• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.9
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• pp.2361-2376
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• 2023

The electrocardiogram (ECG) signal is commonly used to screen and diagnose cardiovascular diseases. In recent years, deep neural networks have been regarded as an effective way for automatic ECG disease diagnosis. The convolutional neural network is widely used for ECG signal extraction because it can obtain different levels of information. However, most previous studies adopt single scale convolution filters to extract ECG signal features, ignoring the complementarity between ECG signal features of different scales. In the paper, we propose a dual-scale network with convolution filters of different sizes for 12-lead ECG classification. Our model can extract and fuse ECG signal features of different scales. In addition, different spatial and time periods of the feature map obtained from the 12-lead ECG may have different contributions to ECG classification. Therefore, we add a spatial-temporal attention to each scale sub-network to emphasize the representative local spatial and temporal features. Our approach is evaluated on PTB-XL dataset and achieves 0.9307, 0.8152, and 89.11 on macro-averaged ROC-AUC score, a maximum F1 score, and mean accuracy, respectively. The experiment results have proven that our approach outperforms the baselines.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10345-10350
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• 2015

Background: Punica granatum (family: Lythraceae) is mainly found in Iran, which is considered to be its primary centre of origin. Studies on pomegranate peel have revealed antioxidant, anti-inflammatory, anti-angiogenesis activities, with prevention of premature aging and reducing inflammation. In addition to this it is also useful in treating various diseases like diabetes, maintaining blood pressure and treatment of neoplasms such as prostate and breast cancer. Objectives: In this study we identified anti-cancer targets of active compounds like corilagin (tannins), quercetin (flavonoids) and pseudopelletierine (alkaloids) present in pomegranate peel by employing dual reverse screening and binding analysis. Materials and Methods: The potent targets of the pomegranate peel were annotated by the PharmMapper and ReverseScreen 3D, then compared with targets identified from different Bioassay databases (NPACT and HIT's). Docking was then further employed using AutoDock pyrx and validated through discovery studio for studying molecular interactions. Results: A number of potent anti-cancerous targets were attained from the PharmMapper server according to their fit score and from ReverseScreen 3D server according to decreasing 3D scores. Conclusion: The identified targets now need to be further validated through in vitro and in vivo studies.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.12
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• pp.2633-2640
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• 2009

We design a small-area, low-power, and high-speed EEPROM for touch screen controller IC. As a small-area EEPROM design, a SSTC (side-wall selective transistor) cell is proposed, and high-voltage switching circuits repeated in the EEPROM core circuit are optimized. A digital data-bus sensing amplifier circuit is proposed as a low-power technology. For high speed, the distributed data-bus scheme is applied, and the driving voltage for both the EEPROM cell and the high-voltage switching circuits uses VDDP (=3.3V) which is higher than the logic voltage, VDD (=1.8V), using a dual power supply. The layout size of the designed 128-KBit EEPROMIP is $662.31{\mu}m{\times}1314.89{\mu}m$.

• Analytical Science and Technology
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• v.21 no.2
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• pp.117-122
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• 2008

Dual scintillator for simultaneous alpha- and beta-ray counting used by detection materials of a surface contamination monitor was developed. In this study, preparation method was not a heat melting method but a solvent method, by which the counting material was manufactured by dissolving the polymer materials with solvent. It was simplified the preparation process. Plastic scintillator for beta-ray counting was prepared by solidifying the casting solution mixed with organic scintillator, polymer, and solvent. ZnS(Ag) scintillator layer was prepared by screen printing the paste solution mixed with ZnS(Ag), paste, and solvent onto the plastic layer. The good counting ability for alpha- and beta-ray using the ZnS(Ag)/plastic dual scintillator prepared and possibility for the counting material of surface contamination monitor was confirmed.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.605-606
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• 2008

The distance detection system receives stereo video input through 2 CCD cameras. Using a decoder, the image is changed to the YCbCr4:2:2 format and only the Y signal is saved in the 4*256*8bit shift register of the Dual-Port SRAM. As a result of the matching procedure, the Depth value, which is the distance information, is saved in SRAM, and the Depth Map is made and output to the TFT-LCD screen.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.2050-2051
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• 2008

디스플레이 산업이 급속도로 발전함에 따라 touch screen 및 panel에 사용되고 있는 ITO(Indium Tin Oxide)박막의 표면저항에 대한 정밀 측정이 요구되고 있으며, 표면저항 측정은 주로 FPP(Four-Point Probe) 원리를 이용한 측정기를 사용하고 있다. 대부분의 면저항 측정기는 single 방식을 적용하고 있으나 이 방식은 가장자리 효과가 크며, 시료의 크기 및 두께와 핀 간격에 대한 보정계수를 적용하여야 하는 단점이 있다. 본 연구는 가장자리 효과가 거의 없고, 보정계수를 적용할 필요가 없는 dual 방식을 적용한 표면저항 측정기를 개발하였다. 개발된 표면저항 측정기는 휴대용으로 누구나 쉽고 정확하게 사용할 수 있으며, 측정 정확도는 지시값의 1.0 % 이하이고, 측정범위는 $4m{\Omega}/sq{\sim}20k{\Omega}/sq$ 이다.

• Radiation Oncology Journal
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• v.10 no.1
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• pp.107-113
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• 1992

Increasing frequency of skin cancer, mycosis fungoides, Kaposi's sarcoma etc, it need to treatment dose planning for total skin electron beam (TSEB) therapy. Appropriate treatment planning for TSEB therapy is needed to give homogeneous dose distribution throughout the entire skin surface. The energy of 6 MeV electron from the 18 MeV medical linear accelerator was adapted for superficial total skin electron beam therapy. The energy of the electron beam was reduced to 4.2 MeV by a $0.5\;cm\times90\;cm{\times}180\;cm$ acryl screen placed in a feet front of the patient. Six dual field beam was adapted for total skin irradiation to encompass the entire body surface from head to toe simultaneously. The patients were treated behind the acryl screen plate acted as a beam scatterer and contained a parallel-plate shallow ion chamber for dosimetry and beam monitoring. During treatment, the patient was placed in six different positions due to be homogeneous dose distribution for whole skin around the body. One treatment session delivered 400 cGy to the entire skin surface and patients were treated twice a week for eight consecutive weeks, which is equivalent to TDF value 57. instrumentation and techniques developed in determining the depth dose, dose distribution and bremsstrahlung dose are discussed.

• Journal of Life Science
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• v.25 no.6
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• pp.656-662
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• 2015

Natural products and natural product structures play a general and highly significant role in drug discovery and development process because it has various merits and potentials for new drug source that have extensive clinical experience, development time contraction, excellent stability and safety. In several neurological disorders, neuronal death and excessive activation of microglia (neuro-inflammation) are observed. A number of drug discovery-related neuronal cell death and neuro-inflammation was studied from natural products, respectively. However, until now, it has not been possible to study dual-protection molecules recorded in the Natural Product library. In the present study, using the natural product-derived library of the Institute for Korea Traditional Medical Industry, we investigated dual-protective molecules against glutamate (a classical excitatory neurotransmitter)-induced oxidative stress mediated neuronal cell death and LPS-induced excessive activated microglial cells (immune cells of the brain). Chrysophanol, extracted from Rheum palmatum, had dual-protective effects against both glutamate-induced neuronal cell death and LPS-induced NO production, triggering proinflammatory cytokines and microglia activation and resulting in neuroinflammation. Flow-cytometry analysis revealed that chrysophanol had a scavenger effect, scavenging glutamate- and LPS-induced reactive oxygen species (ROS) produced by neuronal and microglial cells, respectively. Based on the present study, chrysophanol may have an important protective role against neuronal cell death and neuroinflammation in the brain. The results may be helpful for studying drug development candidates for treating central nervous system disorders.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.

• Proceedings of the KIPE Conference
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• 2007.11a
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• pp.215-217
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• 2007

Recently, the demand for high definition TV is being increased by beginning of the digital broadcasting. The higher resolution of PDP is, the longer addressing time become, then, the sustain period for display image decreases. Because of the reason, dual-scan method which synchronously write information of an image on top and bottom of the screen is used for the high definition PDP. However, as the price competition of PDP becomes severe, we can`t avoid turning to a single-scan method which uses only a half of an expensive address IC. Accordingly, the sustain period becomes much shorter than prior method. In case of XGA level, it is impossible to display, eventually. In this paper, we are going to prove usefulness by realizing negative reset waveform and the driving circuit for high speed addressing.