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A Study on Formulas in "Xi$\v{a}$o' Er Y$\`{a}$o Zh$\`{e}$ng Zh$\'{\i}$ Ju$\'{\e}$(小儿藥証直訣)" (소아약증직결(小兒藥證直訣)에 기재(記載)된 방제(方劑)의 특성분석(特性分析))

  • Cho, Hyun-Jin;Park, Sun-Dong
    • Herbal Formula Science
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    • v.19 no.1
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    • pp.35-49
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    • 2011
  • Objectives : This study aims to reveal the characteristics of formulas in "Xi$\v{a}$o' Er Y$\`{a}$o Zh$\`{e}$ng Zh$\'{\i}$ Ju$\'{\e}$. Methods : For that objectives, We analyzes formulas in "Xi$\v{a}$o' Er Y$\`{a}$o Zh$\`{e}$ng Zh$\'{\i}$ Ju$\'{\e}$. In the text, 132 formulas were described. To comprehend the formulas, we classified them as several bases. Results : After those analyses, we bring to a conclusion as follows. 1. 30 formulas are described that treated convulsive diseases (j$\={i}$ngf$\={e}$ng, 惊風). Next, g$\={a}$n(疳), parasite infection, diarrhea/dysentery, dermatosis and etc were in the order. 2. Classified by the formulation, Yu$\'{\a}$nj$\`{i}$(圓劑) was the best(70 kinds of formulas, 53%). S$\v{a}$nj$\`{i}$(散劑) was a form of 41 formulas(31%). T$\={a}$ngj$\`{i}$(湯劑) and g$\={a}$oj$\`{i}$(膏劑) were a form of 5 formulas each. 10 formulas were assumed the form of w$\`{a}$iy$\`{o}$ngj$\`{i}$(外用劑). 3. We researched in-depth analysis of Yu$\'{\a}$nj$\`{i}$. As a results, dosage, additive(輔料) and the time to take of Yu$\'{\a}$nj$\`{i}$ were decomposed. Also, the formulas that treated convulsive diseases were analyzed by the herbs classification. Conclusions : Though the formulas that treated convulsive diseases were hard to application at local clinic, overall nosology of pediatrics was reflected comparatively. "Xi$\v{a}$o' Er Y$\`{a}$o Zh$\`{e}$ng Zh$\'{\i}$ Ju$\'{\e}$ was expected to play a role for reconsideration of formulas' formulation.

O-and E-polarizers and advanced optical films for LCDs based on Lyotropic Dichroic Dyes

  • Belyaev, S.V.;Khan, I.G.;Malimonenko, N.V.;Kleptsyn, V.F.
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.361-364
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    • 2004
  • Polarizers with high polarizing efficiency and other advanced optical films based on Lyotropic Dichroic Dyes have been developed for LCD and other applications. The developed optical films reveal both rod-like chromophores structure in a case of positive, or O-films and disc-like one for negative, or E-film.

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Protective Action of Ambroxol on the Oxidative Damages of Lipids Hyaluronic Acid and Collagen

  • Ji Young KOH;Yung CHO;Eun Sook HAN;Lee, Chung-Soo
    • Biomolecules & Therapeutics
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    • v.6 no.2
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    • pp.111-118
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    • 1998
  • Ambroxol is thought to have antioxidant ability and some antiinflammatory effect. Effect of ambroxol on the oxidative damages of lipid, collagen and hyaluronic acid was examined. F $e_{2+}$(10 $\mu$M) and 100$\mu$Mascorbate-induced lipid peroxidation of liver microsomes was inhibited by 10 and 100$\mu$M ambroxol, 30$\mu$g/ml catalase and 10 mM DABCO but was not affected by 30$\mu$g/ml SOD and 10 mM DMSO. A 10 and 100$\mu$M ambroxol and 10 mM DABCO inhibited the peroxidative action of 10$\mu$M F $e_{3+}$, 160$\mu$M ADP and 100$\mu$M NADPH on microsomal lipids, whereas inhibitory effects of 30$\mu$g/ml SOD,30$\mu$g/ml catalase and 10 mM DMSO were not detected. The degradation of hyaluronic acid caused by 107M Fe2\\`,5007M H2O2 and 100$\mu$M ascorbate was inhibited by 10 and 100$\mu$M ambroxol,30$\mu$g/ml catalase,10 mM DMSO and 10 mM DABCO, while 30$\mu$g/ml SOD did not show any effect. The cartilage collagen degradation caused by 307$\mu$ F $e_{2+}$,500$\mu$M $H_2O$$_2$ and 200$\mu$M ascorbate was prevented by 100$\mu$M ambroxol. $H_2O$$_2$ and OH . were scavenged by ambroxol, whereas $O_2$, was not removed by it. Ambroxol (100$\mu$M) and 1 mM cysteine reduced DPPH to 1,1-diphenyl-2-picrylhydrazine. In conclusion, ambroxol may inhibit the oxidative damages of lipid, hyaluronic acid and collagen by its scavenging action on oxidants, such as OH . and probably iron-oxygen complexes and exert antioxidant ability.

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A Study of Flow Characteristics of Two Oscillating Cylinders (진동하는 두 개의 실린더 주위의 유동특성에 관한 연구)

  • Lee, Dae-Sung;Yoon, Hyun-Sik;Ha, Man-Yeong
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.31 no.6 s.261
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    • pp.566-573
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    • 2007
  • Flows around two oscillating cylinders in side-by-side arrangement at Re=185 are simulated using an immersed boundary method. The cylinders oscillate vertically in opposite directions in uniform cross-flow. We describe flow patterns, drag and lift forces by varying distance between two cylinders $(1.4{\leq}g{\leq}2.2,\;1.0{\leq}g{\leq}1.8)$ and oscillating frequency ratios $(f_e/f_o=0.8,\;f_e/f_o=1.0\;and\;f_e/f_o =1.2)$. Wake patterns, drag and lift coefficients are affected by both of frequency ratio and gap between two cylinders. Near wakes of each case are classified with the definition of previous studies.

Tumor Suppressor Protein p53 Promotes 2-Methoxyestradiol-Induced Activation of Bak and Bax, Leading to Mitochondria-Dependent Apoptosis in Human Colon Cancer HCT116 Cells

  • Lee, Ji Young;Jee, Su Bean;Park, Won Young;Choi, Yu Jin;Kim, Bokyung;Kim, Yoon Hee;Jun, Do Youn;Kim, Young Ho
    • Journal of Microbiology and Biotechnology
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    • v.24 no.12
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    • pp.1654-1663
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    • 2014
  • To examine the effect of tumor suppressor protein p53 on the antitumor activity of 2-methoxyestradiol (2-MeO-$E_2$), 2-MeO-$E_2$-induced cell cycle changes and apoptotic events were compared between the human colon carcinoma cell lines HCT116 ($p53^{+/+}$) and HCT116 ($p53^{-/-}$). When both cell types were exposed to 2-MeO-$E_2$, a reduction in the cell viability and an enhancement in the proportions of $G_2/M$ cells and apoptotic sub-$G_1$ cells commonly occurred dose-dependently. These 2-MeO-$E_2$-induced cellular changes, except for $G_2/M$ arrest, appeared to be more apparent in the presence of p53. Immunofluorescence microscopic analysis using anti-${\alpha}$-tubulin and anti-lamin B2 antibodies revealed that after 2-MeO-$E_2$ treatment, impaired mitotic spindle network and prometaphase arrest occurred similarly in both cell types. Following 2-MeO-$E_2$ treatment, only HCT116 ($p53^{+/+}$) cells exhibited an enhancement in the levels of p53, p-p53 (Ser-15), $p21^{WAF1/CIP1}$, and Bax; however, the Bak level remained relatively constant in both cell types, and the Bcl-2 level decreased only in HCT116 ($p53^{+/+}$) cells. Additionally, mitochondrial apoptotic events, including the activation of Bak and Bax, loss of ${\Delta}{\psi}m$, activation of caspase-9 and -3, and cleavage of lamin A/C, were more dominantly induced in the presence of p53. The Bak-specific and Bax-specific siRNA approaches confirmed the necessity of both Bak and Bax activations for the 2-MeO-$E_2$-induced apoptosis in HCT116 cells. These results show that among 2-MeO-$E_2$-induced apoptotic events, including prometaphase arrest, up-regulation of Bax level, down-regulation of Bcl-2 level, activation of both Bak and Bax, and mitochondria-dependent caspase activation, the modulation of Bax and Bcl-2 levels is the target of the pro-apoptotic action of p53.

On the History of the Birth of Finsler Geometry at Göttingen (괴팅겐에서 핀슬러 기하가 탄생한 역사)

  • Won, Dae Yeon
    • Journal for History of Mathematics
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    • v.28 no.3
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    • pp.133-149
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    • 2015
  • Arrivals of Hilbert and Minkowski at $G\ddot{o}ttingen$ put mathematical science there in full flourish. They further extended its strong mathematical tradition of Gauss and Riemann. Though Riemann envisioned Finsler metric and gave an example of it in his inaugural lecture of 1854, Finsler geometry was officially named after Minkowski's academic grandson Finsler. His tool to generalize Riemannian geometry was the calculus of variations of which his advisor $Carath\acute{e}odory$ was a master. Another $G\ddot{o}ttingen$ graduate Busemann regraded Finsler geometry as a special case of geometry of metric spaces. He was a student of Courant who was a student of Hilbert. These figures all at $G\ddot{o}ttingen$ created and developed Finsler geometry in its early stages. In this paper, we investigate history of works on Finsler geometry contributed by these frontiers.

Methods for Improving Hand-off of Different Generations in CDMA Mobile Communications

  • Choi, Dong-You;Park, Chang-Kyun
    • The Journal of the Acoustical Society of Korea
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    • v.21 no.2E
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    • pp.91-97
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    • 2002
  • One of the most important things in mobile phone service is Hand-Off (H/O). Meantime soft H/O and softer H/O have been used between the same generations (2G↔2G) and there is little problem. With user's needs and the development of communication technology, the system with different generation coexists and pilot beacon and time-periodic beacon are used for H/O between generations (2.5G↔2G) to start service, but it is not economic and efficient. To improve such problems, ENHHO developed in April 2001 has recently used. Unfortunately, this method also has the defect of momentary cutoff of communication information during the procedure of H/O in case of more than 5 pilot signals. Accordingly, we suggest algorithm to improve the problem of ENHHO and examines its propriety by analyzing the results of field survey using the algorithm.

Effect of particle size distribution on the magnetidc properties of hexagonal strontium ferrite (육방정 스트론튬 페라이트의 자기적 특성에 미치는 입도 분포의 영향)

  • 송창열;신용덕
    • Electrical & Electronic Materials
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    • v.8 no.3
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    • pp.324-331
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    • 1995
  • 0.36[wt%l $SiO_{2}$ and 0.1[wt%] $H_{3}$B $O_{3}$ were added to strontium ferrite magnets of the magnetoplumbite phase SrO.5.7F $e_{2}$ $O_{3}$ to hinder grain growth and accelerate sintering, respectively. This experiment was carried out to investigate effect of particle size distribution as a function of milling time(20, 30, 40, 50, 60, 70 hours) on the magnetic properties of SrO.5.7F $e_{2}$ $O_{3}$ ferrite magnet. The B-H curve, density and the degree of orientation were measured. And the microstructure of ferrite magnets was examined with a SEM. The optimal conditions and properties of the typical sample are the following : The milling time was 60 hours. Magnetic and physical properties are $B_{r}$=4, 000[G], $_{b}$ $H_{c}$=3, 330[Oe], (BH)max=3.786[MGOe], $_{I}$ $H_{c}$=3, 525[Oe], density=5.0063[g/c $m^{3}$] and orientation factor f=0.813.0.813.3.3.

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The structural, optical and photocatalytic properties of $TiO_2$ thin films fabricated by do magnetron sputtering (직류 마그네트론 스퍼터링법으로 제조된 $TiO_2$ 박막의 구조적, 광학적 특성 및 광촉매 효과)

  • Lim, J.M.;Yang, H.H.;Kim, Y.J.;Park, J.Y.;Jeong, W.J.;Park, G.C.
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2003.07a
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    • pp.420-423
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    • 2003
  • [ $TiO_2$ ] thin films were fabricated by DC magnetron sputtering system at by controlling deposition times, ratios of $Ar:O_2$ partial presser ratio and substrate conditions. And the surface, cross-section morphology, microstructure, and composition ratio of the films were analyzed by FE-SEM, TEM and XPS. Besides, the optical absorption and transmittance of the $TiO_2$ films were measured by a UV-VIS-NIR Spectrophotometer, and photocatalytic properties were studied by G C Analyzer & Data Analysis system. As the result, when $TiO_2$ thin film was made at deposition time of 120[min] and $Ar:O_2$ ratio of 60:40, the best structural and optical properties among many thin films could be accepted. The best results of properties were as follows: thickness; $360{\sim}370[nm]$, grain size; 40[m], gap between two peak binding energy, $5.8{\pm}0.05[eV]$ ($2p_{3/2}$ peak and $2p_{1/2}$ peak of Ti was show at $458.3{\pm}0.05[eV]$ and $464.1{\pm}0.05[eV]$ respectively), binding energy; $530{\pm}0.05\;[eV]$, opticalenergy band gap; 3.4[eV].

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Influence of Process Conditions on Properties of Cu2O Thin Films Grown by Electrodeposition (전착법을 이용한 Cu2O 박막 형성 및 공정 조건에 따른 특성 변화)

  • Cho, Jae Yu;Ha, Jun Seok;Ryu, Sang-Wan;Heo, Jaeyeong
    • Journal of the Microelectronics and Packaging Society
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    • v.24 no.2
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    • pp.37-41
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    • 2017
  • Cuprous oxide ($Cu_2O$) is one of the potential candidates as an absorber layer in ultra-low-cost solar cells. $Cu_2O$ is highly desirable semiconducting oxide material for use in solar energy conversion due to its direct band gap ($E_g={\sim}2.1eV$) and high absorption coefficient that absorbs visible light of wavelength up to 650 nm. In addition, $Cu_2O$ has other several advantages such as non-toxicity, low cost and also can be prepared with simple and cheap methods on large scale. In this work, we deposited the $Cu_2O$ thin films by electrodeposition on gold coated $SiO_2/Si$ wafers. We changed the process conditions such as pH of the solution, applied potential on working electrode, and solution temperature. Finally, we confirmed the structural properties of the thin films by XRD and SEM.