• Ocean and Polar Research
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• 제36권2호
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• pp.145-156
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• 2014

Macrobenthic biodiversity in the rocky intertidal areas of the Tae-an region, Republic of Korea, has decreased since the Hebei Spirit oil spill in December 2007. We aimed to investigate ecological roles of Pacific oyster (Crassostrea gigas) because recruitment and growth of oysters are critical to the recovery of damaged rocky shore ecosystem. We surveyed two sites monthly: natural rocky substrate and farming substrate, from July 2012 to January 2013 to identify and compare the changes in macrobenthic fauna. The abundance of young oysters was higher at the natural site. On the other hand, the mean height of oyster on the farming substrate was more than twice as great. The abundance of oyster at the natural site increased until October and then continuously decreased until end of study period. However, the abundance of oyster at the farming site constantly decreased from the beginning of study period. These different growth patterns might be attributable to spatial competition between oyster and a barnacle species (Balanus albicostatus) and environmental factors. At the natural site, physical stress factors including dramatic temperature changes and desiccation a few of the major factors limiting growth during aerial exposure. In addition, motile macrobenthos could be detrimental to oysters because they interrupt filter-feeding activities and hence hamper the growth of oysters. We show the higher recruitment of oysters at the natural site and healthy growth in the farming substrate are due to complicated differences in physical and biological stress factors.

• 동의생리병리학회지
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• 제22권2호
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• pp.377-384
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• 2008

The root of Vitis labrusca, is used as a source of health promoting drug in Korean traditional medicine. It has been reported that root of Vitis labrusca has antioxidant, anti lipid peroxidation and anti-reactive nitrogen species (RNS) activities. The aim of this study was to elucidate the molecular changes of apoptotic signaling pathways in phorbol 12-myristate 13 acetate (PMA)-induced human hepatocellular carcinoma cell line (Hep G2). The root of Vitis labrusca, ethanol extract (RVLEE) was tested for cell viability on Hep G2 cell using the MTT assay. RVLEE exhibited weak cytotoxic activity. However, treatment of Hep G2 cells with RVLEE suppressed PMA-induced cell proliferation. Also, dramatic changes of cell death signals in cellular molecules such as Chk2/Cds1, CIDE-B, CLIMP-63, Bax, Bcl-xL, C-myc, Bcl-2, Bric-5, NIP-3, TRAF2 and BAR but not CIDE-B and DR4. Futhermore, our results showed that the treatment of Hep G2 cells with 25 and $50\; {\mu}g/ml$ of RVLEE suppressed PMA-induced COX-2 gene activity. These data suggest that RVLEE have inhibitory effect of cell proliferation, induction of apoptosis and, thus, may offer therapeutic potential in Hep G2.

• 보건행정학회지
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• 제21권2호
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• pp.249-262
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• 2011

Since May 1st in 2008, the products of ginkgo biloba extract have had to be used with the patient's out-of-pocket payment due to reimbursement restriction guidelines. This study aims to analyze the policy effects of reimbursement restriction on pharmaceutical expenditures using interrupted time series(ITS) analysis. We retrieved monthly NHI claims data for the period between May, 2005 and December 2009. The ingredients identified as a substitute for ginkgo biloba have similar indications based on the similar pharmacological activities. The effects of changes in reimbursement scope were evaluated both for all relevant pharmaceuticals within the same therapeutic class and for 2 separate groups : ginkgo biloba's and its substitutes. According to the study results, restrictions on reimbursement scope resulted in savings of the drug expenditures in the targeted therapeutic class. Direct restriction on ginkgo biloba was associated with a decrease in expenditure level by 60.1% and changes in trend from an average increase rate of 1.4% to an average decrease rate of 1.5% for the therapeutic class, with a dramatic decrease in expenditure level(-191.5%) for ginkgo biloba itself, but with an increased expenditure level(+50.1%) and changes in trend from an average increase rate of 2.0% to an average decrease rate of 1.0% for the substitute group. Further policy to restrict nicergoline was associated with additional decrease in expenditure level for the therapeutic class. Additionally, we could identify the balloon effect - a new policy squeezing one part results in bulging out elsewhere. After the restriction of ginkgo biloba, the utilization of and expenditures on its substitutes increased significantly. In conclusion, we demonstrated that consecutively introduced policies effectively reduced overall expenditures on the therapeutic class of interest. Some ingredients played as a substitute while others did not. Further studies need to be conducted to identify which factors determine a substitute.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제34권3호
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• pp.201-214
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• 2020

2019년 12월 중국 우한(武漢)으로부터 발생한 신종 코로나바이러스(COVID-19)는 전 세계적으로 급속하게 퍼지며 대학수학교육 환경을 대면 방식에서 비대면(Untact, 비접촉) 방식으로 전환시키고 있다. 이로 인해 대부분의 수학 연구자와 교수자들은 2020년 봄부터 인터넷을 활용한 온라인 화상 회의와 온라인 교육 등 새로운 방식을 사용하고 있다. 본 논문에서는 이러한 과정에서 발생한 난점과 이를 극복한 방법들을 소개하고, 비대면 환경에서 교육의 질을 보장하는 대학수학교육의 다양한 사례를 통하여 체득한 노하우(Know-How)를 공유하고자 한다. 이를 통하여 코로나 이후(After Corona, AC) 시대의 대학수학교육과 연구 환경의 변화 가능성에 대하여 논한다. 특히 갑작스런 전면 비대면 방식의 온라인 교육을 진행하면서 교육의 질을 보장하기 위하여 취한 다양한 테크놀로지 활용 및 학생과의 소통에 대하여 언급한다. 마지막으로 비대면 교육환경의 교수·학습에서 당면한 문제에 대한 해결책과 특히 학생의 학습 활동과 학습과정에 기반한 평가의 구체적인 안을 제시하고 언택트 교육의 사각지대에 대하여 논한다.

• 한국비블리아학회지
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• 제23권3호
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• pp.139-155
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• 2012

급속한 정보환경의 변화는 여러 산업에 걸쳐 비즈니스 패러다임을 급격하게 바꾸고 있으며 전 세계적으로 그 확산 속도는 기하급수적으로 증가하고 있다. 이에 도서관에서도 예측 불가능한 변화에 대처하기 위해서 신속하게 반응할 수 있는 능력인 민첩성 역량을 이용하여 정보서비스를 제공해야할 필요가 있다. 특히 원활한 연구 및 교육 활동을 돕기 위해 최신 정보와 방대한 범위의 정보 제공을 하고 있는 대학 디지털도서관에서의 민첩성 역량은 더욱 중요한 요인으로 판단된다. 따라서 본 연구는 민첩성 역량에 대해서 살펴본 뒤 대학 디지털도서관 e-서비스 측정 평가 요인과 민첩성 요인들과의 관계에 대해 알아보고, 또한 민첩성 역량이 이용자의 만족도에 미치는 영향에 대해 분석하였다. 이를 바탕으로 대학 디지털도서관 운영 및 경영에 있어 고려해야할 사안들을 제안하였다.

• 융합보안논문지
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• 제13권6호
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• pp.51-59
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• 2013

3.20, 6.25 등 사이버공격을 받은 우리 정부는 지난 공격의 배후를 지목했으나, 공격행위에 대한 처벌이나 제제에 대해 논할 수 있는 국제적 논의의 장은 없었다. 이렇게 특정 국가가 공격을 주도했음을 입증하는 증거를 갖고 있더라도 규탄, 제재, 처벌 등이 불가능했기에 에스토니아 사태 이후 지속적으로 유사한 악의적 행위들이 반복되고 있다. 현재 사이버안보에 관한 국제적 논의는 크게 국제적 수준, 지역적 수준 및 양자간 협력의 3계층으로 나뉘어 진행되고 있다. 이 중 국제적 사이버안보 규범 논의 방향 정립은 주로 국제연합과 세계 사이버스페이스 총회 2개 축으로 움직이고 있다. 물론 민간 중심의 인터넷 거버넌스 논의나 UN 전문기구인 국제전기통신연합 등에서도 사이버보안 이슈가 논의되고 있으나 본 논문에서는 2013년 주요 성과가 도출된 국제연합의 정부전문가그룹(GGE) 활동 결과와 우리 정부가 주최한 제3차 세계 사이버스페이스 총회의 사이버안보 논의 흐름을 분석하여 2014년부터 시작될 제4차 UN 전문가그룹(GGE)의 활동을 예상해보고 앞으로의 사이버안보 논의 방향을 짚어보고자 한다. 또한 이러한 논의들에 대한 국내 대응전략을 도출해보고자 한다.

• Nutrition Research and Practice
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• 제13권5호
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• pp.367-376
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• 2019

BACKGROUND/OBJECTIVE: The blue honeysuckle berry (Lonicera caerulea var. edulis L.) is a small deciduous shrub belonging to the Caprifoliaceae family that is native to Russia, China, Japan, and Korea. The berry of this shrub is edible, sweet and juicy and is commonly known as the blue honeyberry (BHB). This study examined the anti-diabetic potential of BHB on high-fat-diet-induced mild diabetic mice. The hypoglycemic, and nephroprotective effects of the 12-week oral administration of blue honeyberry extract were analyzed. MATERIALS/METHODS: The hypoglycemic effects were based on the observed changes in insulin, blood glucose, and glycated hemoglobin (HbA1c). Furthermore, the changes in the weight of the pancreas, including its histopathology and immunohistochemical investigation were also performed. Moreover, the nephroprotective effects were analyzed by observing the changes in kidney weight, its histopathology, blood urea nitrogen (BUN), and serum creatinine levels. RESULTS: The results showed that the high-fat diet (HFD)-induced control mice showed a noticeable increase in blood glucose, insulin, HbA1c, BUN, and creatinine levels. Furthermore, growth was observed in lipid droplet deposition related to the degenerative lesions in the vacuolated renal tubules with the evident enlargement and hyperplasia of the pancreatic islets. In addition, in the endocrine pancreas, there was an increase in the insulin-and glucagon-producing cells, as well as in the insulin/glucagon cell ratios. On the other hand, compared to the HFD-treated mice group, all these diabetic and related complications were ameliorated significantly in a dose-dependent manner after 84 days of the continuous oral administration of BHBe at 400, 200 and 100 mg/kg, and a dramatic resettlement in the hepatic glucose-regulating enzyme activities was observed. CONCLUSIONS: By assessing the key parameters for T2DM, the present study showed that the BHBe could act as a potential herbal agent to cure diabetes (type II) and associated ailments in HFD-induced mice.

• 한국의류산업학회지
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• 제21권4호
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• pp.432-451
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• 2019

Companies and brands that practice sustainability pay attention to New Media due to its ability to build a sustainable relationship between companies and consumers. The need for research on specific roles, characteristics, and social media effects on eco-friendly advertising has had rapid growth in marketing programs for sustainable activities especially shown through social media. Information about sustainable fashion has spread to consumers through social media, and multifarious efforts have been made to attract the attention of youth. Despite the dramatic increase in eco-friendly marketing through social media as a part of sustainability, there is a lack of research on the major influences of emotional factors such as ad color and expression in social media. In this context, it is meaningful to identify relationships between emotional responses, advertising value and consumer behavior of sustainable fashion brands in Instagram and implement a suitable advertising type (color vs expression) for consumers. We used 366 responses for the final analysis. Data were analyzed by factor analysis, structural equation modeling using SPSS 18.0 and AMOS 18.0. The results of this study suggest that emotional responses, advertising value have a significant effect on the flow. This study expands on a previously limited research field by verifying consumer responses to image advertising on Instagram, rather than general sustainable fashion marketing. The study results also provide meaningful implications for a relation formation between customers and fashion brands vis-${\grave{a}}$-vis sustainable social media marketing.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.338-351
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• 2003

UV radiation is the most dangerous stress factor among permanent environmental impacts on human skin. Consequences of UV exposure are aberrant tissue architecture, alterations in skin cells including functional changes. Nowadays new kinds of outdoor leisure-time activities and changing environmental conditions make the question of sun protection more important than ever. It is necessary to recognize that self-confident consumers do not consider to change their way of life, they demand modern solutions on the basis of new scientific developments. In the past one fundamental principle of cosmetics was the use of physical and organic filter systems against damaging UV-rays. Today new research results demonstrate that natural protecting cell mechanisms can be activated. Suitable biological actives strongly support the protection function not from the surface but from the inside of the cell. A soy seed preparation (SSP) was proven to stimulate natural skin protective functions. The major functions are an increased energy level and the prevention of DNA damage. These functions can I be defined as biological UV protection. The tumor suppressor protein p53 plays a key role in the regulation of DNA repair. p53 must be transferred into the phosphorylated form to work as transcription factor for genes which are regulating the cell cycle or organizing DNA repair. A pretreatment with SSP increases the phosphorylation rate of p53 of chronically UV-irradiated human keratinocytes significantly. According to the same test procedure SSP induces a dramatic increase in the expression of the tumor suppressor protein p14$^{ARF}$ that is supporting the p53 activity by blocking the antagonist of p53, the oncoprotein Mdm2. Mdm2, a ubiquitin E3-ligase, downregulates p53 and at the same time it prevents phosphorylation of p53. The positive influence of the tumor suppressor proteins explains the stimulation of DNA repair and prevention of sunburn cell formation by SSP, which was proven in cell culture experiments. In vivo the increased skin tolerance against UV irradiation by SSP could be confirmed too. We have assumed, that an increased repair potential provides full cell functionality.y.

• 기술혁신연구
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• 제31권3호
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• pp.1-37
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• 2023

한국 혁신 생태계는 후발 추격자에서 '민간 주도의 건강하고 역동적인 생태계 조성을 위한 정부의 역할이 중요한' 창조적 선도자 단계로 진화해 왔다. 한국의 혁신 생태계는 그동안의 획기적인 발전과 양적 확대에도 불구하고 혁신 성과의 정체 현상, 생태계 내 및 글로벌 연계 활동의 부족 등을 보여주고 있다. 미래 지향적인 혁신 생태계 조성을 위한 차세대 혁신 생태계 모델이 요구되는 상황이다. 기존의 이론적 근거를 바탕으로 혁신 생태계의 바탕을 이루는 것이 기업간 네트워크라는 관점에서 차세대 혁신 생태계의 요소로 기업간 네트워크 외에, 기업 역량, 공공 연구기관, 민간 산업단체, 기술 인프라, 정책 주체를 바탕으로 5개 요소를 설정하고, 불연속적 기술 및 시장 변화에 부응하는 '민간 주도의 건강하고 역동적인' 혁신 생태계로서의 차세대 혁신 생태계 모델을 제시하였고 혁신 생태계구축 역할을 담당하는 정책 주체의 구체적인 방향을 제시하고, 본 연구의 의의를 제시하였다.