• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 춘계학술대회
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• pp.302-305
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• 2009

본 논문에서는 환자나 만성질환자가 공간적으로 구속을 받지 않고 자유롭게 이동이 가능한 상태에서 건강상태 모니터링이 가능한 셀룰러폰(Cellular telephone)에 기반한 통합형 생체신호 계측 및 생체정보 관리가 가능한 생체 관리 시스템을 설계하고자 하였다. 메디컬센서 인터페이스를 센서노드에 부착할 경우 개별적인 센서노드가 필요하기 때문에 생체 디바이스의 문제점을 해결하기 위해서 통합형 메디컬 센서노드 어플리케이션을 설계하였다. 셀룰러폰으로 ECG(Electrocardiogram), 혈압(Blood pressure), 혈당(Blood sugar)과 같은 생체신호를 모니터링해서 비정상적인 생체신호를 판별하며, 당일 측정한 생체신호를 셀룰러폰에 저장해 과거에 측정한 메디컬 기록들과 함께 차트로 리뷰 가능하다. 본 논문에서는 기존의 실시간 생체 모니터링 비해, 개발된 셀룰러폰 기반의 헬스케어용 관리시스템은 고/저혈압, 당료를 갖고 있는 만성질환자가 상시적으로 질병을 관리할 수 있으며, 또한 CDMA의 특성상 넓은 환경에서도 전송이 가능하무로서 무선센서네트워크를 이용하기 위해 CDMA 방식과 통합하였다.

• 대한의용생체공학회:의공학회지
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• 제31권1호
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• pp.14-19
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• 2010

Baroreflex sensitivity (BRS) is a parameter of the cardiovascular system that is reflected in changes in pulse interval (PD and systolic blood pressure (SBP). BRS contains information about how the autonomic nervous system regulates hemodynamic homeostasis. Normally the beat-to-beat SBP measurement and the pulse interval measured from the electrocardiogram (ECG) are required to estimate the BRS. We investigated the possibility of measuring BRS in the absence of a beat-to-beat SBP measurement device. Pulse arrival time (PAT), defined as the time between the R-peak of the ECG and a single characteristic point on the pulse wave recorded from any arterial location was measured by photoplethysmography. By comparing the BRS obtained from conventional measurements with our method during controlled breathing, we confirmed again that PAT and SBP are closely correlated, with a correlation coefficient of -0.82 to -0.95. The coherence between SBP and PI at a respiration frequency of 0.07-0.12 Hz was similar to the coherence between PAT and PI. Although the ranges and units of measurement are different (ms/mmHg vs. ms/ms) for BRS measured conventionally and by our method, the correlation is very strong. Following further investigation under various conditions, BRS can be reliably estimated without the inconvenient and expensive beat-to-beat SBP measurement.

• 제어로봇시스템학회논문지
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• 제13권12호
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• pp.1186-1191
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• 2007

Human driver monitoring system is one of the most important systems for the safety in driving vehicles, and therefore driver assistance system has gained much attention during the last decade. This paper proposed an intelligent driver assistance system which monitors human driver's states from bio-signals such as ECG and Blood Pressure. The proposed system used mamdani fuzzy inference to evaluate the driver's mental strain and generated warning signals to the driver. The approach using bio-signals in driver assistance system is the main issue of the related systems and the preliminary results showed the possibility of further research topics in developing more intelligent embedded systems with bio-signal feedback.

• 융합신호처리학회논문지
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• 제19권3호
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• pp.104-109
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• 2018

심전도와 심탄도를 무구속적으로 동시에 측정하는 시스템을 개발하였다. 제안된 시스템은 의자의 보조 등받이에 설치되어 맥파전달시간(PAT), Pre-ejection period (PEP) 등의 심혈관계 역학 정보를 일상생활에서 무구속적으로 측정하는 것을 목적으로 개발되었다. 본 연구에서는, 의자의 등받이에 부착된 용량성 능동전극과 용량성 접지를 이용한 간접접촉 심전도 (IDC-ECG) 측정 방법에 의해 무구속적으로 심전도를 측정하였으며, 등받이에 부착된 EMFi 압력 센서를 사용하여 무구속적으로 심탄도(ballistocardiogram)를 측정하였다. 제안된 시스템으로 심전도와 심탄도가 무구속적으로 동시에 측정됨을 확인하였으며, 측정된 심탄도는 피검자 사이에서 일정한 패턴을 보이는 것을 알 수 있었다. 또한 심전도의 Q파와 심탄도의 첫 번째 첨두간의 시간차가 pre-ejection period와 높은 상관관계를 보이는 것도 확인할 수 있었다. 이 연구에서 개발된 시스템은 심혈관계의 다양한 지표(심전도, 심박수, PAT, PEP 등)를 무구속적으로 일상생활에서 측정할 수 있음을 보였다.

• 대한간호학회지
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• 제16권1호
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• pp.49-54
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• 1986

As patients on bed rest perform repeated Valsalva maneuver, it is necessary for them to prevent the-danger inherent in repeated Valsalva maneuver through intelligent rehabilitative nursing care. In this regard, it seems to be important to furnish a scientific rationale underlying rehabilitative nursing care. This study was undertaken to find the effects of repeated Valsalva maneuver upon circulation of nor-mal men. The subjects for this study were twenty normal and healthy college students of age from 19 to 26. For the first time, the ECG of standard 12 leads was recorded and the blood pressure was measured under the resting state. And the subjects performed Valsalva maneuver for 10 seconds, then expired air for 2 seconds. After the subjects carried out in this menner for 1 minute, the ECG and the blood pres-sure were recorded and measured again. The Changes of heartbeats, systolic and diastolic pressures after the practice of repeated Valsalva maneuver were compared with those of the letting state. The results obtained were as follows : 1. The heartbeats after the practice of repeated Valsalva maneuver generally increased but did not show statistical significance. 2. The systolic pressure measured after the practice of repeated Valsalva maneuver was higher than that of the resting state. 3. The diastolic pressure measured after the practice of repeated Valsalva maneuver was higher than that of the resting state.

• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.178-186
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• 2007

This study is attempted to correct an error of electronic blood pressure meter with an optical sensor. In general, for a hospitalized patient, ECG, blood pressure, oxygen saturation, and respiration are basically measured to monitor the patient's condition. Opening of a blood vessel after it is occluded by pressurizing the cuff influences the blood flow of peripheral blood vessels as well as oscillation changes in the cuff. Blood vessels are occluded and peripheral blood flow disappears at cuff pressure above the examinee's blood pressure, while blood vessels are opened and peripheral blood flow appears again at cuff pressure under the examinee's blood pressure. Then Disappear-Appear Point Length(DAPL) of peripheral blood flow can be judged with the signal of peripheral blood flow, thus is available as a factor of error correction for electronic blood pressure meter. Also, systolic or diastolic blood pressure can be corrected with Appear-Point-Pressure(APP) of cuff pressure at a point where blood flow occurs and Appear-Maximum Pressure(AMP) of cuff pressure at the maximum amplitude point of peripheral blood flow after peripheral blood flow appears again. For verification, 27 examinees were selected, and their blood value was obtained through experimental procedure of 4 stages including induction of blood pressure change. The examinees were divided into two groups of experimental group and control group, regression analysis was conducted for experimental group, and correction of a blood pressure error was verified with optical signal by applying the regression equation calculated in experimental group to control group. As an experimental result, mean of the whole measurement errors was 5mmHg or more, which did not meet the standard fur blood pressure meter. As a result of correcting blood pressure measurements with data of DAPL, APP, and AMP as drawn out of PPG signal, systolic blood pressure, mean blood pressure, and diastolic blood pressure were $-0.6{\pm}4.4mmHg,\;-1.0{\pm}3.9mmHg$ and $-1.3{\pm}5.4mmHg$, respectively, indicating that mean of the whole measurement errors was greatly improved, and standard deviation was decreased.

• 한국임상수의학회지
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• 제15권2호
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• pp.432-441
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• 1998

The electrocardiogram (ECG) and electrolytes were measured to obtain diagnostic data after experimental obstruction of duodenum in 8 dogs. Clinical signs of these appeared lower heart rate, temperatures respiration and blood pressure than signs of preoperation. In changes of electrolytes and acid-base balances, all dogs appeared hyponatremiai hypochloremia, metabolic alkalosis, and increased pHi HCO3, scot in blood, but potassium values appeared to increase in 3 cases fl-inc.) and to decrease in 5 cases (K- dec.) Two of three in K-inc. and three of five in K-dec. died at 60 hrs and 72 hrs after obstruction respectly. In changes of ECGI amplitudes of the K-inc cases appeared high in T wave and low in R wave, but amplitudes of the K-dec cases appeared low T waver 57 segment and high in R wave. Conduction times of the K-inc appeared the shorted PR intervals but the K-dec appeared the prolonged PR interval. The changes of these appeared apparently in lead II.

• 대한임상독성학회지
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• 제17권1호
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• pp.28-31
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• 2019

Glyphosate herbicides, which are widely used worldwide, are known to have low toxicity. However, excessive intake may cause serious life-threatening complications; therefore, caution is needed when using them. A 51-year-old man visited the hospital after ingesting glyphosate herbicide. At the time of admission, his vital signs were 80/60 mmHg-115/min-20/min-$37.3^{\circ}C$. Electrocardiogram (ECG) showed QRS widening and corrected QT (QTc) prolongation, and blood tests showed metabolic acidosis. Treatment with gastric lavage, activated charcoal, sodium bicarbonate and intravenous lipid emulsion therapy was performed. After 2 hours, his blood pressure increased to 130/90 mg, and no QRS widening was observed on ECG.

• 전기학회논문지
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• 제60권8호
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• pp.1606-1616
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• 2011

The blood pressure measuring equipment, which is being supplied and used most widely by being recognized convenience and accuracy now generally, is oscillometric blood pressure monitor. However, a change in blood pressure is basically influenced by diverse elements such as each individual's physiological status and physical condition. Thus, the measurement of blood pressure, which used single element called oscillation in blood pressure of being conveyed to cuff, is not considered on physiological elements such as cardiovascular system status and blood vessel stiffness index, and on external elements, thereby being quite in error. Accordingly, this study detected diverse bio-signals and body informations in each individual as the measurement subject such as ECG, PPG, and Korotkoff Sound in order to enhance convenience and accuracy of measuring blood pressure in the complex measurement equipment, thereby having extracted regression method for compensation in error of oscillometric blood pressure measurement on the wrist, and having improved accuracy of measuring blood pressure. To verify a method of improving accuracy, the blood pressure value in each of SBP, DBP, MAP was acquired through 4-stage experimental procedure targeting totally 51 subjects. Prior to experiment, the subjects were divided into two groups such as the experimental group for extracting regression method and the control group for verifying regression method. Its error was analyzed by comparing the reference blood pressure value, which was obtained through the auscultatory method, and the oscillometric blood pressure value on the wrist. To reduce the detected error, the blood pressure compensation regression method was calculated through multiple linear regression analysis on elements of blood pressure, individual body information, PTT, HR, K-Sound PSD change. Verification was carried out on improving significance and accuracy by applying the regression method to the data of control group. In the experimental results, as a result of confirming error on the reference blood pressure value in SBP, DBP, and MAP, which were acquired through applying regression method, the results of $-0.47{\pm}7.45$ mmHg, $-0.23{\pm}7.13$ mmHg, $0.06{\pm}6.39$ mmHg could be obtained. This is not only the numerical value of satisfying the sphygmomanometer reference of AAMI, but also shows the lower result than the numerical value in SBP : $-2.5{\pm}12.2$ mmHg, DBP : $-7.5{\pm}8.4$ mmHg, which is the mean error in the experimental results of Brram's research for verifying accuracy of Omron RX-M, which shows relatively high accuracy among wrist sphygmomanometers. Thus, the blood pressure compensation could be confirmed to be made within significant level.

• The Korean Journal of Physiology
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• 제5권1호
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• pp.59-69
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• 1971

Studies were undertaken on the changes in the renal blood flow by relating them with the alterations in the amplitudes in the rheogram of rabbits. The changing pattern of the electrical conductivity was recorded by means of the needle electrodes inserted into the kidney and the surrounding aluminium foil which was grounded. The Impedance Rheograph manufactured by the Narco Company was used. The small artifact which persisted after ligation of the renal vessels was subtracted from the value obtained in each pulsatile wave in the rheogram. The animals were nembutalized intravenously, 30 mg/kg. A plastic canule was inserted into the carotid artery and the arterial blood pressure was monitored continuously with the pressure transducer connected to the physiograph. Stepwise bleedings were performed on the animal. The first bleeding was between 13 to 18 ml in the amount, and it was folowed by consecutive hemorrhages, 5 or 10 ml each time. The total amount of bleeding was summed as much as 1.5-2% of the body weight. Two minutes fter each bleeding th arterial blood pressure, ECG and the rheogram were taken. That was the necessary time to obtain the stabilized picture of each parameter. After closing the bleeding process, the shed blood was retransfused into the animal and the response in the renal blood flow was observed as well as the arterial blood pressure. Particularly the presence or absence of the autoregulatory mechanism in the situation of the hemorrhage was also studied. The results obtained were as follows: 1. In 7 cases out of 22, that was about one third of the total number of experiments, the autoregulatory mechanism of the renal blood flow persisted even in acute hemorrhage, and the decreases in the renal blood flow were less than 10% of the control values even when the arterial blood pressure dropped to 66-87% of the original value obtained before the bleeding. 2. Because of the stepwise bleeding the exact blood pressure at which the renal blood flow reduced as much as one third of the control value could not be obtained. However, the results revealed that the approximate pressure, expressed as percentage of the control value, was 50-60% in 3 cases, 61-70% in 4 cases and 71-80% in 8 cases. In one case the decrease in the renal blood flow exceeded one third of the control value before the pressure dropped to 80% of the control. 3. In 19 cases the decreases in the renal blood flow exceeded one half of the control values by hemorrhage. Then the arterial blood pressure revealed less than 40% of the control value in 6-cases. In 2 cases the pressure was 51-60% of the control pressure. In 5 cases the range of bleed pressure was 61-70%, and in e remaining 6 cases the pressure ranged from 71 to 80% of e control value. 4. Out of 15 cases of retransfusion after definite decreases in the renal blood flow loller·ing the hemorrhage, 9 cases restored their renal blood flow. On the contrary 6 cases showed low values even when the shed blood was retransfused. 5. Theories concerning the mechanism of the autoregulation of the renal blood flow were reviewed for the purpose of explanation of the results obtained. However, there are much to be done before greater satisfaction