• Journal of Information Science Theory and Practice
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• 제10권spc호
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• pp.56-65
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• 2022

Korea Institute of Science and Technology Information (KISTI) is a Worldwide LHC Computing Grid (WLCG) Tier-1 center mandated to preserve raw data produced from A Large Ion Collider Experiment (ALICE) experiment using the world's largest particle accelerator, the Large Hadron Collider (LHC) at European Organization for Nuclear Research (CERN). Physical medium used widely for long-term data preservation is tape, thanks to its reliability and least price per capacity compared to other media such as optical disk, hard disk, and solid-state disk. However, decreasing numbers of manufacturers for both tape drives and cartridges, and patent disputes among them escalated risk of market. As alternative to tape-based data preservation strategy, we proposed disk-only erasure-coded archival storage system, Custodial Disk Storage (CDS), powered by Exascale Open Storage (EOS), an open-source storage management software developed by CERN. CDS system consists of 18 high density Just-Bunch-Of-Disks (JBOD) enclosures attached to 9 servers through 12 Gbps Serial Attached SCSI (SAS) Host Bus Adapter (HBA) interfaces via multiple paths for redundancy and multiplexing. For data protection, we introduced Reed-Solomon (RS) (16, 4) Erasure Coding (EC) layout, where the number of data and parity blocks are 12 and 4 respectively, which gives the annual data loss probability equivalent to 5×10^-14. In this paper, we discuss CDS system design based on JBOD products, performance limitations, and data protection strategy accommodating EOS EC implementation. We present CDS operations for ALICE experiment and long-term power consumption measurement.

• 한국정보시스템학회:학술대회논문집
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• 한국정보시스템학회 2004년도 추계학술대회
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• pp.431-443
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• 2004

Many e-Learning companies are incorporated for the last five years, but most of them are failed or merged by the other company. The main reasons are the absence of competitive strategies and recognition of critical success factors. There are many researches on the critical success factors of Information System (IS) and Electronic Commerce (EC) . We derived e-Learning success factors from the previous IS and EC researches. We classified the success factors into five dimensions, (1) contents management, (2) learner management, (3) business strategy, (4) organizational support and ability, (5) learning management system (LMS), and each dimension has 9 or more success factors measurement items. We surveyed the perceived importance of the success factors from the manager of South Korea e-Learning firms. The paper categorized the items into two or more factors for each dimension by the exploratory factor analysis. Finally, we conducted one-way ANOVA for each success factors by the business model. As a result, there is different importance level for each success factors by the business model. We concluded that each e-Learning company needs different strategies to their business model.

• 한국통신학회논문지
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• 제40권9호
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• pp.1802-1807
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• 2015

클라우드 컴퓨팅 서비스는 가상화 기술을 이용하여 물리적인 IT 자원을 VM 단위로 사용자들에게 비용을 받고 제공하는 서비스이다. 그 중 클라우드 컴퓨팅 기반 가용 자원 경매 모델은 서비스 제공자의 가용 자원을 경매를 통해서 사용자들에게 제공 하는 서비스이다. 서비스 이용자들은 제한 시간 안에 그들의 작업을 처리하기 위해 서비스 제공자에게 자원 이용에 대한 입찰가격을 제시하고 낙찰 가격 보다 높은 경우 자원을 제공 받는다. 본 논문에는 Amazone EC2에서 서비스 이용자의 작업을 완료하는데 요구되는 스팟 인스턴스에 대한 총 경비를 최소화하는 입찰 기법을 제안한다. 일반적으로, 서비스 이용자는 자원을 할당 받기 위해 높은 입찰 가격을 제시할 것이고, 그에 따라 낙찰 가격이 높아짐으로써 서비스 이용자의 실제 작업 비용은 높아지게 된다. 따라서 제안 입찰 기법을 이용하여 낙찰 가격을 낮춤으로써 서비스 이용자의 총 경비를 최소화 할 수 있다. 제안 기법의 성능 분석을 위해 실제 데이터를 이용하여 낙찰 가격과 실제 총 경비를 계산하고, 실제 낙찰 가격 기반의 입찰 기법과 비교함으로써 제안 기법의 성능을 입증하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6327-6332
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• 2012

Esophageal cancer is a common malignant tumor occurring in human esophageal epithelial tissue. The primary purpose of this paper was to define the effects of ${\beta}$-carotene and 1,25-dihydroxyvitamin $D_3$, alone and in combination, on cell proliferation, cell cycle and apoptosis of human esophageal cancer EC9706 cells. Treatment with different concentrations of ${\beta}$-carotene and/or 1,25-dihydroxyvitamin $D_3$. MTT assay showed that ${\beta}$-carotene and 1,25-dihydroxyvitamin $D_3$ significantly inhibited proliferation of EC9706 cells in a dose- and time-dependent manner. Further studies also demonstrated that ${\beta}$-carotene alone or 1,25-dihydroxyvitamin $D_3$ alone caused a marked increase on the induction of apoptosis in EC9706 cells. The percentage of G0/G1-phase cells significantly increased on addition of 1,25-dihydroxyvitamin $D_3$ alone, but there were no significant changes with ${\beta}$-carotene alone. These two agents in combination synergistically inhibited cell growth and induced apoptosis. Therefore, our results indicate that ${\beta}$-carotene and 1,25-dihydroxyvitamin $D_3$ in combination may provide a novel strategy for preventing and treating esophageal cancer.

• 정보학연구
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• 제4권2호
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• pp.83-102
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• 2001

본 연구에서는 최근 들어 인터넷 상거래 물량과 업체의 증가에 따라 그 중요성이 더해가고 있는 택배운송업의 본질을 규명하고 국내외 업체의 사업현황을 개괄적으로 살펴본 다음, 해외 선진택배업체의 전략적 특징과 국내 택배업의 전자상거래 변화추세 및 전자상거래 배송현황을 고찰을 통해 전자상거래시대에 국내 택배업이 지니는 문제점과 전자상거래 물류전략을 구체적으로 지적함으로써 전자상거래 시대에 국내 택배운송업체들의 경쟁력강화에 일조하고자 한다.

• 한국데이타베이스학회:학술대회논문집
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• 한국데이타베이스학회 1999년도 춘계공동학술대회: 지식경영과 지식공학
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• pp.353-359
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• 1999

We present a matrix-based inference algorithm suitable for electronic commerce applications. For this purpose, an Extended AND-OR Graph (EAOG) was developed with the intention that fast inference process is enabled within the electronic commerce situations. The proposed EAOG inference mechanism has the following three characteristics. 1. Real-time inference: The EAOG inference mechanism is suitable for the real-time inference because its computational mechanism is based on matrix computation. 2. Matrix operation: All the subjective knowledge is delineated in a matrix form. so that inference process can proceed based on the matrix operation which is computationally efficient. 3. Bi-directional inference: Traditional inference method of expert systems is based on either forward chaining or backward chaining which is mutually exclusive in terms of logical process and computational efficiency. However, the proposed EAOG inference mechanism is generically bi-directional without loss of both speed and efficiency. We have proved the validity of our approach with several propositions and an illustrative EC example.

• 한국데이타베이스학회:학술대회논문집
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• 한국데이타베이스학회 2001년도 춘계 Conference: CRM과 DB응용 기술을 통한 e-Business혁신
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• pp.323-330
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• 2001

기업간 전자상거래 시장의 규모와 관심이 확대되는 가운데 거래를 원하는 여러 회사가 존재하며 이러한 회사들과 서로 다른 요구를 충족시켜주기 위하여 상거래를 위한 에이전트 개발이 요구되고 있다. 매년 지속적으로 증가하고 있는 기업간 전자상거래 시장 규모의 확대에도 불구하고 국내 중소 기업, 특히 자금과 인력에 있어서 상대적으로 부족한 제조업들의 상거래 활동 지원이 필요하다. 본 연구는 이러한 문제를 해결하기 위하여 이동 에이전트를 설계, 구현하였으며 이동 에이전트는 서버의 부담 및 네트워크 트래픽을 해결할 수 있으며 분산환경에서 전자상거래를 지원이 가능하다. 제안된 이동 에이전트는 판매 에이전트, 구매 에이전트, 저장 에이전트로 구성된다. 판매 에이전트는 판매업체의 제품 판매 활동을 대신하며, 구매 에이전트는 구매업체의 구매 활동을 대신하여 제품을 구매하게 된다. 저장 에이전트는 제품 정보 및 거래하는 시장 정보를 알려주며 제품 정보를 데이터베이스에 기록한다.

• 국제지역연구
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• 제14권1호
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• pp.3-30
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• 2010

왜 국가들은 협력과 갈등을 반복할까? 본 연구의 목적은 강대국인 EU(서유럽/동유럽)와 약소국인 북한 간 비대칭적 갈등과 협력이 "언제" 그리고 "어떻게", 다시 말해서 어떤 요인들에 의해 결정되었는지 그 과정을 분석한 후, 파워의 비대칭적인 강대국과 약소국 간 협력과 갈등 과정의 결정요인을 분석하는 데 있다. 특히 "변화"와 "연속성"의 측면에서 EU와 북한 간 관계에 대한 총체적이고 체계적인 연구를 위해서는 약자인 북한과 강자인 EU가 "언제" 그리고 "어떻게" 갈등과 협력 과정을 겪는지 그 결정요인을 찾는 데 초점을 맞춘다.

• 무역상무연구
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• 제13권
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• pp.699-733
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• 2000

This article analyzes the state-of-play of WTO dispute settlement for first four and a half years. Remarkable points found on this analysis are as follows: First, the Quad consisting of the United States, the European Community (EC), Canada and Japan has participated in the WTO dispute settlement mechanism more frequently than any other WTO member. Second, among developing country members some leading countries such as Korea, Brazil and India have relied actively upon the mechanism to claim and defend their rights and obligations under the WTO rules. Third, bilateral dispute settlements generally have been preferred to multilateral dispute settlements by the panel or Appellate Body. Fourth, observation of the Appellate Body proceedings well shows WTO members' strategy to use every process available to them. Fifth, the provisions of GATT 1994 have been most frequently invoked by the members. GATS and TRIPS Agreement disputes are mainly involved in developed countries, in particular the U.S. and the EC. Sixth, very high winning ratio in the panel and Appellate Body process indicates that complaining parties review the possibility to get favorable rulings even before referring to the Dispute Settlement Body (DSB) and prepare for the case very thoroughly. Seventh, roughly speaking, disputes were settled within two or three years. Therefore, seeking bilateral dispute settlement can be more advantageous to a complaining party than referring to a panel or an arbitrator because of low costs and short time period in dispute settlement. Finally, the DSB approved retaliatory actions for winning complaining parties against the defending parties who had rejected implementation of its rulings and recommendations. In conclusion, it can be said that the WTO dispute settlement mechanism has been operated very successfully for the first four and a half years. It is hoped that continued study on state-of-play of WTO dispute settlement mechanism will be contributory to improved national interest of Korea.

• Biomolecules & Therapeutics
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• 제27권1호
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• pp.117-125
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• 2019

Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the definite anti-angiogenic mechanism of MBZ remains unclear. In this study, we explored the inhibitory mechanism of MBZ in endothelial cells (ECs) and developed a novel strategy to improve its anti-angiogenic therapy. Treatment of ECs with MBZ led to inhibition of EC proliferation in a dose-dependent manner in several culture conditions in the presence of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) or FBS, without selectivity of growth factors, although MBZ is known to inhibit VEGF receptor 2 kinase. Furthermore, MBZ inhibited EC migration and tube formation induced by either VEGF or bFGF. However, unexpectedly, treatment of MBZ did not affect FAK and ERK1/2 phosphorylation induced by these factors. Treatment with MBZ induced shrinking of ECs and caused G2-M arrest and apoptosis with an increased Sub-G1 fraction. In addition, increased levels of nuclear fragmentation, p53 expression, and active form of caspase 3 were observed. The marked induction of autophagy by MBZ was also noted. Interestingly, inhibition of autophagy through knocking down of Beclin1 or ATG5/7, or treatment with autophagy inhibitors such as 3-methyladenine and chloroquine resulted in marked enhancement of anti-proliferative and pro-apoptotic effects of MBZ in ECs. Consequently, we suggest that MBZ induces autophagy in ECs and that protective autophagy can be a novel target for enhancing the anti-angiogenic efficacy of MBZ in cancer treatment.