• 대한예방의학회:학술대회논문집
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• 2002.10a
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• pp.65-66
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• 2002

• Preventive Nutrition and Food Science
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• v.19 no.2
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• pp.59-68
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• 2014

The extracts and pure saponins from the roots of Platycodon grandiflorum (PG) are reported to have a wide range of health benefits. Platycosides (saponins) from the roots of PG are characterized by a structure containing a triterpenoid aglycone and two sugar chains. Saponins are of commercial significance, and their applications are increasing with increasing evidence of their health benefits. The biological effects of saponins include cytotoxic effects against cancer cells, neuroprotective activity, antiviral activity, and cholesterol lowering effects. Saponins with commercial value range from crude plant extracts, which can be used for their foaming properties, to high purity saponins such as platycodin D, which can be used for its health applications (e.g., as a vaccine adjuvant). This review reveals that platycosides have many health benefits and have the potential to be used as a remedy against many of the major health hazards (e.g., cancer, obesity, alzheimer's) faced by populations around the world. Methods of platycoside purification and analysis are also covered in this review.

• Journal of Microbiology and Biotechnology
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• v.22 no.11
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• pp.1580-1587
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• 2012

Japanese encephalitis virus (JEV) envelope (E) protein holds great promise for use in the development of a recombinant vaccine. Purified recombinant E (rE) protein may be useful for numerous clinical applications; however, there are limitations in using the Escherichia coli expression system for producing high-quality rE protein. Therefore, in this study, the yeast expression system was used to generate the rE protein. For protein production using the yeast system, the full-length JEV E gene was cloned into Pichia pastoris. SDS-PAGE and immunoblotting analysis demonstrated that the rE protein had a molecular mass of 58 kDa and was glycosylated. The predicted size of the mature unmodified E protein is 53 kDa, suggesting that post-translational modifications resulted in the higher molecular mass. The rE protein was purified to greater than 95% purity using combined ammonium sulfate precipitation and a SP-Sepharose Fast Flow column. This purified rE protein was evaluated for immunogenicity and protective efficacy in mice. The survival rates of mice immunized with the rE protein were significantly increased over that of Hyphantria cunea nuclear polyhedrosis virus E protein (HcE). Our results indicate that the rE protein expressed in the P. pastoris expression system holds great promise for use in the development of a subunit vaccine against JEV.

• International Journal of Computer Science & Network Security
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• v.22 no.3
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• pp.173-182
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• 2022

Healthcare organizations are overwhelmingly embracing smart value-based care strategies, which focuses on providing superior treatment at a significantly lower cost and quality of service (QoS). For these purposes, fifth generation (5G) of mobile service provides an innumerable improvement that clearly outperforms previous generations e.g., 3G and 4G. However, as with most advancements, 5G is projected to introduce new challenges, prompting the community to think about what comes next. This research was conducted to examine the most recent smart 5G technology applications and the solutions they provide to the healthcare industry. Finally, the paper discusses how the upcoming 6G technology has the potential to transform the future of healthcare sector even beyond the current 5G systems.

• Journal of Distribution Science
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• v.21 no.7
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• pp.117-129
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• 2023

Purpose: With the number of COVID-19 cases declining and generational differences among how people use mobile apps, including health service apps, the goal of this research is to identify and analyze the factors that affect people's attitudes when using the Halodoc health service app during the third year of the pandemic. Research design, data, and methodology: This study proposes a quantitative analysis method based on PLS-SEM modeling. This study has used a questionnaire survey to collect randomized data from 268 Halodoc users from generations Y and Z in Jakarta. Results: Both the Y and Z generations believe there is a significant usefulness factor in the attitude toward using the application. The start of the pandemic period demonstrates that the urgency of using health service applications is no longer determined by performance expectations, effort, or social panic, but rather by these applications' usability. Conclusions: Even though a health service application is no longer considered an urgent service or a priority need, attitudes, and behaviors in using it emphasize the aspect of long-term benefits. These findings supplement other considerations and understandings in application of the Unified Theory of Acceptance and Use of Technology (UTAUT) model in explaining attitudes and intention behaviors.

• Proceedings of the Korea Information Processing Society Conference
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• 2011.11a
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• pp.101-103
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• 2011

E-Health is one of the most promising applications of wireless sensor networks. This paper describes a prototype for e-Health systems. Based on the system, we propose the energy-balanced location-aided routing protocol. The location and energy information of the neighbor Coordinators is collected and stored in the neighbor discovery procedure. And then the Coordinator selects the most suitable neighbor to forward the data. The simulation results show that the proposed protocol has better performance than the three other routing protocols.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.226-232
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• 2018

The rapid pace of growth in internet usage and rich mobile applications and with the advantage of incredible usage of internet enabled mobile devices the Green Mobile Crowd Computing will be the suitable area to research combining with cloud services architecture. Our proposed Framework will deploy the eHealth among various health care sectors and pave a way to create a Green Mobile Application to provide a better and secured way to access the Products/ Information/ Knowledge, eHealth services, experts / doctors globally. This green mobile crowd computing and cloud architecture for healthcare information systems are expected to lower costs, improve efficiency and reduce error by also providing better consumer care and service with great transparency to the patient universally in the field of medical health information technology. Here we introduced novel architecture to use of cloud services with crowd sourcing.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.5
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• pp.311-315
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• 2019

Recently, digital health has gained the attention of physicians, patients, and healthcare industries. Digital health, a broad umbrella term, can be defined as an emerging health area that uses brand new digital or medical technologies involving genomics, big data, wearables, mobile applications, and artificial intelligence. Digital health has been highlighted as a way of realizing precision medicine, and in addition is expected to become synonymous with health itself with the rapid digitization of all health-related data. In this article, we first define digital health by reviewing the diverse range of definitions among academia and government agencies. Based on these definitions, we then review the current status of digital health, mainly in Korea, suggest points that are missing from the discussion or ought to be added, and provide future directions of digital health in clinical practice by pointing out certain key points.

• Journal of Computing Science and Engineering
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• v.5 no.3
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• pp.246-256
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• 2011

Due to the increasingly aging population, there is a rising demand for assistive living technologies for the elderly to ensure their health and well-being. The elderly are mostly chronic patients who require frequent check-ups of multiple vital signs, some of which (e.g., blood pressure and blood glucose) vary greatly according to the daily activities that the elderly are involved in. Therefore, the development of novel wearable intelligent systems to effectively monitor the vital signs continuously over a 24 hour period is in some cases crucial for understanding the progression of chronic symptoms in the elderly. In this paper, recent development of Wearable Intelligent Systems for e-Health (WISEs) is reviewed, including breakthrough technologies and technical challenges that remain to be solved. A novel application of wearable technologies for transient cardiovascular monitoring during water drinking is also reported. In particular, our latest results found that heart rate increased by 9 bpm (P < 0.001) and pulse transit time was reduced by 5 ms (P < 0.001), indicating a possible rise in blood pressure, during swallowing. In addition to monitoring physiological conditions during daily activities, it is anticipated that WISEs will have a number of other potentially viable applications, including the real-time risk prediction of sudden cardiovascular events and deaths.

• Korean Journal of Plant Resources
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• v.25 no.3
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• pp.339-345
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• 2012

The marine carotenoid fucoxanthin can be found in marine brown seaweeds, macroalgae, diatoms, and microalgae, and has remarkable biological properties. Numerous studies have shown that fucoxanthin has considerable potential and promising applications in human health, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. We here investigated the mechanisms by anti-allergic activity of fucoxanthin fraction from Eisenia bicyclis in immunoglobulin E-antigen complex (IgE/DNP-BSA)-stimulated RBL-2H3 mast cells. This study we found that the fucoxanthin inhibits the release of ${\beta}$-hexosaminidase and suppressed not only transcriptional activation of NF-${\kappa}B$, but also phosphorylation of ERK and JNK in IgE/DNP-BSA-treated RBL-2H3 cells. Fucoxanthin may be useful for preventing allergic diseases, including asthma and atopic dermatitis.