• Therapeutic Science for Rehabilitation
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• v.9 no.1
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• pp.56-68
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• 2020

Objective : This study introduces domestic and overseas systematic assessment tools that can identify eating problems of dementia patients based on abnormal behavior observations and turns them into Korean through the verification of content placement by expert groups. Methods : Three types of assessment tools were selected for final development in Korean version through several meetings based on a wide range of relevant literature searches. The 3 selected assessment tools were first translated by the researchers, and a 9-person expert team was used to verify the Content Validity Index. Results : The EBS content equivalence calculation shows that all 6 questions and 1 response item had a CVI value 0.9, and all items were included in Korean EBS without modification. The EdFED content equivalence calculation showed that all 11 questions had CVI value 0.9, which was included in the Korean edition of EdFED without modification. The content equivalence calculation of the FDI showed that all 19 questions had a CVI of 0.8 or higher, and all items were included in the Korean version of the FDI without modification of the item. Conclusion : Korean versions of the EBS, EdFED and FDI, which are based on behavioral observation and diet tools for people with dementia, have been developed. Early determination of problems related to diet in dementia patients and providing proper intervention through observational Korean version assessment tools is vital in terms of strengthening patient nutrition and reducing caregivers' burden.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.758-764
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• 2018

This study was performed to investigate the effects of Occupation based Reminiscence therapy on cognitive function, depression, and quality of life in elderly patients with mild dementia. Thirty-one elderly patients with mild dementia underwent Occupation based Reminiscence therapy for 40 minutes per session, once weekly, for 8 weeks. Montreal Cognitive Assessment Korean Version (MoCA-K), Short Form of Geriatric Depression Scale-Korean Version (SGDS-K), and Geriatric Quality of Life-Dementia (GQOL-D) were used to measure cognitive function, depression level, and quality of life, respectively. Mean MoCA-K score increased from $14.62{\pm}5.07$ before intervention to $16.88{\pm}4.55$ after intervention; mean SGDS-K score decreased from $7.28{\pm}4.28$ to $6.10{\pm}4.09$, and mean GQOL-D score increased from $26.05{\pm}5.45$ to $28.55{\pm}5.74$. Furthermore, these positive changes were all statistically significant. Based on the results of this study, it was concluded Occupation based Reminiscence therapy may positively affect cognitive function, depression, and quality of life in elderly patients with mild dementia.

• 한국노년학
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• v.40 no.2
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• pp.325-340
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• 2020

Early diagnosis and intervention of dementia is critical to minimize future risk and cost for patients and their families. The purpose of this study was to develop and validate Figure-Copy Test(FCT), as a new dementia screening test, that can measure neurological damage and cognitive impairment, and then to examine whether the grading precesses for screening can be automated through machine learning procedure by using FCT imag es. For this end, FCT, Korean version of MMSE for Dementia Screening (MMSE-DS) and Clock Drawing Test were administrated to a total of 270 participants from normal and damaged elderly groups. Results demonstrated that FCT scores showed high internal constancy and significant correlation coefficients with the other two test scores. Discriminant analyses showed that the accuracy of classification for the normal and damag ed g roups using FCT were 90.8% and 77.1%, respectively, and these were relatively higher than the other two tests. Importantly, we identified that the participants whose MMSE-DS scores were higher than the cutoff but showed lower scores in FCT were successfully screened out through clinical diagnosis. Finally, machine learning using the FCT image data showed an accuracy of 73.70%. In conclusion, our results suggest that FCT, a newly developed drawing test, can be easily implemented for efficient dementia screening.

• Korean Journal of Social Welfare Studies
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• v.44 no.2
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• pp.327-358
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• 2013

This study aimed to analyze the trajectories of cognitive function and functional disability, and to identify the impacts of socio-demographic factors on the two variables. Based on the assumption that there are differences according to the progress of cognitive impairment, it focused on examining the differences in trajectories of cognitive function and functional disability between two groups: dementia conversion group and dementia non-conversion group among cognitively normal older adults. This study was conducted based on the data from a 3-wave panel study of a sample of 966 Yeoncheon elderly cohort aged 65 and over between 1997 and 2003. Latent growth curve model and multi-group structural equation modeling were used to examine the hypothesis. Results revealed that dementia conversion group exhibited faster rate of cognitive decline as well as lower initial cognitive level. Difference between two groups was not significant in the initial level of functional disability, yet dementia conversion group showed greater degree of deterioration in the functional disability over time than dementia non-conversion group did. In terms of the influence of socio-demographic factors on cognitive function and functional disability, the cognitive decline was more drastic in the female group, whereas functional decline was more apparent for the male group. The level of education in early life had a strong impact on the cognitive function in later life. Based on these findings, practical implication for high risk groups in cognitive function and functional disability were discussed.

• Journal of Korea Multimedia Society
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• v.15 no.12
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• pp.1449-1455
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• 2012

This paper has developed a system for early diagnosis of senile dementia and mild cognitive impairment (MCI) by developing software to measure the volume of hippocampus. This software consists of two parts; segmentation and analysis. The segmentation part uses ROI and region growing to segment hippocampus region. On the other hand, the analysis part creates a volume rendering of hippocampus. This software is expected contribute in these research fields for dementia diagnosis and its medication planning.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.166-171
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• 2008

PET of the cerebral metabolic rate of glucose is increasingly used to support the clinical diagnosis in the examination of patients with suspected major neurodegenerative disorders, such as Alzheimer's disease. $^{18}F-FDG$ PET has been reported to have high diagnostic performance, especially, very high sensitivity in the diagnosis and clinical assessment of therapeutic efficacy. According to clinical research data hitherto, $^{18}F-FDG$ PET is expected to be an effective diagnostic tool in early and differential diagnosis of Alzheimer's disease. Since 2004, Medicare covers $^{18}F-FDG$ PET scans for the differential diagnosis of fronto-temporal dementia (FTD) and Alzheimer's disease (AD) under specific requirements; or, its use in a CMS approved practical clinical trial focused on the utility of $^{18}F-FDG$ PET in the diagnosis or treatment of dementing neurodegenerative diseases.

• The Journal of the Korea Contents Association
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• v.18 no.10
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• pp.382-393
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• 2018

Patients with dementia are increasing steadily and becoming a social problem. Care workers in hospitals are increasingly interested in emotional labor. Therefore, this study examines the caregiving experience of dementia patients in the nursing home. The effects of emotional labor and exhaustion of nursing home workers on job stress and satisfaction were analyzed and the moderating effect of care experience was analyzed. The results of the study are as follows. First, the caregiver experience of the nursing hospital workers showed the initial mind, the perception of the early dementia patients, the difficulties, the physical and mental limitations, the satisfaction, the experience through nursing practice, and the change of mind about life. Second, emotional labor and burnout have positive effects on job stress. Care experience reduced the impact of emotional labor and exhaustion on job stress. Finally, the relationship between job stress and job satisfaction showed positive influence.

• Environmental Mutagens and Carcinogens
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• v.25 no.1
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• pp.19-24
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• 2005

The Swedish double mutation (KM670/671NL) of amyloid precursor protein (Swe-APP) is associated with early-onset familial Alzheimer's disease (FAD) and increases amyloid beta peptide production. Although APP/A/3 mediated neurotoxicity is observed both in vitro and in vivo, the relationship between mutant APP expression, A/3 production, and neuronal death observed in the brains of FAD patients remains to be elucidated. In this study, we investigated the mechanisms of Swe-APP-induced cell death in HEK293 and NGF-differentiated PC 12 cells. We found that the expression of Swe-APP induced cytochrome C relase, activation of caspase 3 in HEK 293 and NGF-differentiated PC 12 cells. We also show that the reactive oxygen species (ROS) was detected in Swe-APP expressing HEK 293 cells and NGF-differentiated PC 12 cells and that pretreatment with vitamine E attenuated the cellular death, cytochrome C release induced by Swe-APP expression, indicating the involvement of free radical in these processes. These results suggest one of possible apoptotic mechanisms of Swe-APP which could occur through cytochrome C release from mitochondria and this apoptosis inducing effects could be at least in part, due to ROS generation by Swe-APP expression.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.11
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• pp.2054-2060
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• 2016

As the aging society is accelerated, the population with dementia grows significantly faster. Because there is no complete cure of dementia, it is of great importance to detect the disease at a very early stage and prevent its fast aggravation through evaluation of MCI(Mild Cognitive Impairment) which happens before dementia. The current assessment of MCI conducts only in the form of hand-written data and by 1:1 face to face communication between the subjects and the examiners. Due to this, both examiners' fatigue rate and evaluation error rate increase. Further, there are some limitations in utilizing and analyzing data collected. Against the problems, therefore, there is a need to develop a computerized system by which MCI is assessed, and the results are saved and analyzed. This paper presents the development of such a system enabling MCI evaluation, its related data collection and analysis.

• Journal of the Korea Society of Computer and Information
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• v.28 no.10
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• pp.257-266
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• 2023

The aim of this study is to use media big data to understand the characteristics and changes in technology that prevents wandering and missing for dementia patients as well as supports safe walking since 1990 until recently. BigKinds as a media big data was used to conduct an analysis in two stages. In the results, first, the media reports began to be reported in the early 2000s, and it increased after 2014. Second, regarding to the characteristics of changes in technology and device utilization, there has been a change to advanced technology that combines AI and IoT, focusing on GPS. Drone has recently increased in media report, however problems of personal information security need to be resolved. Third, technology development focused on location identification by police and guardians. Based on the results, technology development and community cooperation for dementia patient were discussed.