• Genomics & Informatics
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• v.15 no.4
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• pp.178-182
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• 2017

Next-generation sequencing (NGS) technology has become a trend in the genomics research area. There are many software programs and automated pipelines to analyze NGS data, which can ease the pain for traditional scientists who are not familiar with computer programming. However, downstream analyses, such as finding differentially expressed genes or visualizing linkage disequilibrium maps and genome-wide association study (GWAS) data, still remain a challenge. Here, we introduce a dockerized web application written in R using the Shiny platform to visualize pre-analyzed RNA sequencing and GWAS data. In addition, we have integrated a genome browser based on the JBrowse platform and an automated intermediate parsing process required for custom track construction, so that users can easily build and navigate their personal genome tracks with in-house datasets. This application will help scientists perform series of downstream analyses and obtain a more integrative understanding about various types of genomic data by interactively visualizing them with customizable options.

• Journal of Korean Society for Atmospheric Environment
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• v.19 no.4
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• pp.397-414
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• 2003

The performance of one-particle stochastic Lagrangian models for passive tracer dispersion are evaluated against measurements in horizontally-homogeneous neutrally-stratified atmospheric surface layer. State-of-the-technology models as well as classical Langevin models, all in class of well mixed models are numerically implemented for inter-model comparison study. Model results (far-downstream asymptotic behavior and vertical profiles of the time averaged concentrations, concentration fluxes, and concentration fluctuations) are compared with the reported measurements. The results are: 1) the far-downstream asymptotic trends of all models except Reynolds model agree well with Garger and Zhukov's measurements. 2) profiles of the average concentrations and vertical concentration fluxes by all models except Reynolds model show good agreement with Raupach and Legg's experimental data. Reynolds model produces horizontal concentration flux profiles most close to measurements, yet all other models fail severely. 3) With temporally correlated emissions, one-particle models seems to simulate fairly the concentration fluctuations induced by plume meandering, when the statistical random noises are removed from the calculated concentration fluctuations. Analytical expression for the statistical random noise of one-particle model is presented. This study finds no indication that recent models of most delicate theoretical background are superior to the simple Langevin model in accuracy and numerical performance at well.

• International Journal of Automotive Technology
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• v.1 no.2
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• pp.95-100
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• 2000

The droplet and the turbulent characteristics of a counterflowing internal mixing pneumatic nozzle mainly focused. The measurements were made using a Phase Doppler Particle Analyzer under the different air pressures. The nozzle with tangential-drilled holes at an angle of 30 to the central axis has been designed. The spatial distributions of velocities, fluctuating velocities, droplet diameters and SMD were quantitatively and qualitatively fluctuating velocities were substantially higher than the radial and the tangential ones. This implies that the disintegration process is enhanced with the higher air pressure. The larger droplets were detected near the spray centerline at the upstream while the smaller ones were generated at the downstream. This was attributed to the lower rates of spherical particles which were not subject to instantaneous breakup. However, substantial increases in SMD from the central part tower spray periphery were predictable in downstream regions.

• International Journal of Automotive Technology
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• v.7 no.5
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• pp.527-534
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• 2006

Modern passenger cars with diesel engines are equipped with DOC(diesel oxidation catalyst) for the purpose of reducing HC and CO in the exhaust stream. Cold start exhaust emissions pose troubles here as on gasoline engine vehicles. As a result, some of the diesel passenger cars roll off todays the assembly lines with WCC(warm-up catalytic converter). Oxidation characteristics of the particulates in WCC is analyzed in this study by EEPS(engine exhaust particulate size spectrometer). The maximum number of PM is found to come out of WCC in sizes near 10nm when an HSDI diesel engine is operated under the conditions of high speed and medium to heavy load. When the temperature of the WCC exceeds $300^{\circ}C$, the number of PM smaller than 30 nm in diameter sharply increases upon passing through the WCC. Total mass of emitted PM gets reduced downstream of the WCC under low speed and light load conditions due to adsorption of PM onto the catalyst. Under conditions of high speed and medium to heavy load, the relatively large PM shrink or break into fine particles during oxidation process within the WCC, which results in more mass fraction of fine particles downstream of the WCC.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2010.11a
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• pp.363-366
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• 2010

Among the many different types of wind tunnels, Ludwieg Tube(LT) is the most suitable facility for high Reynolds number testing. Depending on the location of diaphragm, there are two types of LTs. In the present study, a computational work has been carried out to compare the operation characteristics of upstream- and downstream-diaphragm LTs. Two-dimensional, axisymmetric, unsteady, compressible Navier-Stokes equations were solved using a fully implicit finite volume scheme. Based on the present results, the flow mechanism of the starting process was discussed in detail using wave diagrams and characteristics of starting time and working time were investigated.

• Geomechanics and Engineering
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• v.9 no.6
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• pp.709-727
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• 2015

The main aim of this study is to introduce optimal design of homogeneous earth dams with oblique and horizontal drains based on particle swarm optimization (PSO) incorporating weighted least squares support vector machine (WLS-SVM). To achieve this purpose, the upstream and downstream slopes of earth dam, the length of oblique and horizontal drains and angle among the drains are considered as the design variables in the optimization problem of homogeneous earth dams. Furthermore, the seepage through dam body and the weight of dam as objective functions are minimized in the optimization process simultaneously. In the optimization procedure, the stability coefficient of the upstream and downstream slopes and the seepage through dam body as the hydraulic responses of homogeneous earth dam are required. Hence, the hydraulic responses are predicted using WLS-SVM approach. The optimal results of illustrative examples demonstrate the efficiency and computational advantages of PSO with WLS-SVM in the optimal design of homogeneous earth dams with drains.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.689-692
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• 1996

The environment surrounded by industries is represented by the 3Cs : Customers, Competition, and Changes. The 3Cs drive industries to pursue external business targets such as customer's needs and marketplaces with BPR (Business Process Reengineering). BPR addresses core business process. One of these core business processes is product development. This product development process has been reengineered by the concept of CE (Concurrent Engineering). The aim of the paper is to build frameworks of CE to clarify the CE concept. This paper begins with investigating the product development process from the perspectives of three drivers: cost, quality and speed. CE frameworks are then followed. The first frmework is concerned with the CE definition and thus three keyphrases are extracted : from the outset, concurrent design and systematic approach. Concerned with the CE implementation, the second framework is composed of five components: generalist & specialist, cross-function team, enabling tools & techniques, success metrics, and total visibility. This paper concludes that the CE practice is hard to achieve because of the 'dont't-tell-them-early' attitude of upstream people, and the 'wait-and-see' attitude of downstream people. As resolution, a change management program is recommended that changes an employees mind-set. This paper also supposes computer systems which facilitate and keep automatic track of the CE process as engineered. Finally it gives a warning that computer systems alone do not guarantee success without being preceded by process re-engineering.

• Korean Chemical Engineering Research
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• v.50 no.5
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• pp.759-765
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• 2012

As the biodiesel production is increasing rapidly, the crude glycerol, which is principal by-product of biodiesel production, has also been generated in a large amount. Many research studies on value-added utilization of glycerol are under investigation. 1,3-Propandiol is a promising chemical which can be produced from fermentation of glycerol because the application of 1,3-propanediol is mainly in the production of bio-PTT (Poly(trimethylene terephthalate). However, the cost of downstream processes in the biological production of 1,3-propanediol can make a high portion in the total production cost. This review summarizes the present state of separation processes in each step studied for the removal of impurities and the recovery of 1,3-propanediol from its fermentation broth. Furthermore, ATPE (Aqueous Two Phases Extraction) process is suggested as an attractive alternative for the primary separation process of 1,3-propanediol because ATPE is convenient for the simultaneous removal of microbial cells and impurities such as salts of organic acids and the separation of 1,3-propanediol from fermentation broth.

• Journal of the Korean association of regional geographers
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• v.15 no.2
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• pp.192-203
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• 2009

The purpose of this paper is to elucidate the formative processes of depositional landforms in Jiwoo drainage basin which located in the most upstream reach of Namgang River. Through the analysis of morphologic characteristics and sedimentary facies, the formative processes can be summarized as follow: First, the high depositional landforms(Sapyeong, Eungam, Naedongdyttle site) were formed by gelifluction process in the periglacial environment during the last glacial period. And the relative height over river bed of them is getting lower from upper to downstream. The extent of the high depositional landforms is assumed about 1 kilometer downstream far from the confluence of Jiwoo stream and Namgang River. Second, the sediments in the gentle slope at Jangseungbuldle were carried by gelifluction process during the last glacial stage after the deep-weathered bedrock had formed a gentle slope. Third, the high depositional landforms were dissected during warm and humid environment of postglacial stage, and some sediments of them were left in the river bed. Later, as the more upstream high depositional landforms were dissected completely, stream power was getting more than resistance(sediment storage) and the low depositional landforms(Sapyeong, Yongchusa, Deungbangdle site) were formed.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.277.1-277.1
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• 2013

Molecular diagnostics consists of three processes, which are a sample pretreatment, a nucleic acid amplification, and an amplicon detection. Among three components, sample pretreatment is an important process in that it can increase the limit of detection by purifying nucleic acid in biological sample from contaminants that may interfere with the downstream genetic analysis such as nucleic acid amplification and detection. To achieve point-of-care virus detection system, the sample pretreatment process needs to be simple, rapid, and automatic. However, the commercial RNA extraction kits such as Rneasy (Qiagen) or MagnaPure (Roche) kit are highly labor-intensive and time-consuming due to numerous manual steps, and so it is not adequate for the on-site sample preparation. Herein, we have developed a rotary microfluidic system to extract and purify the RNA without necessity of external mechanical syringe pumps to allow flow control using microfluidic technology. We designed three reservoirs for sample, washing buffer, and elution buffer which were connected with different dimensional microfluidic channels. By controlling RPM, we could dispense a RNA sample solution, a washing buffer, and an elution buffer successively, so that the RNA was captured in the sol-gel solid phase, purified, and eluted in the downstream. Such a novel rotary sample preparation system eliminates some complicated hardwares and human intervention providing the opportunity to construct a fully integrated genetic analysis microsystem.