• Journal of Microbiology and Biotechnology
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• 제31권8호
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• pp.1109-1114
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• 2021

Chlamydia pneumoniae is a type of pathogenic gram-negative bacteria that causes various respiratory tract infections including asthma. Chlamydia species infect humans and cause respiratory infection by rupturing the lining of the respiratory which includes the throat, lungs and windpipe. Meanwhile, the function of interleukin-4 (IL-4) in Ch. pneumoniae respiratory infection and its association with the development of airway hyperresponsiveness (AHR) in adulthood and causing allergic airway disease (AAD) are not understood properly. We therefore investigated the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. In this study, Ch. pneumonia strain was propagated and cultured in HEp-2 cells according to standard protocol and infant C57BL/6 mice around 3-4 weeks old were infected to study the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. We observed that IL-4 is linked with Chlamydia respiratory infection and its absence lowers respiratory infection. IL-4R α2 is also responsible for controlling the IL-4 signaling pathway and averts the progression of infection and inflammation. Furthermore, the IL-4 signaling pathway also influences infection-induced AHR and aids in increasing AAD severity. STAT6 also promotes respiratory infection caused by Ch. pneumoniae and further enhanced its downstream process. Our study concluded that IL-4 is a potential target for preventing infection-induced AHR and severe asthma.

• 생명과학회지
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• 제29권9호
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• pp.1002-1009
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• 2019

생애 초기 유해 경험은 우울증의 위험성을 높이며, 성인기 스트레스의 민감성에 영향을 미칠 수 있다. 출생 후 모성 분리(MS)로 인한 성인기 스트레스(장기간 예측 불가능한 스트레스; CUS)의 취약성에 p11 유전자의 후성유전기전이 영향을 미치는 지를 확인하였다. 출생 직후부터 21일 동안 하루 3시간 동안 새끼 생쥐를 어미 생쥐로부터 분리시켜 새끼 생쥐가 성체가 되었을 때 CUS를 3주 동안 매일 적용하였다. Real time PCR기법으로 해마의 p11 발현 양을 측정하였고, 염색질 면역 침전 분석법으로 p11 promoter의 히스톤 H3 아세틸화 및 메틸화 양을 측정하였다. 강제수영검사에서 우울 유사 행동을 측정하였다. MS군 및 CUS군은 p11 mRNA 발현 양을 유의하게 감소시켰으며, MS+CUS군은 CUS군에 비해 p11 발현 양을 유의하게 증가시켰다. 또한 MS+CUS군은 CUS군에 비해 H3 아세틸화를 감소시켰다. 이러한 감소는 HDAC5 mRNA 발현 증가와 일치하였다. MS+CUS군은 CUS군에 비해 H3K4 메틸화를 감소시켰으며, H3K27 메틸화를 증가시켰다. 강제수영검사에서 p11 발현이 가장 많이 감소된 MS+CUS군이 대조군에 비해 더 긴 부동 시간을 나타내었다. 출생 후 모성 분리를 경험하고 성체 기간에 스트레스를 함께 받은 생쥐는 성체기간에만 스트레스를 받은 생쥐보다 훨씬 더 큰 후성유전 변화를 보여주었다. 생애 초기 유해 경험은 해마에서 p11 유전자의 히스톤 변형을 통해 성체 스트레스 효과를 더 악화시키는 것으로 생각된다.

• 보건의료산업학회지
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• 제11권2호
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• pp.105-115
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• 2017

Objectives : The aim of this study was to suggest the optimal cut off for best, very good, good, slightly bad, and bad grades. Methods : The subjects were recruited from 4 areas of South Korea and 487 questionnaires were analyzed. The nominal and continuous self-rated health questions were used to reveal the optimal cut off and the Short Form-12 Health Survey questionnaire (SF-12) was additionally used. Frequency, Pearson's correlation coefficient, and ROC-curve analysis were used; the significance level was <.05. Results : Subjects assigned 15(3.1%), 90(18.5%), 237(48.7%), 130(26.7%), and 15(3.1%) to best, very good, good, slightly bad and bad groups respectively. The self-rated health score was associated with total Component (r=.563, p<.001), Physical Component (r=.520, p<.001) and Mental Component of SF-12 (r=.303, p<.001). The optimal cut off was 80.5, 70.5, 53.5, and 40.5 for best, very good or more, good or more, and under slightly bad respectively and area under curve was 0.898, 0.908, 0.945, and 0.908 accordingly. Conclusions : This study suggests that the self-rated health score and grade could be integrated with the optimal cut off.

• 대한두경부종양학회지
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• 제20권1호
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• pp.62-66
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• 2004

Pilomatricoma is a benign neoplasm of the hair follicle origin which most common occur in the head and neck, particularly in the cheek and preauricular region. This neoplasm is superficially located and stony, hard consistency on palpation and sometimes shows reddish or bluish discoloration on the overlying skin. The diagnosis is confirmed by histopathologic examination. Radiologic evaluation is little diagnostic and fine needle aspiration biopsy often misdiagnose because both tissues from basaloid cell component and shadow cell component should be obtained for correct diagnosis. And Otolaryngologist should consider the possibility of philomatricoma when childhood or early adulthood persion visits with hard, supferficial mass on the parotid or cheek area. The treatment of choice is surgical excision with clear resection margin. In many instances, overlying skin excision is needed. We report 4 cases of philomatricoma arising from preauricular, cheek and posterior neck.

• 한국학교보건학회지
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• 제17권2호
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• pp.97-105
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• 2004

Purpose: This study was undertaken in order to examine the relationships of control, perceived health status, self-efficacy, social support, and demographic characteristics for a health promoting lifestyle in college women, and to determine the factors affecting a health promoting lifestyle of women in the early stage of adulthood. Method: There were 161 students from one university in K city. The instruments used for this study were a survey of general characteristics, a health promoting lifestyle (47 items), control (8 items), perceived health status (6 items), self-efficacy (17 items), and social support (18 items). The data analysis was done by use of mean, percentage, t-test, ANOVA, Pearson Correlation coefficients and stepwise regression with the SPSS Win (Version 10.0) program. Results: The results of this study are as follows : 1) The average item score for the health promoting lifestyle was low at 2.39. In the sub-categories, the highest degree of performance was interpersonal support (2.97), and the lowest degree was health responsibility (1.76). 2) In the relationship between social demographics and a health promoting lifestyle, there were significant differences in age, disease experience, and the family's disease experience. 3) Social support revealed only significant correlations with a health promoting lifestyle. 4) Social support was the highest factor that predicted a health promoting lifestyle in college women (15%). Social support, age and disease experience accounted for 20% in a health promoting lifestyle of college women.

• 한국수정란이식학회지
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• 제29권2호
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• pp.119-125
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• 2014

Although the majority of surviving pigs cloned by somatic cell nuclear transfer (SCNT) appear to be physiologically normal, there is a general lack of detailed hemato-physiologic studies for the period of early adulthood to substantiate this claim. In the present study, we investigated variation in blood chemistry and endocrinological parameters between mesenchymal stem cells (MSCs) derived from cloned and normal age-matched female and male miniature pigs. Cloned females and males showed normal ranges for complete blood count assessments. Biochemical assessments showed that ${\gamma}$-GGT, ALT and cholesterol levels of male and female clones were significantly (P<0.05 or P<0.01, respectively) higher than that of age-matched control miniature pigs. Variations in insulin and IGF-1 were higher in female clones than in male clones and controls. Thus, although female and male cloned miniature pigs may be physiologically similar to normal animals, or at least within normal ranges, a greater degree of physiological and endocrinological variation was found in cloned pigs. The above variation must be taken into account before considering cloned female or male miniature pigs for various biomedical applications.

• 한국보육지원학회지
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• 제16권5호
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• pp.201-218
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• 2020

Objective: The purpose of this study was to investigate the influence of experiences in close relationships with teachers for young children on their depression and to see whether there would be a mediating effect of their self-compassion. Methods: The subjects were 206 teachers recruited from Seoul and five different provinces who currently worked at the kindergarten and child care centers and agreed to participate in the survey. The data were analyzed by means of frequency, percentages, Cronbach's reliability coefficient and Pearson's correlation using SPSS 25.0 and model 4 provided in The PROCESS macro for SPSS 3.4 version. Results: The findings were as followed. First, the teachers' degrees of anxiety and avoidance for their close relationships were below the median scores. In contrast their degree of self-compassion was above the median score. In addition, their level of depression was relatively low. Second, both of the teachers' anxiety and avoidance for their close relationships had a positive impact on their depression and their self-compassion, and there were the partial mediating effect in both cases. Conclusion/Implications: These results imply that the early attachment experience connecting the experience in close relationships in the adulthood is important and that it is necessary to develop a program to enhance teachers' self-compassion to protect their psychological well-being.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제23권1호
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• pp.3-7
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• 2012

Objectives : The early onset of mood symptoms in bipolar disorder has been associated with poor outcomes in many studies. However, aspects of the clinical course of bipolar disorder in children and adolescents are controversial. The goal of this article is to review the clinical characteristics and longitudinal course of children and adolescents with bipolar disorders. Methods : Searches were conducted in MedLine, PsycINFO, KISS, and RISS using the terms phenomenology, clinical course, outcome, BPD, pediatric, children and adolescents. Twenty-one reports were selected : either original articles reporting symptoms and clinical characteristics of subjects (ages 5-18 years), or published articles in reviewed journals about bipolar disorder in children and adolescents. Results : Approximately 70% of subjects with bipolar disorder recovered from their index episode, and 50% had at least 1 syndromal recurrence, particularly depressive episodes. For 60% of the follow-up time, subjects had syndromal or subsyndromal symptoms with numerous changes in symptoms and shifts of polarity. Approximately 20% of BP-II subjects converted BP-I. Conclusion : Bipolar disorders in children and adolescents are characterized by episodic illness with subsyndromal and syndromal episodes with mainly depressive and mixed symptoms and rapid mood changes. Extensive follow-up time is needed to evaluate the continuity of bipolar disorder symptoms from childhood to adulthood.

• 가정과삶의질연구
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• 제20권4호
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• pp.75-87
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• 2002

The purpose of this study was to analyze the effect of spousal attachment on social support the husband provides for his wife, investigate the relationships between spousal attachment and the social support the husband received from the wife, and the view the relationship between the social support provided for the wife and the social support received from the wife during early adulthood. A survey was conducted for this study. The hypotheses were based on adult attachment theory. The results are as fellows: Secure attachment with a spouse had a significant positive effect on motivational support and esteem support provided for the wife. Anxious-avoidant attachment with a spouse had a significant negative effect on instrumental support, social companionship, motivational support, esteem support and informational support provided for the wife. Anxious-ambivalent attachment with a spouse negatively affected instrumental support, social companionship, motivational support, esteem support and informational support provided for the wife. Secure attachment with a spouse was positively related to instrumental support, social companionship, motivational support, esteem support and informational support received from the wife. Anxious-avoidant attachment with a spouse was negatively related to instrumental support, social companionship, motivational support, esteem support and informational support received from the wife. Anxious-ambivalent attachment with a spouse was negatively related to esteem support received from the wife. The results were discussed as they relate to the importance of spousal attachment for a healthy family.

• 성인간호학회지
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• 제26권3호
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• pp.300-309
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• 2014

Purpose: This study was to develop a Health Dieting Competency (HDC) scale to assess self-rated health dieting competence of college students. Methods: The scale was developed as follows: items generated, and tests of validity and reliability. Items were developed through a literature review, review of instruments, and interviews. A panel of four experts reviewed the scale for content validity. Factor analysis, Pearson correlation, descriptive statistics and Cronbach's ${\alpha}$ were used to analyze the data (N=183). Results: In the preliminary stage, thirty-three items were generated. Final items were fourteen that were selected through exploratory factor analysis. The HDC scale was consisted with five factors and fourteen items that were Goal-Directed (5-items), Health Support (2-items), Health Self-Efficacy (3-items), Health Perception (2-items), and Escaping from Health (2-items). The internal consistency of HDC as measured by Cronbach's ${\alpha}$ was .78. Conclusion: Content validity, construct validity, and reliability of the HDC were established. The HDC scale is a reliable and valid instrument for early adulthood youth who are willing to assess health dieting competency.