• 대한감각통합치료학회지
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• 제19권1호
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• pp.24-38
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• 2021

목적 : Evaluation in Ayres Sensory Integration(EASI)의 국내사용을 위해 번역연구를 통한 한글 연구판 EASI를 제시하고, EASI의 구성타당도를 검정하고자 하였다. 연구방법 : EASI의 번역연구는 타문화 적응을 위한 번역 가이드라인의 4단계에 따라 실행하였다. 과정은 번역, 번역내용의 통합과 내용타당도 분석을 거쳤으며, 하위 검사 하나는 역번역을 실시하여 한글 연구판 EASI를 제시하였다. 구성타당도 검증은 3~12세의 일반아동과 감각통합문제를 가진 아동을 대상으로 EASI를 사용하여 평가하였다. 구성타당도는 일반아동과 감각통합문제를 가진 아동 그룹의 집단비교와 학령전기와 학령기 일반아동의 집단비교를 통하여 검증하였다. 집단비교는 Mann Whitney U 검정을 사용하여 분석하였다. 결과 : 번역 내용타당도 검증 결과 20개의 모든 항목은 평균 3.17점 이상을 보였다. 일반아동군과 감각통합문제 아동군의 EASI 영역별 차이를 알아본 결과 4개의 영역 중 감각지각 영역에서 두 그룹간 차이를 보였다(p=0.044). 세부적으로 촉각과 전정감각과 관련된 항목에서 통계학적인 차이를 보였다. 일반아동의 학령전기 아동군와 학령기 아동군의 EASI 영역별 비교에서는 실행, 안구, 자세 및 양측운동통합의 2개 영역에서 통계학적 차이가 있는 것으로 나타났다. 결론 : EASI 번역연구를 통해 제시된 한글판 EASI는 연구용으로 사용하기에 적합하다. 구성타당도 검증결과 일반아동과 진단군 아동의 차이를 설명할 수 있는 항목들과 연령에 따른 차이를 설명할 수 있는 항목들을 제시하였다. 이는 EASI 결과 해석에 고려될 수 있으리라 생각된다. 감각통합 기능의 종합적인 평가와 중재에 대한 근거를 제시하기 위해서는 앞으로 검사자간 신뢰도와 검사-재검사 신뢰도 검증이 필요하며, 추가적인 타당도 검증이 필요하리라 생각된다.

• Nuclear Engineering and Technology
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• 제54권10호
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• pp.3604-3613
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• 2022

The Physical Protection System (PPS) plays an important role and must effectively deal with various adversary attacks in nuclear security. In specific single adversary path scenarios, we can calculate the PPS effectiveness by EASI (Estimated Adversary Sequence Interruption) through Probability of Interruption (P_I) calculation. EASI uses a single value of the probability of detection (P_D) and the probability of alarm communications (P_C) in the PPS. In this study, we develop a multi-path analysis code based on EASI to evaluate the effectiveness of PPS. Our quantification method for P_I considers the variability and uncertainty of P_D and P_C value by Monte Carlo simulation. We converted the 2-D scheme of the nuclear facility into an Adversary Sequence Diagram (ASD). We used ASD to find the adversary path with the lowest probability of interruption as the most vulnerable paths (MVP). We examined a hypothetical facility (Hypothetical National Nuclear Research Facility - HNNRF) to confirm our code compared with EASI. The results show that implementing the variability extension can estimate the P_I value and its associated uncertainty. The multi-path analysis code allows the analyst to make it easier to assess PPS with more extensive facilities with more complex adversary paths. However, the variability of the P_D value in each protection element allows a significant decrease in the PI value. The possibility of this decrease needs to be an important concern for PPS designers to determine the P_D value correctly or set a higher standard for PPS performance that remains reliable.

• 한국임상약학회지
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• 제33권3호
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• pp.178-185
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• 2023

Objective: Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease. Both tralokinumab and dupilumab have been recommended in the European Guideline for the treatment of adult patients with severe AD. In Korea, dupilumab has been approved for patients with moderate to severe AD, and reimbursed for those with severe AD. Since there is no clinical trial directly comparing tralokinumab and dupilumab, we conducted indirect comparison to assess the clinical usefulness in patients with AD. Methods: We selected clinical trials for indirect comparison through a systematic literature review. Individual patient data were available for the tralokinumab clinical trial, and aggregated data were available for the dupilumab clinical trial. Therefore, we employed the Matching-Adjusted Indirect Comparison (MAIC) method. The treatment efficacy was assessed based on whether patients achieved a 75% reduction on the Eczema Area and Severity Index (EASI 75) after drug administration. Results: The difference in the proportion of patients achieving EASI 75 between tralokinumab and dupilumab was 4.7% (95% CI: -7.9 to 17.3). Considering the non-inferiority margin for the EASI 75 achievement rate is -10%, tralokinumab is deemed non-inferior to dupilumab as the lower bound of the CI for the difference in the EASI 75 achievement rate between tralokinumab and dupilumab was within -10%. Conclusion: We conducted a MAIC analysis comparing tralokinumab and dupilumab based on EASI 75 achievement. The findings of this study show that tralokinumab is non-inferior to dupilumab and can be implemented in Korean clinical settings with a therapeutic position comparable to dupilumab.

• 대한한방소아과학회지
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• 제28권1호
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• pp.1-6
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• 2014

Objectives This study aimed to evaluate the effects of atopic care program through observing atopic patients who have lived in atopic-free village located Geumsan of Chungnam province. Methods Seventeen children (boy 7, and girl 10) with atopic dermatitis had moved into atopic-free village of Geumsan, and they have been cared with atopic care program. Atopic dermatitis symptoms were measured every month using SCORAD (Scoring of Atopic Dermatitis) and EASI (Eczema Area and Severity Index) from March, 2012 to September, 2013. The changes of scores were analyzed using paired t-test. Results The median month of residence period was 19.9 months (range from 6 to 42 months). The atopic symptoms were significantly improved on SCORAD (p<0.01) and EASI (p<0.1) respectively. Conclusion Despite the limitation of the small number of study subjects, this study may provide the possibility of natural environment-based therapy for children with atopic dermatitis.

• 한방안이비인후피부과학회지
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• 제23권1호
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• pp.199-214
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• 2010

Objective : Atopic dermatitis (AD) may profoundly affect patient's quality of life (QOL), and also cause economic impact. The aim of our study was to evaluate the quality of life and the economic impact of adult atopic dermatitis patient in Seoul. We also evaluate the relationship of QOL and economic impact with severity of AD. Methods : 30 adult atopic dermatitis patient were included and evaluated by using the SCORAD Index and EASI. Patients were asked to fill in the questionnaires about their quality of life and financial costs during the past year by AD. Data about sleep disturbance and pruritus were also obtained. Pearson's correlation were used for statistical analysis. Results : 1. Among 30 patients, women were 19(63.3%), men were 11(36.7%). The mean age of the patients were 27.3 years old, patients between the ages of 17 and 30 years were 23, over 30 were seven. 2. The mean score of Objective SCORAD was $32.89{\pm}7.30$, Subjective SCORAD was $8.13{\pm}3.53$ and EASI was $9.15{\pm}6.90$이었다. 3. The mean score of Skindex-29 was $28.26{\pm}7.58$, DLQI was $10.17{\pm}5.55$. 4. By analyzing the questionnaire, a monthly average cost of 583,200 won for each patient was determined. Direct cost was 236,800 won and indirect cost was 346,300 won. 5. By analyzing the correlation between the severity of AD and QOL, Objective SCORAD and EASI were positively correlated with QOL(Skindex-29, DLQI) but not significant, meanwhile subjective SCORAD were significantly and positively correlated with QOL(Skindex-29, DLQI). 6. By analyzing the correlation between the severity of AD and economic impact, Objective SCORAD were significantly and positively correlated with direct cost and indirect cost. Also, EASI were significantly and positively correlated with direct cost and oriental medical hospital visits. Conclusions : The above results show that the QOL of the patients with atopic dermatitis is significantly related to their disease severity. Atopic dermatitis patients pay 583,200 won a month, and the economic impact of the patients is significantly related to their disease severity.

• 한방안이비인후피부과학회지
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• 제29권3호
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• pp.249-258
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• 2016

Objectives : The purpose of this study is to report the effectiveness of Hyeongbangdojok-san on 4 seborrheic dermatitis patients who were diagnosed as Soyangin.Methods : 4 seborrheic dermatitis patients were treated by Hyeongbangdojok-san. The effect of treatment was measured by EASI score, VAS score, photographs.Results : EASI score and VAS score decreased as a result of Hyeongbangdojok-san treatment in 4 patients.Conclusions : These case-studies showed an efficient result of using Hyeongbangdojok-san in the seborrheic dermatitis of Soyangin. And an author consider that continuous clinical study will be needed in Korean medical dermatology.

• 한방안이비인후피부과학회지
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• 제24권1호
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• pp.96-110
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• 2011

목적 : 본 임상시험을 통하여 혈열(血熱)형으로 변증된 아토피피부염의 한약 치료 후 임상 효능과 안전성을 관찰함으로써 아토피피부염에 대한 한약치료의 유용성을 평가하고자 한다. 방법 : 본 임상시험은 무작위배정, 이중맹검, 양성대조군, 평행 설계로 진행되었다. 자의에 의해 임상시험 동의서에 서명한 대상자 중 선정기준 및 제외기준에 부합된 36명의 대상자들에게 시험약과 양성대조약 과립제를 1일 3회(5.0g* 3회/ 1일) 4주간 복용하도록 하였다. 36명 중 31명의 환자가 4주간의 치료를 종료하였다(시호청간산 복용군: n = 16, 소풍산 복용군: n =15). 아토피피부염 증상을 평가하기 위해 Scoring atopic dermatitis (SCORAD) index와 Eczemaarea and severity index (EASI) 를 사용하여 시험 시작 전과 4주 후 시험 종료일에 환자들의 피부소견을 평가하였다. 아토피 피부염에 대한 한약치료의 안정성을 평가하기 위하여 치료 전후 혈중 AST, ALT, BUN, creatinine 변화를 검토하여 한약치료의 간/신독성 여부에 대해 조사하였다. 결과 및 결론: 두 군 모두에서 유의하게 SCORAD 점수와 EASI 점수가 감소하였으나 두 군 간의 차이는 유의하지 않았다. 부종/구진, 찰상 항목의 점수에는 두 군 간에 유의한 차이가 관찰되었다. 31명의 환자에게서 한약 치료 후 간장과 신장에 미치는 독성이 발견되지 않았으며 한약투여와 관련된 이상반응은 보고되지 않았다. 위의 결과로부터 시호청간산과 소풍산이 혈열형 아토피피부염에 대한 효과적이고 안전한 치료 방법이 될 수 있을 것으로 생각된다.

• 대한상한금궤의학회지
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• 제6권1호
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• pp.71-78
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• 2014

Objective : This study reports the effect of Gamchosasim-tang on atopic dermatitis. Methods : According to shanghanlun six meridian patterns diagnostic system, We diagnosed Taeyang-byung kyeolhyung. The symptoms of atopic dermatitis were worsen when the patient had bad sleeping habits by stress(心煩不得安). So the patient treated with Gamchosasim-tang for 3 months. The severity of atopic dermatitis was evaluated by SCORAD index, EASI and pictures. Results : After the treatment, SCORAD index and EASI decreased $75.9{\rightarrow}27.9$, $19{\rightarrow}5.7$ each. And sleeping habits also improved. Conclusions : Gamchosasim-tang improved the symptoms of atopic dermatitis on this study. Although Gamchosasim-tang is not an usual treatment for atopic dermatitis, we could prescribe the medicine due to shanghanlun six meridian patterns diagnostic system. And Further research would be needed the relation between bad sleeping habits cased by stress(心煩不得安) and Gamchosasim-tang.

• Smart Structures and Systems
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• 제26권2호
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• pp.135-146
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• 2020

This paper deals with an application of adaptive blind source separation (BSS) method, equivariant adaptive separation via independence (EASI), and Teager Energy Operator (TEO) for online identification of structural modal parameters. The aim of adaptive BSS methods is recovering a set of independent sources from their unknown linear mixtures in each step when a new sample is received. In the proposed approach, firstly, the EASI method is used to decompose structural responses into independent sources at each instance. Secondly, the TEO based demodulation method with discrete energy separation algorithm (DESA-1) is applied to each independent source, and the instantaneous frequencies and damping ratios are extracted. The DESA-1 method can provide the fast time response and has high resolution so it is suitable for online problems. This paper also compares the performance of DESA-1 algorithm with Hilbert transform (HT) method. Compared to HT method, the DESA-1 method requires smaller amounts of samples to estimate and has a smaller computational complexity and faster adaption due to instantaneous characteristic. Furthermore, due to high resolution of the DESA-1 algorithm, it is very sensitive to noise and outliers. The effectiveness of the proposed approach has been validated using synthetic examples and a benchmark structure.

• 한방안이비인후피부과학회지
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• 제34권4호
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• pp.228-236
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• 2021

Objective : The purpose of this study is to report the clinical effectiveness of herbal decoction(Samul-tang hap Soyo-san.) on whole body nummular eczema. Method : A patient suffering from nummular eczema received herbal decoction(Samul-tang hap Soyo-san), acupuncture, and electronic-moxibustion treatment. The effectiveness of treatment was evaluated by EASI, DLQI, photography and subjective evaluation of the patient's improvement of symptoms. Results : After treatment, eczema lesions were remarkably improved. Compared to its peak, EASI improved by 69% and DLQI by 53%. According to photo and symptom changes, purulent exudates were stopped and pruritus was decreased. Conclusion : This study suggests that Samul-tang hap Soyo-san could show effectiveness on nummular eczema.