• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.2A
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• pp.171-179
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• 2009

The porosity in porous media like concrete can be considered as a durability index since it may be a routine for the intrusion of harmful ions and room for the keeping moisture. Recently, modeling and analysis techniques for deterioration are provided based on the pore structure with the significance of durability and the relationship between porosity and durability characteristics is an important issue. In this paper, a series of mortar samples with five water to cement ratios are prepared and tests for durability performance are carried out including porosity measurement. The durability test covers those for compressive strength, air permeability, chloride diffusion coefficient, absorption, and moisture diffusion coefficient. They are compared with water to cement ratios and porosity. From the normalized data, when porosity increases to 1.45 times, air permeability, chloride diffusion coefficient, absorption, and moisture diffusion coefficient decrease to 2.3 times, 2.1 times, 5.5 times and 3.7 times, respectively, while compressive strength decreases to 0.6 times. It was evaluated that these are linearly changed with porosity showing high corelation factors. Additionally, intended durability performances are established from the test results and literature studies and a porosity for durable concrete is proposed based on them.

• Journal of the Korean Society of Food Culture
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• v.22 no.6
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• pp.690-695
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• 2007

This research aimed to Kimchi to be well known in the World, which to be international food on the each nation and each people, each religion cultural area, with having done Kimchi adaptation plan for localization. Among the plan, Kimchi utilization ways with the localization strategy in Turkish dietary life were investigated to the Kimchi preference, improvement points on Turkish view, for the Turkey person it would be able to apply in Turkish food culture, and the results are as follows. 1. According to sex of Chinese cabbage Kimchi preference, men ($M=3.75\;{\pm}\;0.89$) appeared higher than women ($M=3.62\;{\pm}\;0.88$). Color or appearance preference after Chinese cabbage Kimchi taste was investigated in order that red > burnish felt > transparent > yellow, and the smell preference which was hot($M=4.64\;{\pm}\;1.37$) appeared highest. A hot taste felt most intensely, and it was investigated in order that aftertaste> salty taste > sourness > off flavor taste > fermented fish source taste > sweetness> carbonic acid by the followings. For the feeling of texture of Kimchi, the crunch was higher than durable tough(it was visible the consider difference of the sex 2. That the Korean Kimchi hit to a palatable taste, against 109 people (72.2%) answered suitable appetite to this taste, and the reason which was in order of that hot tasty > appearance > chewing texture > red > fermented flavor was investigated. Did not hit to a taste 42 people (27.8%) answer back, with the reason that was investigated in order of hot tasty > appearance > red > fermented flavor > chewing texture. The hot tasty of Kimchi was commonly presented that hit and did not hit to appetite taste against people. 3. Among the Turkish food, similar foods for Kimchi were answered in order of Lahana Tursu (44.2 %) > Kapuska (25.9 %) > Lahana Prasa (11.1%), and similar food category were that Chinese cabbage or various vegetables to be pickling food and to be dressing salad with salt and vinegar. The accompanied or garnished Turkich food category for Kimchi were answered in order of cooking meat (34.1%)> steamed cooking rice (22.7%)> cooking fish (17.0%)> cooking soybean (14.2%). This result was same tendency with steamed cooking rice accompaniment for Kimchi in Korea and Turkey, and could be applied a new main menu like meat cooking and fish cooking dish which matched and accompanied with Kimchi.

• Journal of the Korean institute of surface engineering
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• v.56 no.6
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• pp.412-419
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• 2023

Anion exchange membrane electrolysis is considered a promising next-generation hydrogen production technology that can produce low-cost, clean hydrogen. However, anion exchange membrane electrolysis technology is in its early stages of development and requires intensive research on electrodes, which are a key component of the catalyst-system interface. In this study, we optimized the pressure conditions of the hot-pressing process to manufacture cobalt oxide electrodes for the development of a high uniformity and high adhesion electrode production process for the oxygen evolution reaction. As the pressure increased, the reduction of pores within the electrode and increased densification of catalytic particles led to the formation of a uniform electrode surface. The cobalt oxide electrode optimized for pressure conditions exhibited improved catalytic activity and durability. The optimized electrode was used as the anode in an AEMWE single cell, exhibiting a current density of 1.53 A cm^-2 at a cell voltage of 1.85 V. In a durability test conducted for 100 h at a constant current density of 500 mA cm^-2, it demonstrated excellent durability with a low degradation rate of 15.9 mV kh^-1, maintaining 99% of its initial performance.

• Journal of The Korean Association For Science Education
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• v.27 no.9
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• pp.787-795
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• 2007

The purpose of this study was to examine the effects of experimental learning using Small-Scale Chemistry (SSC) on science achievement and scientific attitude of high school students. SSC experiments were devised for 5 experiment themes of high school science textbook. Two classes were chosen from a high school in Busan and adopted into the comparison group and the experimental group; one group with thirty-four students participated in the class with an experimental learning using the SSC (experimental group), and another group with thirty-seven students participated in the class with the traditional learning (comparison group). The major discoveries of this study were as follows: Experimental learning using SSC has shown a significant difference between two groups in the science achievement of the students. Also there was a statistical difference between these two groups in the test which was conducted after a month to find out the durability of the experiment. Thus, the learning using SSC is assumed to be durable. Furthermore, there was a significant difference in scientific attitude between the two groups. It seemed that the learning using SSC had a good influence on fanning students' scientific attitude. In conclusion, an experimental learning using SSC has a positive effect on scientific achievement, the durability and scientific attitude of the students. We hope to develop suitable and various experimental learning materials using the SSC program that can be adopted in the classroom soon.

• Journal of Veterinary Science
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• v.25 no.1
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• pp.15.1-15.15
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• 2024

Background: The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized anti-canine PD-1 antibody (ca-4F12-E6) and evaluated its therapeutic properties in dogs with advance-staged oral malignant melanoma (OMM), however, their therapeutic effects on other types of canine tumors remain unclear. Objective: The present clinical study was carried out to evaluate the safety profile and clinical efficacy of ca-4F12-E6 in dogs with advanced solid tumors except for OMM. Methods: Thirty-eight dogs with non-OMM solid tumors were enrolled prospectively and treated with ca-4F12-E6 at 3 mg/kg every 2 weeks of each 10-week treatment cycle. Adverse events (AEs) and treatment efficacy were graded based on the criteria established by the Veterinary Cooperative Oncology Group. Results: One dog was withdrawn, and thirty-seven dogs were evaluated for the safety and efficacy of ca-4F12-E6. Treatment-related AEs of any grade occurred in 13 out of 37 cases (35.1%). Two dogs with sterile nodular panniculitis and one with myasthenia gravis and hypothyroidism were suspected of immune-related AEs. In 30 out of 37 dogs that had target tumor lesions, the overall response and clinical benefit rates were 6.9% and 27.6%, respectively. The median progression-free survival and overall survival time were 70 days and 215 days, respectively. Conclusions: The present study demonstrated that ca-4F12-E6 was well-tolerated in non-OMM dogs, with a small number of cases showing objective responses. This provides evidence supporting large-scale clinical trials of anti-PD-1 antibody therapy in dogs.

• IMMUNE NETWORK
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• v.20 no.6
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• pp.48.1-48.11
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• 2020

Hyperprogressive disease (HPD) is a distinct pattern of progression characterized by acceleration of tumor growth after treatment with anti-PD-1/PD-L1 Abs. However, the immunological characteristics have not been fully elucidated in patients with HPD. We prospectively recruited patients with metastatic non-small cell lung cancer treated with anti-PD-1/PD-L1 Abs between April 2015 and April 2018, and collected peripheral blood before treatment and 7-days post-treatment. HPD was defined as ≥2-fold increase in both tumor growth kinetics and tumor growth rate between pre-treatment and post-treatment. Peripheral blood mononuclear cells were analyzed by multi-color flow cytometry to phenotype the immune cells. Of 115 patients, 19 (16.5%) developed HPD, 52 experienced durable clinical benefit (DCB; partial response or stable disease ≥6 months), and 44 experienced non-hyperprogressive progression (NHPD). Patients with HPD had significantly lower progression-free survival (p<0.001) and overall survival (p<0.001). When peripheral blood immune cells were examined, the pre-treatment frequency of CD39⁺ cells among CD8⁺ T cells was significantly higher in patients with HPD compared to those with NHPD, although it showed borderline significance to predict HPD. Other parameters regarding regulatory T cells or myeloid derived suppressor cells did not significantly differ among patient groups. Our findings suggest high pre-treatment frequency of CD39⁺CD8⁺ T cells might be a characteristic of HPD. Further investigations in a larger cohort are needed to confirm our results and better delineate the immune landscape of HPD.

• The Journal of Engineering Geology
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• v.34 no.2
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• pp.163-171
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• 2024

Changes in the soil layer on Dokdo are important both academically and with regard to sustainable conservation and utilization of the islands. Continuous investigation and observation are necessary, as the soil layer is essential to the growth of plants and, therefore, the islands' ecosystem. Such work was carried out for about 8 years using soil erosion measuring bars, which are durable and facilitate simple monitoring of changes in the soil layer. Each bar comprised a rod measuring 30~50 cm long and 1.5 cm in diameter, and the use of stainless steel afforded resistance to corrosion caused by sea breezes. Six measuring bars were installed in the soil layers of each of two islands, Dongdo and Seodo, and measurements were taken one to three times a year from 2014 to 2021. The field measurements indicate that soil was deposited on Dongdo but eroded on Seodo during the observation period. As the measuring bars on Dongdo were located in the central and lower parts of the island, the observed changes in the soil layer resulted mainly from sedimentation of material eroded by weathering or soil runoff from the upper part of the island. In contrast, the measurement locations on Seodo were located in the upper and central parts of the island, where soil erosion and runoff diminished the soil layer at the observation points.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• v.26 no.1
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• pp.1-10
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• 2024

Objective: Endovascular coil embolization is the primary treatment modality for intracranial aneurysms. However, its long-term durability remains of concern, with a considerable proportion of cases requiring aneurysm reopening and retreatment. Therefore, establishing optimal follow-up imaging protocols is necessary to ensure a durable occlusion. This study aimed to develop guidelines for follow-up imaging strategies after endovascular treatment of intracranial aneurysms. Methods: A committee comprising members of the Korean Neuroendovascular Society and other relevant societies was formed. A literature review and analyses of the major published guidelines were conducted to gather evidence. A panel of 40 experts convened to achieve a consensus on the recommendations using the modified Delphi method. Results: The panel members reached the following consensus: 1. Schedule the initial follow-up imaging within 3-6 months of treatment. 2. Noninvasive imaging modalities, such as three-dimensional time-of-flight magnetic resonance angiography (MRA) or contrast-enhanced MRA, are alternatives to digital subtraction angiography (DSA) during the first follow-up. 3. Schedule mid-term follow-up imaging at 1, 2, 4, and 6 years after the initial treatment. 4. If noninvasive imaging reveals unstable changes in the treated aneurysms, DSA should be considered. 5. Consider late-term follow-up imaging every 3-5 years for lifelong monitoring of patients with unstable changes or at high risk of recurrence. Conclusions: The guidelines aim to provide physicians with the information to make informed decisions and provide patients with high-quality care. However, owing to a lack of specific recommendations and scientific data, these guidelines are based on expert consensus and should be considered in conjunction with individual patient characteristics and circumstances.

• Journal of the Korean Wood Science and Technology
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• v.40 no.3
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• pp.164-176
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• 2012

In the present study, rapeseed flour (RSF), which is a by-product from the production of edible oil and biodiesel extracted from rapeseed, was used to develop alternative adhesives for the production of plywood panels. To examine the effects of the enzyme on the adhesive properties and formaldehyde emission of the RSF-based adhesive resins, three enzymes, such as cellulase (CEL), pectinase (PEC) and protease (ALC), were used either separately or together. As a crosslinking agent, PF prepolymers, which were prepared with 1.5, 1.8 and 2.1 mole formaldehyde and 1 mol phenol (1.8-, 2.1- and 2.4-PF), were added into the RSF hydrolyzates. The adhesive resins formulated with CEL- or CEL-PEC-RSF hydrolyzates and 1.8-F/P PF prepolymers exhibited excellent adhesive strengths and formaldehyde emission. The tensile shear strength and formaldehyde emission of the plywood panels bonded with the formulate resins were satisfied with the minimum requirement of the KS standard for ordinary plywood panels (0.6 N/$mm^2$). In addition, formaldehyde emissions of the plywood panels approached to that of E0 specified in the KS standard (0.5 mg/${\ell}$), and even had much better than those of commercial UF glue mixes. Overall, the use of RSF-based adhesive resins for the production of plywood panels might provide durable adhesive properties and an environmentally friendly substitute for petroleum-based adhesive resins. However, further researches - the increase of solid content of RSF-based adhesives for reducing press time and the microscopic observation of plywood specimen for identifying the relationship between tensile shear strength and the penetration of adhesives into wood structure - are required to commercialize the RSF-based adhesives.

• Journal of Animal Environmental Science
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• v.11 no.3
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• pp.161-168
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• 2005

The disinfectants are important to prevention of infectious diseases for livestock and have been used widespreadly in recent years. This study was conducted to determine the effect of the disinfectants on microorganisms with reference to disinfectants concentration and application period in piggery slurry. As material, chemically different four disinfectants were used and no disinfectant, as control. These four disinfectants were Acids, Basic, Aldehydes and Alkalis, respectively. The characteristics pH, moisture content and organic matter of the piggery slurry used in this study were 8.2, $98.6\%,\;0.4\%$, respectively. The initial total microorganisms of piggery slurry were $6.3\times10^5$ cfu/ml, and Escherichia coli, Staphylococcus aureus, Bacillus cereus were $1.2\times10^4,\;4.1\times10^4,\;1.7\times10^4 cfu/ml,$ respectively. The disinfectants were applied at $100\%,\;200\%\;and\;300\%$ concentrations on the piggery slurry surface. It was determined that the effect of disinfectants varied accordance to concentration and application time. The most sensitive microorganisms were Escherichia coli and Staphylococcus aureus, while Bacillus cereus was found to be durable. As a result of this study, the microorganinsms of the piggery slurry are on the decrease by all disinfectants during 2 weeks, but showed a tendency to increase in number after that time. Accordingly, the microorganisms which are concerned in the liquid composting of piggery slurry were not affected by the disinfectant after 2 weeks.