• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3561-3568
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• 2012

The calcium sensing receptor (CaSR) is a member of the largest family of cell surface receptors, the G protein-coupled receptors involved in calcium homeostasis. The role of the CaSR in neoplasia appears to be homeostatic; loss of normal CaSR-induced response to extracellular calcium is observed in cancers of the colon and ovary, while increased release of PTHrP is observed in cancers of the breast, prostate and Leydig cells. Currently CaSR can be considered as a molecule that can either promote or prevent tumor growth depending on the type of cancer. Therefore, recognition of the multifaceted role of CaSR in gliomas and other malignant tumors in general is fundamental to elucidating the mechanisms of tumor progression and the development of novel therapeutic agents. Emphasis should be placed on development of drug-targeting methods to modulate CaSR activity in cancer cells.

• The Journal of Korean Society for School & Community Health Education
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• v.10 no.2
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• pp.55-68
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• 2009

연구목적: 본 연구는 미국 인디애나 주에 소재하는 중학교와 고등학교 학생들 사이의 methamphetamine, MDMA, GHB, and Rohypnol과 같은 약물사용 특성을 파악하고 청소년 약물사용과 관련된 성과 학교 환경에 대한 인지된 안전도 특성을 분석하였다. 연구방법: 본 분석에 사용된 데이터는 Indiana Prevention Resource Center (IPRC)에서 2007 년도에 수행한 음주, 흡연, 약물사용 설문조사(ATOD) 응답자료로서 인디애나 주에 거주하고 있는 6-12 학년 사이의 학생들을 편의추출하여 조사가 가능했던 158,632명의 응답을 얻었다. 연구결과: 로지스틱 회귀분석에서 조사한 4개 약물을 사용하는 학생들의 관심도는 교실에 있을 때, 복도에서 혼자 있을 때, 방과후 활동을 위해 학교에 남아있을 때 불안전하다고 느끼는 약물 미사용자보다 더 높은 경향을 보였다. GHB, MDMA, Rohypnol을 사용한다고 응답한 학생이 여자보다 남자에서 더 많았고 상관관계분석 결과, 메탐페타민을 비롯한 네 가지 약물 사용의 상호간 상관도가 모두 유의미하게 높았다.

• Korean Journal of Health Education and Promotion
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• v.21 no.3
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• pp.67-86
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• 2004

This study attempted to investigate the factors influencing alcohol drinking habit of college students in Korea. To find how many students are alcohol dependents and what factors are related to problem drinking habit, the current study estimated problem drinkers and analyzed the relationship of problem drinking and various factors. In 2000, 736 students reported the questionnaires. Estimated rates of problem drinkers standardized by age were 0.7% of male and 0.5% of female students by NAST, amounting 9,300 college students. Age of initiation of alcohol drinking, alcohol or drug use problems of parents or mends, psychological factors, emotional factors, and two of MMPI scales were significantly different between moderate drinkers and alcohol dependents. The moderate and problem drinkers were significantly different in Mf and Pa average scores. However, economic factors were not significantly different between the moderate drinkers and alcohol dependents. Based on the results, this study suggested that further multivariate studies with large sample need be conducted to investigate the relationship between alcohol dependency and its factors.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4855-4860
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• 2012

Since cancer is one of the leading causes of death worldwide, and there is an urgent need to find better treatment. In recent years remarkable progress has been made towards the understanding of proposed hallmarks of cancer development and treatment. Treatment modalities comprise radiation therapy, surgery, chemotherapy, immunotherapy and hormonal therapy. Currently, the use of chemotherapeutics remains the predominant option for clinical control. However, one of the major problems with successful cancer therapy using chemotherapeutics is that patients often do not respond or eventually develop resistance after initial treatment. This has led to the increased use of anticancer drugs developed from natural resources. The biodiversity of venoms and toxins makes them a unique source from which novel therapeutics may be developed. In this review, the anticancer potential of snake venom is discussed. Some of the included molecules are under clinical trial and may find application for anticancer drug development in the near future.

• YAKHAK HOEJI
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• v.47 no.4
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• pp.252-259
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• 2003

Self-medication is a representative phenomenon in the domain of popular care, originated from perspective of medical pluralism and the pharmacy profession is said to be in the most appropriate position of health care professions to activate self-medication. As any healthcare reform impacts in a country, 2000 institutional separation between medicine and pharmacy implemented in Korea brought a lot of changes in behavior of drug use not only to physicians and pharmacists but also to consumers (patients). In this paper, the reality of self-medication since the institutional separation between medicine and pharmacy was analyzed, based on the empirical data which were collected by the Korea Institute for Health and Social Affairs in 2002. The major finding is that the domain of popular care including self-medication was significantly shrunk, while that of professional care was proportionally expanded. As a result, the following four points were strongly recommended for the purpose of promoting self-medication: i) upgrading the pharmacy education system from 4 year to 6 year level, ii) improvement of continuing education and introduction of GPP (Good Pharmacy Practice), iii) activating 'pharmacal encounter' (i.e., pharmacist-consumer relationship) and iv) promotion of socio-economic research activities and proactive participation in the international self-medication movement of pharmacists in Korea.

• International Journal of Oral Biology
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• v.43 no.4
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• pp.201-207
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• 2018

Porphyromonas gingivalis is among the major etiological pathogens of chronic periodontitis. The virulence mechanisms of P. gingivalis is yet to be identified as its activity is largely unknown in actual disease process. The purpose of this study is to identify antigens of P. gingivalis expressed only in patients with chronic periodontitis using a unique immunoscreening technique. Change Mediated Antigen Technology (CMAT), an antibody-based screening technique, was used to identify virulence-associated proteins of P. gingivalis that are expressed only during infection stage in patients having chronic periodontitis. Out of 13,000 recombinant clones screened, 22 tested positive for reproducible reactivity with rabbit hyperimmune anti-sera prepared against dental plaque samples acquired from periodontitis patients. The DNA sequences of these 18 genes were determined. CMAT-identified protein antigens of P. gingivalis included proteins involved in energy metabolism and biosynthesis, heme and iron binding, drug resistance, specific enzyme activities, and unknown functions. Further analysis of these genes could result in a novel insight into the virulence mechanisms of P. gingivalis.

• Analytical Science and Technology
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• v.35 no.4
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• pp.143-152
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• 2022

In this review, previous studies on the synthesis and characterization of the metal Complexes with paracetamol by elemental analysis, thermal analysis, (IR, NMR and UV-Vis (spectroscopy and conductivity. In reviewing these studies, the authors found that paracetamol can be coordinated through the pair of electrons on the hydroxyl O-atom, carbonyl O-atom, and N-atom of the amide group. If the paracetamol was a monodentate ligand, it will be coordinated by one of the following atoms O-hydroxyl, O-carbonyl or N-amide. But if the paracetamol was bidentate, it is coordinated by atoms (O-carbonyl and N-amide), (O-hydroxyl and N-amide) or (O-carbonyl and O-hydroxyl). The authors also found that free paracetamol and its complexes have antimicrobial activity.

• Journal of Food Hygiene and Safety
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• v.28 no.3
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• pp.207-212
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• 2013

Recent changes in the global climate environment have resulted in a wide variety of climate-related disasters, including floods, tidal waves, forest fires, droughts, etc. In addition, global warming raises the risk of food poisoning, which may increase the spread of infectious diseases and alter their structure. Under these circumstances, it is necessary to provide accurate and persuasive information to consumers so that they can be fully informed of climate change and alter their behavior accordingly. Therefore, the intention of this study was to develop posters and contents for image production related to climate change and food safety. The posters are focused on consumers with headings such as "Climate Change Threatening Food Safety", "Earth getting warmer, your dining table is at risk", "Warning signs ahead for the globe", and more. Five poster drafts were selected initially, and a survey was carried out amongst 1,087 people regarding their preferences, with the most preferred design chosen. The images related to climate change and food safety defined climate change, how it relates to food safety, the risks it poses to the food industry, and lastly, how the public can respond in the future. Therefore, to further communicate the importance of food safety to consumers, the development, education, and promotion of these contents should be performed to provide safety information to consumers in the future.

• Nutrition Research and Practice
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• v.11 no.3
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• pp.240-246
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• 2017

BACKGROUND/OBJECTIVES: Folic acid supplementation before pregnancy is known to significantly reduce the risk of having a baby with neural tube defects (NTDs). Therefore, it is important for women to be aware of the effects of folic acid supplementation before pregnancy. The purpose of this study was to investigate the awareness and preconceptional use of folic acid and to assess the current knowledge about folic acid among low-income pregnant women in Korea. SUBJECTS/METHODS: A questionnaire survey was conducted in 2012. Five hundred pregnant women were selected from the waiting list for the Nutriplus program implemented in public health centers using a multistage clustered probability sampling design. Data from 439 women were analyzed after excluding ones with incomplete answers. RESULTS: Among women who responded to the questionnaire, 65.6% had heard of folic acid before pregnancy, and 26.4% reported on the preconceptional use of folic acid. Women with a university degree or higher education were more likely to be aware of folic acid and to take folic acid in the preconception period. In a multivariate logistic regression, when age, education level, household income, employment status, gravidity, parity, and folic acid awareness were included in the model, folic acid awareness was a strong predictor of preconceptional folic acid use. As of interview, 85.4% and 77.7% of women were aware of the NTD-preventive role of folic acid and the appropriate time to take folic acid, respectively. The main sources of information on folic acid were healthcare professionals (41.2%), friends and family members (31.2%), and the media (26.5%). CONCLUSIONS: Our results suggest that public health strategies are needed to increase the preconceptional use of folic acid among Korean women.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.6 no.3
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• pp.544-558
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• 1999

With the increasing incidence of AIDS, it is probably inevitable that nurses working in hospital and community settings will come in contact with patients with AIDS. Nurses, more than any other health care profession, are on the front line of AIDS patient care. The purposes of this descriptive study were to gather information about registered nurses' knowledge and attitude regarding AIDS. and to provide a basis for the development of continuining education programs for the nurse. Data was gathered in 1988 using self-administered questionnaires given to a convinience sample of two hundred seventy registered nurses from two university hospitals, school nurses and postgraduate students of nursing. Data was analyzed with SAS. The results were as follows. Above 90% of the nurse knew well about definition of AIDS and routes of transmission but nurses relatively lacked knowledge about transmission of HIV in breast milk(69.3%). Less than half knew that drug abuser(44.1%) and sexual partner with IV drug abuser(39.6%) are at high risk for contracting AIDS. Above 70% of the nurse showed reluctance to provide care for surgery. delivery of child birth and hemodialysis of patients with AIDS. The results showed that, given a choice. 41.7% of the nurse would refuse to care for AIDS patients and 48.3% claimed that they should have a right refuse to care for AIDS patients. Reluctance of nursing patient with AIDS appeared to be principally associated with general fear of becoming infected with HIV. 41.8% exhibited a sympathetic attitude toward individual AIDS patient. The study findings suggest that it is necessary to examine the correlations between knowledge and attitude and to develop continuing education programs that alleviate the fear of contagion of the nurse.