• Journal of muscle and joint health
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• v.14 no.1
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• pp.61-69
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• 2007

Purpose: The purpose of the study is to investigate the degree of fatigue and its related factors in women with rheumatoid arthritis. Method: The subjects were 143 patients with rheumatoid arthritis. Data were collected by questionnaires including Multi-Dimensional Assessment of Fatigue(Tack, 1991), Korean Health Assessment Questionnaire(Bae et al., 1991), numeric scale of pain(Lee & Song, 1987), Center for Epidemiologic StudiesDepression, and Korean Sleep Scale(Oh, et al., 1998). The data were analyzed by SPSS WIN 12.0 program using descriptive statistics, Pearson Correlation, and Stepwise Multiple Regression. Result: The result were as follows. 1. The scores of fatigue of subjects averaged $4.95{\pm}1.83$, degree of fatigue was $5.85{\pm}1.98$, and influence of fatigue was $4.04{\pm}2.09$. 2. The mean score of the degree of physical dysfunction, pain, sleep disorder, and depression were $1.42{\pm}0.38,\;8.15{\pm}3.58,\;1.86{\pm}0.67,\;and\;1.85{\pm}0.46$ points respectively. 3. The subject's total fatigue score, physical dysfunction, pain, sleep disorder, and depression was correlated positively(r=.44, r=.28, r=.29, r=.27, p< .01). 4. The main influencing factors on the fatigue were physical dysfunction and sleep disorder. These two main variables made it possible to explain 23.0% of the variance in fatigue. Conclusion: Therefore, nursing interventions for fatigue experienced women with rheumatoid arthritis would be focused to decrease physical dysfunction and sleep disorder.

• Korean Journal of Acupuncture
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• v.19 no.2
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• pp.97-117
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• 2002

Chiropractic is very similar to Oriental Medicine in philosophy on the cause of diseases and in utilization of spinal articulations for diagnosis and treatment. In this paper the spinal area used to treat liver dysfunction in S.O.T. technique, one of chiropractic techniques, was compared to the acupncture points used to cure the same conditions. Because both Oriental medicine and Chiropractic are dealing with autonomic nervous system in regulating abnormal conditions, also the innervation of spinal nerves to those areas was checked. The spinal area that S.O.T. technique utilizes to correct liver dysfunction is transverse processes of T8, which corresponds to B16. Acupncture points from this level down to T12/L1, which are B16, B17, B18, B19, B20, B21, B45, B46, B47, B48, B49, B50, GV6, GV7, GV8 and GV9, all have been applied to control liver function. Apparent discrepency exists in therapeutic areas for liver malfunction between the two natural healing arts. According to the neurology texts, liver is innervated by sympathetic fibers from the 7th-10th thoracic segments and by parasympathetic fibers from vagus nerve. Sympathetic afferent nerves from the liver reach the 7th-12th thoracic spinal cord segments. It can be said all the 7th-12th thoracic spinal cord segments are related to liver function. Therefore the areas used for liver dysfunction in both natural medicine are appropriately selected. However, B16, the Oriental medical equivalent of the main spinal area which is used for lowered liver function in C.M.R.T. Technique, is not utilized as frequent as in Oriental medicine.

• The Journal of Korean Academy of Prosthodontics
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• v.29 no.3
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• pp.121-140
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• 1991

Fifteen dental college students of Chosun University without the abnormal occlusion, the history and symptom of temporomandibular dysfunction(TMD), and who had all permanent teeth except third molar and the fifteen moderate group and the fifteen severe group classified according to Helkimo's dysfunction index among patients on the basis of the symptom of TMD were selected. The occlusal contact, occlusal force and occlusal interference in eccentric movement was studied and analyzed using T-Scan system. The result were as follows : 1. The TLR centering around midsagittal axis was located at $1.42{\pm}0.82mm$ in control group, $3.36{\pm}1.45mm$ in severe group, and as TMD was heavier, occlusal contact was located at the farther point from midsagittal axis. 2. The PLR from the first contact to the fifth contact centering around midsagittal axis was located at $1.73{\pm}1.78mm$ in control group, $3.36{\pm}1.41mm$ in moderate group, and $5.39{\pm}4.32mm$ in severe group, and as TMD was heavier, occlusal contact was located at the farther point from midsgittal axis. 3. The TFB, PFB, RFB and LFB of occlusal contact centering around incisal axis had no significant difference statistically among control group, moderate group, and severe group, and it was located at first molar. 4.The LF and RF was smaller in TMD group than in control group. 5. The LR moment of occlusal force centering around midsagittal axis was located at $178.51{\pm}139.81N.mm$ in control group, $466.25{\pm}296.47N.mm$ in moderate group, and $749.18{\pm}588.18N.mm$ in severe group. And as TMD was heavier, it was located at the farther point from midsagittal axis. 6. The RL and LL of occlusal force centering around incisal axis had not-significance statistically among control group, moderate group, and severe group, and it was at the first molar. 7. The number of occlusal interference of the eccentric movement was increased in the patients of TMD.

• The Korean Journal of Nuclear Medicine
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• v.37 no.3
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• pp.153-161
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• 2003

Purpose: Recently the occurrence of dipyridamole stress-induced short term stunning was proven and it is reported that Bland Altman analysis by repeated acquisition Tl-201 gated myocardial SPECT (gSPECT) revealed the 95% limit of agreement for LVEF was 10.3 %. The purpose of this study was to investigate the clinical value of dipyridamole induced transient LV dysfunction on Tl-201 gSPECT. Materials and Methods: Total 93 patients were included and coronary angiography was peformed in all patients less than 2 month from gSPECT. The patients with myocardial infarction were excluded. All patients underwent both dipyridamole stress and 4-h redistribution Tl-201 gSPECT. Forty nine patients of total 93 showed normal coronary arteries (Group 1) and the remaining 44 patients had coronary artery disease (Group 2). We compared LV EF, EDV and ESV during post-stress and 4-h redistribution period calculated by gSPECT using quantitative gated SPECT software and the incidence of dipyridamole induced transient LV dysfunction between group 1 and 2. The criteria for transient LV dysfunction was defined more decrease ${\geq}11%$ of LVEF during post-stress than 4-h redistribution according to previous reported Bland Altman analysis. Results: During post-stress and 4-h redistribution average of 3.1% increment in LVEF, 6.6% increment in LVEDV and 0.7% decrement in LVESV were shown after stress in Group 1, whereas 4.1% decrement, 9.7% increment and 7.2% increment in Group 2 respectively. Dipyridamole induced transient LV dysfunction was only detected in group 2 (18.2%) and not in group 1. It was more frequently observed in triple vessel disease and left main disease (31.8%, N=22) than one and two vessel disease (4.5%, N=22). Conclusion: As with Tc-99m myocardial agent post-stress LV dysfunction was observed in dipyridamole Tl-201 gSPECT. It was only detected in CAD and more frequently occurred in multivessel disease. Thus this finding seems to provide additional information in the diagnosis of coronary artery disease and prediction of prognosis.

• Korean Journal of Biological Psychiatry
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• v.21 no.4
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• pp.118-127
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• 2014

Along with language, socialization is a unique feature of the human being. There is a continuous debate regarding whether the development of socialization is innate, and conducted by the environment in the growing process, or the result of the interaction of both aspects. If socialization is the result of the interaction with the environment or is an acquired developmental process, the following question rises. "Is there a 'critical period' for the development of socialization?" Although there are a huge number of studies seeking for treatment and solutions for developmental delay or deficits of socialization, it is very complicated question to answer. Historical figures such as 'Hugh Blair' of Borgue in England, and 'the wild boy of Aveyron' in France, seem to have innate socialization deficits. Nowadays patients with non-verbal learning disorder, social communication disorder, or autism spectrum disorder seem to have genetic defects. On the other hand, Harry Harlow's monkey experiments, hikikomori of Japan, Romanian orphans and patients with reactive attachment disorder seem to display social deficits due to environmental factors. However, it is not easy to clearly draw a line between innate or acquired factors. Therefore, rather than subdividing the diseases for etiological and pathophysiological approach to heterogenous groups with the common denominator of social deficit, and for the research of pathophysiology and treatment development, the authors suggest a comprehensive concept of "social dysfunction spectrum."

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.5
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• pp.537-546
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• 1997

It has been postulated that the intracellular taurine is co-transported with $Na^+$down a concentration gradient and prevents the intracellular accumulation of sodium. It is therefore, expected that an elevated level of intracellular taurine prevents the sodium-promoted calcium influx to protect the cellular damages associated with sodium and calcium overload. In the present study, we evaluated the effects of intra- and extracellular taurine on the myocardial $Na^+$and$Ca^{++}$ contents and the cardiac functions in isolated rat hearts which were loaded with sodium by monensin, a $Na^+-ionophore$. Monensin caused a dose-dependent increase in intracellular $Na^+$ accompanied with a subsequent increase in intracellular $Ca^{++}$ and a mechanical dysfunction. In this monensin-treated heart, myocardial taurine content was decreased with a concomittent increase in the release of taurine. The monensin-induced increases in intracellular $Na^+$, $Ca^{++}$ and depression of cardiac function were prevented in the hearts of which taurine content had been increased by high-taurine diet. Conversely, in the hearts of which taurine concentration gradient had been decreased by addition of taurine in the perfusate, the monensin-induced increases in $Na^+$, $Ca^{++}$ and functional depression were accelerated. These results suggest that taurine, depending on the intra-extracellular concentration gradient, can affect intracellular sodium and calcium concentrations, and that an increased intracellular taurine may play a role in protection of myocardial dysfunction associated with the sodium and calcium overload.

• Journal of Korean Physical Therapy Science
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• v.11 no.3
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• pp.28-37
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• 2004

Background: Lumbar joint dysfunction is reported to be the main cause of lower back pain (LBP). The purpose of this study was to evaluate the effect of joint dysfunction on the postural balance of the lower hack and pelvis in different normal activities such as walking or stair management. Also it was studied whether the status of LBP (intensity and duration of LBP, length of treatment) contributes to die pelvic height difference (PHD) in various postures. Subjects: 28 patients with LBP and 32 normal adult volunteers, 60 years of age or younger, who came to the Community Health Center and orthopedic clinics in Incheon, South Korea. Methods: In order to determine the accuracy of the manual angulometer method in measuring the PHD, it was compared to the pelvic x-ray method in selected subjects. In the manual angulometer method, the arm of the angulometer was placed on the top of both iliac crests. The PHD was measured in static upright stance, then one-legged stance, on the affected leg or unaffected leg each time. Information regarding the disease status was obtained through interviews. Visual assessment scale was used to grade the intensity of LBP. Data analysis was performed using SPSS 10.0/PC program. Homogeneity between the two groups was tested by 2-test and t-test. To compare the PHD of the subgroups, we used t-test, F-test and two-way ANOVA. Relationships among dependent variables were analyzed by Pearson correlation analysis. Conclusion: In patients with LBP, lumbar joint dysfunction causes lumbar and pelvic postural asymmetry during normal activities.

• Toxicological Research
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• v.34 no.2
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• pp.133-141
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• 2018

Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that $10{\mu}M$ cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitro and in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/MST-1-linked signal transduction in the animal model.

• The Journal of Korean Medicine
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• v.19 no.1
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• pp.444-469
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• 1998

Premature ejaculation is the most common sexual dysfunction seen in the male, and it is found in 30 to 50% adult male population. It is defined as the inability to control the ejaculatory process for a sufficient length of time during intravaginal containment to satisfy his partner in at least fifty percent of his coital connections The majority of men with premature ejaculation have underlying psychologic origin of performance-anxiety type, but it is not always psychogenic and may also be a presenting symptom in certain organic disorders. In oriental medicine, the point of treatment of premature ejaculation is recovery of the good ejaculatory control, and the treatment can be approached in three ways as psychological therapy involving behavioral therapy, herb drugs, and acupuncture. This study has aims to investigate and summarize the current trend of treatment for premature ejaculation so as to suggest the effective and available way to treat the disease.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.980-990
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• 2003

The effect of Gamigyuibi-tang on the penile erection induced by apomorphine HCI and on the erectile dysfunction induced by p,p-DDE, an environmental hormone derivate of DOT, were monitored using male cats. The changes of penile length, diameter, erectic periods and histological profiles of corpus cavernosum and corpus spongiosum were observed with blood testosterone levels. In conclusion, dose-dependent and significant increase of penile length, diameter, erectic periods and blood testosterone levels were detected in the Gamigyuibitang-dosing groups compared to other groups. In addition, it is also demonstrated that the increasement of congestion of blood vessels and dilation of connective tissues, and decreasement of adipocytes in the corpus cavernosum and/or corpus spongiosum of the Gamigyuibitang-dosing groups. According to these results, it is considered that Gamigyuibitang has some augmentation effect against to apomorphine HCI inducing penile erection and it also suggested that Gamigyuibitang has favorable effect to treatment of erectic dysfunctions induced by p,p-DDE.