• Journal of The Korean Society of Clinical Toxicology
• /
• v.5 no.2
• /
• pp.119-122
• /
• 2007

Paraquat poisoning is a fatal type of herbicide intoxication. It is characterized by multi-organ failure and pulmonary fibrosis with respiratory failure. Intravenous and intramuscular injection of paraquat is rarely described. However, We encountered two fatal cases of acute poisoning caused by paraquat injection. Two patients were admitted to our emergency unit after intravenous and intramuscular injection of 23.8% paraquat (about 476 mg of paraquat). A 37-year-old man diluted 2 ml of 23.8% paraquat solution with 1 ml of normal saline and injected it both intravenously into his left antecubital fossa and intramuscularly into his abdomen in a suicide attempt. He died 5 days later from respiratory failure and acute renal failure. A 92-year-old man was injected intravenously into his right antecubital fossa by his grandson with 2 ml of 23.8% paraquat solution diluted with 1 ml of normal saline. He died 2 days later from early circulatory collapse and multi-organ failure (metabolic acidosis, acute renal failure, coagulopathy). Intravenous and intramuscular injection with a small quantity of paraquat resulted in fatal toxicity in our patients.

• Nuclear Engineering and Technology
• /
• v.49 no.5
• /
• pp.968-978
• /
• 2017

Three small-break loss-of-coolant accident (SBLOCA) tests with safety injection pumps were carried out using the integral-effect test loop for SMART (System-integrated Modular Advanced ReacTor), i.e., the SMART-ITL facility. The types of break are a safety injection system line break, shutdown cooling system line break, and pressurizer safety valve line break. The thermal-hydraulic phenomena show a traditional behavior to decrease the temperature and pressure whereas the local phenomena are slightly different during the early stage of the transient after a break simulation. A safety injection using a high-pressure pump effectively cools down and recovers the inventory of a reactor coolant system. The global trends show reproducible results for an SBLOCA scenario with three different break locations. It was confirmed that the safety injection system is robustly safe enough to protect from a core uncovery.

• Clinical and Experimental Reproductive Medicine
• /
• v.48 no.4
• /
• pp.362-367
• /
• 2021

Objective: The impact of early mechanical removal of cumulus cells on fertilization and embryonic development is not yet precisely known. This study aimed to investigate the effects of early and late cumulus cell removal on fertilization, polyspermy, embryonic development potential, blastocyst development, and clinical outcomes. Methods: A prospective study was conducted of patients who underwent in vitro fertilization between September 2019 and October 2020. Sibling oocytes were randomly allocated after insemination to early cumulus cell removal at 6 hours (group I) and late cumulus cell removal at 16-18 hours (group II). If total fertilization failure (TFF) was determined to have occurred at early cumulus cell removal, rescue intracytoplasmic sperm injection (ICSI) was performed. Fertilization, embryonic development, and pregnancy outcomes were compared. Results: A total of 912 oocytes were assigned to group I (458 oocytes) and group II (454 oocytes). Fertilization, polyspermy, embryo quality, and pregnancy outcomes were not significantly different between both groups. Rescue ICSI enabled fertilization of 79.2% of the TFF oocytes. Conclusion: Early cumulus cell removal at 6 hours had no significant difference in fertilization, polyspermy, embryo development, or obstetric and perinatal outcomes compared to late removal. Early cumulus cell removal combined with early rescue ICSI may have the potential to help couples with TFF.

• Archives of Plastic Surgery
• /
• v.36 no.3
• /
• pp.269-276
• /
• 2009

Purpose: Local skin necrosis after extravasation of adriamycin, a widely used chemotherapeutic agent, is a common problem in cancer patients. The extravasation of chemotherapeutic agents yields severe inflammatory responses, crust formation, skin necrosis, and ulceration. Even though several treatment options have been proposed for extravasation injury, there is still controversy regarding the management of such lesions. Thus the aim of this study was to compare the efficacy of saline injection(Group 1), hydrocortisone injection(Group 2), propranolol injection(Group 3) and early surgical excision as a treatment(Group 4) in a rat extravasation model. Methods: The authors planned forty mature male Sprague - Dawley rats were divided into 4 groups and each group contained 10 rats. Administration of adriamycin($1.0mg/m{\ell}$) $1.5m{\ell}$ by subcutaneous injection on the dorsal side of the rats was followed by protocol. The treatment options were applied 2 hours after adriamycin injection. At the end of the 5th days, the presence and size of ulcers at the injection site were measured. 3 weeks after injection, a histopathologic examination was performed for each treatment and control group. T - tests were used to analyze the differences between the measurements. Results: Propranolol significantly improved tissue recovery compared with control group and other groups. These data suggest that there is little role for saline and hydrocortisone in the treatment of adriamycin extravasation injury. Conclusion: In this study, we compared some treatment methods in adriamycin extravasation model. The findings support the propranolol injection may prevent extravasation injury. However this study was performed in the laboratory using rats, and the results could be different in clinical application. Thus, more needs further investigations and clinical application.

• 연구논문집
• /
• s.33
• /
• pp.5-16
• /
• 2003

Fuel distribution, combustion, and flame propagation characteristics of heavy duty engine with the liquid phase LPG injection(LPLI) were studied in a single cylinder engine. Optically accessible single cylinder engine and laser diagnostics system were built for quantifying fuel concentration by acetone PLIF(planar laser induced fluorescence) measurements. In case of Otto cycle engine with large bore size, the engine knock and thermal stress of exhaust manifold are so critical that lean burn operation is needed to reduce the problems. It is generally known that fuel stratification is one of the key technologies to extend the lean misfire limit. The formation of rich mixture in the spark plug vicinity was achieved by open valve injection. With higher swirl strength(Rs=3.4) and open valve injection, the cloud of fuel followed the flow direction and the radial air/fuel mixing was limited by strong swirl flow. It was expected that axial stratification was maintained with open-valve injection if the radial component of the swirling motion was stronger than the axial components. The axial fuel stratification and concentration were sensitive to fuel injection timing in case of Rs=3.4 while those were relatively independent of the injection timing in case of Rs2.3. Thus, strong swirl flow could promote desirable axial fuel stratification and, in result, may make flame propagation stable in the early stage of combustion.

• Journal of ILASS-Korea
• /
• v.29 no.1
• /
• pp.32-37
• /
• 2024

Macroscopic visualization of non-evaporating sprays was experimentally conducted to investigate spray tip penetration and spray angle under low-density conditions, corresponding to an early injection strategy. Furthermore, injectors with varying injection angles (146° and 70°) and numbers of holes (8 and 14) were employed to examine the impact of injector configuration. Compared to the baseline injector, 8H146, which has 8 holes and a 146° injection angle, the spray tip penetration of the 8H70 injector was found to be longer. This can be attributed to higher momentum due to a smooth flow field between the sac volume and the nozzle inlet, which is located closer to the injector tip centerline. The increase in velocity led to intense turbulence generation, resulting in a wider spray angle. Conversely, the spray tip penetration of the 14H70 injector was shorter than that of the 8H70 injector. The competition between increased velocity and decreased nozzle diameter influenced the spray tip penetration for the 14H70 injector; the increase in momentum, previously observed for the 8H70 injector, contributed to an increase in spray tip penetration, but a decrease in nozzle diameter could lead to a reduction in spray tip penetration. The spray angle for the 14H70 injector was similar to that of the 8H146 injector. Moreover, injection rate measurements revealed that the slope for a narrow injection angle (70°) was steeper than that for a wider injection angle during the injection event.

• Journal of Power System Engineering
• /
• v.21 no.1
• /
• pp.63-69
• /
• 2017

The combustion characteristics of gasoline and diesel were tested in a compression ignition engine. Both fuels were used with same common rail injection system. Combustion experiment showed that low load condition of 0.45 MPa IMEP (indicated mean effective pressure) was tested in metal and optical engines. The gasoline combustion showed higher hydrocarbon and carbon monoxide emissions but lower soot emission compared with diesel combustion. NOx emissions were very high at late injection timing but significantly decreased at early injection timing due to the lean combustion resulted from vigorous mixing process. Direct combustion visualization showed that the diesel combustion was dominated by diffusion combustion exhibiting soot incandescence and the gasoline combustion was mostly consisted of premixed combustion showing blue chemiluminescence.

• Biomolecules & Therapeutics
• /
• v.2 no.3
• /
• pp.298-302
• /
• 1994

Wistar albino rats were injected subcutaneously with mercuric chloride (5 mg/kg) to define the early biochemical determinants that participate in the pathogenesis of mercuric chloride-induced hepatotoxicity, especially focusing on oxygen free radicals, we studied malondialdehyde(MDA) level and the activities of catalase and superoxide dismutase in the liver of rats at 24, 48 and 72 hr after the injection of mercuric chloride. MDA levels at 24, 48 and 72 hr after the injection of mercuric chloride increased as compared with that of control group. The activities of catalase and superoxide dismutase at 24, 48 and 72hr after the injection of mercuric chloride decreased as compared with that of control group. These results suggest that the depression of the activities of catalase and superoxide dismutase resulting from excessive oxygen free radicals is an important determinant in pathogenesis of mercuric chloride-induced hepatotoxicity.

• Journal of fish pathology
• /
• v.16 no.3
• /
• pp.139-146
• /
• 2003

We have investigated the biological effects of recombinant IL-1$\beta$ (rIL-1$\beta$) on the expression of antiviral genes such as Myxovirus-3 (MX-3) and Interferon regulating factor-1 (IRF-1), which are related to type I interferon. When ten micrograms of rIL-1$\beta$ were treated, we observed the stimulatory effect on the expression of these antiviral genes. Interestingly, at the early stage of stimulation, these genes were down-regulated and then up-regulated by the results obtained that the expressions of these genes were decreased at day 1 post-injection and gradually increased at day 3 post-injection. Thus, the stimulatory effect of rIL-1$\beta$ on the expression of MX-3 and IRF-3 gene might be an indirect stimulatory effect because significant up-regulation was delayed until day 3 post-injection.

• Transactions of the Korean hydrogen and new energy society
• /
• v.13 no.3
• /
• pp.233-241
• /
• 2002

To achieve hydrogen power system with high performance and stable operation, the COVimep of hydrogen fueled engine with direct injection was evaluated with the change of engine speed, injection timing, air-fuel equivalence ratio and spark timing. And the cause of cycle variation was analyzed by using coefficient of variation in combustion period defined in this study. the results showed that the cycle variation of hydrogen fueled engine is mainly dependent on the early combustion period.