• BMB Reports
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• v.48 no.10
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• pp.583-588
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• 2015

Microtubule actin crosslinking factor 1 (MACF1), a widely expressed cytoskeletal linker, plays important roles in various cells by regulating cytoskeleton dynamics. However, its role in osteoblastic cells is not well understood. Based on our previous findings that the association of MACF1 with F-actin and microtubules in osteoblast-like cells was altered under magnetic force conditions, here, by adopting a stable MACF1-knockdown MC3T3-E1 osteoblastic cell line, we found that MACF1 knockdown induced large cells with a binuclear/multinuclear structure. Further, immunofluorescence staining showed disorganization of F-actin and microtubules in MACF1-knockdown cells. Cell counting revealed significant decrease of cell proliferation and cell cycle analysis showed an S phase cell cycle arrest in MACF1-knockdown cells. Moreover and interestingly, MACF1 knockdown showed a potential effect on cellular MTT reduction activity and mitochondrial content, suggesting an impact on cellular metabolic activity. These results together indicate an important role of MACF1 in regulating osteoblastic cell morphology and function.

• International Journal of Advanced Culture Technology
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• v.8 no.3
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• pp.148-158
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• 2020

With the limited product information available in the m-shopping context, product-naming strategies affect consumer choices by expressing the key product features or the brand's images. Given the increasing dominance of the mobile commerce in consumption across various product categories, few studies have examined the role of product naming in consumer choices in the m-shopping. In filling the research gap, this study empirically analyzes the influence of the perceived diagnosticity of product names in m-shopping on consumer attitude towards the product. Moreover, the study tests the moderating influences of the individual characteristics of consumers (i.e., age, gender, and m-shopping experience) in the dynamics of the perceived diagnosticity impacting the product evaluations. The results of the study using an online survey reveal that the perceived diagnosticity of the product names significantly increases consumer attitude towards the product. Additionally, the moderating effects of gender, age, and m-shopping experience are all found significant: (1) The positive influence of the perceived diagnosticity of the product names is greater for males than for females. (2) The older the respondent, the more statistically significant the positive influence on diagnosticity. (3) The more respondents having m-shopping experience, the more positive the impact of the diagnosticity. Implications and limitations of the study are discussed.

• 한국신재생에너지학회:학술대회논문집
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• 2009.11a
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• pp.600-605
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• 2009

A general purpose viscous flow solver Ansys CFX is used to study a Savonius type wave energy converter in a 3D numerical viscous wave tank. This paper presents the results of a computational fluid dynamics (CFD) analysis of the effect of blade configuration on the performance of 3 bladed Savonius rotors for wave energy extraction. A piston-type wave generator was incorporated in the computational domain to generate the desired incident waves. A complete OWC system with a 3-bladed Savonius rotor was modeled in a three dimensional numerical wave tank and the hydrodynamic conversion efficiency was estimated. The flow over the rotors is assumed to be two-dimensional (2D), viscous, turbulent and unsteady. The CFX code is used with a solver of the coupled conservation equations of mass, momentum and energy, with an implicit time scheme and with the adoption of the hexahedral mesh and the moving mesh techniques in areas of moving surfaces. Turbulence is modeled with the k.e model. Simulations were carried out simultaneously for the rotor angle and the helical twist. The results indicate that the developed models are suitable to analyze the water flows both in the chamber and in the turbine. For the turbine, the numerical results of torque were compared for all the cases.

• Journal of the Korea Society for Simulation
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• v.19 no.3
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• pp.37-43
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• 2010

In field, one can observe without difficulties that two flocks are intersected or combined with each other. For example, a fish flock in a stream separates into two part by obstacles (e.g. stone) and rejoins behind the obstacles. The dynamics of two flocks guided by their leader were studied in the situation where the flocks cross each other with a crossing angle, ${\theta}$, between their moving directions. Each leader is unaffected by its flock members whereas each member is influenced by its leader and other members. To understand the dynamics, I investigated the order parameter, ${\phi}$, defined by the absolute value of the average unit velocity of the flocks' members. When the two flocks were encountered, the first peak in ${\phi}$ was appeared due to the breaking of the flocks' momentum balance. When the flocks began to separate, the second peak in ${\phi}$ was observed. Subsequently, erratic peaks were emerged by some individuals that were delayed to rejoin their flock. The amplitude of the two peaks, $d_1$ (first) and $d_2$ (second), were measured. Interestingly, they exhibited a synchronized behavior for different ${\theta}$. This simulation model can be a useful tool to explore animal behavior and to develop multi-agent robot systems.

• Korean Journal of Construction Engineering and Management
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• v.24 no.5
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• pp.3-11
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• 2023

Building information modeling (BIM) can help to visualize and manage the building-related information at the object-based level, and it is possible to help link the tasks in the network of Hanok construction. While many studies have significant interest in using BIM for modern construction, there is only few studies to observe the use of BIM for traditional construction, commonly called Hanok construction in South Korea. Hence, the main goal of this study is to develop a system dynamic model for investigating how the BIM can be widely used for Hanok construction. To this end, this study identified the factors influencing the BIM uses for the Hanok construction, developed a causal loop diagram (CLD) to investigate the interrelationships among the factors, and provided a final model based on the mathematical definitions. Based on the scenario analysis, it is demonstrated that the support to building Hanok and education cost for BIM positively influence activating and using the BIM for the Hanok construction. Based on the dynamics of the factors identified in this study, it is important to consider expanding support for Hanok construction and education cost for BIM to successfully integrate and utilize BIM in the construction industry.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.6
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• pp.925-932
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• 2007

This study was designed to measure the effect of regrowth age of Digitaria decumbens (D. decumbens) on the intake and dynamics of digesta in the rumen of rams. Six Black-belly rams (mean liveweight: 51.6 (s.d. 0.68) kg) fitted with rumen cannulae were fed twice daily a 14-, 28-, 42- and 56-day old fresh D. decumbens successively for 4 experimental periods. The daily dry matter intake decreased curvilineary from 75.2 to 48.5 (s.e. 2.0) g/kg $BW^{0.75}$ as the age of the D. decumbens grass increased from 14 to 56 days. Dry matter intake for the first 3 h after the morning meal was 863.6, 598.3, 576.4 and 401.5 (s.e. 55.6) g for the 14-, 28-, 42- and 56-day old grasses respectively. The pool of NDF in the rumen at the end of the 3-h feeding period did not vary significantly among the four diets. Twelve hours after the beginning of the morning meal, the pool of NDF increased with the forage regrowth age. Within the total pool of NDF, the pool of large particles tended to increase with the regrowth age. It was concluded that high intake was associated with fast evacuation of NDF from the rumen. Moreover, digestion (cellulolysis) rate and degree of particle reduction by rumination are highly correlated, though speed of physical degradation of forage seems to be the driving force behind intake.

• Journal of Korean Society on Water Environment
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• v.32 no.1
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• pp.70-79
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• 2016

Based on the soil moisture data assimilation suggested in the first paper (I), we estimated root zone soil moisture and evaluated drought severity using remotely sensed (RS) data. We tested the impacts of various spatial resolutions on soil moisture variations, and the model outputs showed that resolutions of more than 2-3 km resulted in over-/under-estimation of soil moisture values. Thus, we derived the 2 km resolution-scaled soil moisture dynamics and assessed the drought severity at the study sites (Chungmi-cheon sites 1 and 2) based on the estimated soil/root parameters and weather forcings. The drought indices at the sites were affected mainly by precipitation during the spring season, while both the precipitation and land surface characteristics influence the spatial distribution of drought during the rainy season. Also, the drought severity showed a periodic cycle, but additional research on drought cycles should be conducted using long-term historical data. Our proposed approach enabled estimation of daily root zone soil moisture dynamics and evaluation of drought severity at various spatial scales using MODIS data. Thus, this approach will facilitate efficient management of water resources.

• Korean System Dynamics Review
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• v.14 no.3
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• pp.25-49
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• 2013

As global competition for green car, that is environmentally friendly car, is getting tougher, the governments and the related industries are putting their core efforts in its diffusion. However, the green car sales are disappointing so far. To overcome the gridlock, it is necessary to develop concrete analytical framework to understand the diffusion process. Based on causal loop analysis from the previous work, we have identified main variables and relationships of them in the diffusion process and developed a stock-flow diagram and mathematical formula for the main components. The model would be applied for further quantitative simulation on the diffusion process of green car and other innovative goods as well. Also, we have suggested constructive insights for the policy makers and for the related industries. First, it is important to increase consumers' willingness to consider through marketing and word of mouth to accelerate the diffusion process. Second, in the perspective of the industry, the market share of green car should be increased at the earliest possible stage and this could be done by enhancing each components of green car attractiveness(e.g. price, driving range, social infra). Third, companies should develop a balanced investment between consumer and technology sector through a flexible financial policy. Fourth, the government continuously has the role of investing in the related R&D and social infra building. We expect the green car diffusion model and related formula from the research can provide meaningful tools to analyze the diffusion process of other new and innovative goods based on its deep researched literature review.

• Journal of the Korean Magnetic Resonance Society
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• v.8 no.2
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• pp.77-85
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• 2004

$^1$H-detected $^{15}$N NMR was employed to investigated the effect of mutation (Y14F) on the dynamic properties of catalytic residues in ${\Delta}^5$-3- ketosteroid isomerase (KSI) from Conamonas testosteroni. In particular, the backbone dynamics of the catalytic residues have been studied in free enzyme and its complex with a steroid ligand, 19-nortestosterone hemisuccinate, by $^{15}$N relaxation measurements. The relaxation data were analyzed using the model-free formalism to extract the model-free parameters (S$^2$, ${\tau}_e$, and R$_{ex}$). The results show that the mutation causes a significant decrease in the order parameter (S$^2$) for the catalytic residues of free Y14F KSI, presumably due to breakdown of the hydrogen bond network by mutation. In addition, the order parameters of Phe-14 and Asp-99 increased slightly upon ligand binding, indicating a slight restriction of the high-frequency (pico- to nanosecond) internal motions of the residues in the complexed Y14F KSI, while the order parameter of Tyr-55 decreased significantly upon ligand binding.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.153-153
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• 2021

Storm Storm event is one of major issues in South Korea due to devastating damage at its landfall. A series of statistical study on the historical typhoon records consistently insist that the typhoon translation speed (TS) is on slowdown trend annually, and thus provides an urgent topic in assessing the extreme storm surge under future climate change. Even though TS has been regarded as a principal contributor in storm surge dynamics, only a few studies have considered its impact on the storm surge. The landfall angle (LA), another key physical factor of storm surge also needs to be further investigated along with TS. This study aims to elucidate the interaction mechanism among TS, LA, coastal geometry, and storm surge synthetically by performing a series of simulations on the idealized geometries using Delft3D FM. In the simulation, various typhoons are set up according to different combinations of TS and LA, while their trajectories are assumed to be straight with the constant wind speed and the central pressure. Then, typhoons are subjected to make landfall over a set of idealized geometries that have different depth profiles and layouts (i.e., open coasts or bays). The simulation results show that: (i) For the open coasts, the maximum surge height (MSH) increases with increasing TS. (ii) For the constant bed level, a typhoon normal to the coastline resulted in peak MSH due to the lowest effect of the coastal wave. (iii) For the continental shelf with different widths, the slow-moving typhoon will generate the peak MSH around a small LA as the shelf width becomes narrow. (iv) For the bay, MSH enlarges with the ratio of L/E (the length of main-bay axis /gate size) dropping, while the greatest MSH is at L/E=1. These findings suggest that a fast-moving typhoon perpendicular to the coastline over a broad continental shelf will likely generate the extreme storm surge hazard in the future, as well as the slow-moving typhoon will make an acute landfall over a narrow continental shelf.