• Title/Summary/Keyword: Early adjustment

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The Study on the Adjustment Methods for Investment Strategies of Government R&D in Field of Drug Development: Focusing on R&D Investment Effects (신약개발 분야 정부 연구개발 투자전략 조정방안 연구: R&D 투자효과를 중심으로)

  • Moon, Kwansik;Hong, Miyoung;Kim, Eun Jeong
    • Journal of Korea Technology Innovation Society
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    • v.18 no.3
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    • pp.444-467
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    • 2015
  • Government has accounted an R&D investment on drug development for the highest share among biotechnology sector. Since competitive investments between each agencies, issues on efficiency or effectiveness of the duplicate investments have been raised continuously. In this research, we investigated the effectiveness of the investment through analysis of portfolio on drug development R&D, journals, patents, and performance of the each process. As a result, reliable technology for current market demands could not compute productive outcome at the early process of the development. On the other hand, grants which support non-clinical process of the development has produced the high-quality patents for active utilization. Moreover, analysis of the performance of the process, which affects rate of success on the drug development, showed decreased efficiency compared to global average. Therefore, we proposed the strategies of reflecting the market demands and bridging between stages without interruption for maximizing the efficiency and effectiveness on investment of drug development R&D. Furthermore, strategies for concentrated support on each process should be prepared for the success of final drug development.

『Bonchojeonghwa(本草精華)』, Medical Historical Approach to Bibliographic Notes (『본초정화(本草精華)』의 해제(解題)에 관한 역사학적(醫史學的) 접근)

  • Kim, Hong-Kyoon
    • The Journal of Korean Medical History
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    • v.24 no.2
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    • pp.25-55
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    • 2011
  • The currently existing "Bonchojeonghwa (本草精華)" is a manuscript without the preface and the epilogue, composed of 2 books in 2 volumes. This book is a quintessence of knowledge on science of medicinal ingredients (medicinal phytology I herbal science) as well as an trial of new development in Chosun medical science. I.e. this book includes surprising change representing medical science in Chosun dynasty as a single publication on science of medicinal ingredients. It holds a value essential to clinician as a specialized book in medicinal ingredients, and Includes richer content on medicinal ingredients than any other books published before. In addition, it is away from boring list-up of superfluous knowledge as seen in "Bonchokangmok(本草綱目)" published in China, and well summarizes essential knowledge which can be used within a range of medicines available in Korea. This book has an outstanding structure that can be even used in today's textbook on science of medicinal ingredients, as it has clear theory, system and classification. Because it handles essential learning points prior to prescription to disease, it is possible to configure new prescription and adjustment of medicinal materials. Moreover, this book can play a good role for linguistic study at the time of publication, because it describes many drugs in Hangul in many parts of the book. "Bonchojeonghwa" includes a variety of animals, plants and mineral resources in Korea, like "Bonchokangmok" which was recently listed in UNESCO. As such, it has a significance in natural history as well as pharmacy in Korean Medicine. It has various academic relationships all in biologic & abiologic aspects. It has importance in sharing future biological resources, building up international potential, setting up the standard for biologic species under IMF system, and becoming a base for resource diplomacy. We should not only see it as a book on medicinal ingredients in terms of Oriental Medicine, but also make an prudent approach to it in terms of study strengthening Korea's national competitiveness. After bibliographical reviewing on the features & characteristics of the only existing copy of "Bonchojeonghwa" housed in Kyujanggak(奎章閣) of Seoul National University, the followings are noted. First, "Bonchojeonghwa" is a specialized book on medicinal ingredients voluntarily made by private hands to distribute knowledge on drugs in the desolate situation after Imjinoeran (Japanese Invasion in 1592), without waiting for governmental help. Second, it raised accessibility and practicality by new editing. Third, it classified 990 different kinds of drugs into plant, animal, and mineral at large, and dassified more in detail into 15 'Bu' and 48 'Ryu' at 258 pages. Fourth, the publication of this book is estimated to be around 1625~1633, at the time of Injo's reign in 17th century. Fifth, it contains the existing & up-to-date knowledge at the time of publication, and it is possible to see the supply-demand situation by Hangul descriptions in 149 places in the book. By the fact that there are many linguistic evidences of 17th century, explains well when the book was published.

A Study of father's care giving in infancy (아버지의 영아 돌봄에 관한 문헌연구)

  • Kim, Young-Hee
    • Korean Parent-Child Health Journal
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    • v.1
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    • pp.75-87
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    • 1998
  • These days social and economical changes have influence on the structure of family and the role of family members. Working mothers and widowers with children are increasing because of economical difficulties. Support from relatives are decreasing because of the conspicuous trend toward nuclear families. According to these reasons androgynous fathers are required. Today's fathers in Korea socially and culturally have learned about traditional parenting, but they are changing their fathering styles to meet the demands of the times. However they don't have their own fathering models. Therefore nurses who hold an advantageous position to teach and support from clinic have to encourage them to care their infants. The purposes of this study were to define father's care giving in infancy, understand influencing factors on fathering, and the differences between fathering and mothering, then contribute to nursing implementation for supporting fathers. This study was designed to review references about father's care giving. The results were follows: Six aspects of parent participation were direct care. indirect care, play, decision-making concerning the child, amount of time of sole responsibility for the child and overall availability to the child. Direct care involved feeding, bathing, going to child if child awakens. dressing, putting child to bed, taking child to doctor, nurse, or dentist, transporting child to and from sitter, day care, or school, washing child's hair. Indirect care involved cleaning up after child, preparing child's food, fixing child's broken playthings, washing child's clothes, arranging baby-sitting, shopping for child's toys and clothes, transporting baby-sitter to and from your home. Young fathers were gradually participating in direct care like feeding, taking child to doctor. Father's care giving stimulated mothering and promoted parent-infant relationship. Influencing factors of fathering would be divided into father characteristics, surrounding factors, infant attributes. Father characteristics were age, role perception, relationship with parent. Surrounding factors were the opportunity of early contact, support system, spouse's expectation, marital adjustment, feeding type, past experience of care giving. Infant attributes were temperament, behavior, age, sex. The differences between fathering and mothering were reviewed. Fathers were poor at care giving. but their caring was similar to mother's. This subtle difference positively worked upon infant's growth and development. On the basis of these theoretical data, nurses can empower fathers to cooperate with mothers in caring infants.

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Recent Fertility and its Policy Implications (최근의 출산력과 정책적 함의)

  • Park, Kyung-Ae
    • Korea journal of population studies
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    • v.30 no.3
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    • pp.137-156
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    • 2007
  • Total fertility rate (TFR) increased from the lowest 1.08 in 2005 to 1.13 in 2006, and a debate is made whether the increase is temporary or continuous as a result of various pro-natal policies. This study intends to explore policy implications revealed in recent fertility change using vital statistics. For this purpose, tempo-adjusted fertility rate by birth order, fertility rate by age of mother and birth order, age-specific fertility for married, and age-specific divorce rate for married are analyzed. The increase of TFR and births for 2006 is largely due to increase of first births at early thirties with slowdown of delayed first marriage and first child birth. The increase of female population (the third wave effect of baby boom) and first marriages of late twenties in 2006 and 2007 would lead to increase of fertility during 2007-2008. But further increase is uncertain because of the decrease trend of marital fertility and increase trend of never-married for twenties. TFRs for first and second births reduced rapidly, while TFRs for third and above births showed no changes, and second births were largely affected by tempo adjustment of fertility. Thus, constructing social environment for first and second births is more effective and necessary than encouraging third births. In addition, social responsibility of child care, child-women health issues due to delayed births, and the need for multi-cultural family support system are discussed.

Manifestation of Cognitive Function in Geriatric Patient with Subjective Memory Complaint (주관적 기억력 저하를 호소하는 노인 환자의 인지기능 양상)

  • Park, Han-Kyul;Kim, Jin-Sung;Lee, Jong-Bum;Seo, Wan-Seok;Koo, Bon-Hoon;Bai, Dai-Seg
    • Journal of Yeungnam Medical Science
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    • v.27 no.1
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    • pp.27-36
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    • 2010
  • Purpose : The purpose of this study was to find out cognitive function of the patients with subjective memory complaint. Material and Methods : From March 1st 2005 to May 31st 2009, 155 normal individuals without any medical illness who visited Yeungnam University Hospital to undergo medical checkup with neurocognitive test was enrolled, and checked by using Cognitive Assessment & Reference Diagnostic System. Results : 107 of the patients had normal cognitive function, 21 patients (about 15%) were diagnosed with dementia, and 10 patients (about 7%) were diagnosed with considerable psychiatric illness, such as depression, anxiety disorder, adjustment disorder. In amnesia, agnosia, aphasia, attention, calculation, dysexecution, Dementia group and Psychiatric illness group has worse score than Normal individuals group. But, in apraxia, Dementia group has worse score than Psychiatric illness group and Normal individual group. Conclusion : Because the patients with subjective memory complaint can be diagnosed as any psychiatric illness as well as dementia, sensitive screening test and early psychiatric approach is needed.

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Teaching Strategy Development of Secondary School Chemistry Based on the Cognitive Levels of Students and the Cognitive Demands of Learning Contents (학습자의 인지수준과 학습내용의 인지요구도를 고려한 중등화학 학습전략 개발에 대한 연구)

  • Kang, Soon Hee;Park, Jong Yoon;Jeong, Jee Young
    • Journal of the Korean Chemical Society
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    • v.43 no.5
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    • pp.578-588
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    • 1999
  • The purpose of this study is to develope the more effective chemistry teaching strategy through analyzing the demanded cognitive levels of contents in high school chemistry I textbooks and the cognitive levels of students who learn these textbooks. For this purpose, the levets of cognitive development stages of 821 second grade students of high schools in Seoul City were anaIyzed using the GALT short version test. The demanded cognitive levels of understanding the contents of chemistry I textbooks in high school were analyzed using the curriculum analysis taxonomy developed by CSMS (Concept in Secondaly Mathematics and Science) program of the Great Britain. The resuIts showed that the proportion of students in the concrete operational stage, the transition stage, and the formal operational stage was l0.7%, 43.0% and 46.3%, respectively. The demanded levels of textbook contents were mostly the early formal operational stages. The concepts demanded the level of the late formal operational stage were 'atomic and molecular weight', 'stoichiometry of chemical reaction', and 'periodic properties of elements'. The results will be helpful for teachers in knowing what concepts are difficult for students to understand and in planning strategies for teaching those concepts. To demonstrate the application of the results obtained in this study, an example of developing teaching strategy which includes the adjustment of cognitive level of contents was shown.

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Research on Ginseng Production During the Past 20 years (인삼재배 분야의 과거 20년 연구)

  • Park, Hoon
    • Journal of Ginseng Research
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    • v.20 no.4
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    • pp.472-500
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    • 1996
  • Researches on mineral nutrition, physiology and phyrsiological diseases, . cultivaction methods. brceding. pest control quality management and extension during 1976-1995 in Korea were reviewed Review in brceding and pest control was restricted to the researches directely related to cultivaction. Mineral nulrient up take. partion and varicos factors such as top dreasing. Light intersity etc. and interrelationship between minerals were investigated. Top dressing was not effective due to low minera1 requorement Physiological characteristics on tempelature light and water were well elucidated and applied to assess traditional cultivation method and its inovation. Photosyrnthetic pigments. light harvest proteins and activity of related enzymes were studied. In nitrogen metabolism arginine, praline, ammonium, threonine appeared to have important role in re growth of shoot Saponin metabolism was studied in relation to growth and new ginsenosides were found but physiological role of saponin was not clearly elucidated yet Endogenous growth regulators were reported and various erogenous growth regulators were studied for growth stimulation. short stem and seed pruning etc. Various physiological diseases were investigated for cause and control measures were established. Water culture was little studied Forest culture was studied but not retched the recommendable stage Drip irrigation straw mulching. seasonal shading and soil preparation method including soil fertility adjustment were established for practical application. Shading materials completely changed to polyethylene net and materials of polymers The research on ginseng cultivation in paddy field opened the way to establish the permanent ginseng cultivation plantation Ginseng harvester and seeder were developed in the late 1950s. Transplanted and many other machines were developed in the early 1990s. In ginseng breeding only pure line selection was of practical significance several verities were at the stage of seed propagation at ginseng plantations. Mutation breeding (${\gamma}$-ray. X-ray chemicals) was not successful. The research on plantlet formation through tissue culture was a little progressed but still far behind to vegetative propagation. Disease control research was concentrated in the isolation and identification of pathogans. their ecological charactelistics and biological control and soil humigation. Potato root rot nematodes was found and control method was established. Insect and small animal control research was greatly progresses in identification, ecological investigation, and ecological and physical control. Weed control was less important due to the development of mulching method of ridge and ditch. Quality factors of raw ginseng in relation to red ginseng process were extensively studied. Traditional quality measures were elucidated in accordance with modern analytical chemistry resulting in the importance of peptides in the centrat part rather than ginsenosides For large root production growth promoting rootzone micrcorganisms (PGPRM) were isolated and active compounds were identified. Field test on PGPRM was on going. Varictus methods formality improvement through cultivation were developed. Management research of ginseng production was rare Extension was active throuch official and private organizations and through workshop for the extension specialists, and direct lectures to grower's. Extension services made the researcher to understand the existing problems at grower's fields. Research environment for ginseng production was in prime time only for three years when Korea Ginseng Research Institute was established then gradually aggravated.

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The Effect of Vision and Hearing Limitation on the Onset of Disability among Korean Elderly with the Consideration of Social Participation and Depression (시력·청력제한이 노년기 장애 발생에 미치는 영향 연구: 사회참여와 우울을 중심으로)

  • Koo, Bon Mi
    • 한국노년학
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    • v.37 no.1
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    • pp.1-14
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    • 2017
  • The purpose of this study was to examine the effect of vision and hearing limitation on the onset of disability among Korean elderly with the consideration of social participation and depression. Study population consisted of 2,670 people aged 65 and above who participated in both the 1st(2006) and 2nd(2008) wave of the Korean Longitudinal Study of Aging(KLoSA), and also reported no ADL or IADL disability in 2006. As the results, first, it found that vision and hearing limitation, social participation, and depression were significant risk factors for the onset of IADL disability in unadjusted analysis. After multivariable adjustment, however, only vision limitation showed significant association with the onset of IADL disability. Second, in the logistic analysis with four categorized variables(vision/hearing limitation + social participation, vision/hearing limitation + depression), the elderly who had vision or hearing limitation had a significantly 1.7 times higher odds ratio for disability onset if they also had low social participation compared with those who had no vision or hearing limitation, and high social participation. Whereas, depression was not significantly associated with the relationship between vision or hearing limitation, and disability onset. The study suggests that the intervention program developed to prevent social isolation of older people with vision or hearing limitation, may be helpful to reduce and postpone the risk of disability onset as well as early detection and treatment of vision or hearing problems.

A Short-term Longitudinal Study of Depression and Life Satisfaction of the Elderly: Focusing on Living Arrangement (여성 노인의 거주형태에 따른 우울과 삶의 만족도에 대한 단기종단연구)

  • Jeon, Byeong Joo
    • 한국노년학
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    • v.37 no.4
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    • pp.853-870
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    • 2017
  • This study examined the changes of depression and life satisfaction among the elderly living together in group-home and congregate housing. And in this course, it was to verify the practical effects of the recent government and local authority community life of elderly people by comparing them with the groups of elders living alone. The study was divided into Time 1 and Time 2, and 205 person's data were used for the final analysis. PASW Statistics 18.0 was utilized to analysis the data of this study, because it is difficult to explain the results of this analysis, secondary qualitative research has been used to identify additional contextual information. The major results of this study are as follows. First, the depression of the subjects was significantly improved in the case of living in group-home and congregate housing, and it was significantly worse in the group of elders living alone. Second, the life satisfaction of survey subjects was significantly improved when living in congregate housing, group-home was significantly worse, and the group of elders living alone were not statistically significant but slightly worse. Third, mixed research methods were applied to make accurate interpretation of changes of life satisfaction of the elderly living in group-home. Based on the results of this study, it is possible to establish appropriate measures for the elderly to improve early adjustment and quality of life in community life. And the community life of the elderly can contribute to a real social safety net by solving the blind spot of welfare. At the national level, it can be utilized as a standard reference to improve and strengthen existing policies by providing data that can simultaneously examine the performances and problems of various policies related to housing or the welfare of the elderly.

The Experiences of the Newly Admitted Elderly Residents in Nursing Home (노인요양시설 거주노인의 입소초기 경험)

  • Goh, Jinkyung;Hwang, Inok;Oh, Heeyoung
    • 한국노년학
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    • v.29 no.2
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    • pp.477-488
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    • 2009
  • Purpose: This study was conducted to investigate newly admitted nursing home resident's experience and adjustment problems in the early stage of institutionalization. Method: In depth interviews was done on 6 elderly residents who were newly admitted. Data from the interview were analyzed using theme analysis method. Results: Results showed that reasons for Institution admission were decreasing physical health and cognitive functioning. Residents reported that difficulties they experienced in institution life were lack of individualized care, loss of autonomy and privacy associated with the demands of group living, and loss of control over activities of daily living. Conclusion: Efforts need to be made to maintain the residents' decision-making and autonomy. Listening intentionally, offering choices, and promoting personal identity might be utilized to reduce relocation stress and enhance adaptation to nursing home living.