• Mycobiology
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• 제48권3호
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• pp.219-227
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• 2020

Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent prostate cancer cell line. Results demonstrated that both hexane (GF-EH) and butanol (GF-EB) fraction of G. formosanum ethanol extract inhibited DU145 cell viability in a dose-dependent manner. GF-EH induced cell-cycle arrest in G1 phase of DU145 cells via downregulation of cyclin E2 protein expression. In addition, GF-EB triggered extrinsic apoptosis of DU145 cells by activating caspase 3 gene expression resulting in programed cell death. Above all, both GF-EH and GF-EB show lower toxicity to normal human fibroblast cell line compared to DU145 cell, implying that they possess specific drug action on cancer cells. This study provides a molecular basis of G. formosanum extract as a potential ingredient for treatment of androgen-independent prostate cancer.

• 한국전기전자재료학회논문지
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• 제18권3호
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• pp.276-283
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• 2005

Magnetic tunneling transistor (MTT) device using the amorphous n-type Si semiconductor film for base and collector consisting of the [CoFe/NiFe](free layer) and Si(top layer) multilayers was used to study the spin-dependent hot electron magnetocurrent (MC) and tunneling magnetoresistance (TMR) at room temperature. A large MC of 40.2 % was observed at the emitter-base bias voltage ( $V_{EB}$ ) of 0.62 V. The increasing emitter hot current and transfer ratio ( $I_{C}$/ $I_{E}$) as $V_{EB}$ are mainly due to a rapid increase of the number of conduction band states in the Si collector. However, above the $V_{EB}$ of 0.62 V, the rapid decrease of MC was observed in amorphous Si-based MTT because of hot electron spin-dependent elastic scattering across CoFe/Si interfaces.

• 한국세라믹학회지
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• 제45권11호
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• pp.707-712
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• 2008

Plasma resistant nanocrystalline $Y_2O_3$ films were deposited on alumina substrates through the electron-beam PVD technique. Increasing substrate temperature to $600^{\circ}C$ resulted in the textured microstructures with significantly enhanced adhesion force of the coating to the substrate. During the exposure to fluorine plasma, erosion rate of the coated specimen was higher than that of a sintered yttria specimen, but significantly lower than that of a single crystalline alumina. Considering the adhesion and erosion behaviors observed in the coated specimen prepared at $600^{\circ}C$, the deposition technique appears effective in reducing contamination particles generated from the ceramic parts in the plasma environment.

• Earthquakes and Structures
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• 제17권3호
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• pp.307-315
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• 2019

Building prediction and control theory have been drawing the attention of many scientists over the past few years because design and control efficiency consumes the most financial and energy. In the literature, many methods have been proposed to achieve this goal by trying different control theorems, but all of these methods face some problems in correctly solving the problem. The Evolutionary Bat (EB) Algorithm is one of the recently introduced optimization methods and providing researchers to solve different types of optimization problems. This paper applies EB to the optimization of building control design. The optimized parameter is the input to the fuzzy controller, which gives the status response as an output, which in turn changes the state of the associated actuator. The novel control criterion for guarantee of the stability of the system is also derived for the demonstration in the analysis. This systematic and simplified controller design approach is the contribution for solving complex dynamic engineering system subjected to external disturbances. The experimental results show that the method achieves effective results in the design of closed-loop system. Therefore, by establishing the stability of the closed-loop system, the behavior of the closed-loop building system can be precisely predicted and stabilized.

• Journal of Radiation Protection and Research
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• 제46권1호
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• pp.8-13
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• 2021

Background: Salmonella enteritidis (SE) was the main cause of the pandemic of foodborne salmonellosis. The surface of eggs' shells can be contaminated with this bacterium; however, washing them with sodium hypochlorite solution not only reduces their flavor but also heavily impacts the environment. An alternative to this is surface sterilization using low-energy electron beam. It is known that irradiation with 1 kGy resulted in a significant 3.9 log reduction (reduction factor of 10,000) in detectable SE on the shell. FAO/IAEA/WHO indicates irradiation of any food commodity up to an overall average dose of 10 kGy presents no toxicological hazard. On the other hand, the Food and Drug Administration has deemed a dose of up to 3 kGy is allowable for eggs. However, the maximum dose permitted to be absorbed by an edible part (i.e., internal dose) is 0.1 Gy in Japan and 0.5 Gy in European Union. Materials and Methods: The electron beam (EB) depth dose distribution in the eggshell was calculated by the Monte Carlo method. The internal dose was also estimated by Monte Carlo simulation and experimentation. Results and Discussion: The EB depth dose distribution for the eggshells indicated that acceleration voltages between 80 and 200 kV were optimal for eggshell sterilization. It was also found that acceleration voltages between 80 and 150 kV were suitable for reducing the internal dose to ≤ 0.10 Gy. Conclusion: The optimum irradiative conditions for sterilizing only eggshells with an EB were between 80 and 150 kV.

• 분석과학
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• 제19권4호
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• pp.333-341
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• 2006

PVP-protected Ag, Pd and $Pt_{50}-Ru_{50}$ colloids were prepared independently by using ${\gamma}$-irradiation and electron beam (EB) at ambient temperature. UV-visible spectra of these colloids show the characteristic bands of surface resonance and give evidence for the formation of nanoparticles. Transmission electron microscopy (TEM) experiments were used to know the morphology of nanoparticles prepared by ${\gamma}$-irradiation and EB. The size of Ag, Pd, and $Pt_{50}-Ru_{50}$ nanoparticles prepared by ${\gamma}$-irradiation was ca. 13, 2-3, 15 nm, respectively. While, the size of Ag, Pd, and $Pt_{50}-Ru_{50}$ nanoparticles prepared by EB was ca. 10, 6, and 1-3 nm, respectively. Cyclic voltamograms (CV) were recorded for the Au electrodes immobilized with these nanoparticles. CVs indicated the modifications in the surface as a result of immobilization.

• Asian-Australasian Journal of Animal Sciences
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• 제22권6호
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• pp.774-780
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• 2009

The objectives of this study were to test the efficacy of induction of estrus and determine the timing of ovulation in relation to preovulatory LH and estrogen surges in cycling Murrah buffaloes subjected to Heatsynch protocol (GnRH-$PGF_2{\alpha}$-Estradiol benzoate). In experiment 1, the buffaloes (n = 10) were treated with Heatsynch protocol and observed for estrus and ovulation. In experiment 2 and 3, 30 cycling Murrah buffaloes were used to investigate the efficacy of Heatsynch protocol in terms of conception rates in summer (experiment 2) and winter (experiment 3) seasons. Fixed time A.I. was performed in all the buffaloes at 48 and 60 h post-estradiol benzoate (EB) injection. All buffaloes responded to the Heatsynch protocol with expression of estrus for which ovulations were induced in 8 buffaloes (80%). Mean time interval from the EB injection to ovulation was 50.0${\pm}$2.0 h (range 44.0 to 60.0 h). The interval from the end of LH surge to ovulation was 18.5${\pm}$2.47 h (range 8 to 26 h). The interval from end of estrogen surge to ovulation was 26.75 ${\pm}$2.07 h (range 22 to 36 h). Mean LH peak after EB injection occurred at 20.81${\pm}$1.61 h (range 14 to 28 h) and mean estrogen peak after EB injection occurred at 9.62${\pm}$1.03 h (range 7 to 16 h). Hence, the mean estrogen peak preceded the mean LH peak by 11 h. It was observed that the percentage of conceptions to total number of estruses for control buffaloes was 18 and 30 in summer and winter, respectively, whereas it increased to 26 and 40 in Heatsynch treated buffaloes in respective seasons. The results suggest the possibility of using Heatsynch treatment followed by fixed time A.I. in buffaloes for fertility improvement, especially since the incidence of silent heat in buffaloes is very high.

• 한국발생생물학회지:발생과생식
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• 제19권1호
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• pp.43-51
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• 2015

Connexin (Cx) is a complex which allows direct communication between neighboring cells via exchange of signaling molecules and eventually leads to functional harmony of cells in a tissue. The initial segment (IS) is an excurrent duct of male reproductive tract and expression of numerous genes in the IS are controlled by androgens and estrogens. The effects of these steroid hormones on gene expression in the IS during postnatal development have not extensively examined. The present research investigated expressional modulation of Cx isoforms in the IS by exogenous exposure to estrogen agonist, estradiol benzoate (EB), or androgen antagonist, flutamide (Flu), at weaning age. Two different doses of EB or Flu were subcutaneously administrated in 21-day old of male rats, and expressional changes of Cx isoforms in the adult IS were analyzed by quantitative real-time PCR. Treatment of a low-dose EB ($0.015{\mu}g/kg$ body weight) resulted in an increased expression of Cx31 gene and a decreased expression of Cx37 gene. A high-dose EB ($1.5{\mu}g/kg$ body weight) treatment caused an increase of Cx31 gene expression. Increased levels of Cx30.3 and Cx40 transcripts were observed with a low-dose Flu ($500{\mu}g/kg$ body weight) treatment. Treatment of high-dose Flu (50 mg/kg body weight) led to expressional increases of Cx30.3, 40, and 43 genes. Our previous and present findings suggest differential responsiveness on gene expression of Cx isoforms in the IS by androgens and estrogens at different postnatal ages.

• 한국ITS학회 논문지
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• 제8권6호
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• pp.46-54
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• 2009

본 연구는 무인신호위반단속장비의 사고감소 효과를 다루고 있다. 연구의 목적은 EB (Empirical Bayes)방법을 이용하여 사고감소 효과를 분석하는데 있다. 이를 위해 무인신호위반단속장비가 설치된 28개 교차점 728건의 사고자료를 이용한다. 연구의 주요결과는 다음과 같다. 첫째, 단순사고건수 방법의 사고감소 효과는 20.74%로 분석되었다. 둘째, 포아송과 음 이항 회귀모형을 이용하여 SPF모형이 개발되었으며, 과분산계수가 0에 가까워 포아송 회귀모형이 음이항 회귀모형보다 더 적합한 것으로 평가되었다. 아울러 포아송 모형의 ${\rho}^2$값이 0.409로 나타나 통계적으로 유의한 모형으로 분석되었다. 마지막으로, EB방법을 이용한 분석 결과, 사고가 3.89%에서 29.23% 감소된 것으로 나타났다.

• 대한전자공학회논문지TC
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• 제46권10호
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• pp.52-56
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• 2009

본 논문에서는 WCDMA LCR-TDD 시스템에서 ARQ 방식을 적용한 하향 링크 TSTD (Time Switched Transmit Diversity)에서 전력 램핑이 적용된 경우의 성능을 계산한다. 제안된 전력 램핑 방식은 ARQ 방식을 적용한 TSTD에서 수신측이 에러체크를 수행한 후 송신측으로 응답신호 (ACK or NACK 신호)를 전송하고 전송된 응답신호가 NACK 신호인 경우 전력을 램핑하여 해당 에러 프레임을 재전송한다. 시뮬레이션 결과는 3km/h의 이동국 속도에서 프레임 오류 확률 (Frame Error Rate)이 1%일 때 제안된 방법이 기존의 ARQ방식을 적용한 TSTD보다 약 0.7dB의 평균 Eb/N0의 성능이득이 있으며, 평균 Eb/N0가 0dB일 때 약 2.5%의 수율 개선이 있음을 보여준다.