• Journal of Microbiology and Biotechnology
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• v.29 no.8
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• pp.1273-1280
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• 2019

Edwardsiella piscicida is the causative agent of edwardsiellosis, which has caused enormous economic losses worldwide. In our previous research, an attenuated live vaccine known as WED and based on the virulent strain E. piscicida EIB202 can effectively protect turbots against edwardsiellosis via intraperitoneal injection, while vaccination by immersion exhibits a weaker effect. During the development of the immersion vaccine, we surprisingly found the counts of ${\Delta}pEIB202/EIB202$ colonized on zebrafish were 100 times lower than those of EIB202. However, pEIB202 carries 53 predicted ORFs and has several copies in E. piscicida EIB202, impeding the study of its function. Thus, the replication region is located at a 1,980 bp fragment (from 18,837 to 20,816 bp), containing a transcriptional repressor and a replication protein. Moreover, the minimal replication plasmid, named pRep-q77, has low copies in both E. coli and E. piscicida, but is more stable in E. piscicida than in E. coli. This work lays a foundation for further examination of the function of the virulence plasmid pEIB202.

• Tuberculosis and Respiratory Diseases
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• v.42 no.2
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• pp.165-174
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• 1995

Background: Exercise is one of the most common precipitants of acute asthma encountered in clinical practice. The development of airflow limitation that occurs several minutes after vigorous exercise, i. g. exercise-induced bronchoconstriction(EIB), has been shown to be closely correlated with the nonspecific bronchial hyperresponsiveness, which is the hallmark of bronchial asthma. All previous reports that assessed the correlation of EIB to nonspecific bronchial hyperresponsiveness have focused on airway sensitivity($PC_{20}$) to inhaled bronchoconstrictor such as methacholine or histamine. However, maximal airway narrowing(MAN), reflecting the extent to which the airways can narrow, when being exposed to high dose of inhaled stimuli, has not been studied in relation to the degree of EIB. Methods: Fifty-six children with mild asthma(41 boys and 15 girls), aged 6 to 15 years(mean${\pm}$SD, $9.9{\pm}2.5$ years) completed this study. Subjects attended the laboratory on two consecutive days. Each subject performed the high-dose methacholine inhalation test at 4 p.m. on the first day. The dose-response curves were characterized by their position($PC_{20}$) and MAN, which was defined as maximal response plateau(MRP: when two or three data points of the highest concentrations fell within a 5% response range) or the last of the data points(when a plateau could not be measured). On the next day, exercise challenge, free running outdoors for ten minutes, was performed at 9 a.m.. $FEV_1$ was measured at graduated intervals, 3 to 10 minutes apart, until 60 minutes after exercise. Response(the maximal ${\triangle}FEV_1$ from the pre-exercise value) was classified arbitrarily into three groups; no response((-) EIB: ${\triangle}FEV_1$<10%), equivocal response ($({\pm})$EIB:10%<${\triangle}FEV_1$<20%) and definite response($({\pm})$EIB:${\triangle}FEV_1$>20%). Results: 1) When geometric mean $PC_{20}$ of the three groups were compared, $PC_{20}$ of (+) EIB group was significantly lower than that of (-)EIB group. 2) There was a close correlation between $PC_{20}$ and the severity of EIB in the whole group(r=-0.568, p<0.01). 3) Of the total 56 subjects, MRP could be measured in 36 subjects, and the MRP of these subjects correlated fairly with the severity of EIB(r=0.355, p<0.05) 4) The MAN of (+) EIB group was significantly higher than that of (-)EIB group(p<0.01). 5) The MAN correlated well with the severity of EIB in the whole group(r=0.546, p<0.01). Conclusion: The degree of MAN as well as bronchial sensitivity($PC_{20}$) to methacholine is correlated well with the severity of EIB. The results suggest that the two main components of airway hyperresponsiveness may be equally important determinants of exercise reactivity, although the mechanism may be different from each other. The present study also provides further evidence that EIB is a manifestation of the increased airway reactivity characteristic of bronchial asthma.

• Proceedings of the KIEE Conference
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• 2007.04a
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• pp.420-422
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• 2007

Nowadays, the demand for home networking system is gradually increasing. But most of vendors use their own protocols. KNX/EIB ( European Installation Bus / Konnex) is a standard protocol approved as an European (EN 50090 - EN 13321-1) and a World-wide standard (ISO/IEC 14543). In this study, we develop on/off and dimming lighting control system using BIM. In this system, BIM communicates to micro-controller using PEI(Physical External Interface) communication. And this enables including more KNX/EIB communication objects in lighting control system, and providing lighting control algorithm. The technology in this paper can help to adapt the world-wide standards.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.41 no.2
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• pp.1-8
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• 2004

In this paper, we proposed ARAHE(Adaptive Resource Allocation algorithm for HIPERLAN/2 with Error channel). It uses EIB(Error Indication Bits) for efficient resource allocation. We evaluate the performance of ARAHE by simulation and the result shows ARAHE has better performance than current method in the case of delay, utilization and TSR(Transmission Success Rate).

• 한국벤처창업학회:학술대회논문집
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• 2023.04a
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• pp.29-38
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• 2023

그간 Venture Debt은 벤처기업의 스케일업을 촉진하는 수단으로 인식되어 왔으나, 경기하강 국면에서는 투자유치가 여의치 않은 벤처기업에 유동성을 제공하는 자금공급수단으로서의 중요성이 부각된다. 한편, 2023년 3월 SVB의 파산으로 Venture Debt 취급기관의 지속가능성에 대한 우려가 부각되었다. 이에 본 연구에서는 대출재원의 지속가능성을 염두에 두고, 경기침체기 대안적 자금 공급수단으로서 Venture Debt 활성화방안을 연구하였다. 선행연구들은 주로 전통적 Venture Debt을 분석대상으로 하였으나, 본 연구에서는 벤처생태계의 성장과 경기사이클 변화에 따라 다양해지고 있는 Venture Debt을 유형별로 분석하였다. Venture Debt 유형을 전통적, Growth형, 유동성 지원형으로 구분하고, 각각 SVB, EIB(유럽투자은행), 해외 벤처유동성 지원사례를 중심으로 구조적 특징과 차이점을 분석하였고, 직접대출방식과 BDC 등 간접대출방식을 비교 분석하였다. 이와 함께, 경제성, 시장성, 대출재원 확보가능성 차원에서 국내 도입환경에 대한 실무적·법률적 검토를 병행하였다. 본 연구에서는 국내 활성화방안으로 채권형 BDC 활성화를 통한 민간재원 활용, 벤처전용 유동성지원 프로그램 마련, 제2데스밸리 극복을 위한 Growth형 벤처대출 도입, 독립형 워런트 발행을 위한 법적 근거 마련 등을 제안한다.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.2 no.1
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• pp.91-100
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• 1996

Radiotherapy is an irreplaceable method of cancer treatment but, it has various side effects, especially damage to the hemopoietic system. A lot of radioprotectors have been found but they also have toxic effects. Many kinds of crude drugs(Oriental Chinese medicine)with low toxicity have been reported to promote the recovery from radiation damage. Recently, the trial to combine radiotherapy with herbal treatment of cancer patients shows a desirable result, an enhancement in recovery of the blood system.. This study was performed to determine whether prescriptions to support the healthy energy and strengthen the body resistence, Buzhongyiqi-tang and Siliu-tang, promote the recovery of splenocytes of N:GP(s) mice from radiation damage. We investigated the proliferative effect of Buzhongyiqi-tang, Siliu-tang and EIB(ethanol insoluble fraction of Buzhongyiqi-tang) on N:GP(S)mice splenocytes before or after ${\gamma}$-irradiation. We also investigated the morphology of splenocytes cultured with these herbs. Buzhongyiqi-tang and Siliu-tang promoted the proliferation of splenocytes in a concentration of 0.1 mg/ml compared with normal control(p<0.001). After 1-5Gy of ${\gamma}$-irradiation they also showed the effect of recovery of hemopoietic cells, especially in Buzhongyiqi-tang(4Gy:p<0.005; 5Gy:p<0.05). In addition, EIB(ethanol insoluble fraction of Buzhongyiqi-tang) showed the highest proliferative effect of all agents suggesting that more effective fractions could be found from crude herbs or prescriptions. These results suggest that it is possible to make use of Buzhongyiqi-tang, Siliu-tang or EIB as radio-protective agents.

• The Korean Journal of Nuclear Medicine
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• v.27 no.2
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• pp.223-232
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• 1993

Technetium labeled isonitrile analogues are widely used as myocardial perfusion imaging agents. We synthesized and characterized a new isonitrile compound, ethyl 3-isocyanobutyrate(EIB). Proton and $^{13}C$ NMR spectroscopy and thin layer chromatography with a $C_{18}$ coat was performed. EIB was easily labeled with $^{99m}TcO_4^-$- with sodium dithionite. The labeling efficiency measured by RP-HPLC was over 95%. The labeled product was stable with dilution in normal saline and with prolonged incubation at room temperature. There was no formation of secondary products or free $^{99m}TcO_4^-$. In vivo kinetics study of $^{99m}Tc$ (I) labeled EIB in rabbits showed adequate myocardial uptake, good contrast against lung background, and relatively rapid liver clearance. The heart to lung ratio was over 2.5 and the heart to liver ratio was approximately from 0.4 to 5 at 60 minutes post injection. Hepatic clearance of $^{99m}Tc-MIBI$ was faster ($t_{1/2}$=6 minutes) than that of $^{99m}Tc-MIBI$. In vivo kinetics observed in dog was similar to that in rabbit but there was faster gallbladder filling, and thus lower liver background. SPECT imaging of the canine myocardium showed favorable imaging characteristics. However, biodistribution in mice demonstrated a myocardial % injected dose/organ of less than 0.1%. This was thought to be due to interspecies difference in plasma esterase activity. In human plasma, $^{99m}Tc$ ( I ) labeled EIB was stable for at least 2 hours, without production of secondary products by HPLC. We conclude that ethyl 3-isocyanobutyrate may be a potential new myocardial perfusion imaging agent and deserves further investigation as to its usefulness for clinical use.

• Proceedings of the Korean Information Science Society Conference
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• 2002.04b
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• pp.382-384
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• 2002

컴포넌트 기 반 소프트웨어 개발에서 구현에 사용되는 각 컴포넌트의 성능을 이 해하는 것은 중요하다. 본 논문은 Black Box의 관점에서 EIB 컴포넌트의 성능을 측정하는 방댄 과 이 측정 방법을 지원하는 성능 측정 도구의 설계 구현에 대하여 설명한다 본 도구는 대상 컴포넌트에 대 한 영 향을 최소화하기 위하여 클라이언트 시스템에서 동작하여 성능을 측정할 수 있도록 설계되었다. 또한 사용자가 적은 노력으로 새로운 컴포넌트의 성능을 측정 할 수 있도록 테스트 프로그램을 자동으로 생성한다. 본 연구의 결과는 상용 컴포넌트의 시장에 등장하는 여러 컴포넌트의 성능을 객관적 인 방법으로 비교 측정 할 수 있는 효과적인 수단이 될 것으로 기대된다.

• Journal of Industrial Technology
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• v.28 no.A
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• pp.43-49
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• 2008

The track of high-speed railway get deteriorated according as using it. In that case, the maintenance jobs are needed for improvement of track quality. A scheduling problem for the track maintenance of high-speed railway is to determine the jobs should be performed daily. In the problem, the set of jobs for maintenance is given. Each job has it's parameters such as due date, emergency level, and processing time. In addition, jobs can be worked during a certain fixed time when the train doesn't move. In this study, we developed a mathematical model of the scheduling problem for the maintenance of high-speed railway and solved the problem using the ILOG CPLEX library.

• Journal of Korea Multimedia Society
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• v.5 no.4
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• pp.468-476
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• 2002

Nowadays for reliable software and cost reduction there are many research works on software development based on component. One of the challenge in designing a component-based system is determining which components are required and where they fit in the overall system architecture. In this paper, we developed a EJB component for transforming RDB instances to XML documents. Accordly users can build XML applications based on relational database just by assembling this component. Consequently they can reduce time and cost for developing their XML applications.