• 제목/요약/키워드: Drop out of College

검색결과 105건 처리시간 0.03초

골형성부전증의 착상전 유전진단을 위한 분자유전학적 방법의 조건 확립과 적용 (Establishment and Application of Molecular Genetic Techniques for Preimplantation Genetic Diagnosis of Osteogenesis Imperfecta)

  • 김민지;이형송;최혜원;임천규;조재원;김진영;송인옥;강인수
    • Clinical and Experimental Reproductive Medicine
    • /
    • 제35권2호
    • /
    • pp.99-110
    • /
    • 2008
  • 목 적: 착상전 유전진단은 환아를 출산할 가능성이 높은 부부들에게 정상아의 출산 기회를 제공해주는 보조생식술의 하나로서 널리 시행되고 있다. 골형성부전증은 상염색체 우성 유전질환으로서 뼈와 피부를 구성하는 결합조직의 이상으로 뼈가 잘 부러지는 특징을 가지고 있으며, 질환의 95% 이상은 COL1A1 또는 COL1A2 유전자의 이상으로 발병한다고 알려져 있다. 본 논문에서는 골형성부전증 환자 2 가계를 대상으로 5 주기의 착상전 유전진단을 시행하여 임신에 성공한 사례에 대해 보고하고자 한다. 연구방법: 착상전 유전진단 수행 전에 환자의 단일 림프구에서 증폭성공률과 allele drop-out (ADO) rate을 확인하기 위하여 임상전 검사를 수행하였다. 각각 원인 돌연변이로 확인된 COL1A1 유전자 c.2452G>A와 c.3226G>A를 가지고 있는 골형성부전증 2 가계를 대상으로 5 주기의 착상전 유전진단을 시행하였다. 생검한 할구로부터 원인 돌연변이를 진단하기 위하여 nested PCR 후 HaeIII 제한효소를 이용한 restriction fragment length polymorphism (RFLP) 분석방법과 direct sequencing 방법을 이용하여 진단을 실시하였다. 결 과: Genomic DNA를 이용하여 COL1A1 유전자 검사를 해 본 결과 각 가계의 원인 돌연변이는 c.2452G>A와 c.3226G>A임을 재확인하였으며, 단일세포를 이용한 임상전 검사 결과 첫 번째 사례의 경우 94.2%의 증폭성공률과 22.5%의 ADO rate을 나타내었고, 두 번째 사례의 경우 98.1%의 증폭성공률과 1.9%의 ADO rate를 나타내었다. 착상전 유전진단 결과 첫 번째 사례의 경우, 3 주기의 착상전 유전진단에서 총 34개의 배아 중 31개의 배아에서 진단에 성공하여 91.2% (31/34)의 진단성공률을 나타내었고, 총 19개의 정상 배아 중 8개의 배아 (2.7개/배아이식)를 이식하였다. 세 번째 주기에서 임신에 성공하였고 제왕절개로 건강한 아이를 분만하였다. 두 번째 사례의 경우 2 주기의 착상전 유전진단을 시행하였으며, 총 19개의 배아 모두 진단에 성공하여 100.0% (19/19)의 진단성공률을 나타내었고, 총 11개의 정상 배아 중 4개 (2개/배아이식)의 배아를 이식하였다. 두 번째 착상전 유전진단에서 임신에 성공하였고, 건강한 아이를 분만하였다. 결 론: 착상전 유전진단을 통한 골형성부전증 환자 2 가계에서의 성공적인 임신과 출산은 국내에서 처음으로 보고되는 임상 결과로, 본원의 착상전 유전진단방법은 효과적이고 확실한 방법으로써 앞으로도 더 많은 단일 유전자 이상의 유전질환을 가진 환자들에게 적용하게 될 것이며, 이는 이와 유사한 유전질환을 가지고 있거나 유전질환의 이환 가능성이 있는 부부들에게 정상아의 임신과 출산의 기회를 더욱 많이 제공할 수 있을 것이다.

K-식(式) 침전관(沈澱管)에 의한 간질충란(肝蛭蟲卵) 간이검사법(簡易檢査法) (An Easy Detection Method of Fasciola Eggs by Kim's Sedimental Tube)

  • 김교준;김상근;허민도
    • 대한수의학회지
    • /
    • 제23권1호
    • /
    • pp.105-110
    • /
    • 1983
  • The studies carried out to investigate the detection method of Fasciola eggs from positive cattle feces in the intradermal reaction method with laborsaving composition of sieves and Kim's sedimental tube method. The results obtained are summarized as follows: 1. The detection method of Fasciola eggs was improved by 3 meshes (100mesh, 150mesh, 250mesh) for filteration of fecal fluid contained Fasciola eggs. 2. Third type of tube in the 3 kinds of sedimental tube had the highest recovers rate of Fasciola eggs. Thus, this type of tube was selected and called as Kim's sedimental tube. 3. A-II, A-III, B-III and C-III type by Kim's sedimental tube method had the recovery rates of eggs in the 1st drop as ranged 99 to 100% and, A-I, B-II, C-II as 71 to 91%. 4. These Type of tubes were useful to detect Fasciola eggs and to shorten the time of the diagnostic procedures. 5. The Kim's sedimental tube method showed high recovery rates and convenient procedures as compared with other detection methods reported. In addition, the EPG value can also be obtained by this method. Therefore, it is desirable that the Kim's sedimental tube method could be recommended to clinicians.

  • PDF

A Two level Detection of Routing layer attacks in Hierarchical Wireless Sensor Networks using learning based energy prediction

  • Katiravan, Jeevaa;N, Duraipandian;N, Dharini
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • 제9권11호
    • /
    • pp.4644-4661
    • /
    • 2015
  • Wireless sensor networks are often organized in the form of clusters leading to the new framework of WSN called cluster or hierarchical WSN where each cluster head is responsible for its own cluster and its members. These hierarchical WSN are prone to various routing layer attacks such as Black hole, Gray hole, Sybil, Wormhole, Flooding etc. These routing layer attacks try to spoof, falsify or drop the packets during the packet routing process. They may even flood the network with unwanted data packets. If one cluster head is captured and made malicious, the entire cluster member nodes beneath the cluster get affected. On the other hand if the cluster member nodes are malicious, due to the broadcast wireless communication between all the source nodes it can disrupt the entire cluster functions. Thereby a scheme which can detect both the malicious cluster member and cluster head is the current need. Abnormal energy consumption of nodes is used to identify the malicious activity. To serve this purpose a learning based energy prediction algorithm is proposed. Thus a two level energy prediction based intrusion detection scheme to detect the malicious cluster head and cluster member is proposed and simulations were carried out using NS2-Mannasim framework. Simulation results achieved good detection ratio and less false positive.

전문대학 신입생의 대학 교육서비스 만족도 상승 요인에 관한 연구 (A Study on Factors of Increasing Satisfaction with College Education for Freshmen in College)

  • 이종하;한성일
    • 한국콘텐츠학회논문지
    • /
    • 제21권3호
    • /
    • pp.390-399
    • /
    • 2021
  • 본 연구는 전문대학 신입생들이 대학생활에 안정적으로 적응하고, 대학의 교육서비스에 대한 만족도를 향상시킬 수 있는 요인들을 분석해보고자 진행되었다. 학생들의 개인적인 특성과 대학생활 관련 특성, 대학생활적응에 대한 변화가 대학교육 만족도를 상승시키는지 분석하였다. 총 368명의 대학생활적응검사(CAT)의 각 하위요인에 대한 1, 2차의 차이를 분석한 결과 학문적 통합성과 사회적 통합성에서 인문계 고등학교 졸업생들이 상승하는 모습을 보였고, 사회적 통합성은 정시입시 유형의 학생들이 높았다. 대학교육 만족도의 상승을 종속변수로 하여 중다회귀분석을 실시한 결과 언어점수가 낮을수록, 학문적 통합성, 진로정체성, 대학만족도, 교수와의 관계, 경제적 안정성, 학업지속 안정성의 긍정적 변화가 대학교육 만족도는 상승시키는 요인으로 분석되었다. 이러한 결과를 바탕으로 전문대학 학생의 대학교육 만족도를 높이기 위한 다양한 학생지원 프로그램을 제시하였다.

Development of Acid Rain Model Instrument and Its Application in Environmental Education

  • Ma, Chang-Jin;Shin, Eun-Sang
    • Asian Journal of Atmospheric Environment
    • /
    • 제9권3호
    • /
    • pp.222-227
    • /
    • 2015
  • The environmental education with ideal teaching tools (e.g., a small-scaled experimental kit) is essential for raising the public's, especially student's, awareness of many environmental issues. This study was undertaken to develop a do-it-yourself model instrument of acid rain and estimating its applicability to the environmental education. Our novel model tool consists of a body (17 cm width, 6 cm depth, and 17 cm height), an acid gas injector, acid four rain reservoirs, and a drop supply pump. An alternative model instrument that can be more readily assembled was also suggested. Based on our novel approach, we carried out several model experiments with educatees (i.e., high school and college students, and adults). The results of questionnaires indicated that educatees achieved a very deep understanding of acid rain through an experienced model experiment. A 77 to 89% of educatees experienced the reappearance experiment of acid rain by our model instrument felt that it was very useful as a teaching tool of environmental education.

담도 종양 혈전을 동반한 간세포암종 (Hepatocellular Carcinoma with Bile Duct Tumor Thrombi)

  • 신혜선;홍지영;한정우;도화미;김기정;김도영;안상훈;최기홍
    • Journal of Yeungnam Medical Science
    • /
    • 제28권2호
    • /
    • pp.180-186
    • /
    • 2011
  • Obstruction of the bile duct owing to the direct extension of a tumor is occasionally found in patients with a hepatic neoplasm, but bile duct tumor thrombus caused by the intrabiliary transplantation of a free-floating tumor is a rare complication of hepatocellular carcinoma A 50-year-old woman was diagnosed with HCC with bile duct tumor thrombi. She received transarterial chemoembolization (TACE) because her liver function was not suitable for surgery at the time of diagnosis. After TACE, infected biloma occurred recurrently. Thus, resection of the HCC, including the bile duct tumor thrombi, was performed. Six months after the surgery, recurred HCC in the distal common bile duct as drop metastasis was noted. The patient was treated with tomotherapy and has been alive for three years as of this writing, without recurrence. The prognosis of HCC with bile duct tumor thrombi is considered dismal, but if appropriate procedures are selected and are actively carried out, long-term survival can occasionally be achieved.

  • PDF

Study on the Acceptability and Effectiveness of an Oral Contraceptive Among Iud Drop-outs in Rural Korea

  • Yang, J.M.;Bang, S.;Song, S.W.;Youn, B.B.
    • Journal of Preventive Medicine and Public Health
    • /
    • 제1권1호
    • /
    • pp.51-66
    • /
    • 1968
  • During a period of about one year(November '66 to December '67), the Yonsei University College of Medicine conducted a field trial of the oral contraceptive(Ovulen) in order to study its acceptability and use-effectiveness among IUD drop-outs in Koyang county. We can summarize the outstanding findings from this investigation as follows; 1. 61.4% of the IUD drop-outs interviewed (911 women) wanted to use the pill. Most of the reasons for not wanting to use it(352 women) pertained to either use of other contraceptive methods(98) or subfecundity(150) following IUD terminations. Only 83 out of 911 women gave reasons related to the difficulty of obtaining pills. Therefore, we can state that most IUD drop-outs if still in need of a contraceptive methods are in favor of trying the pill, and especially so if this method is conveniently available. 2. The 467 women or 37% of those who terminated IUD use actually visited the clinic for medical screening, and only 11 of them or 2.4% were rejected because of pregnancy and other medical reasons such as cervical erosion, myoma, breast mass, etc. 5.5% or 25 of the 456 women who received the first cycle did not take a single pill during the study period. 3. When we defined those 431 women who accepted and took one or more tablets we found that women over age 30, with 4 or more children, and/or with a higher educational level were the best prospects for recruitment. 4. In accuracy of use, about two thirds of the users started taking the pill on the 5 th day as directed for the first three cycles, but the percentages rose sharply to about 80% in later cycles. Tardiness in starting pill use in the first cycle may have occurred partly because they had to return to the clinic monthly to get each new cycle. Among acceptors who did not quit between cycles, 80 to 90% were regular users, missing two or less tablets in each cycle. 5) More than 60% of the users felt well and sometimes lost their pre-acceptance symptoms. especially dysmenorrhea. However, 27.4% (58 women) had side effects attributable to the pill compund as nausea, vomiting, indigestion, breast tenderness, decreased lactation or breakthrough bleeding. 25.0% (53 women) also complained of medical diseases or symptoms not related to the pill, especially during the first three cycles. However, as the confidence and experience of the client and the field workers grew, the incidence of unrelated medical complaints quickly fell to a lower level in the later cycles. 6. As of the end of this study, on December 31, 1967, 49.2% (212 women) had discontinued the use of the pill for medical reasons as well as for the non medical reasons. Only one case terminated use due to a pregnancy after taking pills. The cumulative continuation rates (by the life table method), were 58.9%, 51.9%, 41.0% at the end of 3 months, 6 months and one year, respectively. These rates are lower than in the U.S. studies. Even when we add the retaking group to the first segment, the continuation rate goes up only about 5% above the first segment rates mentioned above. Possible explanations are different dosages, the newerness of the method and the use of only one point for pill distribution in the country together with a monthly return for cycle 1, 2, 3, and 4-6.

  • PDF

Piglets' Surface Temperature Change at Different Weights at Birth

  • Caldara, Fabiana Ribeiro;dos Santos, Luan Sousa;Machado, Sivanilza Teixeira;Moi, Marta;de Alencar Naas, Irenilza;Foppa, Luciana;Garcia, Rodrigo Garofallo;de Kassia Silva dos Santos, Rita
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제27권3호
    • /
    • pp.431-438
    • /
    • 2014
  • The study was carried out in order to verify the effects of piglets' weight at birth on their surface temperature change (ST) after birth, and its relationship with ingestion time of colostrum. Piglets from four different sows were weighed at birth and divided into a totally randomized design with three treatments according to birth weight (PBW): T1 - less than 1.00 kg, T2 - 1.00 to 1.39 kg, and T3 - higher than or equal to 1.40 kg. The time spent for the first colostrum ingestion was recorded (TFS). Images of piglets' surface by thermal imaging camera were recorded at birth (STB) and 15, 30, 45, 60, and 120 min after birth. The air temperature and relative humidity were recorded every 30 min and the indexes of temperature and humidity (THI) were calculated. A ST drop after 15 min from birth was observed, increasing again after sixty minutes. Positive correlations were found between the PBW and the ST at 30 and 45 min after birth. The PBW was negatively correlated with the TFS. The THI showed high negative correlations (-0.824 and -0.815) with STB and after 15 min from birth. The piglet's surface temperature at birth was positively correlated with temperature thereof to 15 min, influencing therefore the temperatures in the interval of 45 to 120 min. The birth weight contributes significantly to postnatal hypothermia and consequently to the time it takes for piglets ingest colostrum, requiring special attention to those of low birth weight.

차량용 라디에이터의 성능향상에 관한 연구 (Improvement of the Cooling Radiator System for Vehicles)

  • 이창규;이상우;허윤근
    • 농업과학연구
    • /
    • 제33권2호
    • /
    • pp.107-114
    • /
    • 2006
  • An all-aluminum radiator made of aluminum was more excellent on environment friendliness, productivity, and cooling efficiency than the plastic tank radiator which was currently widely used in same size as above. A newly designed and manufactured radiator with all parts made of aluminium was ready to re-use without any disassembly process in recycle system so as to improve environment friendliness with low waste cost. Several manufacturing processes of the current plastic tank radiator such as O-ring inserting, and clinching of core to the tank, were eliminated on the manufacturing processes of the all-aluminium radiator, which would increase productivity and reduce production cost. Design criterion of all-aluminum radiator was presented by carrying out theoretical analysis of cooling capacity and there was no difference between analytical data and measurements. Cooling capacity of the all-aluminum radiator increased generally 13% up compared with the plastic radiator even though the pressure drop of air increased.

  • PDF

용융금속에 의한 Ceramic Oxides에서의 Wetting에 관한 연구 (A Stydy on the Wetting of Ceramic Oxides by Molten Metal)

  • 이석권;임응극;김환
    • 한국세라믹학회지
    • /
    • 제20권4호
    • /
    • pp.289-296
    • /
    • 1983
  • The Wetting of fusion cast $Al_2O_3$ brick and $Al_2O_3 -ZrO_2$ brick by liquid Ag was studied by the sessile drop technique in Ar atmosphere. In this experiment the specimens were photographed per 2$0^{\circ}C$with increasing temperature from 96$0^{\circ}C$ melting point of Ag. And the method of photographing was carried out by shadow technique. The cosine of the contact angle increased linearly with increasing temperature in both systems. And the relation between the cosine of the contact angle and the temperature was Cos$\theta$=1.132+$0.75{\times}10^{-3}T$ for $Al_2O_3$ brick and Cos$\theta$=-1.706+$1.125{\times}10^{-3}T$ for $Al_2O_3 -ZrO_2$ brick In both systems the contact angle decreased as the surface of substrate became smoother. The work of adhesion which was 503.5ergs/$cm^2$ for $Al_2O_3$brick and 393.6 ergs/cm2 for $Al_2O_3 -ZrO_2$ brick at 96$0^{\circ}C$ increased parabolically with increasing temperature in both system.

  • PDF