• BMB Reports
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• v.47 no.9
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• pp.488-493
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• 2014

Adaptor protein FADD forms the death inducing signaling complex (DISC) by recruiting the initiating caspases-8 and -10 through homotypic death effector domain (DED) interactions. Cellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of death ligand-induced apoptosis downstream of death receptors, and FADD competes with procaspase-8/10 for recruitment for DISC. However, the mechanism of action of FADD and c-FLIP proteins remain poorly understood at the molecular level. In this study, we provide evidence indicating that the death effector domain (DED) of FADD interacts directly with the death effector domain of human c-FLIP. In addition, we use homology modeling to develop a molecular docking model of FADD and c-FLIP proteins. We also find that four structure-based mutants (E80A, L84A, K169A and Y171A) of c-FLIP DEDs disturb the interaction with FADD DED, and that these mutations lower the stability of the c-FLIP DED.

• Journal of Microbiology and Biotechnology
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• v.19 no.2
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• pp.167-171
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• 2009

The effects of culture conditions on succinic acid production and its possible scale-up have been studied. Mannheimia succiniciproducens LPK7, engineered for enhanced production of succinic acid and reduced by-product secretion, was used for the experiments. Mannheimia succiniciproducens LPK7 is a knock-out strain of wild type deficient in the ldhA, pflB, and pta-ackA genes, and is derived from Mannheimia succiniciproducens MBEL55E. Process optimization of factors including optimal temperature, pH, carbon source, and nitrogen source was performed to enhance the production of succinic acid in flasks. To observe scale-up effects, batch fermentation was carried out at various working volumes. At a working volume of 7.0 l, the final succinic acid concentration and yield were 15.4g/l and 0.86g/g. This result shows similar amount of succinic acid obtained in lab-scale fermentation, and it is possible to scale up to larger fermentors without major problems.

• Journal of Intelligence and Information Systems
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• v.9 no.2
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• pp.171-184
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• 2003

A project planning is one of the most important processes that determines success and failure of the project. A pre-project planning is also essential job for information system implementations at the early stage of project planning, especially for management information system like ERP. However, pre-project planning is very difficult, because lots of factors and their relationships should be considered. Pre-project planning of ERP implementation has been done by project manager's own knowledge and experiences. In this article, we propose a system that help project manager to make a pre-project plan of ERP project with case-based reasoning(CBR) framework. The proposed CBR system saves previous cases of ERP pre-project planning in the case base. Then, the system finds the most similar case with the current pre-project planning problem. Project manager can make a pre-project plan by adjusting the most similar case. From the interview with project managers, we collect some field cases of ERP implementation. We organized these cases by using XML(Extensible Markup Language), which is good for representing hierarchical information. XML gives us some flexibilities to correct and maintain cases. We make a prototype system, PPSS(Project Planning Support System) that help project manager to make a pre-project plan of ERP implementations. The object of the system is to support project manager to make a pre-project plan of ERP. We hope the result of the study can be applied to other information systems. Our research would be extended to cover other stages of project planning.

• KCI Concrete Journal
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• v.14 no.4
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• pp.171-177
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• 2002

Antifungal agents are used to impart antibacterial or bactericidal properties to commodities and various articles used in industries and can be classified into two broad groups i.e organic and inorganic. Inorganic antifungal agents comprise of Ag, Zn, or Cu, etc. These elements tend to exhibit high level of antifungal activities, non-uniform dispersion in substrates, and have poor properties in expensive and cheap adhesiveness. In this study, the organic antifungal agent was used for the purpose of investigating the antifungal activity of antifungal agent activated-cement mortar (AACM) on the aspergilus niger of various fungus which can be easily discovered in the interiors and exteriors of buildings. In addition, an experiment on the basic physical properties of AACM such as compressive and flexural strength was carried out. The conclusion of this investigation revealed that a dosage increase of antifungal agent exhibits a high inhibitory effect on the aspergilus niger, and although there is a slight decrease in the strength of AACM, the strength of AACM was almost equal to that of inactivated cement mortar.

• Korean Journal of Health Education and Promotion
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• v.20 no.3
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• pp.171-188
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• 2003

This study, based on stages of behavioral change, was aimed at suggesting strategies for the adoption of moderate drinking habits for community-based health education designed to help rural people. An interview survey was conducted during the period from March 4 to April 5, 2002 by sampling 467 rural people living in 6 villages covered by a public healthcare clinic. The results of this study can be summarized as follows； 1. The perceived non-moderate drinkers were less prepared for behavioral change. 2. The heavier drinking habits were ‘drinking alone’, ‘meals accompanied by drinking’ and ‘drinking twice or more at a time’. The agricultural off-season and the custom of brewing liquor at home were negative environmental factors for moderate drinking. 3. The predisposing factors affecting moderate drinking were recognition of health, expectation of the drinking effect, etiquette encouraging overdrinking and control of drinking. The reinforcing factors were stress from ordinary life and perception of being loved. The enabling factor was accessibility to the public healthcare clinic. 4. Rural residents are less motivated to participate in health education for moderate drinking. Based on the above findings, health education strategies for each stage can be suggested as follows： 1) Pre-contemplation stage： improvement of perception, motivation, sharing of experiences, and reawakening. 2) Contemplation/preparation stag e： measurement of value, departure from the inertia against a change, formation of a habit, and reinforcement of the behavior. 3) Action/maintenance stage： creation of a social atmosphere, encouragement of participation, change of life style, and improvement of environment.

• Convergence Security Journal
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• v.6 no.4
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• pp.171-177
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• 2006

The hacking aspect of recent times is changing, the phishing attack which uses a social engineering technique is becoming the threat which is serious in Information Security. It cheats the user and it acquires a password or financial information of the individual and organization. The phishing attack uses the home page which is fabrication and E-mail and acquires personal information which is sensitive and financial information. This study proposes the establishment of National Fishing Response Center, complement of relation legal system Critical intelligence distribution channel of individual and enterprise.

• Proceedings of the KIEE Conference
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• 2002.07a
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• pp.169-171
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• 2002

The western route of KEPCO's 765kV transmission line has been tentatively operating as 345kV voltage before commercial operation. After finishing the test operation of 765kV substation in 2002. KEPCO decided to operate the 765kV line for commercial operation. During the applying of 765kV voltage to the transmission line, double circuit transmission line will be operated with two voltage grades of 765kV and 345kV. Because the earthing switch is installed on both end of transmission line, we had estimated the electrostatic induction voltage and electromagnetic induction current before the line energizing in order to confirm the ratings of earthing switch. The induced voltage and current is very important for the maintenance of parallel circuit. This paper describes the simulation study of electrical phenomena such as electrostatic induction voltage from the parallel line and electromagnetic induction current from the parallel circuit. The transmission line model was developed by EMTP (Electro-Magnetic Transient Program).

• Proceedings of the KIEE Conference
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• 2003.07e
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• pp.171-173
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• 2003

Digital environment that is represented to internet is displacing business way of industry and business achievement way with the fast speed being giving great change on life whole, improve existence business process utilizing internet and Web connection technology, information superhighway to tradition industrialist manufacture and e-transformation's propulsion that wish to maximize productivity and administration efficiency is spread vigorously. In this paper, we wish to accomplish generation equipment's heighten stability and believability through remote monitoring and control of PV system. This paper describes the design of the monitoring system for sensing the monitoring data and indirect controlling of the PV system. Most of the conventional monitoring system depend on the special hardware and software. Basic design goal of monitoring system is to provide the convenience for the user and the portability for the system. In order for the system to fulfill its requirements, it was designed using Labview GUI facility based on the Windows 2000 environment of IBM PC compatible and Add-on card based on the TCP/IP protocol. Advantage of the monitoring system are a personnel expenses curtailment effect, free of the place restriction and unmanned system of the generation plants, etc.

• Corrosion Science and Technology
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• v.2 no.4
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• pp.171-177
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• 2003

The electronic properties of the passive film formed on Fe-20Cr ferritic stainless steel in pH 8.5 buffer solution containing 0.05 M EDTA (ethylene diammine tetraacetic acid) were examined by the photocurrent measurements and Mott-Schottky analysis for the film. XPS depth profile for the film demonstrated that Cr content in the outermost layer of the passive film was higher in the solution with EDTA than that in the solution without EDTA, due to selective dissolution of Fe by EDTA. In the solution with EDTA, the passive film showed characteristics of an amorphous or highly disordered n-type semiconductor. The band gap energies of the passive film are estimated to be ~ 3.0 eV, irrespective of film formation potential from 0 to 700 $mV_SCE$ and of presence of EDTA. However, the donor density of the passive film formed in the solution with EDTA is much higher than that formed in the solution without EDTA, due to an increase in oxygen vacancy resulted from the dissolution of Fe-oxide in the outermost layer of the passive film. These results support the proposed model that the passive film formed on Fe-20Cr in pH 8.5 buffer solution mainly consists of Cr-substituted $\gamma$-$Fe_2O_3$.

• Annual Conference on Human and Language Technology
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• 2001.10d
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• pp.171-174
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• 2001

현재, 전자메일을 정보전달의 수단이나 광고등의 목적으로 많이 이용하게 되면서, 메일 수신자는 원치 않는 상업적 광고, 불필요한 정보등의 스팸메일을 여과 없이 수신하게 되는 경우가 많아졌다. 이로 인하여 업무효율성 감퇴, 시간 낭비, 자원 낭비 등의 많은 문제점을 야기시키고 있다. 이러한 문제점을 해결하기 위한 기존의 메일 필터링 시스템들은 송신자의 주소나 도메인, 제목 등의 메일 헤더정보만을 이용하거나, 사용자가 정의한 문장이 본문 내용에 나타날 때 필터링하는 방식들이 주류를 이루고 있다. 그러나 이러한 방식들은 메일의 내용에 대한 근본적인 필터링이 불가능하다. 본 논문에서는 메일의 내용을 파악하기 위해 메일의 내용을 대표할 수 있는 체언정보를 추출하여, 카이제곱 통계량 공식을 통해 단어 가중치를 부여하고, 이를 문서분류를 위한 로그단어 빈도 가중치 공식에 적용하여 스팸메일을 필터링하는 방식을 제시한다. 본 논문에서 제안한 방법으로 실험한 결과, 스팸메일을 필터링하는데 84.61%의 재현율과 83.01%의 정확율을 얻을 수 있었다.