages of 20 and 70 years. FJHN is mostly caused by mutations in the uromodulin gene located at 16p12. The course of FJHN is highly variable. Treatment includes management for hyperuricemia, gout and progressive kidney disease. Individuals with gout have been usually treated with allopurinol. But controversy exists as to whether uric acid lowering therapy prevents the progression of chronic kidney disease.