• Hwankyungkyoyuk
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• v.15 no.1
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• pp.18-30
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• 2002

So far, the environmentally responsible behavior(ERB) model has been applied successfully to explain environment behaviors. But the ERB model has several limitations such as underestimation of social factors on environment behaviors. This study planned to point out that the emotional aspects should be considered seriously for explaining human's behaviors to conserve the environment in the ERB model. In this study, the effects of emotional aspects, such as perceived severity or perceived danger, on environment behaviors were investigated and the protective motivation theory(Rogers, 1983) and the ERB-based tentative model were compared Results showed that teenagers in urban areas realized clearly the severity and danger of environmental threats and do environmentally responsible behaviors more than ones in rural areas. Two model's goodness of fit to explain observed environment behaviors were analyzed through the regression analysis and the AMOS analysis. In the regression analysis, self-efficacy, confirmity toward social norm, and knowledge were involved in the regression equation as statistically meaningful variables in the ERB-based tentative model and self-efficacy and perceived severity were involved in the protective motivation theory. Especially, the AMOS analysis showed that the protective motivation theory was more valid model lot explaining environment behaviors than the ERB-based tentative model. In conclusion, it is reasonable that emotional aspects should be considered as meaningful variables for explaining environment behaviors.

• Biomolecules & Therapeutics
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• v.30 no.5
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• pp.409-417
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• 2022

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, and accumulating evidence indicates that mitochondrial dysfunction is associated with progressive deterioration in PD patients. Previous studies have shown that sinapic acid has a neuroprotective effect, but its mechanisms of action remain unclear. The neuroprotective effect of sinapic acid was assayed in a PD mouse model generated by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as in SH-SY5Y cells. Target protein expression was detected by western blotting. Sinapic acid treatment attenuated the behavioral defects and loss of dopaminergic neurons in the PD models. Sinapic acid also improved mitochondrial function in the PD models. MPTP treatment increased the abundance of mitochondrial fission proteins such as dynamin-related protein 1 (Drp1) and phospho-Drp1 Ser616. In addition, MPTP decreased the expression of the REV-ERB α protein. These changes were attenuated by sinapic acid treatment. We used the pharmacological REV-ERB α inhibitor SR8278 to confirmation of protective effect of sinapic acid. Treatment of SR8278 with sinapic acid reversed the protein expression of phospho-Drp1 Ser616 and REV-ERB α on MPTP-treated mice. Our findings demonstrated that sinapic acid protects against MPTP-induced PD and these effects might be related to the inhibiting abnormal mitochondrial fission through REV-ERB α.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.6947-6951
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• 2015

Background: Oral carcinoma (OC) remains one of the most difficult malignancies to cure. Hesa-A is an Iranian herbal-marine compound that has shown promising anti-tumor properties against various human tumors. However, its mechanism of action remains to be addressed. The present study was conducted to evaluate the effect of two doses of Hesa-A on mRNA expression of erb$\backslash$b2 as a main prognosticator tumor marker for OC in an animal model. Materials and Methods: A total of 60 rats were randomly divided into 5 groups of 12 animals each. Rats in carcinoma groups received 0, 250 and 500mg/kg body weight doses of Hesa-A 3 times a day. The other two groups were considered as treated and untreated control groups. At the end of the experiment, animals were sacrificed and tongue tissues subjected to H and E staining and real time PCR. Results: Our results showed that compared to the control group, erb$\backslash$b2 was over-expressed ~ 30% in the carcinoma group. After treatment with 250mg/kg and 500mg/kg body weight of Hesa-A, erb$\backslash$b2 levels dropped by 24.1% and 3.4 % respectively compared to the control carcinoma group (p<0.01, p<0.0001). Moreover, there was a significant relation between erb$\backslash$b2 mRNA content and observed pathological changes in studied groups (p<0.05). Conclusions: These data provide insight into mechanism(s) by which Hesa-A may improve clinical outcome of oral carcinoma by affecting oncogene erb$\backslash$b2 expression and suggest Hesa-A as an effective chemotherapeutic agent in treatment of HER+tumors.

• Journal of Digital Convergence
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• v.12 no.10
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• pp.265-270
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• 2014

Existing speech recognition algorithm have a problem with not distinguish the order of vocabulary, and the voice detection is not the accurate of noise in accordance with recognized environmental changes, and retrieval system, mismatches to user's request are problems because of the various meanings of keywords. In this article, we proposed to event based semantic ontology inference model, and proposed system have a model to extract the speech recognition feature extract using ERB filter. The proposed model was used to evaluate the performance of the train station, train noise. Noise environment of the SNR-10dB, -5dB in the signal was performed to remove the noise. Distortion measure results confirmed the improved performance of 2.17dB, 1.31dB.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6219-6225
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• 2014

Background: Increasing evidence from animal, epidemiological and clinical investigations suggest that dietary anthocyanins have potential to prevent chronic diseases, including cancers. It is also noteworthy that human epidermal growth factor receptor 2 (ErbB2) protein overexpression or ErbB2 gene amplification has been included as an indicator for metastasis and higher risk of recurrence for breast cancer. Materials and Methods: The present experiments investigated the anti-metastasis effects of black rice anthocyanins (BRACs) on ErbB2 positive breast cancer cells in vivo and in vitro. Results: Oral administration of BRACs (150 mg/kg/day) reduced transplanted tumor growth, inhibited pulmonary metastasis, and decreased lung tumor nodules in BALB/c nude mice bearing ErbB2 positive breast cancer cell MDA-MB-453 xenografts. The capacity for migration, adhesion, motility and invasion was also inhibited by BRACs in MDA-MB-453 cells in a concentration dependent manner, accompanied by decreased activity of a transfer promoting factor, urokinase-type plasminogen activator (u-PA). Conclusions: Together, our results indicated that BRACs possess anti-metastasis potential against ErbB2 positive human breast cancer cells in vivo and in vitro through inhibition of metastasis promoting molecules.

• Molecules and Cells
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• v.41 no.8
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• pp.742-752
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• 2018

Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of dopaminergic (DAergic) neurons, particularly in the substantia nigra (SN). Although circadian dysfunction has been suggested as one of the pathophysiological risk factors for PD, the exact molecular link between the circadian clock and PD remains largely unclear. We have recently demonstrated that $REV-ERB{\alpha}$, a circadian nuclear receptor, serves as a key molecular link between the circadian and DAergic systems. It competitively cooperates with NURR1, another nuclear receptor required for the optimal development and function of DA neurons, to control DAergic gene transcription. Considering our previous findings, we hypothesize that $REV-ERB{\alpha}$ may have a role in the onset and/or progression of PD. In the present study, we therefore aimed to elucidate whether genetic abrogation of $REV-ERB{\alpha}$ affects PD-related phenotypes in a mouse model of PD produced by a unilateral injection of 6-hydroxydopamine (6-OHDA) into the dorsal striatum. $REV-ERB{\alpha}$ deficiency significantly exacerbated 6-OHDA-induced motor deficits as well as DAergic neuronal loss in the vertebral midbrain including the SN and the ventral tegmental area. The exacerbated DAergic degeneration likely involves neuroinflammation-mediated neurotoxicity. The $REV-erb{\alpha}$ knockout mice showed prolonged microglial activation in the SN along with the over-production of interleukin $1{\beta}$, a pro-inflammatory cytokine, in response to 6-OHDA. In conclusion, the present study demonstrates for the first time that genetic abrogation of $REV-ERB{\alpha}$ can increase vulnerability of DAergic neurons to neurotoxic insults, such as 6-OHDA, thereby implying that its normal function may be beneficial for maintaining DAergic neuron populations during PD progression.

• Proceedings of the IEEK Conference
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• 2002.07c
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• pp.1717-1720
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• 2002

Objective quality measurement schemes that in- corporate properties of the human auditory system. The basilar membrane(BM) acts as a spectrum analyzer, spatially decomposing the signal into frequency components. Each filterbank is an implementation of the ERB, gam-machirp function. This filterbank is level-dependent asymmetric compensation filters. And for the validation of the auditory model, we calculate the CPD. Quality measurement is obtained from the result.

• Nuclear Engineering and Technology
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• v.27 no.4
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• pp.518-531
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• 1995

A study has been Peformed to investigate the thermal margin increase by replacing the single-channel analysis model with a multichannel analysis model. h new critical heat flux(CHF) correlation, which is applicable to a 17$\times$17 Korean Fuel Assembly(KOFA)-loaded core, was developed on the basis of the local conditions predicted by the subchannel analysis code, TORC. The hot sub-channel analysis was carried out by using one-stage analysis methodology with a prescribed nodal layout of the core. The result of the analysis shooed that more than 5％ of the thermal margin can be recovered by introducing the TORC/KRB-1 system(multichannel analysis model) instead of the PUMA/ERB-2 system(single-channel anal)sis model). The thermal margin increase was attributed not only to the effect of the local thermal hydraulic conditions in the hot subchannel predicted by the code, but also to the effect of the characteristics of the CHF correlation.

• Proceedings of the IEEK Conference
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• 2003.07e
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• pp.2144-2147
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• 2003

Objective quality measurement schemes that incorporate properties of the human auditory system. The basilar membrane (BM) acts as a spectrum analyzer, spatially decomposing the signal into frequency components. Filterbanks were used to complementing the linearity of BM. Each filterbank is an implementation or the Equivalent rectangular Bandwidth (ERB), gammachirp function. This filterbank is level-dependent asymmetric compensation filters. And for the validation of the auditory model, we calculate the calculated perceived difference(CPD).