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http://dx.doi.org/10.7732/kjpr.2012.25.3.339

Suppressive Effects of Fucoxanthin on Degranulation in IgE-antigen complex-stimulated RBL-2H3 Cells  

NamKoong, Seung (Department of Physical Therapy, Kangwon National University)
Joo, Hae-Mi (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd.)
Jang, Seon-A (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd.)
Kim, Ye-Jin (Department of Herbal Medicine Resource, Kangwon National University)
Kim, Tae-Seong (Department of Herbal Medicine Resource, Kangwon National University)
Sohn, Eun-Hwa (Department of Herbal Medicine Resource, Kangwon National University)
Publication Information
Korean Journal of Plant Resources / v.25, no.3, 2012 , pp. 339-345 More about this Journal
Abstract
The marine carotenoid fucoxanthin can be found in marine brown seaweeds, macroalgae, diatoms, and microalgae, and has remarkable biological properties. Numerous studies have shown that fucoxanthin has considerable potential and promising applications in human health, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. We here investigated the mechanisms by anti-allergic activity of fucoxanthin fraction from Eisenia bicyclis in immunoglobulin E-antigen complex (IgE/DNP-BSA)-stimulated RBL-2H3 mast cells. This study we found that the fucoxanthin inhibits the release of ${\beta}$-hexosaminidase and suppressed not only transcriptional activation of NF-${\kappa}B$, but also phosphorylation of ERK and JNK in IgE/DNP-BSA-treated RBL-2H3 cells. Fucoxanthin may be useful for preventing allergic diseases, including asthma and atopic dermatitis.
Keywords
Allergy; ${\beta}$-Hexosaminidase; MAPK; NF-${\kappa}B$;
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1 Yang, L., L. Cohn, D.H. Zhang, R. Homer, A. Ray and P. Ray. 1998. Essential role of nuclear factor B in the induction of eosinophilia in allergic airway inflammation. J. Exp. Med. 188:1739-1750.   DOI   ScienceOn
2 Lee, J., S.J. Lee and K.T. Lim. 2012. CTB glycoprotein (75 kDa) inhibits IgE releasing, TNF-${\alpha}$ and IL-6 expressed by bisphenol A in vivo and in vitro. Food Chem. Toxicol. 50 (6):2109-2117.   DOI
3 Matsuda, H., Q. Wang, K. Matsuhira, S. Nakamura, D. Yuan and M. Yoshikawa. 2008. Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein- 1 in RBL-2H3 cells. Phytomedicine 15:177-184   DOI   ScienceOn
4 Namkoong, S., S.C. Kang, H. Do, K.H. Jang, S.A. Jang, M.G. Choung and E.H. Sohn. 2011. Immunomodulatory effects of supplementation with extracts from the marine brown alga Eisenia bicyclis on macrophages. J. Korean Plant Res. 24(3): 298-303.   과학기술학회마을   DOI
5 Naal, R.M., J. Tabb, D. Holowka and B. Baird. 2004. In situ measurement of degranulation as a biosensor based on RBL- 2H3 mast cells. Biosens Bioelectron. 20(4):791-796.   DOI
6 Park, H.J., D.H. Jung, H. Joo, N.S. Kang, S.A. Jang, J.G. Lee and E.H. Sohn. 2010. The comparative study of anti-allergic and anti-inflammatory effects by fermented red ginseng and red ginseng. J. Korean Plant Res. 23(5): 393-485 (in Korean).   과학기술학회마을
7 Peng, J., J.P. Yuan, C.F. Wu and J.H. Wang. 2011. Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: metabolism and bioactivities relevant to human health. Mar. Drugs. 9(10):1806-1828.   DOI
8 Soter, N.A. 1989. Morphology of atopic eczema. Allergy 44 (Suppl 9):16-19.   DOI
9 Theoharides, T.C. and D. Kalogeromitros. 2006. The critical role of mast cells in allergy and inflammation. Ann. NY Acad. Sci. 1088:78-99.   DOI
10 Ding, A.H., C.F. Nathan and D.J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412.
11 Gilfillan, A.M. and C. Tkaczyk. 2006. Integrated signaling pathways for mast-cell activation. Nat. Rev. Immunol. 6: 218-230.   DOI   ScienceOn
12 Kang, K., H.J. Hwang, D.H. Hong, Y. Park, S.H. Kim, B.H. Lee and H.C. Shin. 2004. Antioxidant and antiinflammatory activities of ventol, a phlorotannin-rich natural agent derived from Ecklonia cava, and its effect on proteoglycan degradation in cartilage explant culture. Res. Commun. Mol. Pathol. Pharmacol. 115-116:77-95.
13 Hu, T., D. Liu, Y. Chen, J. Wu and S. Wang. 2010. Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro. Int. J. Biol. Macromol. 46: 193-198.   DOI
14 Huang, F., K. Yamaki, X. Tong, L. Fu, R. Zhang, Y. Cai, R. Yanagisawa, K. Inoue, H. Takano and S. Yoshino. 2008. Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine. Int. Immunopharmacol. 8:502-507.   DOI
15 Joe, M.J., S.N. Kim, H.Y. Choi, W.S. Shin, G.M. Park, D.W. Kang and Y.K. Kim. 2006. The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. Biol. Pharm. Bull. 29:1735-1739.   DOI
16 Karin, M. and A. Lin. 2002. NF-${\kappa}$B at the crossroads of life and death. Nat. Immunol. 3:221-227.
17 Kim, S.M., Y.F. Shang and B.H. Um. 2011. A preparative method for isolation of fucoxanthin from Eisenia bicyclis by centrifugal partition chromatography. Phytochem. Anal. 22 (4):322-329.   DOI
18 Barnes, P.J. 2008. Role of GATA-3 in allergic diseases. Curr. Mol. Med. 8:330-334.   DOI