• 대한약리학회지
• /
• 제5권2호
• /
• pp.121-127
• /
• 1969

Antimuscarinic agent like antispasmodic actions of licorice alkaloidal fraction, obtained from the Glycyrrhiza glabra L., was compared with that of atropine quantitatively. For this purpose, the author calculated the kinetic constants and $ED_{50}$ for acetylcholine antagonism by these drugs on rat ileum and guinea-fig ileum longitudinal muscle according to Paton's theoretical equations describing the combination of an antagonist drug with its receptors. The results are as follows. 1. On rat ileum. a) Licorice alkaloidal fraction $K_1$ (association rate constant)=$4.078{\times}10^2\;(s^{-1}\;gm^{-1}\;ml)$ $K_2$ (dissociation rate constant)=$6.986{\times}10^{-4}\;(s^{-1})$ $ED_{50}(K_2/K_1)=1.772{\times}10^{-6}(gm/ml)$ b) Atropine $K_1=5.136{\times}10^6$, $K_2=7.714{\times}10^{-4}$, $ED_{50}=1.408{\times}10^{-10}$ 2. On guinea-pig ileum longitudinal muscle a) Licorice alkaloidal fraction $K_1=1.30{\times}10^2$, $K_2=1.25{\times}10^{-3}$ $ED_{50}=9.58{\times}10^{-6}$ b) Atropine $K_1=5.75{\times}10^6$, $K_2=1.54{\times}10^{-3}$ $ED_{50}=2.68{\times}10^{-10}$ Above results present that 1 r of licorice alkaloidal fraction has equal fotency of acetylcholine antagonism with $8.5{\times}10^{-5}r$ of atropine on rat ileum, $2.8{\times}10^{-5}r$ on guinea-pig ileum longitudinal muscle. This facts suggest that the site and numbers of licorice alkaloid receptors of guinea-pig ileum are different from that of rat ileum. Besides, it also gives a suggestion that licorice alkaloidal fraction may be a partial antagonist on guinea-pig ileum in this experimental conditions.

• 정보관리학회지
• /
• 제13권2호
• /
• pp.97-120
• /
• 1996

본 연구는 듀이십진분류표의 인쇄형과 전자형 비교 및 이용 연구로 60명의 문헌정보학과 학생들을 대상으로 실시한 분류기호 작성에 관해 기술하고 있다. 4개의 다른 난이도로 이루어진 자료를 프로그램화된 듀이십진분류표 소개 책자로부터 선정하여 간단한 교육과 훈련을 하고 난후에 2문제씩 1차와 2차로 나누어 분류기호를 만들어 보게 하였다. 분류기호 작성 시간을 측정하고 분류과정과 결과 및 소요 시간을 기록하였다. 정확한 분류기호의 작성이 전자분류표의 사용에서 보다 신속하게 이루어졌지만 인쇄분류표를 사용한 학생들이 보다 많은 정확한 분류기호를 제공하였다. 또한 전자분류표의 인터페이스와 시스템 사양을 학생들이 제대로 적용하지 못했음에도 불구하고 인쇄분류표보다 전자분류표를 사용하면서 분류 작업에 더 많은 흥미를 느낀 것으로 나타났다. 영어 성적과 분류결과 성적의 상관관계를 측정한 결과ㅏ, 인쇄형으로 시작한 반은 부정적인 관계로까지 나왔고, 전자형으로 시작한 반은 극히 낮은 정적 관계로 나타났다. 총평점과 분류 결과 성적과도 아주 미약한 정적 관계만이 있었고 분류 소요 시간과 분류 결과 성적은 오히려 부정적인 관 瓮\ulcorner나타났다.

• 한국세라믹학회지
• /
• 제51권5호
• /
• pp.466-471
• /
• 2014

Hydrous zirconia particles were prepared from $ZrOCl_2$ aqueous solution using an electro-dialysis [ED] process. For the preparation of $(Zr,Y)(OH)_4$ precipitates, 3 mol% $YCl_3$ was added into $ZrOCl_2$ aqueous solution. During the hydrolysis of 0.5 mol/L $(Zr,Y)OCl_2$ solution at $90^{\circ}C$ a slurry solution was obtained. The ED process was used for the removal of chlorine from the slurry solution. Two kinds of slurry solution were sampled at the beginning and end of the ED process. The morphology of hydrous zirconia particles in the solution was observed using an inverted optical microscope and an FE-SEM. The hydrous zirconia particles were nano-crystalline, and easily coagulated with drying. Yttrium stabilized zirconia [YSZ] powder could be obtained by the calcination of $(Zr,Y)(OH)_4$ precipitates prepared from a $(Zr,Y)OCl_2$ solution by the ED process. The coagulated dry powders were shaped and sintered at $1500^{\circ}C$ for 2 h. The sintered body showed a dense microstructure with uniform grain morphology.

• Current Research on Agriculture and Life Sciences
• /
• 제7권
• /
• pp.231-235
• /
• 1989

Choline과 choline esters인 acetylcholine, methacholine, carbachol, bethanechol이 토끼의 적출장관 운동에 미치는 영향과 각 약물의 $pD_2$값을 산출하여 각각 비교를 하였다. Choline은 최대유효농도가 $10^{-2}M$이었으며 $ED_{50}$은 $2.4{\times}10^{-3}M$이었고 $pD_2$값은 2.619이었다. Acetylcholine은 최대유효농도가 $10^{-4}M$이었으며 $10^{-9}M$에서는 거의 효과가 나타나지 않았고 $ED_{50}$은 $0.5{\times}10^{-5}M$이었고 $pD_2$값은 5.154이었다. Methacholine은 최대유효농도가 $10^{-5}M$이었으며 $10^{-9}M$에서는 거의 효과가 나타나지 않았고 $ED_{50}$은 $9{\times}10^{-5}M$이었고 $pD_2$값은 6.045이었다. Carbachol은 최대유효농도가 $10^{-5}M$이었으며 $10^{-11}M$에서는 거의 효과가 나타나지 않았고 $ED_{50}$은 $5.7{\times}10^{-7}M$이었고 $pD_2$값은 6.244이었다. Bethanechol은 최대유효농도가 $10^{-4}M$이었으며 $10^{-8}M$에서는 거의 효과가 나타나지 않았고 $ED_{50}$은 $3.3{\times}10^{-6}M$이었고 $pD_2$값은 5.480이었다. Choline esters는 토끼의 적출장관 운동에 대하여 수축을 일으켰으며 각 약물의 potency의 순서는 carbachol이 가장 강하게 나타났고 methacholine, bethanechol, acetylcholine, choline의 순으로 나타났다.

• Archives of Pharmacal Research
• /
• 제9권4호
• /
• pp.215-217
• /
• 1986

Steroidal nitrosoureas have been synthesized and their antitumor activity on L 1210 cells was evaluated, N-(2-Chloroethyl)-N-nitrosocarbamoyl-3-aza-A-homo-5$\alpha$-cholestane (5a) showed significantly low $ED_{50}$ value of 1.6 $\nu$g/ml whose activity is equivalent to that of methyl-CCNU ($ED_{50}$ = 1.7 mg/ml).

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1998년도 추계학술대회 논문집 학회본부 C
• /
• pp.844-846
• /
• 1998

In this study, Brass endcap with 2, 3, 5, and 7mm contact surface and 0.6, 0.9, 1.2, 1.5mm conical cavity depths was fabricated by the punch die while keeping the cavity diameter constant 9.25mm then displacement characteristics of the cymbal actuators with each of brass endcap thickness were measured under an applied voltage $60V_{max}$. Dispacement increased with increasing contact surface and resonant frequency decreased with increasing contact surface, cymbal actuator with 7mm contact surface and 1.5mm endcap cavity depth exhibits $35.89{\mu}m$ displacement and 18.8kHz resonant frequency, displacement increased with increasing endcap cavity depth while contact surface was kept constant at 3mm and Below a endcap thickness of 0.2mm, Differences in displacement between 1.2mm and 1.5mm cavity depth appeared at $0.18{\mu}m$. that is, displacement of cymbal actuator with 1.2mm over cavity depth saturated nearly.

• 성인간호학회지
• /
• 제17권5호
• /
• pp.813-821
• /
• 2005

Purpose: The purpose of this study was to examine descriptors of dyspnea and clinical characteristics in patients with COPD at ED visit. Method: The study design was a descriptive survey, and 46 patients with COPD complaining of dyspnea were participated during their visits to the ED of C university hospital in G city, from October 1, 2004 to April 8, 2005. Result: The qualitative characteristics of dyspnea at the time of decision to the ED visit were short of breath (71.7%), tight (32.6%), hard to breathe (15.2%), smothering or suffocating (10.9%), gasping (8.7%), couldn't breathe (6.5%), constricted (2.2%), and hunger for air (2.2%). In the item of dyspnea checklists, My chest felt tight was the most common description among subjects. As the result of factor analysis of dyspnea checklists, the first factor was characterized rapid and shallow, the second was suffocating/smothering, the third was hunger for air, and the fourth was constricted. Conclusion: This study suggests that a checklist of dyspnea descriptors based on this findings would be utilized as a tool of initial and ongoing assessment for dyspneic patients with COPD in the ED after identifying the validity and reliability of the checklist.

• 한국CDE학회논문집
• /
• 제11권4호
• /
• pp.303-314
• /
• 2006

The exchange of CAD (Computer Aided Design) models between different CAD systems and to downstream applications such as manufacturing has become very important to modem industry. One serious current issue is that the process cannot automatically import existing 3-D solid models in a variety of commercial CAD formats into the process without manually re-mastering the model in current standard including "SIEP AP(Application Protocol) 203 Edition 1" To fully integrate technical data from the design agency to the shop floor, design intent and validated 3D geometry of feature based parametric CAD model should be brought into the standardized processes. To overcome this limitation, AP203 Edition 2 (Ed.2) and its related STEP parts such as Part55, Part108, Part109, Part111 and Part112 are starting to be available to handle this problem. The features in Part111 are harmonized with the machining features available in AP224. This paper is focused on two mapping technologies: CAD to Part111 mapping and Pat111 to AP224 mapping including case studios and it will provide the guideline about what should be done next in the AP203 Ed.2 to AP224 mapping. The final goal of this project is to integrate technical data from CAD to AP224 based manufacturing information through AP203 Ed.2.

• 한국체육학회지인문사회과학편
• /
• 제54권1호
• /
• pp.619-629
• /
• 2015

이 연구의 목적은 섭식장애 증상이 있는 여자대학운동선수와 일반여자대학생의 특성을 파악하고, 위험요인을 분석하는데 있다. 378명의 운동선수와 567명의 일반여대생이 참여하였다. 각 참여자는 자기기입형 검사지(섭식장애검사지/이상섭식 검사지, SATAQ, RSES)가 사용되었다. 운동선수집단에서 22명, 221명이 각각 섭식장애와 이상섭식으로 나타났으며, 비운동선수 집단에서 22명, 205명이 섭식장애와 이상섭식으로 분류되었다. 섭식장애와 이상섭식 증상을 가지고 있는 두 집단의 특성 중 각각 6가지와 7가지 변인에서 통계적으로 유의한 차이가 있는 것으로 나타났다. 단계적 회귀분석의 결과 섭식장애/이상섭식 증상이 있는 운동선수집단과 비운동선수 집단의 위험요인은 다르게 나타났다. 마름에 대한 갈망과 자존감은 두 집단에서 필수요인이었지만, 운동선수집단에서는 신체불만족, 완벽주의, 내재화 요인 또한 주요 요인으로 나타났다. 이는 섭식장애/이상섭식을 가지고 있는 여자 대학 운동선수들이 다양한 형태의 위험요소를 가지고 있는 것이라 할 수 있다.

• Journal of Nutrition and Health
• /
• 제51권4호
• /
• pp.316-322
• /
• 2018

Purpose: The Glycyrrhiza uralensis species (Leguminosae) as a medicinal biocompound, and one of its root components, isoliquritigenin (ISL), which is a flavonoid, has been reported to have anti-tumor activity in vitro and in vivo. However, its function in bone formation has not been studied yet. In this study, we tested the effect of Glycyrrhiza uralensis (ErLR) and baked Glycyrrhiza uralensis (EdLR) extracts on osteoblast proliferation, alkaline phosphatase (ALP) activity, and bone-related gene expression in osteoblastic MC3T3-E1 cells. Methods: MC3T3-E1 cells were cultured in various levels of ErLR (0, 5, 10, 15, $20{\mu}g/mL$), EdLR (0, 5, 10, 15, $20{\mu}g/mL$), or ISL (0, 5, 10, 15, $20{\mu}M$) in time sequences (1, 5, and 20 days). Also, isoliquritigenin (ISL) was tested for comparison to those two biocompound extracts. Results: MTT assay results showed that all three compounds (ErLR, EdLR, and ISL) increased osteoblastic-cell proliferation in a concentration-dependent manner for one day. In addition, both ErLR and EdLR compounds elevated the osteoblast proliferation for 5 or 20 days. Extracellular ALP activity was also increased as ErLR, EdLR, and ISL concentration increased at 20 days, which implies the positive effect of Glycyrrhiza species on osteoblast mineralization. The bone-related marker mRNAs were upregulated in the ErLR-treated osteoblastic MC3T3-E1 cells for 20 days. Bone-specific transcription factor Runx2 gene expression was also elevated in the ErLR- and EdLR-treated osteoblastic MC3T3-E1 cells for 20 days. Conclusion: These results demonstrated that Glycyrrhiza uralensis extracts may be useful for preventing osteoporosis by increasing cell proliferation, ALP activity, and bone-marker gene expression in osteoblastic cells.