• 한국해양바이오학회지
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• 제1권4호
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• pp.243-251
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• 2006

Dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp., is known to exhibit significant selective cytotoxic activity against a small panel of human tumor cell lines, however, the mechanisms of which are poorly understood. In the present study, it was investigated the further possible mechanisms by which dideoxytetrosynol A exerts its anti-proliferative action in cultured human leukemia cell line U937. We observed that the proliferation-inhibitory effect of dideoxypetrosynol A was due to the induction of G1 arrest of the cell cycle and apoptosis, which effects were associated with up-regulation of cyclin D1 and down-regulation of cyclin E without any change in cyclin-dependent-kinases (Cdks) expression. Dideoxypetrosynol A markedly induced the levels of Cdk inhibitor p16/INK4a expression. Furthermore, down-regulation of phosphorylation of retinoblastoma protein (pRB) by this compound was associated with enhanced binding of pRB and the transcription factor E2F-1. The increase in apoptosis was associated with a dose-dependent up-regulation in pro-apoptotic Bax expression and activation of caspase-3 and caspase-9. Dideoxytetrosynol A decreased the levels of cyclooxygenase (COX)-2 mRNA and protein expression without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin E2 (PGE2) synthesis. Furthermore, dideoxytetrosynol A treatment markedly inhibited the activity of telomerase, and the expression of human telomerase reverse transcriptase (hTERT), a main determinant of the telomerase enzymatic activity, was progressively down-regulated by dideoxytetrosynol A treatment in a dose-dependent fashion. Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of dideoxytetrosynol A.

• Journal of Preventive Medicine and Public Health
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• 제45권4호
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• pp.251-258
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• 2012

Objectives: The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the correlations between the methylation and clinical parameters in Korean colorectal cancer (CRC) patients. Methods: Hypermethylation profiles of nine genes (RASSF1, APC, $p16^{INK4a}$, Twist1, E-cadherin, TIMP3, Smad4, COX2, and ABCB1) were examined with 100 sets of cancer tissues and 14 normal colorectal tissues. We determined the hypermethylation at a given level by a percent of methylation ratio value of 10 using quantitative methylation real-time polymerase chain reaction. Results: Nine genes' hypermethylation levels in Korean CRC patient tissues were increased more higher than normal colorectal tissues. However, the amounts of $p16^{INK4a}$ and E-cadherin gene hypermethylation in normal and CRC tissues were not significantly different nor did TIMP3 gene hypermethylation in adjacent normal and cancer tissues differ significantly. The hypermethylation of TIMP3, Ecadherin, ABCB1, and COX2 genes among other genes were abundantly found in normal colorectal tissues. The hypermethylation of nine genes' methylation in cancer tissues was not significantly associated with any clinical parameters. In Cohen's kappa test, it was moderately observed that RASSF1 was related with E-cadherin, and Smad4 with ABCB1 and COX2. Conclusions: This study provides evidence for different hypermethylation patterns of cancer-associated genes in normal and CRC tissues, which may serve as useful information on CRC cancer progression.

• International Journal of Advanced Culture Technology
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• 제11권3호
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• pp.268-276
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• 2023

Ukiyo-e, a pivotal facet of Japanese art, had a profound impact on Western art during the 19th century, contributing to the emergence of Impressionism and Post-Impressionism. Notably, Katsushika Hokusai's "Great Wave" remains an enduring masterpiece. Ukiyo-e's historical trajectory is intricately linked to the socio-cultural context of its time. Japan's early artistic influences derived from China, evolving through the Nara and Heian periods. Ukiyo-e emerged from the Yamato-e tradition, characterized by its transition from religious themes to secular subjects. Zen Buddhism's influence during the Muromachi Shogunate shifted focus to ink wash painting, which eventually became accessible to the masses. The Azuchi-Momoyama period introduced lavish, colorful works. The Edo Shogunate upheld Kano School for the elite, while folklore painting gained popularity among the commoners, leading to the creation of Ukiyo-e. Ukiyo-e diversified its subjects, including beauty, geisha, sumo, landscapes, and more. The Asakusa district's "Shin-Yoshiwara" added to its vibrant themes. By the late 19th century, Ukiyo-e transcended its roots, encompassing landscapes, wildlife, and beyond. I explore Ukiyo-e's aesthetics and its influence on Impressionism, focusing on "The Three Masters of Ukiyo-e" - Kiyotagawa Komaro, Katsushika Hokusai, and Utagawa Hiroshige.

• 한국인쇄학회지
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• 제14권1호
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• pp.31-45
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• 1996

For the purpose of study on the printability of domestic art papers, the physical properties of domestic coated paper for offset printing were investigated. 25 kinds of sample papers were prepared and were examined in accordance with KS and TAPPI standard testing method i.e., basis weight, density, opacity, gloss, roughness, smoothness, brightness, and K&N absorption. IGT printability tester was used to obtain the printability parameters, such as maximum ink requirement of paper Y, limiting printing density D print through, and density smoothness constant m value.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2008년도 춘계학술대회 논문집
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• pp.565-566
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• 2008

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2005년도 International Meeting on Information Displayvol.I
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• pp.321-323
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• 2005

We report a microcapsule-based electronic ink display technique, containing hollow titania particles which were prepared via a complex coacervation method using gelatin and gum arabic. In order to reduce density mismatch between nanoparticels and dielectric medium, hollow titania particles were introduced. Microcapsules were then prepared using gelatin to improve the elasticity of the microcapsule wall and their electrophoretic characteristics were $investigated^1$

• 광학세계
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• 통권139호
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• pp.34-35
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• 2012

한국후지제록스(대표 정광은, www.fujixerox.co.kr)는 지난 3월 15일 서울 중구 정동에 위치한 본사에서 기자간담회를 갖고 디지털 인쇄기 신제품 및 디지털 인쇄 전용지 프로디지털(pro-digital) 출시를 통해 디지털 인쇄시장 공략에 박차를 가할 계획이라고 밝혔다. 한국후지제록스가 선보인 '컬러 800 프레스'와 '컬러 1000 프레스 LGD(Low Gloss Dry Ink)' 신제품은 다양한 인쇄사업에 맞게 유연하게 구성할 수 있는 것이 강점이다. 컬러 1000 LGDI는 광택 없는 매트한 느낌의 코팅 효과를 옵션으로 제공한다. 또 무림페이퍼와 디지털 인쇄 전용지 '프로디지털'을 출시하고 전용지 시장도 공략하고 있다. 프로디지털은 토너 점착성이 높고 고온 인쇄 시 품질 불량을 방지한다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2007년도 한국컴퓨터종합학술대회논문집 Vol.34 No.1 (C)
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• pp.209-212
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• 2007

E-Learning 혹은 원격 강의 환경에서 아바타 애니메이션과 annotation을 이용한 강의 컨텐츠를 제작 하는 것은 많은 시간과 비용을 요구한다. 본 논문에서는 웹 환경에서 아바타 애니메이션과 디지털 잉크(Digital ink) 기능을 지원하는 강의 컨텐츠를 디자인하고 공유하기 위한 아바타 기반 Annotation(Avatar Augmented Annotation), 즉 AAA 인터페이스 기법을 제안한다. AAA를 이용하여 강사는 복잡한 프로그래밍 언어나 스크립트를 사용하지 않고도 필기형식의 펜 입력을 통해 애니메이션과 Annotation이 복합된 강의 컨텐츠를 디자인 할 수 있다. 입력된 정보는 AAA를 통하여 XML 형식의 스크립트로 표현되고 이것은 강의 컨텐츠에 적용되어 아바타와 Annotation이 결합된 생동감있는 컨텐츠를 만들어낸다. 실험을 통하여 AAA 시스템은 기존의 온라인 교육 컨텐츠에 비해 교육적으로 효과적임을 알 수 있었다.

• 한국전기전자재료학회논문지
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• 제24권5호
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• pp.374-380
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• 2011

In this paper a printing process for patterning electrodes on large area substrate was developed by combining screen printing with reverse off-set printing. Ag ink was uniformly coated by screen printing. And then etching resist (ER) was patterned in the Ag film by reverse off-set printing, and then the non-desired Ag film was etched off by etchant. Finally, the ER was stripped-off to obtain the final Ag patterns. We extracted the suitable conditions of reverse Using the process we successfully fabricated gate electrodes and scan bus lines of OTFT-backplane used for e-paper, in which the diagonal size was 6 inch, the resolution $320{\times}240$, the minimum line width 30 um, and sheet resistance 1 ${\Omega}/{\Box}$.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.1219-1225
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• 2003

According to the increase of lifetime and efficiency, the interest in the pLED has dramatically increased recently because pLED can be applied to large-size and flexible displays. The core process in the manufacture of pLED is the printing process of red, green and blue light emitting polymers (LEP), and inkjet printing method is one of the promising technology to print red, green and blue LEP on glass substrates. In this work, we developed a multi-head inkjet patterning system with 3 heads for each color. The developed inkjet patterning system is composed of the precise positioning system, head controller circuit, real-time ink drop evaluation system, maintenance system, and stable ink supply system. Finally, we investigated the stability and reliability of the system by printing red, green and blue LEP on the dummy substrate.