• Parasites, Hosts and Diseases
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• v.61 no.3
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• pp.231-239
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• 2023

Toxoplasma gondii is an intracellular parasitic organism affecting all warm-blooded vertebrates. Due to the unavailability of commercialized human T. gondii vaccine, many studies have been reported investigating the protective efficacy of pre-clinical T. gondii vaccines expressing diverse antigens. Careful antigen selection and implementing multifarious immunization strategies could enhance protection against toxoplasmosis in animal models. Although none of the available vaccines could remove the tissue-dwelling parasites from the host organism, findings from these pre-clinical toxoplasmosis vaccine studies highlighted their developmental potential and provided insights into rational vaccine design. We herein explored the progress of T. gondii vaccine development using DNA, protein subunit, and virus-like particle vaccine platforms. Specifically, we summarized the findings from the pre-clinical toxoplasmosis vaccine studies involving T. gondii challenge infection in mice published in the past 5 years.

• Therapeutic Science for Rehabilitation
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• v.10 no.1
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• pp.19-35
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• 2021

Objective : This study aimed to systematically examine studies on the life-space mobility in community-dwelling elderly and analyze and summarize the research trends. Methods : The Embase and PubMed databases were searched for articles on the life-space mobility of community-dwelling elderly published between January 2010 and January 2020. Based on the selection and exclusion criteria of the 335 articles, a total of 27 articles were finally selected and analyzed. Results : As a results, 11 (40.7%) cohort studies had evidence level II. This study showed that the participants in the studies were healthy elderly (81.5%), and the University of Alabama Life-Space Assessment (UAB-LSA) used the most participants (88.9%). Of the foci of the 27 finally selected studies, 8 (29.6%) were physical, 8 (29.6%) were psychosocial, 6 (22.2%) were cognitive, and 2 (7.4%) were social, and 3 (11.1%) were others. The life-space mobility of the elderly needs to be analyzed from a multidimensional point of view, and not based on a single factor such as the physical, cognitive, psychosocial, or social. Conclusion : The results of this study are expected to verify causality through the study of life-space mobility for the elderly staying in various communities and provide future directions for the study on the mobility of the elderly's and the development of community-based intervention programs.

• Genes and Genomics
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• v.40 no.11
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• pp.1169-1180
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• 2018

Cave shrimps from the genera Typhlatya, Stygiocaris and Typhlopatsa (TST complex) comprises twenty cave-adapted taxa, which mainly occur in the anchialine environment. Anchialine habitats may undergo drastic environmental fluctuations, including spatial and temporal changes in salinity, temperature, and dissolved oxygen content. Previous studies of crustaceans from anchialine caves suggest that they have possessed morphological, behavioral, and physiological adaptations to cope with the extreme conditions, similar to other cave-dwelling crustaceans. However, the genetic basis has not been thoroughly explored in crustaceans from anchialine habitats, which can experience hypoxic regimes. To test whether the TST shrimp-complex hypoxia adaptations matched adaptive evolution of mitochondrial OXPHOS genes. The 13 OXPHOS genes from mitochondrial genomes of 98 shrimps and 1 outgroup were examined. For each of these genes was investigated and compared to orthologous sequences using both gene (i.e. branch-site and Datamonkey) and protein (i.e. TreeSAAP) level approaches. Positive selection was detected in 11 of the 13 candidate genes, and the radical amino acid changes sites scattered throughout the entire TST complex phylogeny. Additionally, a series of parallel/convergent amino acid substitutions were identified in mitochondrial OXPHOS genes of TST complex shrimps, which reflect functional convergence or similar genetic mechanisms of cave adaptation. The extensive occurrence of positive selection is suggestive of their essential role in adaptation to hypoxic anchialine environment, and further implying that TST complex shrimps might have acquired a finely capacity for energy metabolism. These results provided some new insights into the genetic basis of anchialine hypoxia adaptation.

• Architectural research
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• v.15 no.4
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• pp.175-182
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• 2013

This study aims to explore age-related differences with the assessment tools in the web-based 3D virtual model house and to propose the 3D model house criteria which everyone can use easily. The participants came from three age groups, ranging from their 20s to their over 40. Presence, Usability and Space perception and cognition in the experiment for navigating and evaluating the web-based 3D model house were measured and compared through one-way ANOVA and two-way ANOVA. The results and conclusions are as follows. (1) The younger the participants were, the more positive they evaluated the experiment on Presence. However, 20s needed higher presence than other two groups. (2) 30s and over 40 groups evaluated that the 3D virtual model house was more efficient than an actual model house on Usability. When the participants were younger, the values of 'expressivity' factor were higher. (3) The younger the participants were, the more positive they perceived the virtual environment (VE) on Space perception and cognition scale. There were no significant differences in the selection of dwelling size and the floor plan type. There were no significant differences of interaction effects between age and online gaming experience on Presence and Usability. The results of the current study demonstrate that there are differences among age groups and older groups have difficulty navigating and assessing in a VE. Although older groups take longer to adapt in the VE, they regard the 3D model house as an effective tool for purchase of house.

• Journal of agricultural medicine and community health
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• v.20 no.2
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• pp.121-131
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• 1995

This study aims 1) To explicate the multidimensional structure of a widely used measure of subjective well-being, the Philadelphia Geriatric Center(PGC) Morale Scale is used to measure health in elderly populations and 2) To examine the relationship between the socioeconomic status and related variables, health and physical disability and subjective well-being in elderly populations. The selection of subjects was determined through a survey of 672 rural dwelling elderly persons(269 males and 403 females) aged 60 years and over. The respondents were interviewed by 18 trained health workers using the questionnaire from July 4 to July 9 in 1994. The subjects were surveyed again during the period from August 1 to August 6 in 1994 to conform the questionnaire's reliability. Subjective well-being was evaluated using the Revised Questionnaire of the Philadelphia Geriatric Center(PGC) Moral Scale(17 items, Lawton, 1975). The results are as follows : 1) The item scores were intercorrelated and subjected to a principal component analysis. A rotated three-factor solution was done, accounting for 40.9% of the total variance. Thus, the PGC morale Scale can be derived from three stable factors : Factor 1 was explained "Lonely Dissatisfaction(7 items)", Factor 2 was explained "Agitation (5 items)", Factor 3 was explained "Attitude Towards Own Aging (5 items)". Further, these factors have a high degree of internal consistency, as determined by Cronbach's alpha : 0.7852. 2) The total mean score of PGC Morale Scale was 8.73. Sex, Age, Education, Current disease, Family type, Economic status, ADL, IADL were significantly difference in mean scores of PGC morale scale. 3) In the results of stepwise multiple regression analysis of subjective well-being. the most contributing factors were economic status, IADL, current disease, family type, sex and the R square was 0.23.

• Journal of Environmental Science International
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• v.18 no.12
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• pp.1417-1426
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• 2009

As the damages due to natural disasters continue to increase, a growing interest is being witnessed in such studies that focus on preventive measures to reduce damages rather than on their recovery. As such, the U.S. has been actively conducting projects to develop new models that can forecast potential damages due to natural disasters and widely employing them in actual cases. With no specific models developed in Korea yet, this study aimed to introduce an overseas typhoon model as part of the advanced efforts and apply it the actual cases occurring across the nation. This model estimates wind loads by measuring the impact of a strong wind upon buildings, and measurements require a number of parameters. Those parameters should include the types and dimensions of buildings and the type of the roofs. As for the FPHLM(Florida Public Hurricane Loss Model), a precedent model for our study, we were able to take advantage of number of the statistics and detailed categorizations on the residential buildings in the U.S., which enabled us to select the representative building types and produce their wind loads. With no sufficient relevant statistics available for the nation, however, we may not be able to readily measure the wind loads on the nation's residential buildings. Therefore, this study tried to choose the representative types, heights and dimensions of the buildings for the measurement of wind loads. We consequently came up with a representative house having an area between 62.81 and $95.56m^2$, either a flat roof or hip roof, a height of 2.6 m, an side ratio of 1.5, and the width and length of the mean $85m^2$ sized house being 11,300 mm and 7,530 mm, respectively.

• Journal of Power Electronics
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• v.15 no.1
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• pp.190-201
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• 2015

This paper uses the switching function approach to present a simple state model of the Vienna-type rectifier. The approach introduces the relationship between the DC-link neutral point voltage and the AC side phase currents. A novel direct power control (DPC) strategy, which is based on the sliding mode control (SMC) for Vienna I rectifiers, is developed using the proposed power model in the stationary ${\alpha}-{\beta}$ reference frames. The SMC-based DPC methodology directly regulates instantaneous active and reactive powers without transforming to a synchronous rotating coordinate reference frame or a tracking phase angle of grid voltage. Moreover, the required rectifier control voltages are directly calculated by utilizing the non-linear SMC scheme. Theoretically, active and reactive power flows are controlled without ripple or cross coupling. Furthermore, the fixed-switching frequency is obtained by employing the simplified space vector modulation (SVM). SVM solves the complicated designing problem of the AC harmonic filter. The simplified SVM is based on the simplification of the space vector diagram of a three-level converter into that of a two-level converter. The dwelling time calculation and switching sequence selection are easily implemented like those in the conventional two-level rectifier. Replacing the current control loops with power control loops simplifies the system design and enhances the transient performance. The simulation models in MATLAB/Simulink and the digital signal processor-controlled 1.5 kW Vienna-type rectifier are used to verify the fast responses and robustness of the proposed control scheme.

• Korean Journal of Ecology and Environment
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• v.47 no.4
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• pp.258-272
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• 2014

Bats hibernating in caves and unused mines were surveyed during six hibernation periods (from December to February, 2005 and 2011) in Korea. We recorded 13,288 individuals of 11 species at 140 hibernacula (60 caves and 80 abandoned mines): Rhinolophus ferrumequinum (n=3,509), Eptesicus serotinus (n=6), Hypsugo alaschanicus (n=349), Miniopterus fuliginosus (n=5,919), Murina hilgendorfi (n=417), Myotis aurascens (n=294), Myotis bombinus (n=2), Myotis formosus (n=401), Myotis macrodactylus (M.mac, n=151), Myotis petax (n=2,131) and Plecotus ognevi (n=109). We studied the thermal preference and selection of hibernacula of seven dominant bat species. Four species (Myotis petax, Hypsugo alaschanicus, Plecotus ognevi and Murina hilgendorfi) hibernated mainly at the cold site below than $7^{\circ}C$, while three species (Myotis formosus, Rhinolophus ferrumequinum and Miniopterus fuliginosus) hibernated at warm site above than $7^{\circ}C$. Rhinolophus ferrumequinum had broad-ranged temperature zone for their hibernating site. The mean body temperature of each species was $2.64{\pm}0.98^{\circ}C$ for Murina hilgendorfi, $2.76{\pm}1.68^{\circ}C$ for Hypsugo alaschanicus, $2.78{\pm}0.98^{\circ}C$ for Plecotus ognevi, $4.52{\pm}1.02^{\circ}C$ for Myotis petax, $7.83{\pm}1.94^{\circ}C$ for Miniopterus fuliginosus, $9.19{\pm}2.35^{\circ}C$ for Rhinolophus ferrumequinum and $13.64{\pm}0.76^{\circ}C$ for Myotis formosus, respectively. The body temperatures of hibernating bats were closely related to the rock surface temperatures rather than the ambient temperatures. In conclusion, the diversity of bats community in hibernacula were closely related to the range of inner ambient temperature of hibernacula, and more species of bats were occupied at sites presenting a broad range of ambient temperatures.

• Korea Real Estate Review
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• v.28 no.2
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• pp.35-47
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• 2018

Securing a stable residential location is one of the most important decisions that must be made in the modern society. On this matter, both individuals and their families must decide on where to live after taking into consideration various analyses. Contributing attributes in the selection of our dwelling place are crucial. In this research, influencing variables were derived from the intention to move by focusing on the characteristics of the household and traffic conditions, while implications were suggested through a comparison of urban characteristics. Suwon was selected as the case study. The result of the analysis showed the city of Suwon has longer communal satisfaction, relies on self-sufficiency, and is conscious of parking regulation. Preferences for rental housing, having infants and elementary school kids, high savings, and commuter convenience in Suwon and Gyeonggi-do ranked higher in the hierarchy of the intention to move. Compared to Gyeonggi-do, Suwon was influenced by commuters in the city and parking regulation-related variables. Meanwhile, Gyeonggi-do was affected by the lack of public transportation facilities and traffic congestion. Suwon, on the other hand, has a high share of passenger car ownership, so it seems that the psychological stability of parking space is significant. This research will contribute in the policy-making of Suwon, especially on the subject of migration prediction of citizens and real estate location selection, through analyses of variables related to the intention to move to a new residence.

• Korean Journal of Ecology and Environment
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• v.56 no.4
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• pp.375-383
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• 2023

To determine the cause of the population decline in Gobiobotia naktongensis, substrate preference and burying behaviour were investigated in this study. In general, the species was shown to prefer a substrate size of 1 mm or less, depending on the flow. In addition, the burying depth varied according to the size of the fish and increased with a decrease in water temperature. Our findings showed that the main cause of the population reduction was the physical changes in the substrate structure due to the dams or barrages construction. Notably, the accumulation of silt and mud in the substrate upon the formation of an upstream lentic water region for structural construction and bed armouring caused by scouring and reduced downstream inflow of fine sediment were deterministic in the fish habitat changes, causing problems in burying. As sand substrate structure is critical for the survival and inhabitation of psammophilous species, efficient strategies should be developed with proper habitat management to reduce the anthropogenic damage