• Title/Summary/Keyword: ERE$

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Inhibitory Effects of Curcuminoids on $17{\beta}$-hydroxysteroid Dehydrogenase Type 1 Activity in Animal Livers

  • Lee, Sung-Eun;Park, Byeoung-Soo;Kim, Hye Jin;Lee, Eun-Woo;Yum, Jong Hwa
    • Biomedical Science Letters
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    • v.19 no.2
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    • pp.147-152
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    • 2013
  • 17-${\beta}$-hydroxysteroid dehydrogenase type 1 ($17{\beta}$-HSD type 1) mediates the reaction of $17{\beta}$-estradiol (E2) production from estrone (E1). Inhibitory effects of curcuminoids on $17{\beta}$-HSD type 1 activity were investigated to find a lead compound for treating estrogen-dependent diseases including breast cancer. Among curcuminoids, demethoxycurcumin showed potent inhibitory effect ($IC_{50}=2.7{\mu}M$) on mouse $17{\beta}$-HSD type 1. Curcuminoids also displayed their inhibitory effects on the production of $17{\alpha}$-estradiol which is a carcinogenic metabolite produced by the enzyme. Bisdemethoxycurcumin ($IC_{50}=1.3{\mu}M$) showed potent inhibitory effect on the $17{\alpha}$-estradiol production by chicken $17{\beta}$-HSD type 1. Curcuminoids did not inhibit ERE transcriptional activity with and without E2. Taken together, curcuminoids can be used for treating and preventing E2-dependent diseases via inhibition on $17{\beta}$-HSD type 1 activity.

Comparative Study on MARC Formats:based on -KORMARC·CHINESE MARC and JAPAN MARC(I) (MARC 포맷에 관한 비교연구(比較硏究)(I) -KORMARC·CHINESE MARC·JAPAN MARC를 중심(中心)으로-)

  • Oh, Dong-Geun
    • Journal of the Korean Society for information Management
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    • v.3 no.1
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    • pp.136-158
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    • 1986
  • This comparative analysis is a preliminary study for the Integrated format in MARC systems in Korea, Taiwan and Japan. For this purpose, it analyzes KORMARC, CHINESE MARC and JAPAN MARC formats, dividing them into the structure of the record, its contents, and content designation. The results of this analysis shows that t~ere is no compatibility among these three formats due to the differences in the organization and division of the data elements and the deficiency of the data elements themselves.

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Buying Motivations for Imported and Domestic formal Suits among Married Women (기혼여성의 수입 정장의류와 국산 정장의류의 구매동기 연구)

  • 박혜정;박재옥
    • The Research Journal of the Costume Culture
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    • v.11 no.1
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    • pp.1-10
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    • 2003
  • The purpose of this study is to identify differences that married exist between married women´s buying motivations for imported and domestic formal two piece suits and to test the role of socioeconomic variables on those differences. Sample selection criteria included married women lit in8 in ,seoul. Korea, between ages 30∼59. Purposive sampling method was used to secure respondents It with experience with imported formal two-piece suits. Of 400 distributed. 246 usable questionnaires were returned. Statistical analysis of results included factor analysis, and paired t-tests. For both imported and domestic suits, the most important buying motivation was utilitarian, with qualify the most important consideration. Purchases of domestic suits were more influenced by factors such as advertisements, economics, impulse buying, approval of others, and current fashionability of style than were the purchases of imported suits. On the other hand, purchases of imported suits u·ere more influenced by factors such as prestige and utilitarian motivation than were purchases of domestic suits. For most socioeconomic variables, respondents indicated significant differences in their motivations for buying imported suits and domestic suits. The results of this study suggest the need for implementing different marketing strategies for imported suits and domestic suits.

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The Empirical Study on Unfair Terms in Services Contract and Consumer Problems (서비스약관과 관련된 소비자문제의 실증연구)

  • 박수경
    • Journal of the Korean Home Economics Association
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    • v.36 no.5
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    • pp.89-106
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    • 1998
  • Standard contsacts are drafted by one side only and therefore naturally favour that party. The other party must either adhere to those terms or abandon the transaction entirely. Accordingly the terms in these contracts tend to by quite harsh, especially so in consumer transactions. The objectives of this study are to examine the degree of consumer knowledge practical use, experience of consumer problems on service contract terms and to investigate the factors which influence on the degree of experience of consumer problems related the contract terms. The data used in this empirical study included 685 consumers experienced transactions with the terms in the last two years in Seoul. Statistics used for data analysis ere Reliability, Frequencies, Means, Standard Deviation and Multiple Regression Analysis. The conclusions can be summarized as follows. 1) Actually, consumers experienced many problems related the service-contract terms, despite regulation of unfair contract terms. 2) The level of education and purchasing experience variables have affected positively to the level of consumer problem experiences related the contract terms. 3) The effect of trend and characteristics of contract terms are variables with the type of contract terms. Therefore the regulation of the contract terms have to by differently enforced according to the type of contract terms.

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Computation of the ERF from the OTF (OTF계산값을 이용한 ERF계산)

  • 심상현
    • Korean Journal of Optics and Photonics
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    • v.4 no.2
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    • pp.140-144
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    • 1993
  • A computer program for computing the edge response function(ERF) from the optical transfer function( 0TF) was developed. The ERFs of un-aberrated optical system and aberrated optical system were studied by the use of that program. We calculated the ERFs of the optical systems with a single aberration and with a combined aberration. In sagittal case, the ERE of the optical system with defocus or spherical aberration was worse than that with coma. In tagential case, the ERF of the optical system with coma was worse than that with defocusing or spherical aberraion. Both the shape and the position of ERF were varied with coma, but only the position of ERF was varied with distortion, in tangential case.

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Survey on the Spider-fauna and their Seasonal Fluctuation in Paddy Fields of Taegu, Korea (대구의 논거미상과 그 계절적 변동에 대한 조사)

  • Paik Kap-Yong;Kim Jin-Sik
    • Korean journal of applied entomology
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    • v.12 no.3
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    • pp.125-130
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    • 1973
  • To study the faunal compositiion of spiders as natural enemies of the insect pests and their seasonal fluctuation in paddy fields of Taegu, the survey was carried out 12 times between June and September. 1971. 1. The spiders collected in paddy field of Taegu during the survey period were 45 species of 30 genera of 10 families. 2. In percentage composition the spiders of the genus Pirata were most abundant. Among the other genera, the species of the genus Neoscona, Lycosa, and Marpisa were more abundant in the above-written order. 3. Pirata subpiraticus, Neoscona doenitzi, Lycosa sp., Pardosa T-insignita and Marpisa magister were the 5 major species of abundant spiders. 4. Comparing the spider-fauna of the paddy field of Korea with that of Japan, Taiwan and Thailand, 2 species of 2 genera of the family Gnaphosidae were found in Korea only The abundant and common species It·ere deeply different each other. 5. Pirata subpiraticus, Lycosa sp. and Pardosa T-insignita appeared abundantly between June and July while Neoscona doenitzi and Marpisa magister were few in these periods. But no Pirata subpiraticus, Lycosa sp. and Pardosa T-insignita appeared in August while Neoscona doenitzi and Marpisa magister were abundant in this period. Then, in September as between June and July, Pirata subpiraticus, Lycosa sp. and Pardosa Tinsignita were abundant while Neoscona doenitzi and Marpisa magister decreased.

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Effect of lysozyme and glycine on the Mageoly brewing process (Lysozyme 및 glycine의 첨가가 막걸리의 품질에 미치는 영향)

  • Lee, Sung-Ki;Kim, In-Ho;Min, Byong-Yong
    • Applied Biological Chemistry
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    • v.33 no.3
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    • pp.252-256
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    • 1990
  • Characteristics of brewing product, Mageoly mashes diluted by the same ratio of water was investigated for alcohol formation, pH change, acid formation nucleotide content and sensory evaluation stored at $3^{\circ}C\;or\;30^{\circ}C$ during 7 days. Each sample was mixed with lysozyme 270ppm and glycine 0.27%, or lysozyme 450ppm and glycine 0.45% on the secondary brewing process in Mageoly brewing. The brewing was not affected by addition of lysozyme and glycine mixture. When the lysozyme-glycine mixture was added during brewing, that resulted in a decrease in pH, a suppression of acid formation and an increase in IMP and inosine content Therefore ere was significantly improved in taste and palatability.

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Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.)

  • Park, Eun-Ryong;Lee, Hae-Jung;Kim, Kyong-Su
    • Preventive Nutrition and Food Science
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    • v.5 no.3
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    • pp.119-125
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    • 2000
  • Volatile flavor components of two strawberry (Fragaria ananassa Duch.) varieties, Bogyojosaeng and Suhong, ere extracted by SDE(Simultaneous steam distillation and extraction) using a mixture of n-pentane and diethylether (1:1, v/v) as an extract solvent. Analysis of the concentrate by capillary gas chromatography and gas chromatography-mass spectrometry led to the identification of 146 and 153 components in Bogyojosaengand Suhong respectively. There were 49 esters, 25 alcohols, 20 ketones, 24 aldehyds, 6 acids, 9 terpenes and terpene derivatives, 2ethers, 11 unknowns and miscelaneous in Bogyojosaeng and 67 ethers, 9 unknowns and miscellaneous in Suhong. Among these, (E)-2-hexenyl acetae (4.56%) in Bogyojosaeng and (E)-nerolidol (12.38%) in Suhong were major compounds and aceticacid, (E)-2-hexenal, hexyl acetate, ethyl acetate, ethyl butanoate, methyl butanoate, ethyl hexanoate and ${\gamma}$-dodecalactone were the main components in each sample, though there were several differences in composition and threshold of volatile compounds. Total contents of volatile components isolated and identified in Bogyojosaeng an Suhong were 9.010 and 12.527 mg/kg, respectively.

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A Study on the Type and Symbolism of Yopae in the Ere of the Three Kingdoms - Mainly Classifying the Type of the Big Yopae - (삼국시대(三國時代) 요패(腰佩)의 형식(形式) 및 그 상징성(象徵性)에 대한 연구(硏究) - 대형요패(大形腰佩)의 형식분류(形式分類)를 중심(中心)으로 -)

Characteristics in Height Determination considering Gravity Field (동력장을 고려한 높이결정의 특성에 관한 연구)

  • 유복모;양인태;손덕재
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.5 no.1
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    • pp.32-42
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    • 1987
  • Global change and local fluctuation of earth's gravity field play important roles in accurate vertical positioning as well as in accurate horizontal positioning. Regarding the impotance, in this study, the concept of gravity potential theory connected with the influence of gravity field and every kind of height were discussed. Various kind of heights using the observed gravity and leveling data were computed and analysed to study the influence of earth's gravity field in accurate vertical positioning. Taking the route from Busan to Kyongju and investigating the ratios ($\Delta$H/dH) of height defferences (dH) between calculated heights considering gravity field and leveling height to relative heights (dH) between adjacent stations, we get the result that the values by correction formula increase linearly according to latitude, and the values by gravity potential ere strongly influenced by pseudo topography.

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