• 생물정신의학
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• 제24권3호
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• pp.129-133
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• 2017

Objectives Obsessive-compulsive disorder (OCD) is a disabling psychiatric disorder, and more attention is recently paid on the quality of life (QoL) in OCD patients. The Euro-QoL-5D (EQ-5D) is a widely used self-report to calculate a single score which represents 'health utilities'. The aim of this study was to assess the health-related QoL for patients with OCD using the EQ-5D and to examine the relationship between health-related QoL and symptom severity. Methods Seventy-three patients with a Diagnostic and Statistical Manual of Mental Disorders (DSM-5) diagnosis of OCD were recruited from the outpatient clinic in Seoul National University Hospital. Symptom severity was assessed using the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and QoL was assessed with the EQ-5D-5L questionnaire. Using Korean valuation study, a single score of QoL was calculated. Results Most of the OCD patients were relatively young (< 45 years) with the mean YBOCS total score of 19.33. The mean EQ-5D score was 0.71 and significantly correlated with symptom severity (r = -0.483, p < 0.001). 25% of the EQ-5D score was predicted by the YBOCS total score (b = -0.011, p < 0.001) by regression analysis. Conclusions OCD patients suffer from lower health-related QoL and QoL significantly decreased as symptom severity increased. The results of the EQ-5D would enable further studies on QoL comparison across medical disease and mental disorders.

• 대한불안의학회지
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• 제8권1호
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• pp.9-15
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• 2012

Objectives : The purpose of this study was to assess the health-related quality of life (HRQoL) for patients with panic disorder using EQ-5D and EQ-VAS, and to examine the relationship between health-related quality of life and clinical outcomes following treatment. Methods : 29 patients with panic disorder were recruited from the Seoul Metropolitan area and 20 patients were followed up after two months of outpatient treatment. The Panic Disorder Severity Scale (PDSS) was used to assess the severity of the panic disorder and the changes in symptoms. HRQoL was assessed with EQ-5D and EQ-VAS at baseline and at two months of treatment. Results : All enrolled panic disorder patients showed significantly impairment of HRQoL in view of the subscales of EQ-5D, EQ-VAS index scores. The severity of PDSS was correlated the HRQoL in the panic patients. After treatment, the EQ-5D, EQ-VAS index scores showed significant improvement. Conclusion : Panic disorder patients suffer from lower HRQoL as well as from symptoms of the disorder. They showed clinical improvement and a restored HRQoL with treatment. These outcomes suggest using the EQ-5D, EQ-VAS such as the HRQoL in the assessment of patients with panic disorder is essential.

• Journal of Preventive Medicine and Public Health
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• 제50권6호
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• pp.361-368
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• 2017

Objectives: This study aimed to explore dimensions in addition to the 5 dimensions of the 5-level EQ-5D version (EQ-5D-5L) that could satisfactorily explain variation in health-related quality of life (HRQoL) in the general population of South Korea. Methods: Domains related to HRQoL were searched through a review of existing HRQoL instruments. Among the 28 potential dimensions, the 5 dimensions of the EQ-5D-5L and 7 additional dimensions (vision, hearing, communication, cognitive function, social relationships, vitality, and sleep) were included. A representative sample of 600 subjects was selected for the survey, which was administered through face-to-face interviews. Subjects were asked to report problems in 12 health dimensions at 5 levels, as well as their self-rated health status using the EuroQol visual analogue scale (EQ-VAS) and a 5-point Likert scale. Among subjects who reported no problems for any of the parameters in the EQ-5D-5L, we analyzed the frequencies of problems in the additional dimensions. A linear regression model with the EQ-VAS as the dependent variable was performed to identify additional significant dimensions. Results: Among respondents who reported full health on the EQ-5D-5L (n=365), 32% reported a problem for at least 1 additional dimension, and 14% reported worse than moderate self-rated health. Regression analysis revealed a $R^2$ of 0.228 for the original EQ-5D-5L dimensions, 0.200 for the new dimensions, and 0.263 for the 12 dimensions together. Among the added dimensions, vitality and sleep were significantly associated with EQ-VAS scores. Conclusions: This study identified significant dimensions for assessing self-rated health among members of the general public, in addition to the 5 dimensions of the EQ-5D-5L. These dimensions could be considered for inclusion in a new preference-based instrument or for developing a country-specific HRQoL instrument.

• 대한지역사회영양학회지
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• 제19권5호
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• pp.479-489
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• 2014

Objectives: This study intended to determine significant factors that influence the health-related quality of life ("HRQoL"; EuroQol 5 Dimension health-related quality of life (EQ_5D) & EuroQol visual analogue scale (EQ_VAS)) of the elderly in Korea. Methods: This study was based on 3,903 subjects aged 65 years or more who participated in the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V), 2010~2012. The HRQoL was analyzed by various factors (general characteristics, health habits, mental health, chronic diseases, nutrient intakes). SPSS statistics for complex samples (Windows ver. 21.0) was used. Results: The HRQoL was higher in the males, those with higher educational level or higher income level while it was lower in those belong to single households. In particular, the EQ_5D was significantly higher in the group who reported walking practice, moderate physical activity (male), and the group who reported no vigorous physical activity (female). The EQ_VAS was significantly higher in the group who reported walking practice. Both EQ_5D and EQ_VAS were significantly lower in the group with stress, melancholy, suicidal thinking, and osteoarthritis. EQ_5D was significantly lower in the group with < 75% Estimated Energy Requirements (EER) in energy intake, and with < Estimated Average Requirements (EAR) in iron or niacin intake. A stepwise regression analysis revealed that i) higher educational level (male), and good self-rated health status significantly increased the EQ_5D, ii) age, alcohol intake (male), melancholy (female), suicidal thinking, osteoarthritis, and niacin intake deficiency (male) significantly decreased the EQ_5D, iii) higher income level (male) and good self-rated health status significantly increased the EQ_VAS, and iv) age (male), stress, suicidal thinking (female) and osteoarthritis significantly decreased the EQ_VAS. Conclusions: This study suggested that general characteristics, mental health, osteoarthritis, and niacin intake were associated with the HRQoL. Prospective research of long-term control is needed to establish the causal relationship between factors and the HRQoL.

• 대한지역사회영양학회지
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• 제20권6호
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• pp.423-432
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• 2015

Objectives: In Korea, the percentage of elderly is increasing at an unprecedented rate, and is expected to account for 40% of the population by 2060. This massive demographic change stresses the importance of research on aging as it is necessary to improve the quality of life (QoL) of this population. This study aimed to examine the health-related quality of life (HRQoL) of the rural elderly and to clarify its association with the nutrient adequacy ratio (NAR). Methods: A cross-sectional study was performed in S-gun, Chonbuk, a critical agricultural area. The elderly people without abnormal physical functioning composed our study population and the data were collected by personal visits to 336 elderly people aged over 65 years (110 males and 226 females). Subjects were interviewed with questionnaires pertaining to general characteristics and EuroQol (EQ-5D). Nutrient intakes were assessed two days by 24-hours recall method. Subjects were defined as high QOL group if EQ-5D index with Nam's model was above the median. Results: Generally, EQ-5D index was lower in women than in man, and lower in older subjects than in younger subjects. The percentages of people below the median were 42% (low QoL group) and 58% (high QoL group) were found to be the above the median. The high QoL group had higher NAR, especially for vitamin C, vitamin B1, vitamin B2 and folate. All dimensions in the EQ-5D were affected by NAR of some nutrients and especially anxiety/depression dimension was significantly correlated with NAR of 5 nutrients (protein, calcium, iron, vitamin C and vitamin B1) and EQ-5D scores. Conclusions: HRQol was significantly reduced in elderly with increasing age and this was more pronounced in women than in man. The NAR of some nutrients were associated with the EQ-5D index, especially anxiety/depression dimension, among rural elderly.

• 한국산업보건학회지
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• 제20권2호
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• pp.79-87
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• 2010

Objectives: The purpose of this study was to investigate the symptoms of work-related musculoskeletal disorders (WMSDs), the influence of the WMSDs on the health-related quality of life (HRQoL), and to identify the differences of WMSDs and HRQoL between greenhouse farmers and paddy farmers. Methods: Subjects were 34 greenhouse farmers and 56 paddy farmers who were living in a rural community. The sociodemographic characteristics, health-related behavior, working characteristics, WMSDs and HRQoL were investigated. WMSDs symptoms were measured by a selfassessed questionnaire on musculoskeletal disorders symptoms and HRQoL was measured by the Euro Quality of Life (Euroqol) EQ-5D index. The differences on the WMSDs, EQ-5D and it's related factors between the groups were assessed with t-test and ${\chi}^2$-test. Results: Greenhouse farmers were longer the working hours per day and working duration than paddy farmers. The level of prevalence of the WMSDs in greenhouse farmers is higher than in paddy farmers. The EQ-5D index of greenhouse farmers and paddy farmers were 0.819 and 0.874, respectively. Overall, the mean value of EQ-5D index was significantly lower greenhouse farmers than paddy farmers. Conclusions: These results showed that the HRQoL for farmers are strongly influenced by WMSDs and agicultural type in that we are aware of the need to comply with regulations of WMSDs, especially greenhouse farmers.

• 치위생과학회지
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• 제14권3호
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• pp.417-423
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• 2014

이 연구는 국민건강영양조사를 이용하여 우리나라 만 65세 이상 노인을 대상으로 보철 상태에 따른 건강관련 삶의 질을 조사하여, 노인의 구강건강증진의 기초자료를 확보하고자 하였으며, 다음과 같은 결론을 얻었다. 전체 연구대상자의 HRQoL은 0.86이었으며, 성별에 따른 HRQoL은 남자에서 0.90에 비해 여성에서 0.82로 남자가 유의하게 높았으며, 월 평균 소득이 증가할수록, 학력수준이 높을수록, 상실치아 개수가 낮을수록 HRQoL이 유의하게 높았다. 연구대상자 중 고정성 가공의치와 총의치 필요한 대상자는 HRQoL이 유의하게 낮았으며, 부분의치와 총의치를 장착하지 않은 대상자에서 HRQoL이 유의하게 높았다. EQ-5D의 현재의 건강 상태 5개의 항목에서 운동능력 항목은 부분의치 장착군에서 비장착군에 비해 어려움에 대한 응답한 비율이 높았으며, 자기관리 항목에서 총의치장착군에서 어려움이 있다고 응답한 비율이 높았다. 불안/우울 항목에서 총의치 장착군이 비장착군에 비해 어려움이 있다고 응답한 비율이 높았다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3345-3350
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• 2015

Background: Evaluation of health-related quality of life (HRQOL) in cervical cancer patients is important in order to design the interventions for improving patient outcomes. Reports of HRQOL among cervical cancer patients in Indonesia are limited. Moreover, measurement using EQ-5D-3L is to our best knowledge has hitherto not been performed. This study aimed to examine the HRQOL of cervical cancer patients in Indonesia using EQ-5D-3L. Materials and Methods: A cross-sectional study was conducted by interviewing cervical cancer patients using the EQ-5D-3L questionnaire. Percentages of patients who reported having problems in each dimension of EQ-5D as well as EQ-5D index score (utility) were calculated. Results: Our findings indicated that the most frequent reported problems were pain/discomfort (67.8%) followed by anxiety/depression (57.5%). The mean of EQ-5D VAS was 75.8 (SD=17.0). The mean (SD) utility scores were 0.85 (0.19), 0.76 (0.20), 0.71 (0.21), and 0.77 (0.13) for cervical cancer patients in stage I, II, III, and IV, respectively. Conclusions: Cervical cancer significantly affects patient HRQOL. Efforts should be made to improve the quality of life of cervical cancer patients especially in terms of pain /discomfort and anxiety/depression reduction.

• Journal of Preventive Medicine and Public Health
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• 제41권6호
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• pp.434-441
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• 2008

Objectives: This study was conducted to measure the decline in the health-related quality of life (HRQoL) associated with some diseases in South Korean adults. Methods: The EQ-5D health states in the 2005 National Health and Nutrition Examination Survey (NHNES) and the Korean EQ-5D valuation set were used to obtain the EQ-5D indexes of the study subjects. Each disease group was defined when the subjects reported to the NHNES that they were diagnosed with the corresponding disease during the previous 1 year by physicians. Since the distributions of the EQ-5D indexes in each subgroup were negatively skewed, median regression analysis was used to estimate the effects of specific diseases on the HRQoL. Median regression analysis produced estimates that approximated the median of the EQ-5D indexes and there are more robust for analyzing data with many outliers. Results: A total of 16,692 subjects (6,667 patients and 10,025 people without any disease) were included in the analysis. As a result of the median regression analysis, stroke had the strongest impact on the HRQoL for both males and females, followed by osteoporosis, osteoarthritis, rheumatic arthritis, and herniation of an intervertebral disc. While asthma had a significant impact on the HRQoL only in men, cataract, temporo-mandibular dysfunction, and peptic ulcer significantly affected the HRQoL only in women. Conclusions: Stroke and musculoskeletal diseases were associated with the largest losses of the HRQoL in Korean adults.

• 한국엔터테인먼트산업학회논문지
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• 제13권8호
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• pp.357-365
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• 2019

본 연구의 목적은 대사증후군을 가진 사람의 성별, 연령에 따른 건강관련 삶의 질(EQ-5D)의 차이를 확인하는 것이다. 국민건강영양조사(KNHANES VI-2)에 응답한 5,021명의 자료를 이용하여 대사증후군 판정을 하였으며, IBM SPSS STATISTICS 25.0의 복합표본분석을 적용한 빈도분석, 교차분석과 Complex Samples GLM과 Complex Samples t-test를 사용하였다. 연구결과 EQ-5D 지수에 있어서 남성이 여성보다 다소 높았다(p<.001). 연령별로는 청장년(19~39세), 중년(40~65세), 노년(65세 이상)의 순서로 높게 확인되었다(p<.001). 대사증후군 여부로는 대사증후군에 속하지 않는 경우가 대사증후군을 가진 경우보다 추정치가 높게 나타났으나 통계적으로 유의하지는 않았다. 대사증후군 여부로는 대사증후군이 있는 경우에 그렇지 않은 경우보다 건강관련 삶의 질이 추정치에서 낮음으로 나타났으나 통계적으로 유의하지 않았다(p>.05). 한편, 전체 모집단(population)에서 성인을 대상으로 복합표본을 적용한 독립표본 t 검정(Complex Samples Independent t-test)을 통해 성별 간 대사증후군 유병여부에 따른 EQ-5D는 여성의 경우 대사증후군에 속하지 않은 경우가 대사증후군에 속하는 경우 보다 높은 지수가 확인되었으며 통계적으로 유의한 차이가 확인되었다(p<.01).