Browse > Article

Biological effect of recombinant IL-1$\beta$ on the expression of antiviral genes in the gill of rainbow trout, Oncorhynchus mykiss  

Hyun, Do Jeong
Publication Information
Journal of fish pathology / v.16, no.3, 2003 , pp. 139-146 More about this Journal
Abstract
We have investigated the biological effects of recombinant IL-1$\beta$ (rIL-1$\beta$) on the expression of antiviral genes such as Myxovirus-3 (MX-3) and Interferon regulating factor-1 (IRF-1), which are related to type I interferon. When ten micrograms of rIL-1$\beta$ were treated, we observed the stimulatory effect on the expression of these antiviral genes. Interestingly, at the early stage of stimulation, these genes were down-regulated and then up-regulated by the results obtained that the expressions of these genes were decreased at day 1 post-injection and gradually increased at day 3 post-injection. Thus, the stimulatory effect of rIL-1$\beta$ on the expression of MX-3 and IRF-3 gene might be an indirect stimulatory effect because significant up-regulation was delayed until day 3 post-injection.
Keywords
Recombinant IL-1β, Oncorhynchus mykiss, Myxovirus-3, Interferon regulating factor-1
Citations & Related Records
연도 인용수 순위
  • Reference
1 Au, W. C., Su, Y., Raj, N. K. B. and Pitha, P. M.: Virus-mediated induction of interferon A gene requires cooperation between multiple binding factors in the interferon alpha promoter region. J. Biol. Chem., 268:24032-24040, 1993
2 Collet, B., Mazzoni, D., Hovens, G.C.J., Hirono, I., Aoki, T. and Secombes, C. J.: Cloning and expression analysis of rainbow trout Oncorhynchus mykiss interferon regulatory factor 1 and 2 (IRF-1 and IRF-2). Dev. Comp. Immunol., 27:111-126, 2003   DOI   ScienceOn
3 Hong, S., Peddie, S., Campos-Perez, J.J., Zou, J. and Secombes, C. J.: The effect of intraperitoneally administered recombinant II-1 $\beta$on immune parameters and resistance to Aeromonas salmonicida in rainbow trout. Dev. Comp. Immunol., 27:801-812, 2003   DOI   ScienceOn
4 Kamijo, R., Harada, H., Matsuyama, T., Bosland, M., Gerecitano, J., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., Mak, T. W., Taniguchi, T. and Vilcek, J.: Requirement for transcription factor IRF-1 in NO synthetase induction in macrophages. Science, 263:1612-1615, 1994   DOI
5 Overbergh, L., Valckx, D., Waer, M. and Mathieu, C.: Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine, 11:305-312, 1999   DOI   ScienceOn
6 Robertsen, B., Trobridge, G. and Leong, J.A.: Molecular cloning of double-stranded RNA inducible MX genes from Atlantic salmon. Dev.Comp. Immunol., 21:397-412, 1997   DOI   ScienceOn
7 Simon, A., Fah, J., Haller, O. and Staeheli, P.: Interferon-regulated MX genes are not responsive to interleukin-1, tumour necrosis factor, and other cytokines. J. Virology, 65:968-971, 1991
8 Warfel, A. H. and Zucker-Franklin, D.: Down-regulation of macrophage lysozyme by lipopolysaccharide and interferon. J. Immunol., 137:651-655, 1986
9 Halminen, M.,Ilonen, J., Julkunen, I., Ruuskanen, O., Simell, O. and Makela, M. J.: Expression of MxA protein in blood lymphocytes discriminates between viral and bacterial infections in febrile children. Pediatric Research, 9:583-590, 1997
10 Zou, J., Grabowski, P.S., Cunningham, C. and Secombes, C.J.: Molecular cloning of interleukin-1beta from rainbow trout reveals no evidence of an ice cut site. Cytokine, 11:552-560, 1998   DOI   ScienceOn
11 Samuel, C.E.: Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology, 183:1-11, 1991   DOI   ScienceOn
12 Trobridge, G.D., Chou, P. P. and Leong, J.A.C.: Cloning of the rainbow trout Mx2 and Mx 3 cDNAs and characterisation of trout Mx protein in salmon cells. Journal of Virology, 71:5304-5311, 1997a
13 Paulsen, S., M., Engstad, R.E. and Robertsen, B.: Enhanced lysozyme production in Atlantic salmon macrophages treated with yeast $\beta$-glucan and bacterial lipopolysaccharide. Fish & Shellfish Immunol., 11:23-37, 2001   DOI   ScienceOn
14 Miyamoto, M., Fujita, T., Kimura, Y., maruyama, M., Harada, H., Sudo, Y., Miyata, T. and Taniguchi, T.: Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to the IFN-$\beta$ gene regulatory elements. Cell, 54:903-913, 1988   DOI   ScienceOn
15 OGarra, A. and Vieira, P.: Polymerase chain reaction for detection of cytokine gene expression. Curr. Opin. Immunol., 4:211-215, 1992   DOI   ScienceOn
16 Hong, S., Zou, J., Crampe, M., Peddie, S., Scapigliati, G., Bols, N., Cunningham, C. and Secombes, C. J.: The production and bioactivity of rainbow trout (Oncorhynchus mykiss) recombinant II-1$\beta$. Vet. Immunol. Immunopathol., 81: 1-14, 2001   DOI
17 Gilliland, G., Perrin, S., Blanchard, K. and Bunn, H. F.: Analysis of cytokine mRNA and DNA: Detection and quantitation by competitive polymerase chain reaction. Proc. Natl. Acad. Sci. USA, 87:2725-2729, 1990   DOI   ScienceOn
18 Kanangat, S., Solomon, A. and Rouse, B. T.: Use of quantitative polymerase chain reaction to quantitative cytokine messenger RNA molecules. Mol. Immunol., 29:1229-1236, 1992   DOI   ScienceOn
19 Abdollahi, A., Lord, K.A., Hoffman-Liebermann, B. and Liebermann, D. A.: Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin-6 and leukaemia inhibitory factor: role in growth inhibition. Cell Growth Differ., 2:401-407, 1991
20 Davidson, J., Smith, T. and Martin, S.A.M.: Cloning and sequence analysis of rainbow trout LMP2 cDNA and differential expression of the mRNA. Fish & Shellfish Immunol., 9:621-632, 1999   DOI   ScienceOn
21 Dinarello, C.A.: Biological basis for Interleukin-1 in disease. Blood, 87:2095-2147, 1996
22 Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T. and Taniguchi, T.: Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell, 58:729-739, 1989   DOI   ScienceOn
23 Fujita, T., Reis, L. F. L., Watanabe, N., Kimura, Y., Miyamoto, M., Taniguchi, T. and Vilcek, J.: Induction of the transcription factor IRF-1 and interferon-$\beta$ mRNAs by cytokines and activators of second-messenger pathways. Proc. Natl. Acad. Sci. U. S. A., 86:9936-9940, 1989b   DOI   ScienceOn
24 Peddie, S., Zou, J., Cunningham, C. and Secombes, C.J.: Rainbow trout recombinant IL-1$\beta$ and derived peptides induced migration of head kidney leucocytes in vitro. Fish & Shellfish Immunol., 11:697-709, 2001   DOI   ScienceOn
25 Trobridge, G.D. and Leong, J. A.C.: Characterisation of a rainbow trout Mx gene. Journal of Interferon and Cytokine research, 15:691-702, 1995   DOI   ScienceOn
26 Fujita, T., Kimura, Y., Miyamoto, M., Barsoumian, E. L. and Taniguchi, T.: Induction of endogenous IFN-a and IFN-b genes by a regulatory transcription factor IRF-1. Nature, 377:270-272, 1989a
27 Nygaard, R., Husgard, S., Sommer, A.-I., Leong, J.-A. C. and Robertsen, B.: Induction of MX protein by interferon and double-stranded RNA in salmonid cells. Fish & Shellfish Immunol., 10:435-450, 2000   DOI   ScienceOn
28 Trobridge, G.D., Chou, P. P., Kim, C. H. and Leong, J. A. C.: Induction of Mx protein of rainbow trout in vitro and in vivo with poly I:C dsRNA and infectious heamatopoietic necrosis virus. Disease of Aquatic Organisms, 30:91-98, 1997b   DOI   ScienceOn