• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.45-51
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• 2015

Background: The current study examined health-related quality of life (QoL) for patients with esophageal/gastric cardia precursor lesions or cancer before and after treatment to facilitate improved prevention and treatment. Materials and Methods: Patients with different stages of esophageal/gastric cardia lesions completed two QoL questionnaires, EORTC QLQ-C30 and supplemental QLQ-OES 18, before primary treatment, and at 1, 6 and 12 months after treatment. Results: Fifty-nine patients with precursor lesions, 57 with early stage cancer, and 43 with advanced cancer responded to our survey. Patients with precursor lesions or early stage cancer reported better QoL overall than those with advanced cancer before treatment (p<0.01). Global QoL scores before treatment and at 1 month after treatment were $71{\pm}9$ versus $69{\pm}9$ (p>0.01), $71{\pm}8$ versus $61{\pm}11$ (p<0.01), $67{\pm}11$ versus $62{\pm}9$ (p<0.01) for three stages of lesions. At 6 months after treatment, some QoL measures recovered gradually in precursor lesion and early cancer patients, while some continuously deteriorated in advanced cancer patients. At 12 months, all QoL scores were comparable to baseline for patients with precursor lesions (p>0.01), while global QoL, social, pain, and insomnia scores for early stage and advanced cancer were inferior to corresponding baseline levels (difference between means>5, p<0.01). At this time point, compared with patients with early stage cancer, those with advanced cancer showed worse QoL with all function and most symptom measures (p<0.01). Conclusions: Patients with precursor lesions or early stage esophageal/gastric cardia cancer show better QoL than those with advanced cancer. This indicates that screening, early diagnosis and treatment may improve the QoL for esophageal/gastric cardia cancer patients. Target intervention and counseling should be given by health care providers during treatment and follow-up to facilitate QoL improvement.

• Reproductive and Developmental Biology
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• v.38 no.4
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• pp.147-158
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• 2014

Differentiated nuclei can experimentally be returned to an undifferentiated embryonic status after nuclear transfer (NT) to unfertilized metaphase II (MII) oocytes. Nuclear reprogramming is triggered immediately after somatic cell nucleus transfer (SCNT) into recipient cytoplasm and this period is regarded as a key stage for optimizing reprogramming. In a recent study (Dai et al., 2010), use of m-carboxycinnamic acid bishydroxamide (CBHA) as a histone deacetylase inhibitor during the in vitro early culture of murine cloned embryos modifies the acetylation status of somatic nuclei and increases the developmental competence of SCNT embryos. Thus, we examined the effects of CBHA treatment on the in vitro preimplantation development of porcine SCNT embryos and on the acetylated status of histone H3K9 on cloned embryos at the zygote stage. We performed the three groups SCNT: SCNT (NT), CBHA treatment at the porcine fetus fibroblast cells (PFFs) used as donor cells prior to SCNT (CBHA-C) and CBHA treatment at the porcine SCNT embryos during the in vitro early culture after oocyte activation (CBHA-Z). The PFFs were treated with a $15{\mu}M$ of CBHA (8 h) for the early culture and the porcine cloned embryos were treated with a $100{\mu}M$ concentration of CBHA during the in vitro early culture (10 h). Cleavage rates and development to the blastocyst stage were assessed. No significant difference was observed the cleavage rate among the groups (82.6%, 76.4% and 82.2%, respectively). However, the development competence to the blastocyst stage was significantly increased in CBHA-Z embryos (22.7%) as compared to SCNT and CBHA-C embryos (8.6% and 4.1%)(p<0.05). Total cell numbers and viable cell numbers at the blastocyst stage of porcine SCNT embryos were increased in CBHA-Z embryos as compared to those in CBHA-C embryos (p<0.05). Signal level of histone acetylation (H3K9ac) at the zygote stage of SCNT was increased in CBHA-Z embryos as compared to SCNT and CBHA-C embryos. The results of the present study suggested that treatment with CBHA during the in vitro early culture (10 h) had significantly increased the developmental competence and histone acetylation level at the zygote stage.

• The Journal of the Korean dental association
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• v.18 no.10 s.137
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• pp.853-857
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• 1980

The auther embedded the clinically differently used direct resins to the oral submucosa of the rabbits, and compared the tissue reactions to the direct resins with that to the indirect resins. The results were as follows: 1. Direct resins showed more lympocytes infiltration than indirect resins at the early stage of the embedding, but the same degree of the appearance of lympocytes infiltration as indirect resin at the late stage of the embedding. And the formation of fibrosis around the embedding showed the irregular finidng. 2. Fibrosis of direct resin showed the tendency to be finer than indirect resin at the early stage of the embedding, but direct resin formed the similar fibers capsule to that of indirect resin at the late stage of the embedding.

• Korean Journal of Animal Reproduction
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• v.13 no.3
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• pp.127-133
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• 1989

This study was undertaken to understand development stage of ovary and changes of hormones concentration from February to May in the Israeli carp, Cyprinus carpio. The results obtained in these experiments are as follows ; 1. Serum LH levels began to increase sharphy in March, coinciding with the onset of rapid ovarian development. 2. LH levels were well correlated with changes in gonadosomatic index. 3. Dramatic increase in gonadosomatic index occurred during the months of March. 4. Ripe stage(Stage Ⅴ) rapidly increase in March. 5. Early perinucleolus oocyte radpily develop into late perinucleolus oocytes in March. 6. The vitellogenic phase begins as these late perinucleolus oocytes become transformed into early maturing oocytes through the accumulation of yolk. 7. The cytoplasm completely fills with yolk as oocytes reach the late maturing stage. 8. Changes in the microscopic appearances of the ovaries were well correlated with changes in both gonadosomatic index and macroscopic appearance. 9. It is concluded from these observations that LH plays a major role in sexual maturation of the Israeli carp.

• Journal of the korean academy of Pediatric Dentistry
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• v.3 no.1
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• pp.7-11
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• 1976

The author measured the degree of development and the eruption pattern of first permanent molars with orthopantomography in 553 Korean children(male; 302, female; 251) from 4 to 9 years old. The orthopantomographs were obtained from dept. of pedodontics, college of dentistry, Seoul National University. The results of the studies were as follows: 1. Upper first permanent molars were erupted with distal inclination of about 30 degrees in the early stage and they gradually moved in the mesial direction by bodily movement of the tooth to be in contact with the disto-proximal surface of primary secondary molars in the late stage. 2. Lower first permanent molars were erupted with mesial inclination in the early stage and moved mesially by tipping movement of the tooth to be in contact with the disto proximal surface of the second primary molars in the late stage. 3. The eruptive forces were considered to be main etiologic factors of space closure after the premature loss of primary molars.

• Journal of Korea Technology Innovation Society
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• v.8 no.3
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• pp.1175-1198
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• 2005

The objective of the study is to verify the relationship between technology valuation indexes and corporate's performance in ventures by business operating periods. The result of the study is expected to be useful in loan evaluation, investment decision, internal management decision making and business improvement. The results of study is as follows. First, in early stage ventures, we find that three major valuation index(technology feasibility, economic efficiency, productivity) are significant ex-ante variables which are discriminating between firms' going concern and firms' failure. Second, in growth stage ventures, we find that three major valuation index(business feasibility, general marketability, technology marketability) are significant ex-ante variables which are discriminating between firms' going concern and firms' failure. Third, in early stage ventures, we find that at least thirty-eight minor valuation index elements are significant ex-ante variables which are discriminating between firms' going concern and firms' failure and in growth stage ventures, thirty-one minor valuation index elements are significant in various analysis' results.

• International conference on construction engineering and project management
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• 2007.03a
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• pp.635-641
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• 2007

The construction starts its business by receiving the order from client and owner. The client presents requirements and related information so that the desired result can come out while the designer and the builder express and implement the building according to set objectives and goals of project based on information on project environment and presented requirements. Because the construction project makes decisions on such objectives at its early stage and previous stage becomes the situation for decision making of next stage as the computation to implement decisions get performed. Accordingly, this study has mentioned necessity of requirement analysis and systematization of construction project, analyzed the work of construction's early stage and resented a plan for objective of construction project requirement definition model in which requirements engineering has been applied and using it while making decisions on designing.

• Journal of the Korea Safety Management & Science
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• v.15 no.4
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• pp.401-405
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• 2013

Fund-raising is critical to start-up and early stage company. We try to analyse a status of fund-raising in start-up and early stage company, and a correlation between angel investment and start-up. With last 10 years' data sheets, we find that angel investment is not related with start-up fund raising.

• Journal of the Korea Institute of Military Science and Technology
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• v.6 no.4
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• pp.38-44
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• 2003

In this paper configuration design is viewed as an engineering discipline that plays a key role in the design integration process at early-stage development of a complex and large-scale product. Taking as an instance an aircraft development program that Korean engineers had experienced in Lockheed-Martin company, the process of early-stage configuration design is recapitulated and then a role model of effective design integration activities is presented.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2006.06a
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• pp.333-334
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• 2006

Extinguishing a fire at an early stage is most important to prevent spreading of a fire in Unmanned Engine Room. The most proper fire extinguish system was analyzed after examining the Automatic spread Extinguish System, which is mostly installed in Unmanned Engine Room, reproduced in the condition of real Unmanned Engine Room.