• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7656-7666
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• 2015

The purpose of this study was to explore the determinants of subjective happiness among Korean adolescents and to supply basic data for enhancing to subjective happiness among Korean adolescents. This study used the 2014 Korean Youth Health Risk Behavior On-lin Survey data. It conducted a secondary data analysis of 72,060 cases. It conducted frequency analysis, t-test, ANOVA and multiple regression analysis by SPSS 18.0. Although various independent variables influenced on emotional support(t=44.335, p<,001), gender(t=27.730, p<.001), grade(t=25.347, p<.001), economic status(t=-25.345, p<.001), living arrangement(t=-6.158, p<.001), school record(t=-7.512, p<.001), father's educational status(t=-2.378, p<.001), subjective health status(t=46.062, p<.001), depression(t=-23.837, p<.001), sleep(t=19.871, p<.001), level of stress(t=-78.685, p<.001), alcohol(t=-13.481, p<.001) and drug use(t=-2.671, p<.01), smoking(t=-11.988, p<.001), breakfast(t=4.443, p<.001), activity(t=4.757, p<.001) were key factors of subjective happiness among Korean adolescents. The findings of this study were as follow: male middle students, who had emotional support, higher economic status, school record and father's educational level, living with family showed higher levels of subjective happiness. It also having good subjective health status, not depressed, more sufficient sleep, lower stress, no experience of drinking, smoking and drugs, more physical activity and having breakfast showed higher levels of subjective happiness.

• Analytical Science and Technology
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• v.17 no.2
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• pp.130-144
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• 2004

Recently, the air pollution in A and B industrial area has become one of the most important issues, then 60 VOCs in the area were measured using a highly sensitive method. The VOCs were adsorbed onto Carbotrap using air sampler and subsequently desorbed by a thermal desorber system into gas chromatograph-mass spectrometry (TDS-GC-MS). The peaks of all compounds had good chromatographic properties and offered very sensitive response for the EI-MS (SIM). Method detection limits (MDL) ranged from 0.01 to 0.1 ppt(v/v), and linearities of calibration curves were over 0.995. We analyzed total 90 atmosphere air samples of A and B industrial complex using the method. Benzene, toluene, ethylbenzene, xylene, n-hexane, fluorotrichloromethane, carbon tetrachloride, 1,2-dichloroethane, 1,1,1-trichloroethane, trichloroethylene, tetrachloroethylene, styrene, 1,3,5-trimethylbenzene, 1,2,4-trimethylbenzene, sec-butylbenzene and naphthalen were identified as the major compounds in the air, and their average concentrations were 0.81, 5.02 1.30, 3.0, 0.81, 37.9, 0.07, 0.15, 0.15, 0.79, 0.06, 0.33, 0.03, 0.12, 0.23, and 0.35 ppb(v/v), respectively. The concentrations of VOCs were low in summer and high in fall or winter. When the concentrations detected in air compare with WHO's norm, no case exceed it.

• Parasites, Hosts and Diseases
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• v.53 no.5
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• pp.515-524
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• 2015

The objectives of this study was to conduct a survey on schistosomiasis and soil-transmitted helminth (STH) infections in order to come up with feasible control strategies in Lake Victoria basin, Tanzania. Depending on the size of the school, 150-200 schoolchildren were recruited for the study. Duplicate Kato-Katz stool smears were prepared from each child and microscopically examined for Schistosoma mansoni and STHs. Urine specimens were examined for Schistosoma haematobium eggs using the filtration technique. After the survey, mass drug administration was done using praziquantel and albendazole for schistosomiasis and STHs infections, respectively. A total of 5,952 schoolchildren from 36 schools were recruited for the study and had their stool and urine specimens examined. Out of 5,952 schoolchildren, 898 (15.1%) were positive for S. mansoni, 754 (12.6%) for hookworms, 188 (3.2%) for Ascaris lumblicoides, and 5 (0.008%) for Trichuris trichiura. Out of 5,826 schoolchildren who provided urine samples, 519 (8.9%) were positive for S. haematobium eggs. The results revealed that intestinal schistosomiasis, urogenital schistosomiasis, and STH infections are highly prevalent throughought the lake basin. The high prevalence of intestinal and urogenital schistosomisiasis in the study area was a function of the distance from Lake Victoria, the former being more prevalent at localities close to the lake, whilst the latter is more so away from it. Control of schistosomiasis and STHs in the study area requires an integrated strategy that involves provision of health education to communities, regular treatments, and provision of adequate safe water supply and sanitation facilities.

• Journal of Food Hygiene and Safety
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• v.32 no.2
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• pp.96-100
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• 2017

Through the increasing use of internet and smart device, consumers can search the information what they want to find. The information has been accumulated and become into a big data. Analyzing the big data regarding key words associated with foods and foodborne pathogens could be a method for predicting foodborne illness outbreaks, especially in school food services. Therefore, the objective of this study was to elucidate the correlations between key words associated with foods and food safety issues. Frequencies of the key words for foodborne pathogens and food safety issues were searched using an internet portal site from January 1, 2012 to December 31, 2014. In addition, foodborne outbreak data were collected from Ministry of Food and Drug Safety for the same period of time. There was correlation between the time having maximum key word frequencies of foods and foodborne pathogens, and the time for foodborne illness outbreak occurred. In addition, the search frequencies for foods and foodborne pathogens were generally increased right after foodborne outbreaks occurred. However, in some cases foodborne outbreaks occurred after the search frequencies for certain seasonal foods increased These results could be useful in food safety management for reducing foodborne illness and in food safety communication.

• YAKHAK HOEJI
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• v.58 no.5
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• pp.349-356
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• 2014

With the advent of highly active anti-retroviral therapy (HAART), the perceptions of HIV therapy have changed from treating acute and terminal diseases to managing complex chronic diseases. Due to needs for specialists with professional knowledge on anti-retroviral therapies, pharmacists have been recognized as established and integral members in HIV multi-disciplinary care teams. Nevertheless, the roles of Korean pharmacists for HIV/AIDS therapy were highly limited. According to the transition of '2+4'-year pharmacy school curricula in Korea, it is necessary for pharmacy students to possess improved knowledge about and proper attitudes toward HIV/AIDS as future pharmacists. However, there have been little studies regarding the assessment of HIV/AIDS knowledge, attitudes, and risk perceptions of pharmacy students in Korea. Thus, this study was to examine Korean pharmacy students' knowledge levels, attitudes, and risk perceptions about HIV/AIDS and compare them according to pharmacy educational systems. The self-reported questionnaire was utilized to collect data. Total 238 students responded to the survey questionnaires. Most pharmacy students who participated in this study knew that the main transmission routes of HIV were unprotected sex, unscreened blood, occupational exposure, and intravenous drug use. However, they did not properly know post exposure prophylaxis for HIV. The pharmacy students under '2+4'-year curricula were more competent with treatment, care, counseling for HIV patients than those under 4-year curricula. Most pharmacy students thought that all healthcare students and professionals should receive mandatory HIV testings. The results from this study may contribute to developing new educational programs about HIV/AIDS. Additionally, further studies regarding the changes of Korean pharmacy students' attitudes and risk perceptions will need to be performed after they participate in these kinds of the programs.

• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.469-480
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• 2018

Objective: Pharmacogenomic-based antidepressant treatment (PGATx) may result in more precise pharmacotherapy of major depressive disorder (MDD) with better drug therapy guidance. Methods: An 8-week, randomized, single-blind clinical trial was conducted to evaluate the effectiveness and tolerability of PGATx in 100 patients with MDD. All recruited patients were randomly allocated either to PGATx (n=52) or treatment as usual (TAU, n=48) groups. The primary endpoint was a change of total score of the Hamilton Depression Rating Scale-17 (HAMD-17) from baseline to end of treatment. Response rate (at least 50% reduction in HAMD-17 score from baseline), remission rate (HAMD-17 score ${\leq}7$ at the end of treatment) as well as the change of total score of Frequency, Intensity, and Burden of Side Effects Ratings (FIBSER) from baseline to end of treatment were also investigated. Results: The mean change of HAMD-17 score was significantly different between two groups favoring PGATx by -4.1 point of difference (p=0.010) at the end of treatment. The mean change in the FIBSER score from baseline was significantly different between two treatment groups favoring PGATx by -2.5 point of difference (p=0.028). The response rate (71.7 % vs. 43.6%, p=0.014) were also significantly higher in PGATx than in TAU at the end of treatment, while the remission rate was numerically higher in PGATx than in TAU groups without statistical difference (45.5% vs. 25.6%, p=0.071). The reason for early drop-out associated with adverse events was also numerically higher in TAU (n=9, 50.0%) than in PGATx (n=4, 30.8%). Conclusion: The present study clearly demonstrate that PGATx may be a better treatment option in the treatment of MDD in terms of effectiveness and tolerability; however, study shortcomings may limit a generalization. Adequately-powered, well-designed, subsequent studies should be mandatory to prove its practicability and clinical utility for routine practice.

• 한국노년학
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• v.32 no.3
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• pp.747-758
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• 2012

Detecting probable Alzheimer's disease (AD) at an early stage is crucial in slowing the progression of the disease and initiating drug therapy for more effective symptom management. Therefore, this study aimed to identify linguistic features that allow us to distinguish between patients with AD and normal controls. This paper reports on characteristics of spontaneous speech in subjects in three stages of AD (questionable, mild, moderate) compared with education- and age-matched normal controls. Four components of speech were measured in Korean native speakers with AD and normal aging: speech tempo, hesitation (measured in seconds), rate of articulation errors, and rate of grammatical errors. The results revealed significant differences in most of these speech components among the four groups, including significant differences between normal controls and the questionable AD group in the areas of speech tempo and rate of grammatical errors. Phonological? articulatory ability was preserved in questionable AD, and grammatical ability was preserved in questionable and mild AD. Subjects with moderate AD were severely impaired in grammatical ability. Prospective assessments of spontaneous speech skills using a dialogue and picture-description task are useful in detecting the subtle, spontaneous speech impairments that AD causes even in its early stage.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.90-99
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• 2021

This study was conducted to provide basic data for improving nursing management practice by comparing and analyzing the perceptions of nursing students and clinical instructors about the importance of the learning contents of nursing management and their practical experience. The final 343 copies were analyzed using the Mann-Whitney test and cross-analysis, targeting 4th-grade students and clinical instructors at three universities. Both nursing students and clinical instructors recognized 'communication', 'interpersonal relationship', 'responsibility', 'trust', and 'morality' as important factors in the evaluation items of practice. Among the top 10 most importantly recognized items among nursing-management practice learning content, six items ('infection control', 'nursing record management', 'patient nursing management', 'drug management', 'patient safety', and 'nursing malpractice') were matched in the two groups. Moreover, clinical instructors recognized that interpersonal relationships and relationship ethics were important, while nursing students chose legal responsibility. As a result of the practical experience analysis between the two groups, nursing students had high experience of indirect participation, but the clinical instructors had a high experience of direct instruction. A plan is needed to reduce the difference by establishing an organic partnership relationship between the university and practice institutions and increase the experience of direct practice of nursing students.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.246-252
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• 2020

This study used the raw data of the 15th (2019) Korean Youth Health Risk Behavior Survey to investigate the risk factors of the health-risk behaviors of Korean multicultural adolescents on the subjective oral symptoms. The scope of the multicultural family was limited to children of immigrant women's families married to Korean men and immigrant male families married to Korean women, and 572 were selected as the final study subjects. The sociodemographic variables were surveyed as gender, grade, economic level, and school performance. The health risk behaviors included drinking, smoking, medication, stress, sleep satisfaction, suicidal thoughts, depression, and brushing before bedtime. The oral symptoms examined were toothache, gum pain, and halitosis. As a result, toothache was related to drinking, toothbrushing before sleep, stress, sleep satisfaction, suicidal thoughts, and depression. Gum pain was associated with drug use, sleep satisfaction, suicidal thoughts, and depression. Halitosis was associated with medication, brushing before sleep, stress, suicidal thoughts, and depression. In terms of health risk factors, drinking, stress, and sleep satisfaction were risk factors for toothache. Smoking, sleep satisfaction, and suicidal thoughts were risk factors for gum pain. The presence of toothbrushing and stress were risk factors for halitosis. In conclusion, a policy system is needed to support oral health education programs nationally at times, such as after-school activities or club activities, to promote oral health for teenagers.

• BMB Reports
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• v.54 no.11
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• pp.575-580
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• 2021

Cisplatin is widely known as an anti-cancer drug. However, the effects of cisplatin on mitochondrial function and autophagy-related proteins levels in the skeletal muscle are unclear. The purpose of this study was to investigate the effect of different doses of cisplatin on mitochondrial function and autophagy-related protein levels in the skeletal muscle of rats. Eight-week-old male Wistar rats (n = 24) were assigned to one of three groups; the first group was administered a saline placebo (CON, n = 10), and the second and third groups were given 0.1 mg/kg body weight (BW) (n = 6), and 0.5 mg/kg BW (n = 8) of cisplatin, respectively. The group that had been administered 0.5 mg cisplatin exhibited a reduced BW, skeletal muscle tissue weight, and mitochondrial function and upregulated levels of autophagy-related proteins, including LC3II, Beclin 1, and BNIP3. Moreover, this group had a high LC3 II/I ratio in the skeletal muscle; i.e., the administration of a high dose of cisplatin decreased the muscle mass and mitochondrial function and increased the levels of autophagy-related proteins. These results, thus, suggest that reducing mitochondrial dysfunction and autophagy pathways may be important for preventing skeletal muscle atrophy following cisplatin administration.