• Toxicological Research
• /
• 제13권3호
• /
• pp.215-222
• /
• 1997

The features of seizure-related brain injuries in rats poisoned i.p. with diisopropylfiuorophosphate were investigated. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were pretreated i.m. 30 min and 10 min, respectively. before diisopropylfluorophosphate (10 mg /kg, $2LD_50$) poisoning to reduce the mortality and eliminate peripheral signs. Diisopropylfluorophosphate induced severe limbic seizures, and early necrotic and delayed apoptotic brain injuries. The necrotic brain injury, which was closely related to seizure intensity, was exerted as early as 1 hr predominently in hippocampus and piriform cortex. showing spongiform change (malacia) of neurophils in severe cases, in contrast to a typical apoptotic (TUNEL-positive)pattern after 12 hr in thalamus, and a mixed type in amygdala. Nitric oxide content in cerebrospinal fiuid significantly increased after 2 hr, reaching a maximal level at 6 hr. Pretreatment with $_L-N^G$-nitroarginine, an inhibitor of nitric oxide synthase, reduced nitric oxide content and attenuated only apoptotic brain injury in all four brain regions examined without affecting seizure intensity and necrotic injury. Taken together, early necrotic and delayed apoptotic brain injuries induced by diisopropylfiuorophosphate poisoning in rats may be related to seizure intensity and nitric oxide production, respectively.

• 아동학회지
• /
• 제21권1호
• /
• pp.283-294
• /
• 2000

The purpose of this study was to determine early childhood education(ECE) and early childhood special education(ECSE) teachers' perceptions of (a)important teacher competencies needed for working in inclusive early childhood programs and (b)current levels of these competencies. Sixty-two ECE teachers and 77 ECSE teachers responded to the survey developed for this study. There were no differences between the ECE teachers and ECSE teachers in the ratings of importance of the competency domains. However, the ECSE teachers had significantly higher perceptions than the ECE teachers of their self-proficiency on competencies related to child development, curriculum and instruction, assessment procedures, working with other adults, and professionalism. Both the ECE and ECSE teachers perceived the greatest need for further training in competencies related to assessment procedures and working with families and other adults.

• 환경영향평가
• /
• 제20권3호
• /
• pp.269-279
• /
• 2011

Sustainability assessments tend to integrate ecological, social, and economic concerns. Sustainability assessment could be considered the highest rung in the assessment ladder. Broad strategies that seek to integrate individual SEA(Strategic Environmental Assessment) could be subjected to a sustainability assessment. Sustainability assessment could incorporate global and transboundary effects and priorities into SEA and project-level EIA(Environmental Impact Assessment). SEA could provide an environmental context and direction for project-level EIA. Procedural and substantive EIA requirements can be addressed through tiering such as sustainability assessment, SEA, project-level EIA. In Korea, PERS(Prior Environmental Review System) that has been utilized to evaluate administrative plans related with various kinds of development projects should be evolved not only to incorporate environmental impacts into early stage decision-making, but also to implicate sustainability assessments that include social equity and economic efficiency. Integration of SEA and sustainability assessment can be initiated through the application of DPSIR (Driving Force - Pressure - State - Impact - Response ) framework that was developed by European Environmental Agency.

• 성인간호학회지
• /
• 제25권2호
• /
• pp.113-124
• /
• 2013

Purpose: Purposes of this study were to develop a reliable and valid checklist to assess and manage post-stroke dysphagia and to identify its utilization. Methods: The first step was to develop checklist through systematic literatures reviews, to test the content validity from 11 clinical experts, and to test the construct validity and the internal consistency from 97 patients with post-stroke dysphagia. The second step was to identify clinical use of the checklist from the same 97 patients. Results: A total of 18 items compromised the assessment checklist and 64 items for intervention checklist. Internal consistencies of assessment checklist and intervention checklist were .84 and .98, respectively. In both checklists, level of utilization of general appearance was the highest, while that of early signs of aspiration was the lowest. The utilization levels of two checklists were significantly higher among patients who were less than 60 years old, and had liquid diet, facial paralysis, and previous history of aspiration pneumonia. Conclusion: We found that the checklists were reliable and valid. Further study is needed to develop specific strategies to improve nurses' use of assessment and intervention checklists for post-stroke dysphagia.

• 한국CDE학회논문집
• /
• 제16권2호
• /
• pp.146-155
• /
• 2011

As the seriousness of environmental pollution being on a rise, a low carbon and environment-friendly design for energy efficiency has been issued. With respect to energy in the construction industry, an adoption of BIM which is possible for the various energy performance assessments in the early design phase has been actively working on. In the most cases of energy performance assessment, the data compatibility from the lack of standard software and format became a problem and the improvement for data compatibility system has been needed. This study is to develop the IFC based IDF converter as a middleware which connects between BIM software and energy analysis software. For the building energy performance assessment, Energy Plus and IFC are selected for the standard energy analysis software and its file format. Parameters are organized by steps and the integrated material library is built so it is trying to reduce the existing problem of energy software interface as much as possible. The development of IDF Converter will promote the spread of related fields with increasing the BIM standard and the utilization of energy performance assessment.

• Environmental Analysis Health and Toxicology
• /
• 제25권1호
• /
• pp.19-26
• /
• 2010

Discharged materials from the point or non-point source are released into the sea, and as the results, marine environment is directly affected. We must estimate the impacts of contaminants to marine pollution rapidly and accurately. Therefore, it is needed on early warning system for appreciating marine environmental impacts, and required a bioassay to evaluate abnormal changes. A bioassay test was developed to examine the effects of heavy metal contaminants on the early life stages of the marine annimals. We have studied the effects of metals on early development of a sea urchin species, Strongylocentrotus intermedius. S. intermedius embryos were tested with six metals (Cu, Ag, Zn, Cd, Cr, Ni) and showed the highest sensitivity to Cu as well as the lowest sensitivity to Cd. The order of biological impact for metals was Cu>Ag>Ni>Zn>Cr>Cd. In accordance with the results, sea urchins embryos can provide biological criteria for seawater quality assessment. The sensitivity of developmental bioassay whith S. intermedius is at intermediate level among marine organisms commonly used in aquatic bioassays. And this sea urchin can be routinely employed as a test organism for ecotoxicity assays.

• 대한소아치과학회지
• /
• 제40권1호
• /
• pp.72-81
• /
• 2013

최근 2세에서 5세 사이 소아의 우식 발생율이 상당히 증가하고 있다. 유아기우식증(Early Childhood Caries)은 향후 영구치의 우식 발생 가능성에 대한 예측인자이며 사회 저소득층과 다문화 가정 자녀에서 특히 발생빈도가 높은데, 이는 충분히 예방과 관리가 가능하다. 만1세때부터 정기적으로 치과를 방문하고 이 때 우식위험도를 체계적으로 평가하여 환자들에게 맞춤형 예방 전략을 제시할 수 있기 때문이다. 유아기우식증의 예방을 위한 CAMBRA (Caries Management by Risk Assessment)에 대해 가장 최신의 개념과 사용법을 소개하고자 한다. 소아치과의사는 CAMBRA를 통해 개개인의 위험인자를 분석하여 연령에 따른 적절한 예방법을 수립하고 향후 우식 발생시 치료방향의 지침을 정하게 된다.

• Korean Journal of Radiology
• /
• 제25권1호
• /
• pp.86-102
• /
• 2024

Early diagnosis, accurate assessment, and localization of peritoneal metastasis (PM) are essential for the selection of appropriate treatments and surgical guidance. However, available imaging modalities (computed tomography [CT], conventional magnetic resonance imaging [MRI], and 18fluorodeoxyglucose positron emission tomography [PET]/CT) have limitations. The advent of new imaging techniques and novel molecular imaging agents have revealed molecular processes in the tumor microenvironment as an application for the early diagnosis and assessment of PM as well as real-time guided surgical resection, which has changed clinical management. In contrast to clinical imaging, which is purely qualitative and subjective for interpreting macroscopic structures, radiomics and artificial intelligence (AI) capitalize on high-dimensional numerical data from images that may reflect tumor pathophysiology. A predictive model can be used to predict the occurrence, recurrence, and prognosis of PM, thereby avoiding unnecessary exploratory surgeries. This review summarizes the role and status of different imaging techniques, especially new imaging strategies such as spectral photon-counting CT, fibroblast activation protein inhibitor (FAPI) PET/CT, near-infrared fluorescence imaging, and PET/MRI, for early diagnosis, assessment of surgical indications, and recurrence monitoring in patients with PM. The clinical applications, limitations, and solutions for fluorescence imaging, radiomics, and AI are also discussed.

• 한국보육학회지
• /
• 제18권1호
• /
• pp.193-216
• /
• 2018

본 연구의 목적은 유아교사의 정서노동이 심리적 소진에 미치는 영향에서 원장의 변혁적 및 거래적 리더십의 조절효과를 분석하는데 있다. 본 연구대상은 경기도에 소재한 유치원 및 어린이집에 재원 중인 교사 211명을 대상으로 하였다. '유아교사 정서노동 검사도구', '원장의 변혁적 및 거래적 리더십 검사도구', 그리고 '유아교사의 심리적 소진 검사도구'를 사용하여 연구자료를 수집하였으며 수집된 자료는 Pearson 적률 상관계수와 위계적 중다회귀분석을 통해 검증하였다. 연구결과, 첫째, 유아교사의 정서노동은 심리적소진과 정적상관관계가 나타났으며 원장의 변혁적 및 거래적 리더십은 심리적 소진과 부적 상관관계가 나타났다. 둘째, 유아교사의 정서노동은 심리적 소진에 정적예측변인으로 나타났다. 셋째, 원장의 변혁적 및 거래적 리더십은 심리적 소진에 부적예측변인으로 나타났다. 넷째, 원장의 변혁적 리더십은 심리적 소진의 하위영역 중 직문환경 불만족에 조절효과가 나타났으며, 원장의 거래적 리더십은 심리적 소진의 하위영역 중 신체정서적 고갈에 조절효과가 나타났다.

• 대한원격탐사학회지
• /
• 제37권3호
• /
• pp.503-514
• /
• 2021

쌀 수급 조절 정책의 합리적 수립을 지원하기 위해서는 벼 재배면적의 조기 추정이 필요하다. 본 연구는 국내 벼 주산지인 김제시를 대상으로 Sentinel-1 위성영상을 활용하여 이앙이 마무리되는 7월 초순 벼 재배면적을 조기에 추정하기 위해 최적의 훈련자료 수집을 위한 무인기(UAV) 영상 활용 방안을 제시하고자 수행하였다. 5월부터 7월 초까지 수집한 Sentinel-1 위성영상은 ESA에서 제공하는 SNAP(SeNtinel application platform, Version 8.0)프로그램으로 전처리하고 팜맵을 활용하여 농경지만을 추출하였다. 벼 재배지 중심 지역과 벼·콩 혼재지 무인기 영상 촬영 영역을 혼합하여 훈련자료로 선정하여 김제시 전체 벼 재배지를 추정한 결과, 정확도와 카파 계수는 각각 89.9%, 0.774로 가장 좋은 결과를 보였는데, 이는 김제시 전역을 대상으로 무작위 표본조사를 수행하여 분류한 결과와 비교 시 전체 정확도 1% 내외, 카파 계수 0.02~0.04 범위에서 차이를 보여 벼 재배지 조기 추정을 위한 무인기 영상 활용 가능성을 확인할 수 있었다.