• Maxillofacial Plastic and Reconstructive Surgery
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• 제42권
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• pp.35.1-35.6
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• 2020

Background: Miescher's cheilitis granulomatosa (MCG) is a rare chronic inflammatory disease and is known as the monosymptomatic clinical form of Melkersson-Rosenthal syndrome (MRS). It is characterised by swelling of one or both lips and more frequently affects the upper lip. Histopathological findings show the presence of numerous inflammatory infiltrates and granuloma formations. Pharmacological treatments and surgery have provided results that are positive yet insufficiently stable in the long term. The clinical case described is of a 68-year-old female patient with a diagnosis of MCG of the upper lip. Case presentation: The patient was diagnosed and treated at the Oral Medicine and Oral Pathology outpatient clinic of Maxillofacial and Odontostomatology Unit, Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico. The patient was recommended localised treatments of photobiomodulation (PBM) using a diode laser with a 635 nm and 980 nm dual-wavelength (λ) approach, a 600-micron fibre, and a handpiece with a 1-cm-diameter lens at 300 mW. Three treatments a week were administered for four weeks for a total of 12 treatment sessions (T₁-T₁₂). After that, the patient had a long follow-up period of about 2 years. The therapeutic results were clear from the initial stages of treatment. There was an immediate, gradual, and consistent reduction in labial swelling. A reduction in the size of the lip by about 35% at T₁₀-T₁₂ was observed, returning the size and volume of the upper lip within the normal clinical range. The painful symptoms subsided after the seventh treatment (T₇). The histopathological check at 3 months and the follow-up in particular confirmed the disease was in remission with satisfactorily stable treatment results. Moreover, the patient did not use any other treatments on the area from the early laser treatments through to the end of the follow-up period. Conclusions: Our experience describes a clinical case of MCG treated with PBM and effectively resolved with a reduction of the lip swelling. The real success of the treatment emerged over time, showing that the tissue healing was stable. In absence of any collateral phenomena, this confirms the effective and documented therapeutic potential of PBM for chronic inflammatory infiltrates.

• 대한기관식도과학회지
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• 제16권2호
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• pp.145-148
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• 2010

Background: Laryngeal papillomatosis, which is cased by human papillomavirus, is the most common benign neoplasm of the larynx. However, the prognosis of this disease remains really unpredictable. The aim of this paper is to determine whether any clinical features at the time of diagnosis could predict its course. Material and Method: Eighty-six patients treated at our institution during the last 20 years were analyzed retrospectively. All patients had microsurgery under general anesthesia. All patients' follow-up period was more than 1 year. We divided the patients into 1) Juvenile versus adult group based on their age 20, 2) single surgical method with laser versus dual surgical method with laser and microdebrider group, and 3) single subsite versus multiple subsites group. And we compared the therapeutic outcome. Results: The recurrence rate was 100% (15 patients) in the JP group and 56% (40 patients) in the AP group. Juvenile versus adult group was the only independent prognostic factor by univariate, and multivariate analysis. Microdebrider resection technique and multiple subsites were not associated with treatment result. Time period from the first surgery to recurrence detection was different statistically only for the age group. The number of surgery in the JP group ranged from 1 to 31 (mean 8.8). In the AP group the number of surgery ranged from 1 to 25 (mean 3.7). It was statistically different. Conclusion: Prognosis for the laryngeal papillomatosis remains unpredictable. Only patients' age was the only independent prognostic factor.

• 한국항행학회논문지
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• 제10권1호
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• pp.13-19
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• 2006

본 논문에서는 FCC의 방사 스펙트럼 제한 규정에 따라 5 GHz-WLAN 주파수 대역을 억제한 DS-UWB 가우시안 임펄스 생성기를 제안하고, 이를 실험적으로 구현하였다. 단극 구형파를 가우시안 임펄스로 변환하기 위해 SRD를 이용한 첫 번째 임펄스 생성기와 반도체 레이저의 이득 스위칭을 이용한 두 번째 임펄스 생성기로 구성된 2단 구조의 임펄스 생성기를 사용하였다. 출력된 가우시안 임펄스의 폭은 약 180 psec로 매우 짧다. 또한 WLAN 주파수 대역을 제거하기 위해 4단 링 공진기 구조의 고차 미분 가우시안 필터를 설계 및 제작하여 최종적으로 WLAN 신호 대역은 약 25 dB의 억제 효과를 갖는 DS-UWB 신호의 발생기를 실험적으로 구현하였다.

• 디지털융복합연구
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• 제18권11호
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• pp.187-194
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• 2020

본 연구는 최근 새로운 제조 수단으로 각광받고 있는 3D프린팅 기술의 통합제어 시스템과 품질개선을 위한 모니터링 SW 기술개발을 위한 프레임워크 및 연구개발 방향을 제시하고자 한다. 이를 위해 본 연구에서는 금속프린팅 기술로 조명되고 있는 DED와 PBF 3D프린팅 기술의 통합 제어기술 개발 Framework와 최근 반도체 장비 등에서 큰 관심을 받고 있는 음향센서를 이용한 모니터링 기술 등 품질 개선을 위한 4가지 모니터링 기술을 제안 소개하고자 한다. 본 연구를 위하여, 국내 3D프린팅 전문기업인 (주)컨셉션, 원광이엔텍(주), (주)디이엔티 등에서 개발 중인 국내 최신 금속 3D프린팅 시스템 장비를 활용하여 연구하였으며(1KW급 Dual Laser PBF 및 DED 프린팅 시스템), 2017년 이래 지속적인 연구개발을 수행해온 경험을 바탕으로 다음세대 3D프린팅 개발자를 위한 연구초안을 제시함으로서 국내 3D프린팅 기술 발전 및 연구개발 협력을 위한 기초자료를 제시하고자 한다.

• The Journal of Advanced Prosthodontics
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• 제2권1호
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• pp.7-13
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• 2010

Although most researchers agree that platelet-rich plasma (PRP) is a good source of autogenous growth factors, its effect on bone regeneration is still controversial. The purpose of this study was to evaluate whether increasing angiogenic factors in the human PRP to enhance new bone formation through rapid angiogenesis. MATERIAL AND METHODS. In vitro, the human platelets were activated with application of shear stress, $20\;{\mu}g/ml$ collagen, 2 mM $CaCl_2$ and 10U thrombin/$1\;{\times}\;10^9$ platelets. Level of vascular endothelial growth factor (VEGF) and platelet microparticle (PMP) in the activated platelets were checked. In the animal study, human angiogenic factors-enriched PRP was tested in 28 athymic rat's cranial critical bone defects with $\beta$-TCP. Angiogenesis and osteogenesis were evaluated by laser Doppler perfusion imaging, histology, dual energy X-ray densinometry, and micro-computed tomography. RESULTS. In vitro, this human angiogenic factors-enriched PRP resulted in better cellular proliferation and osteogenic differentiation. In vivo, increasing angiogenic potential of the PRP showed significantly higher blood perfusion around the defect and enhanced new bone formation around acellular bone graft material. CONCLUSION. Angiogenic factor-enriched PRP leads to faster and more extensive new bone formation in the critical size bone defect. The results implicate that rapid angiogenesis in the initial healing period by PRP could be supposed as a way to overcome short term effect of the rapid angiogenesis.

• Restorative Dentistry and Endodontics
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• 제40권3호
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• pp.195-201
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• 2015

Objectives: The use of chitosan nanoparticles (CNPs) in endodontics is of interest due to their antibiofilm properties. This study was to investigate the ability of bioactive CNPs to remove the smear layer and inhibit bacterial recolonization on dentin. Materials and Methods: One hundred bovine dentin sections were divided into five groups (n = 20 per group) according to the treatment. The irrigating solutions used were 2.5% sodium hypochlorite (NaOCl) for 20 min, 17% ethylenediaminetetraacetic acid (EDTA) for 3 min and 1.29 mg/mL CNPs for 3 min. The samples were irrigated with either distilled water (control), NaOCl, NaOCl-EDTA, NaOCl-EDTA-CNPs or NaOCl-CNPs. After the treatment, half of the samples (n = 50) were used to assess the chelating effect of the solutions using portable scanning electronic microscopy, while the other half (n = 50) were infected intra-orally to examine the post-treatment bacterial biofilm forming capacity. The biovolume and cellular viability of the biofilms were analysed under confocal laser scanning microscopy. The Kappa test was performed for examiner calibration, and the non-parametric Kruskal-Wallis and Dunn tests (p < 0.05) were used for comparisons among the groups. Results: The smear layer was significantly reduced in all of the groups except the control and NaOCl groups (p < 0.05). The CNPs-treated samples were able to resist biofilm formation significantly better than other treatment groups (p < 0.05). Conclusions: CNPs could be used as a final irrigant during root canal treatment with the dual benefit of removing the smear layer and inhibiting bacterial recolonization on root dentin.

• 한국초전도ㆍ저온공학회논문지
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• 제10권2호
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• pp.16-19
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• 2008

Angular dependence of critical current density of SmBCO coated conductor fabricated by co-evaporation method was investigated. For comparison, three samples were fabricated by a co-evaporation method and one sample was fabricated by a pulsed laser deposition process. The deposition system, named EDDC (Evaporation using Drum in Dual Chambers), is a batch type co-evaporation system, which is composed of reaction chamber and evaporation chamber. The normalized critical current density ratio ($I_c/I_c$(H//ab-plane)) of EDDC-SmBCO samples was found to be higher than that of PLD-YBCO sample in the whole range of angle. While the EDDC-SmBCO samples evidently had a peak at the angle of H//c-axis in the plot of the angular dependence of critical current, the normalized critical current of PLD-YBCO sample decreased monotonically without any peak as angle increased. The field dependence of critical current under the magnetic field parallel to the normal direction of those samples showed similar aspect in the range of $0\;G{\sim}5000\;G$.

• Journal of Periodontal and Implant Science
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• 제47권4호
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• pp.219-230
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• 2017

Purpose: The purpose of this study was to compare the characteristics of single- and dualspecies in vitro oral biofilms made by static and dynamic methods. Methods: Hydroxyapatite (HA) disks, 12.7 mm in diameter and 3 mm thick, were coated with processed saliva for 4 hours. The disks were divided into a static method group and a dynamic method group. The disks treated with a static method were cultured in 12-well plates, and the disks in the dynamic method group were cultured in a Center for Disease Control and Prevention (CDC) biofilm reactor for 72 hours. In the single- and dual-species biofilms, Fusobacterium nucleatum and Porphyromonas gingivalis were used, and the amount of adhering bacteria, proportions of species, and bacterial reduction of chlorhexidine were examined. Bacterial adhesion was examined with scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results: Compared with the biofilms made using the static method, the biofilms made using the dynamic method had significantly lower amounts of adhering and looser bacterial accumulation in SEM and CLSM images. The proportion of P. gingivalis was higher in the dynamic method group than in the static method group; however, the difference was not statistically significant. Furthermore, the biofilm thickness and bacterial reduction by chlorhexidine showed no significant differences between the 2 methods. Conclusions: When used to reproduce periodontal biofilms composed of F. nucleatum and P. gingivalis, the dynamic method (CDC biofilm reactor) formed looser biofilms containing fewer bacteria than the well plate. However, this difference did not influence the thickness of the biofilms or the activity of chlorhexidine. Therefore, both methods are useful for mimicking periodontitis-associated oral biofilms.

• 전기전자학회논문지
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• 제25권4호
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• pp.782-785
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• 2021

본 논문에서는 열화상 카메라를 적용한 개인 맞춤형 냉각관리 시스템을 제안한다. 제안하는 장비는 열화상 카메라를 이용하여 사용자의 진행 전 피부 온도와 진행 후 피부온도의 차이에 따라 냉기 배출량 및 시스템을 제어한다. 피부의 온도가 비정상적으로 낮아지면 냉기공급을 차단하여 안전사고 발생 가능성을 방지한다. 피부 온도 감지센서를 열화상 카메라 온도측정으로 대체하여 경제적이고, 열화상 이미지로 온도를 확인할 수 있으므로 시각화가 가능하다. 또한, 제안하는 장비는 열화상 카메라를 적용한 개인 맞춤형 냉각관리 시스템의 안전을 위해 레이저 포인터를 듀얼로 사용하여 초점 거리를 산출하여 피부와의 거리를 측정하는 센서의 감도를 개선시킨다. 제안된 장비의 성능을 평가하기 위하여 외부공인 시험기관에서 실험하였다. 첫 번째로 측정된 온도 범위는 -100℃~-160℃로 측정되어, 현재 현장에서 사용되는 최고 수준인 -150~-160℃(cryo generation/미국) 보다 넓은 온도 범위를 나타내었다. 또한 오차는 ±3.2%~±3.5%로 측정되어 현재 현장에서 사용되는 최고 수준인 ±5%(CRYOTOP/중국) 보다 우수한 결과를 나타내었다. 두 번째로 측정된 거리 정확도는 ±4.0% 이하로 측정되어, 현재 현장에서 사용되는 최고 수준인 ±5%(CRYOTOP/중국) 보다 우수한 결과를 나타내었다. 세 번째로 질소 사용량은 최대 0.15 L/min 미만으로 확인되어, 현재 현장에서 사용되는 최고 수준인 6 L/min(POLAR BEAR/미국) 보다 우수한 결과를 나타내었다. 따라서 본 본문에서 제안한 열화상 카메라를 적용한 개인 맞춤형 냉각관리 시스템의 성능의 우수함이 판별되었다.

• 방사성폐기물학회지
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• 제9권4호
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• pp.207-217
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• 2011

UV-Vis 분광광도법과 시간분해 레이저 유도 형광분광법(TRLFS)을 이용하여 흄산의 모사 리간드로 사용한 2,6-Dihydroxybenzoate(DHB)와 U(VI)의 착물형성반응을 조사하였다. U(VI)-DHB 착물 고유의 전하이동 흡수 스펙트럼을 분석한 결과, 착물형성반응은 우라늄-리간드 비가 1:1 또는 1:2 착물을 형성하는 이중 평형반응이며, 산도에 따라 착물종의 분포가 변한다는 것을 밝혔다. 계산된 착물형성상수 (log $K_1$ and log $K_2$)는 $12.4{\pm}0.1$과 $11.4{\pm}0.1$이다. 이에 더하여, TRLFS 방법으로 조사한 결과, DHB는 U(VI) 화학종들의 형광 소광제(quencher)로서 역할을 한다는 것을 확인하였다. 특히, 확인된 U(VI) 화학종 모두(${UO_2}^{2+}$, $(UO_2)_2{(OH)_2}^{2+}$과 $(UO_2)_3(OH)_5{^+})$에서 정적 (static) 및 동적 (dynamic) 소광작용이 공존하는 것으로 관찰되었다. 시간분해 형광 스펙트럼으로부터 리간드 농도에 따른 U(VI) 화학종의 형광세기와 형광수명을 측정하였으며, Stern-Volmer 식을 이용하여 분석하였다. 결정된 정적소광계수(KS)는 ${UO_2}^{2+}$, $(UO_2)_2{(OH)_2}^{2+}$ 과 $(UO_2)_3(OH)_5+$에 대하여 각각 $4.2{\pm}0.1$, $4.3{\pm}0.1$ 과 $4.34{\pm}0.08$이다. Stern-Volmer 식을 이용한 분석 결과, 단일 또는 이중 배위자 구조(mono- and bi-dentate)의 U(VI)-DHB 착물이 모두 정적소광효과에 관여하는 바닥상태 착물임을 확인하였다.