• IMMUNE NETWORK
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• v.15 no.3
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• pp.161-166
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• 2015

Early growth response (Egr)-1 is a $Cys_2-His_2-type$ zincfinger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from $Egr1^{-/-}$mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between $Egr1^{-/-}$ and WT mice. However, $Egr1^{-/-}$ B cells gave rise to fewer plasma cells than WT B cells. Consistently, $Egr1^{-/-}$ mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.23 no.3
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• pp.63-79
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• 2020

The present study was to investigate the growth response and nutrient absorption in three willow species (Salix gracilistyla, S. koreensis and S. chaenomeloides) treated with nitrogen source (NH₄⁺:NO₃^- rate; 200:0, 150:50, 100:100, 50:150, 200:0) for a period of 90days. The height, dry weight and chlorophyll contents of three species of willows were found to be highest at 50:150 (NH₄⁺:NO₃^-) treatment. NO₃^--N was more effective than NH₄⁺-N in the early growth of three species of willows. The increase in percentage of NO₃^--N handling, T-N, NO₃^--N in plant tissue increased. The analysis of C, N and mineral content in various parts revealed that the amounts of C, N, K, Ca and Mg were higher in leaves than those in the stems and the roots. However, the amount of NO₃^--N and P were higher in roots than those in the leaves and the stems. Salix koreensis was excellent, followed by S. chaenomeloides and S. gracilistyla in absorption of nitrate nitrogen. Higher percentage of NO₃^--N, the amounts of T-N, NO₃^--N, P₂O₅, K, Na, Ca, and pH in soil were decreased.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.13 no.3
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• pp.36-45
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• 2010

To analyze the relationship between climatic factors (monthly mean temperature and total precipitation) and tree-ring growths of Quercus mongolica Fischer (Mongolian oak) with different topographic sites in Mt. Worak, more than 10 trees were selected from each of seven stands. Two cores from each tree were measured for ring width. After crossdating, each ring-width series was double standardized by fitting first a negative exponential or straight regression line and secondly a 60-year cubic spline. Seven stands were categorized in two groups using cluster analysis for tree-ring index patterns. Cluster I (four stands) was located in higher elevation (550-812 m) with aspects of east, west and northwest, and cluster II (three stands) was located in rather lower election (330-628 m) with aspects of north and northwest. The aspects of two clusters were not significantly different. Response-function analysis showed a significant positive response to March precipitation for both clusters. It indicates that moisture supply during early spring season is important to radial growth because the cambial growths of ring-porous species, such as Mongolian oak, start before leaf growth. Cluster II showed a positive response to the precipitation of middle and late growing season, too.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.27 no.5
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• pp.424-430
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• 2005

The oral cavity is humid environment mainly due to the continuous salivary flow. The reaction of oral mucosa to fluid flow is important for homeostasis and pathogenesis. The objective of this study is the screening the change of gene expression after the application of fluid induced shear stress (FISS) on the gingival fibroblast using cDNA microarray assay. The immortalized human gingival fibroblasts were grown and FISS was applied using a cone viscometer at a rotational velocity of 40 rpm, respectively for periods of 2 and 4 hours. The synthesis of cDNA was done from the extracted total RNA and cDNA microarray assay was done subsequently. The genes that showed over 1.6 in the Cy3/Cy5 or the Cy5/Cy3 value were regarded as genes influenced significantly by the FISS application ion (/M/>0.7). The " RUNX-1" was increased its expression in 2 hours group and " RUN and SH3 domain containing 1" was increased its expression in 4 hours group. The "CC020415", "cyclin L1", "interferon regulatory factor1", "early growth response 1", "immediate early response 2", and "immediate early response 3" genes were increased their expression in 2 and 4 hours after FISS application. In conclusion, we could find many genes that were probably related to the FISS application. Interestingly, most of them were placed in similar molecular pathways and these findings improve the reliability of chip data and usefulness in overall screening. From this experiment, we could find many items for further study and it will make improvement in the understanding of intracellular events in response to FISS.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.42 no.1
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• pp.112-118
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• 1997

This study was conducted to obtain basic information on the desalinization in newly reclaimed tideland. A desalinization experiment with leaching method was carried out using the soil samples collected in Haenam tideland, and the early growth response of winter barley to salt stress during the desalinization was investigated by measuring emergence rate, plant height, leaf area and fresh weight. The soil in Haenam tideland was saline-sodic with 59mS / cm of electrical conductivity and pH 8.0, and the soil texture was silty loam with 16％ clay and 75％ silt. Depth of water for desalinization(DWD) to decrease the electrical conductivity below 4mS /cm was 140mm in 5cm depth soil and 240mm in 20cm depth soil. The value of pH of soil and leaching water increased from 8.0 to 8.3 until the electrical conductivity decreased to about 6mS / cm during the desalinization. .The emergence rate of winter barley was over 75％ in the DWD above 80mm and showed no significant difference with the DWD. The DWD for the normal growth of winter barley seedling was above 120mm at 1 and 2 weeks after sowing(WAS), and above 160mm at 3 and 4 WAS. The leaf area and fresh weight showed no response for salt stress with the DWD above 12mm at 2 WAS, and above 16mm at 3 WAS. It was estimated that the electrical conductivity of soil saturation extract for the normal growth of winter barley during early seedling growth stage in new reclaimed tideland would be below 9mS / cm in 20cm depth soil.

• Asian-Australasian Journal of Animal Sciences
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• v.6 no.3
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• pp.401-410
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• 1993

Day-old male and female broilers obtained from commercial strain (Hubbard) were used in this study. At 7 days of age, all chicks were weighed individually (female 0.11 kg and male 0.12 kg in average) and divided into 5 group of 45 birds each group with no replicate in each treatment group as follows: 1. fed ad libitum; 2. fed 75% ad libitum; 3. fed 65% ad libitum; 4. fed 55% ad libitum; 5. fed 45% ad libitum. Chicks were restricted for 10 days (d 7 through 17) of a 56-day trial. Chicks were fed a commercial starter diet (crude protein (CP) 23.8% and metabolizable energy (ME) 3,070 kcal/kg) for 21 days, and commercial finisher diet (CP 20% and ME 3,160 kcal/kg) from 22 to 56 days of age. When chicks were feed-restricted at an early age, compensatory growth did not immediately occur following refeeding. Body weights of restricted chicks were not equal to the ad libitum chicks before 49 days of age. At 56 dyas of age, body weights of restricted chicks were heavier (p<0.01). Abdominal fat values of female chicks fed ad libitum was not significantly different from those fed 45% to 75% ad libitum. Carcass fat values of restricted female chicks were lower than those of control chicks when female chicks were fed either 55% or 45% ad libitum. Furthermore, feed efficiencies of restricted chicks were better. The response of chicks to early feed restriction might depend on the degree of feed restriction, and sex. Factors contributing carcass fat included energy loss, fat protein ratio of carcass, fatty acid synthesis in the liver and triglyceride content of the liver. The heavier body weights in the restricted chicks might be correlated with the lower growth rate during period of feed restriction.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.47 no.4
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• pp.311-318
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• 2002

Planting date of soybeans [Glycine max (L.) Merr.] is one of production components in cultural systems. The objective of the current study was to identify the components of soybean production and cultural practices encompassing planting dates and cultivars that respond to dry matter accumulation, harvest index and yield components. Three determinate soybean cultivars were planted on May 13 (early), June 3 (mid), and June 24 (late). Planting density was 60$\times$15cm with 2 seeds (222,000 plants per ha). Soybean plants were sampled every 10 days interval from the growth stages of V5 to R8 and separated into leaves including petioles, stems, pods, and seeds. Dry matter accumulations, harvest indices, and yield components were measured. Early planting had taken 55 days from VE to R2 and late planting taken 39 days indicating reduced vegetative growth. Early planting showed higher leaf, stem, pod and seed dry weights than late planting. However, late planting appeared to be higher harvest index and harvesting rate. Vegetative mass including leaf and stem increased to a maximum around R4/R5 and total dry weight increased to a maximum around R5/R6 and then declined slightly at R8. The highest seed yield was obtained with mid planting and no difference was found between early and late plantings. Cultivar differences were found among planting dates on growth characteristics and yield components. The results of this experiment indicated that soybean yield in relation to planting dates examined was mainly associated with harvest index and harvesting rate, and planting date of cultivars would be considered soybean plants to reach the growth stage of R4/R5 after mid August for adequate seed yield.

• Journal of The Korean Ophthalmological Society
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• v.59 no.11
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• pp.1030-1038
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• 2018

Purpose: To evaluate whether early visual acuity response at 4 weeks after the first intravitreal anti-vascular endothelial growth factor (VEGF) injection or 4 weeks after the third injection in neovascular age-related macular degeneration (nAMD) is associated with 12-month follow-up outcome. Methods: Thirty treatment-naive patients (30 eyes) with nAMD, treated with intravitreal anti-VEGF, were retrospectively included. Initially, all patients were injected at least three times for three consecutive months and followed up with a pro re nata regimen for at least 12 months. The relationship between 4 weeks after the first and third anti-VEGF injections in visual acuity response was explored, including the mean change from baseline in best-corrected visual acuity (BCVA). The mean change in BCVA was classified into three groups according to visual improvement: <1, 1-<3, or ${\geq}3$ logMAR line(s) in BCVA. The associations among baseline characteristics (gender, age, duration of symptoms, initial BCVA, central macular thickness, and intraocular pressure) and visual acuity responses 4 weeks after the first and third anti-VEGF injections were also assessed. Results: The proportions of eyes with <1, 1-<3, and ${\geq}3-line(s)$ improvement at 4 weeks after the first injection were 6 eyes (20%), 7 eyes (23.3%), and 17 eyes (56.6%), respectively. The proportions of eyes with <1, 1-<3, and ${\geq}3-line(s)$ improvement at 4 weeks after the third injection were 9 eyes (30%), 9 eyes (30%), and 12 eyes (40%), respectively. A BCVA response ${\geq}3-lines$ improvement at 4 weeks after the third injection showed significant associations with ${\geq}3-line(s)$ improvement and BCVA response at 12 months in multiple logistic and linear regression analyses (p = 0.04). Conclusions: In this study, BCVA response ${\geq}3-lines$ improvement at 4 weeks after the third injection showed a significant association with ${\geq}3-line(s)$ improvement and BCVA response at 12 months.

• Journal of The Korean Society of Grassland and Forage Science
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• v.8 no.3
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• pp.123-127
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• 1988

Even though grass species are one of major importance in livestock industry, the response of intergeneric hybridization of Lolium and Festuca and interspecific hybridization of Lolium m.X Lolium p. to Korean climatic condition has not been adequately documented. This reasearch was conducted to examine the growth characteristics and dry matter yield of Festulolium, cv. Felopa and C-Stamm N 66 and hybrid ryegrass, cv. Maja and Tetilelite. 1. The early growth of Italian ryegrass was better than that of hybrid ryegrass and Festulolium. The plant length and helght of Italian ryegrass were longerltaller than those of hybrid ryegrass and Festulolium, but the number of tillers of Italian ryegrass was less than that of hybrid ryegrass and Festulolium. 2. Festulolium and hybrid ryegrass were more tolerant than Italian xyegrass to winter killing, 70-80% of tillers was survived. 3. After wintering, early spring growth of hybrid ryegrass and Festulolium were better than that of Italian ryegrass. Dry matter yield of hybrid ryegrass and Festulolium were more than that of Italian ryegrass. 4. Spikes of hybrid ryegrass and Festulolium (C-Stamm N66) were more than those of Italian ryegrass. Seed yield per $m^2$ of hybrid ryegrass and Italian ryegrass were almost same, but that of Festulolium was lower.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.14 no.1
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• pp.33-44
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• 2011

The influence of nutrition during early life on physical growth as well as mental development has been thoroughly discussed in the literature. The physical dimensions of the body are greatly influenced by nutrition, particularly during the period of rapid growth in early childhood. Nutritional status affects every pediatric patient's response toillness. Good nutrition is important for achieving normal growth and development. It is indicated that permanent impairment of the central nervous system may result from dietary restriction of imbalance during certain periods of life. If children under 3 years of age show a good nutritional status, it may be assumed that they are well nourished. Several common diseases of children such as iron deficiency, chronic constipation and atopic dermatitis are known food related diseases. Patients with chronic illness and those at risk of malnutrition should have detailed nutritional assessments done. Components of a complete nutritional assessment include a medical history, nutritional history including dietary intake, physical examination, anthropometrics (weight, length or stature, head circumference, midarm circumference, and triceps skinfold thickness), pubertal staging, skeletal maturity staging, and biochemical tests of nutritional status. The use of age, gender, and disease-specific growth charts is essential in assessing nutritional status and monitoring nutrition interventions. Nutrition assessment and dietary counseling is helpful for the cure of disease, and moreover, the prevention of illness.