• Journal of Ginseng Research
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• v.45 no.6
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• pp.676-682
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• 2021

Background: Red ginseng has been found to improve ocular perfusion and dry eye syndrome in glaucomatous eyes; however, its effects on visual function and vision-related quality of life have not been investigated. This study sought to evaluate the effects of red ginseng on visual function and vision-related quality of life in glaucoma patients using contrast sensitivity and a questionnaire. Methods: Participants were randomly assigned to two groups in this prospective, randomized, double-blind study: in one group, red ginseng was taken first, followed by a placebo, and in the other, placebo was taken first, followed by red ginseng. We measured and compared changes in contrast sensitivity and vision-related quality of life between the two groups. Contrast sensitivity was measured using OPTEC® 6500P, and vision-related quality of life was evaluated using the 25-item National Eye Institute Visual Function Questionnaire. One-way and two-way repeated measure analyses of variance were used for the comparison. Relationships between respective changes in dry eye syndrome and contrast sensitivity were also analyzed. Results: Daytime contrast sensitivity and ocular pain improved after the administration of red ginseng. Nighttime contrast sensitivity was improved in early or moderate glaucoma. Improved contrast sensitivity was not associated with improvement in dry eye syndrome. Conclusion: Red ginseng could improve contrast sensitivity and ocular pain in patients with glaucoma. The mechanism underlying improvement in contrast sensitivity appears to be associated with enhanced retinal perfusion or retinal ganglion cell function, but not dry eye syndrome.

• Archives of Plastic Surgery
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• v.49 no.4
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• pp.473-478
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• 2022

Background We investigate the effect of involutional blepharoptosis (IB) surgery based on dry eye symptoms by analysis using objective and subjective measures. Methods We recorded various parameters from patients that underwent levator advancement surgery for IB, totaling 125 eyes (total 65 patients, 5 unilateral, 60 bilateral). Subjective assessment comprised a questionnaire on dry eye-related quality of life score (DEQS), a summary score calculated from DEQS, and six-grade evaluation, the patient's own measure of eye comfort. Objective assessment comprised marginal-reflex distance-1 (MRD-1), measurement of tear film breakup time, and superficial keratopathy (SPK) existence by slit lamp microscope. Results Subjective assessments showed that IB patients had improvement of dry eye symptoms and eye comfort when surgery increased MRD-1. On the other hand, objective assessments showed that the presence of SPK is suspected when the postoperative MRD-1 level is 3 mm or higher. Conclusion IB surgery must not only increase MRD-1 value, but also to perform maintenance of the appropriate ocular surface condition. From our parameters, we suggest postoperative MRD-1 value should be maintained at < 3 mm to safe and effective of IB surgery.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.247-253
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• 2015

Purpose: The purpose of this study was to compare and analyze the ocular surface and the palpebral conjunctiva of categorized subjects, which were divided into normal eye group and dry eye group, by using a thermal camera. Methods: Subjects were 144 eyes of 72 normal university students, who didn't have any corneal disease, abnormal lacrimal ducts, medical records regarding ocular surgeries, or experience of using contact lens. Subjects were divided into two groups, which were normal eye group and dry eye group, based on the results of TBUT, Schirmer I test, and McMonnies test. After categorizing the subjects, the temperature of the subjects' ocular surface and the palpebral conjunctiva were measured and analyzed by using a thermal camera (Cox CX series, Answer co., Korea). Results: In the normal eye group's Central Ar.1, Nasal Ar.2, Temporal Ar.3, Superior Ar.4, Inferior Ar.5, the measured amount of temperature change on each area was $-0.13{\pm}0.08$, $-0.14{\pm}0.08$, $-0.12{\pm}0.08$, $-0.14{\pm}0.08$, $-0.10{\pm}0.09(^{\circ}C/sec)$. The dry eye group's results were $-0.17{\pm}0.08$, $-0.16{\pm}0.07$, $-0.16{\pm}0.08$, $-0.17{\pm}0.09$, $-0.15{\pm}0.08(^{\circ}C/sec)$. When compared with the normal eye group, the values of Ar.1, Ar.3, Ar.5 were significantly different in the dry eye group(p<0.05). The amount of temperature change, which was observed on the palpebral conjunctiva(Ar.1:central, Ar.2: nasal, Ar.3: temporal) of the normal eyes, measured by thermography, was $34.36{\pm}1.12$, $34.17{\pm}1.10$, $34.07{\pm}1.12^{\circ}C$ on each area. Same values taken from the dry eye group was $33.55{\pm}0.94$, $33.43{\pm}0.97$, $33.51{\pm}1.06^{\circ}C$ on each area. The values of Ar.1, taken from the dry eye group, had a significant difference, compared to the values of the normal eye group(p=0.05). Conclusion: The temperature of the ocular surface decreased faster on the dry eyes, compared to the normal eyes. The temperature measured on the palpebral conjunctiva of the dry eyes were also lower than the normal eyes. The temperature changes on the ocular surface, observed with a thermal camera, were objective values to assess the stability of tear films, and might provide useful data for studies related to dry eye syndrome.

• Journal of the Korea Convergence Society
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• v.8 no.1
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• pp.61-69
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• 2017

This study was to identify the correlation between dry eye syndrome, upper extremity pain, depression and addictive smart phone use among college students. Data were collected from 286 college students using a self-report questionnaire. 15.0% of participants have an addictive smart phone use. There were significant differences by dry eye syndrome(t=-4.38, p<.001), neck pain(t=-2.60, p<.05) and depression(t=-4.15, p<.001) according to the addictive smart phone use. Dry eye syndrome(r=.332, p<.001), neck pain(r=.143, p<.05), hand pain(r=.138, p<.05) and depression(r=.402, p<.001) were positively related to addictive smart phone use. Strategies to diminish depression, and to prevent dry eye syndrome and neck pain in college students will be an important intervention component to prevent addictive smart phone use and health problems in future studies.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.2
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• pp.94-104
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• 2017

By analyzing the research of Dry Eye Syndrome that have been published in the Journals of Korean Medicine, we wished to provide fundamental data for clinical application's development We found 13 research papers related to Dry Eye Syndrome in Electronic databases(OASIS, RISS, NDSL, KISS) from 1995 to 2016. We subdivided the research into published year, published journal, the type of study, methods, etc. 13 research are composed of 4 systematic reviews, 2 clinical studies, and 7 clinical trials. According to the studies, patients with Dry Eye Syndrome tend to be chronic and have Yin-deficieny, and in their clinical trials, various Korean medical treatments were introduced. In the research, Korean medical treatments can be expected positive impact on Dry Eye Syndrome. But we think a variety of clinical treatment methods and additional studies are needed to increase.

• Research in Community and Public Health Nursing
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• v.25 no.1
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• pp.12-23
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• 2014

Purpose: The purpose of this study is to investigate influence of cellular phone videos and games on dry eye syndrome in university students. Methods: A randomized comparison group pre-post design is used. Sixty university students were randomly assigned to either a video or a game group. Frequencies of blinking, dry eye symptoms scores and amounts of tears were measured. Thirty subjects watched cellular phone video programmes and the other 30 subjects played cellular phone games for 61 minutes. In addition, frequencies of blinking were measured three times during treatment, once immediately after a treatment and twice at an interval of 20 minutes after subsequent treatments. Results: Post-test scores of frequencies of blinking significantly decreased, dry eye symptoms scores including amounts of tears significantly increased greater than pre-test scores in both groups. But there were no significant differences between the groups. Frequencies of blinking were significantly different with respect to the time spent using cellular phone. In both groups, the lowest frequencies of blinking were shown after 40 minutes of cellular phone use. Conclusion: This study shows that using cellular phone has negative influence on dry eye syndrome and eyes require a resting period after cellular phone use over 40 minutes.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.2
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• pp.93-99
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• 2013

Purpose: The aim of this study was to develop a dry eye test method using a paper based microfluidic device that improves inaccuracy caused by using one of current point-of-care dry eye tests such as Shirmer's. Methods: Wax printed hydrophilic chromatography papers were dyed with anthocyanin extracts to detect colorimetric display of liquid samples with varying pH. Fluid distribution rates were measured using artificial tears and human tears directly from 32 subjects. Results: With Shirmer's, fluid distribution rates with small amount of samples (less than $0.5{\mu}l$) were not displayed. However, with paper based microfluidic device, fluid imbibition distances over time were clearly showed. Also clinical results of dry eye from newly developed paper based microfluidic device showed correlation with the results from tear break up time tests. Conclusions: The newly developed paper based microfluidic devices were easy to use and exhibited more accurate clinical results than current dry eye point of care tests such as Shirmer's.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.93-103
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• 2016

This study consisted of descriptive research to determine the prevalence of dry eye disease using the Ocular Surface Disease Index (OSDI) questionnaire targeting workers in hospitals to understand the differences between general and health related characteristics depending on whether people have dry eye disease, and to determine the influencing factors of the disease. The subjects were 502 (Male: 51, Female: 451) general hospital employees in G-city. The data were collected from October 1 to October 31, 2015. Logistic regression was used to analyze the data. The results showed that hospital workers' prevalence of dry eye disease was 76.1%. Factors influencing DED in this population included currently having or adjusting medication (OR: 4.73), among those who felt their eyes dry, those who visited clinics and received medical treatment (artificial tears) (OR: 2.37), those who felt eye dryness (OR: 2.23), and not eating regularly (OR: 0.55). Moreover, 54.0% of those who had dry eye disease reported serious conditions. Accordingly, education to manage the risk factors of the disease and improve lifestyle is needed to prevent and manage dry eye disease.

• Journal of the Korean Society of School Health
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• v.31 no.3
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• pp.178-185
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• 2018

Purpose: This study aims to examine the effects of auriculotherapy on reducing signs of dry eye syndrome. Methods: This study is based on a pretest-posttest nonequivalent control group design. The participants who scored higher than 13 on the Ocular Surface Disease Index (OSDI) were divided randomly into two groups, the experimental group (n=45) and the control group (n=44). Auriculotherapy was performed by researchers for 2 weeks. For the experimental group, seed stickers were applied to the eye, liver, shenmen, and tubercle point of their ears. The pretest and the posttest included the same questionnaires of the OSDI as well as the Visual Function Questionnaire (NEI-VFQ25) and the eye fatigue. Data were analyzed by descriptive statistics, $x^2$ test, t-test and paired t-test, using SAS 20.0 program. Results: The difference in the OSDI's scores showed a significant decrease between the pretest and the posttest (t=-4.12, p<.001) in the experimental group. No significant difference was found in the NEI-VFQ25 (t=-0.10, p=.921, t=-0.91 p=.374). However, the experimental group showed a significant decrease in eye fatigue (t=5.78, p<.001), whereas the control group showed no difference (t=1.38, p=.18). Conclusion: Auriculotherapy can be used effectively on relieving the symptoms of dry eye syndrome and eye fatigue. However, the quality of life related to eyes was not improved by auriculotherapy.

• Medical Lasers
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• v.8 no.2
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• pp.50-58
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• 2019

Background and Objectives Low-level light therapy (LLLT) is an application of low-power light for various purposes such as promoting tissue repair, reducing inflammation, causing analgesia, etc. A previous study suggested the effect of light emitting diode (LED) light with the wavelength of 740 nm for promoting wound healing of corneal epithelial cells. This current study aimed to confirm the effect of LLLT for managing inflammation of a dry eye disease (DED) mouse model. Materials and Methods A total of 50C57BL/6 female mice were randomly grouped into 5 groups to compare the effect of LLLT:1) Control group, 2) Only LLLT group, 3) Dry eye group, 4) LLLT in dry eye group, and 5) Early treatment group. DED was induced with 4 daily injections of scopolamine hydrobromide and desiccation stress for 17 days, and LLLT at 740 nm was conducted once every 3 days. To analyze the effect of LLLT on the DED mouse model, tear volume, corneal surface irregularities, and fluorescence in stained cores were measured, and the level of inflammation was assessed with immunohistochemistry. Results The DED mouse model showed significant deterioration in the overall eye condition. After LLLT, the amount of tear volume was increased, and corneal surface irregularities were restored. Also, the number of neutrophils and the level of inflammatory cytokines significantly decreased as well. Conclusion This study showed that LLLT at 740 nm was effective in controlling the corneal conditions and the degree of inflammation in DED. Such findings may suggest therapeutic effects of LLLT at 740 nm on DED.