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CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

  • Hashim, Natasha;Jamalludin, Zulaikha;Ung, Ngie Min;Ho, Gwo Fuang;Malik, Rozita Abdul;Ee Phua, Vincent Chee
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.13
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    • pp.5259-5264
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    • 2014
  • Background: CT based brachytherapy allows 3-dimensional (3D) assessment of organs at risk (OAR) doses with dose volume histograms (DVHs). The purpose of this study was to compare computed tomography (CT) based volumetric calculations and International Commission on Radiation Units and Measurements (ICRU) reference-point estimates of radiation doses to the bladder and rectum in patients with carcinoma of the cervix treated with high-dose-rate (HDR) intracavitary brachytherapy (ICBT). Materials and Methods: Between March 2011 and May 2012, 20 patients were treated with 55 fractions of brachytherapy using tandem and ovoids and underwent post-implant CT scans. The external beam radiotherapy (EBRT) dose was 48.6Gy in 27 fractions. HDR brachytherapy was delivered to a dose of 21 Gy in three fractions. The ICRU bladder and rectum point doses along with 4 additional rectal points were recorded. The maximum dose ($D_{Max}$) to rectum was the highest recorded dose at one of these five points. Using the HDRplus 2.6 brachyhtherapy treatment planning system, the bladder and rectum were retrospectively contoured on the 55 CT datasets. The DVHs for rectum and bladder were calculated and the minimum doses to the highest irradiated 2cc area of rectum and bladder were recorded ($D_{2cc}$) for all individual fractions. The mean $D_{2cc}$ of rectum was compared to the means of ICRU rectal point and rectal $D_{Max}$ using the Student's t-test. The mean $D_{2cc}$ of bladder was compared with the mean ICRU bladder point using the same statistical test. The total dose, combining EBRT and HDR brachytherapy, were biologically normalized to the conventional 2 Gy/fraction using the linear-quadratic model. (${\alpha}/{\beta}$ value of 10 Gy for target, 3 Gy for organs at risk). Results: The total prescribed dose was $77.5Gy{\alpha}/{\beta}10$. The mean dose to the rectum was $4.58{\pm}1.22Gy$ for $D_{2cc}$, $3.76{\pm}0.65Gy$ at $D_{ICRU}$ and $4.75{\pm}1.01Gy$ at $D_{Max}$. The mean rectal $D_{2cc}$ dose differed significantly from the mean dose calculated at the ICRU reference point (p<0.005); the mean difference was 0.82 Gy (0.48-1.19Gy). The mean EQD2 was $68.52{\pm}7.24Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$, $61.71{\pm}2.77Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$ and $69.24{\pm}6.02Gy_{{\alpha}/{\beta}3}$ at $D_{Max}$. The mean ratio of $D_{2cc}$ rectum to $D_{ICRU}$ rectum was 1.25 and the mean ratio of $D_{2cc}$ rectum to $D_{Max}$ rectum was 0.98 for all individual fractions. The mean dose to the bladder was $6.00{\pm}1.90Gy$ for $D_{2cc}$ and $5.10{\pm}2.03Gy$ at $D_{ICRU}$. However, the mean $D_{2cc}$ dose did not differ significantly from the mean dose calculated at the ICRU reference point (p=0.307); the mean difference was 0.90 Gy (0.49-1.25Gy). The mean EQD2 was $81.85{\pm}13.03Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$ and $74.11{\pm}19.39Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$. The mean ratio of $D_{2cc}$ bladder to $D_{ICRU}$ bladder was 1.24. In the majority of applications, the maximum dose point was not the ICRU point. On average, the rectum received 77% and bladder received 92% of the prescribed dose. Conclusions: OARs doses assessed by DVH criteria were higher than ICRU point doses. Our data suggest that the estimated dose to the ICRU bladder point may be a reasonable surrogate for the $D_{2cc}$ and rectal $D_{Max}$ for $D_{2cc}$. However, the dose to the ICRU rectal point does not appear to be a reasonable surrogate for the $D_{2cc}$.

Studies on bionomical characteristics of Papilio xuthus (호랑나비(Papilio xuthus)의 생육특성에 관한 연구)

  • Lee, Sang-Hyun;Kim, Se-Gwon;Kim, Nam-Ee;Bae, Kyoung-Sin;Choi, Young-Cheol
    • Journal of Sericultural and Entomological Science
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    • v.51 no.2
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    • pp.173-179
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    • 2013
  • This study was investigation for primary bionomical characteristics, emergence rate of wintering type pupa and oviposition preference, of Papilio xuthus. The emergence rate of wintering type pupa stored at cold chamber($4{\pm}1^{\circ}C$) was 85%, after 10 months. The average emergence rate of wintering type pupa during storage was 89.6%, and the emergence periods were $7.9{\pm}1.9days$ in room temperature. Mating ratio in large oviposition room, $6,000{\times}6,000{\times}3,500$ mm($W{\times}L{\times}H$), was $86.7{\pm}5.8%$ higher than $63.3{\pm}15.3%$ in small room, $2,500{\times}3,000{\times}2,000$ mm($W{\times}L{\times}H$). But the number of eggs in the large room were $137.0{\pm}16.5$ fewer than $141.7{\pm}20.4$ in the small room. As a result of oviposition preference experiment on three different host plants, 10 mated female laid $141.7{\pm}27.8$ on the leaves of Phellodendron amurensew more than $67.7{\pm}20.6$ on Zanthoxylum schinifolium and $77.0{\pm}21.8$ on Citrus unshiu. The egg periods were $4.4{\pm}0.8$ days after oviposition, and the hatchability was 92.2% in $25^{\circ}C$ room condition. The larval period were $19.9{\pm}2.1$ days in the high temperature, long day condition($25^{\circ}C$, 14L : 10D). The headwidth of each developmental larval stage were $0.72{\pm}0.02$(1st), $1.19{\pm}0.02$(2nd), $1.65{\pm}0.05$(3rd), $2.43{\pm}0.07$(4th), $3.21{\pm}0.12$(5th). The pupal ratio was 91.6%. The pupal period were $8.8{\pm}0.9$ days, and the emergence rate was 92.2%.

Lipid Components of Sea Squirt, Halocynthia roretzi, and Mideuduck, Styela clava (우렁쉥이 및 미더덕의 지방질성분)

  • Lee, Eung-Ho;Oh, Kwang-Soo;Lee, Tae-Hun;Ahn, Chang-Bum;Chung, Young-Hun;Kim, Kyung-Sam
    • Korean Journal of Food Science and Technology
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    • v.17 no.4
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    • pp.289-294
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    • 1985
  • Total lipid (TL) content of sea squirt (Ureungsweng-ee), Halocynthia roretzi, and Mideuduck, Styela clava, were 2.0%, 2.1%, respectively. Reviewing the composition of each lipid fraction in total lipids of sea squirt and Mideuduck, it was found that contents of neutral lipids (NL) (36.6%, 36.3%) and phospholipids (PL) (46.2%, 44.5%) were high, while that of glycolipids (GL) (17.2%, 19.2%) was low. The NL of sea squirt and Mideuduck were mainly consisted of triglyceride (49.0%, 59.6%) and free sterol (25.8%, 22.0%), and followed by diglyceride (9.4%, 7.7%), monoglyceride (6.0%, 4.2%), free fatty acid (4.6%, 1.9%) and esterified sterol and hydrocarbon (5.2%, 4.4%). And main lipids in PL were phosphatidylcholine (48.6%, 46.7%) and phosphatidylethanolamine (32.4%, 35.0%), and followed by phosphatidylinositol (9.8%, 7.0%), phosphatidylserine (5.7%, 5.8%) and an unknown substance (3.5%, 5.5%). Fatty acid composition was not significantly different among TL, NL, PL and GL contained in sea squirt and Mideuduck. The major fatty acids of TL in sea squirt and Mideuduck were eicosapentaenoic (21.3%, 18.3%), docosahexaenoic (16.3%, 14.2%), palmitic (13.8, 16.3%) and oleic acid (8.5%, 7.0%), respectively. Fatty acid composition of PL and NL were similar to those of TL. In case of GL fraction the major fatty acids were gadoleic (15.7%, 14.7%), palmitic (13.5%, 14.7%), stearic (11.6%. 9.8%) and oleic acid (8.0%, 8.1%).

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Effects of Processing Method on Performance and Nutrient Digestibility in Growing-finishing Pigs Fed Lupine Seeds

  • Yang, Y.X.;Kim, Y.G.;Heo, S.;Ohh, S.J.;Chae, B.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.20 no.8
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    • pp.1229-1235
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    • 2007
  • Three trials were conducted to study the effect of processing method on performance, apparent nutrient and amino acid digestibilities in growing-finishing pigs fed lupine seeds. Ground, expanded or flaked lupine seed was prepared for the trials. In trial 1, a total of 72 growing barrows ($Landrace{\times}Large$ $White{\times}Large$, initial BW of $54.22{\pm}5.87$ kg) were allocated to three treatment diets containing 15% percent of differently processed lupine seed for 28 days. Each treatment had four replicates comprising 6 pigs each. In trial 2, a total of 48 finishing barrows ($Landrace{\times}Large$ $White{\times}Large$, initial BW of $84.40{\pm}6.84$ kg) were subjected to three treatments for 21 days. The experimental design was the same as trial 1 except for supplementation with 20% of lupine seed. Each treatment had four replicates comprising 4 pigs each. To evaluate the ileal digestibility of amino acids, a total of 9 barrows ($Landrace{\times}Large$ $White{\times}Large$), with an average initial BW of $41.07{\pm}1.98$ kg, were fed with ground, expanded or flaked lupine for 7 days. Each pig was surgically equipped with a simple T-cannula fitted in the distal ileum. Amino acid composition and presence of anti-nutritional factors (ANFs) in processed lupine sources were also evaluated. The results showed that there was no significant difference (p>0.05) in lupine amino acid composition due to the different processing methods. Expanded and flaked lupine significantly decreased (p<0.05) the concentration of ANFs compared with ground lupine. There was no effect (p>0.05) on the growth performance in growing pigs. However, processing method had a significant effect (p<0.05) on average daily gain (ADG), average daily feed intake (ADFI) and feed conversion ratio (FCR) in finishing pigs. There was no effect (p>0.05) of the different processing methods on the digestibility of dry matter (DM), gross energy (GE), ether extract (EE), Calcium (Ca) and phosphorus (P), but expanded lupine could significantly increase (p<0.05) the apparent digestibility of CP in finishing pigs. Furthermore, expanded lupine had a higher (p<0.05) apparent ileal digestibility for most indispensable and dispensable amino acids compared with ground and flaked lupine. It was concluded that expanded lupine could be beneficial in improving lupine's quality and improve performance and nutrient utilization in growing-finishing pigs.

Effect of Barley Mixtures on Forage Production and Soil Characteristics in Dry Riverbed of Ansancheon (안산천에서 청보리 혼파조합이 사초 생산성과 토양 특성에 미치는 영향)

  • Kim, Jong-Duk;Ko, Ki-Hwan;Kwon, Chan-Ho
    • Korean Journal of Organic Agriculture
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    • v.21 no.4
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    • pp.701-710
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    • 2013
  • This experiment was carried out to determine the forage production and soil characteristics in mixtures of barley and annual legumes at riverbed. The dry matter (DM) and total digestible nutrients (TDN) in barley and hairy vetch mixture were higher compared to other mixtures. Barley, single cropping was the highest in DM content. Comparing different mixtures, barley and crimson clover mixture was higher than other mixtures in DM contest. The crude protein (CP) content of barely and hairy vetch mixture was highest, but ether extract (EE) and TDN contents were lower than other mixtures. Barely and hairy vetch mixture significantly removed organic matter and phosphorus from riverbed through forage production (P<0.05). The total nitrogen (TN) of barley and hairy vetch mixture was highest because of high nitrogen fixation in riverbed soil. Single barley was highest in organic matter (OM) of soil. Comparing different mixtures, barley and crimson clover mixture was higher than other mixtures in OM contest. The available P2O5 of soil in barley and crimson clover mixture and barley and rape mixture were higher than others, and that of barley and hairy vetch was lower than other mixtures. The barely and hairy vetch mixture was highest in cation exchange capacity (CEC) content. Therefore barley and hairy vetch mixture is more suitable in forage mixtures because of high forage production and protein, and reduction of soil phosphorus in riverbed.

Statistical Estimates from Black Non-Hispanic Female Breast Cancer Data

  • Khan, Hafiz Mohammad Rafiqullah;Ibrahimou, Boubakari;Saxena, Anshul;Gabbidon, Kemesha;Abdool-Ghany, Faheema;Ramamoorthy, Venkataraghavan;Ullah, Duff;Stewart, Tiffanie Shauna-Jeanne
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.19
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    • pp.8371-8376
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    • 2014
  • Background: The use of statistical methods has become an imperative tool in breast cancer survival data analysis. The purpose of this study was to develop the best statistical probability model using the Bayesian method to predict future survival times for the black non-Hispanic female breast cancer patients diagnosed during 1973-2009 in the U.S. Materials and Methods: We used a stratified random sample of black non-Hispanic female breast cancer patient data from the Surveillance Epidemiology and End Results (SEER) database. Survival analysis was performed using Kaplan-Meier and Cox proportional regression methods. Four advanced types of statistical models, Exponentiated Exponential (EE), Beta Generalized Exponential (BGE), Exponentiated Weibull (EW), and Beta Inverse Weibull (BIW) were utilized for data analysis. The statistical model building criteria, Akaike Information Criteria (AIC), Bayesian Information Criteria (BIC), and Deviance Information Criteria (DIC) were used to measure the goodness of fit tests. Furthermore, we used the Bayesian approach to obtain the predictive survival inferences from the best-fit data based on the exponentiated Weibull model. Results: We identified the highest number of black non-Hispanic female breast cancer patients in Michigan and the lowest in Hawaii. The mean (SD), of age at diagnosis (years) was 58.3 (14.43). The mean (SD), of survival time (months) for black non-Hispanic females was 66.8 (30.20). Non-Hispanic blacks had a significantly increased risk of death compared to Black Hispanics (Hazard ratio: 1.96, 95%CI: 1.51-2.54). Compared to other statistical probability models, we found that the exponentiated Weibull model better fits for the survival times. By making use of the Bayesian method predictive inferences for future survival times were obtained. Conclusions: These findings will be of great significance in determining appropriate treatment plans and health-care cost allocation. Furthermore, the same approach should contribute to build future predictive models for any health related diseases.

The Development and Validation of the Survey of Students' Affective Characteristics in the Non-Cognitive Domain of Mathematics Learning (수학학습 정의적 영역 검사 도구 개발 연구)

  • Lee, Hwan Chul;Kim, Hyung Won;Ee, Ji-hye;Yi, Hyun Sook;Ko, Ho Kyoung
    • School Mathematics
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    • v.19 no.2
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    • pp.267-287
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    • 2017
  • Fostering students' positive affect related to mathematics such as attitudes toward mathematics and dispositions toward learning mathematical concepts is one of the major goals of school mathematics programs. In this study, we collected data from students at the 4-1 grade levels to develop an instrument that measures students' affect regarding mathematics learning. To develop the instrument, we first conducted focus group interviews, which we recorded, transcribed, and analyzed. We sorted the results according to seven components of the non-cognitive domain of mathematics learning, which drew from taxonomical constructs of previous research. We then conducted a pilot study in which we administered the instrument as a pretest and a posttest. We chose the final items based on confirmatory factor analysis and a reliability test of the pre and posttest scores. The final instrument contains 24 items, which are classified according to the seven components: interest, attitudes, value, external motivation, internal motivation, learning conation, and efficacy. We anticipate this instrument will be useful for studies that need to measure students' non-cognitive characteristics in relation to learning mathematics.

A Survey on the Status of Shoe-last Production for Handmade Shoes - Focused on Seongsu-dong Complex - (수제화 라스트 생산 현황 조사 - 성수동 지역을 중심으로 -)

  • Hong, Eun-Hee;Park, Myung-Ja;Jeong, Jae-Chul;Uh, Mi-Kyung
    • Journal of the Korea Fashion and Costume Design Association
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    • v.19 no.4
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    • pp.93-104
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    • 2017
  • This study is a basic study to develop shoe last design technology to enhance and revitalize the competitiveness of the handmade shoes. In-depth interviews were conducted with four manufacturers in Seongsu-dong to identify the production status and design technology of shoe lasts. The result of the research is as follows. Firstly, shoe lasts for adults are produced at intervals of 5mm between 245mm-285mm for men's shoes, and between 220-260mm for women's shoes. The production rate of women's shoes was high in the order of general type, boot type, and sandal type while men's shoes mainly produce general type. Secondly, the master last size and ball girth rating for men's and women's shoes were analyzed to EE-EEE grade at 260mm and D grade at 235mm. The length of the master last for men's shoes is 276-290mm, the heel width is 60-65mm, the ball width is 88-90mm, the ball girth is 250mm, and the waist girth is 248mm. The length of the master shoe last for women's shoes is 236-245 mm, the heel width is 50-55mm, the ball width is 78-80mm, the ball girth is 211~213mm, and the waist girth is 213~215mm. Thirdly, the last grading deviation is 5mm in length, the heel width is 0.5mm, the ball girth is 3.5mm, and the ball with is 1.2mm. The ball girth dimensions of Oxford type, slip-on type, and sneakers type are made at 250mm, 248mm, and 245mm for men's shoes. For women's shoes, the ball girth dimensions of pump type, loafer & boot type, and sandal type are made at 211~213mm, 214~215mm, and 211mm. Fourthly, t+he construction of the automation system is insufficient and almost completely depends on manual production.

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Effects of Inoculants on the Quality of Round Baled Grass Silage (유산균제 첨가가 라운드베일 목초 사일리지의 품질에 미치는 영향)

  • Kim, Jong-Geun;Chung, Eui-Soo;Seo, Sung;Ham, Jun-Sang;Yoon, Sei-Hyung;Lim, Young-Chul
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.26 no.3
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    • pp.139-146
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    • 2006
  • This experiment was conducted to determine the effect of microbial inoculant on the quality of round baled grass silage at experimental field of Grassland and Forages Division, National Livestock Research Institute, RDA, Suwon from 1997 to 1998. The experiment was consist of randomized block design with three replications. The treatments were three different inoculant (control, inoculant A, B and C). The contents of ether extract(EE), crude protein(CP) and in vitro dry matter digestibility(IVDMD) in inoculant treatment plots were higher than those in control. Silages treated by Inoculant A, Band C had significantly lower acidity than that of control silage (p<0.05). Dry matter(DM) content of control silage was higher than those of inoculant treated silage. There were significant differences in organic acid contents among treatments(p<0.05). Lactic acid was increased with inoculant treatment, but, acetic and butyric acid was decreased. The DM loss of all silages were decreased with inoculant treatment and quality grade of inoculant treated silage was higher than that of control. Results of this study indicate that addition of microbial inoculant will improve the fermentation and quality of round baled grass silage.

Effect of Germanium Treatment in Culture Medium on Germanium Absorption by Callus Induced from Brown Rice (배지내 게르마늄 처리가 현미 유도 캘러스의 게르마늄 흡수에 미치는 영향)

  • 권태오;남궁승박;박병우
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.41 no.6
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    • pp.729-735
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    • 1996
  • This study was carried out to investigate the effect of Germaniwn(Ge) treatment in the culture media on the Ge absorption by the callus induced from brown rice cv. Dongjinbyeo. MS medium was more effective on the growth ratio of callus and the content of Ge and some inorganic elements except K in callus than N$_{6}$ medium. The more Ge treatment in the N$_{6}$ or MS medium, the more Ge absorption by the callus, but the growth ratio of callus and the content of Ca, Mg, and K in callus were decreased. The content of Fe, Mn, Zn, and Cu was increased under treatment up to 100~200mg /$\ell$ Ge, but tended to be decreased under treatment more than that of Ge concentration. Under treatment less than 150mg /$\ell$ Ge, GeO$_2$(inorganic Ge) was more effective on the Ge absorption by callus than Ge-132(organic Ge), but Ge-132 was more effective on the Ge ab-sorption by callus and the activity of callus in case of treatment more than 150mg /$\ell$ Ge. The lower pH of culture medium, the higher Ge content in the callus. When callus was cultured on medium supplemented with Ge and 0.1~1.0mM of citric acid or myo-inositol, content of Ge and some inorganic elements in callus, as well as growth and dry weight of callus, were tend to increase in comparison to control, but myo-inositol was more effective on them than citric acid.cid.

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