Browse > Article
http://dx.doi.org/10.9713/kcer.2012.50.5.759

Separation Processes of Biologically Produced 1,3-Propanediol  

Hong, Yeon-Ki (Department of Chemical and Biological Engineering, Korea National University of Transportation)
Publication Information
Korean Chemical Engineering Research / v.50, no.5, 2012 , pp. 759-765 More about this Journal
Abstract
As the biodiesel production is increasing rapidly, the crude glycerol, which is principal by-product of biodiesel production, has also been generated in a large amount. Many research studies on value-added utilization of glycerol are under investigation. 1,3-Propandiol is a promising chemical which can be produced from fermentation of glycerol because the application of 1,3-propanediol is mainly in the production of bio-PTT (Poly(trimethylene terephthalate). However, the cost of downstream processes in the biological production of 1,3-propanediol can make a high portion in the total production cost. This review summarizes the present state of separation processes in each step studied for the removal of impurities and the recovery of 1,3-propanediol from its fermentation broth. Furthermore, ATPE (Aqueous Two Phases Extraction) process is suggested as an attractive alternative for the primary separation process of 1,3-propanediol because ATPE is convenient for the simultaneous removal of microbial cells and impurities such as salts of organic acids and the separation of 1,3-propanediol from fermentation broth.
Keywords
1,3-Propanediol; PTT; Glycerol; Downstream Processes; ATPE;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Li, Z., Teng, H. and Xiu, Z., "Extraction of 1,3-Propanediol from Glycerol-based Fermentation Broths with Methanol/Phosphate Aqueous Two-Phase System," Proc. Biochem., 46, 586-591(2011).   DOI   ScienceOn
2 Aydogan, O., Bayraktar, E., Mehmetoglu, U., Kaeding, T. and Zeng, A.-P., "Selection and Optimization of an Aqueous Two- Phase System for the Recovery of 1,3-Propanediol from Fermentation Broth," Eng. Life. Sci., 10, 121-129(2010).
3 Cho, M.-H., Joen, S. I., Pyo, S.-H., Mun, S. and Kim, J.-H., "A Novel Separation and Purification Process for 1,3-Propanediol," Proc. Biochem., 41, 739-744(2006).   DOI   ScienceOn
4 Xiu, Z.-L. and Zeng, A.-P., "Present State and Perspective of Downstream Processing of Biologically Produced 1,3-Propanediol and 2,3-Butanediol," Appl. Microbiol. Biotechnol., 78, 917-926 (2008).   DOI   ScienceOn
5 Malinowski, J. J., "Reactive Extraction for Downstream Separation of 1,3-Propanediol," Biotechnol. Prog., 16, 76-79(2000).   DOI   ScienceOn
6 Hao, J., Liu, H. J. and Liu, D., "Novel Route of Reactive Extraction to Recover 1,3-Propanediol from a Dilute Aqueous Solution," Ind. Eng. Chem. Res., 44, 4380-4385(2005).   DOI   ScienceOn
7 Hao, J., Xu, F., Liu, H. and Liu, D., "Downstream Processing of 1,3-Propanediol Fermentation Broth," J. Chem. Technol. Biotechnol., 81, 102-108(2006).   DOI   ScienceOn
8 Hong, Y. K. and Hong, W. H., "Removal of Acetic Acid from Aqueous Solutions Containing Succinic Acid and Acetic Acid by Tri-n-octylamine," Sep. Purif. Technol., 42, 151-157(2005).   DOI   ScienceOn
9 Han, D. H., Hong, Y. K. and Hong, W. H., "Separation Characteristics of Lactic Acid in Reactive Exraction and Stripping," Korean J. Chem. Eng., 17, 528-533(2000).   DOI   ScienceOn
10 Hong, Y. K., "Purification of 1,3-Propanediol for Production of Polytrimethylene terephthalate(PTT) from Biomass," Adv. Mater. Res., 320, 191-195(2011).   DOI
11 Greve, A. and Kula, M. R., "Cost Structure and Estimation for the Recycling of Salt in a Protein Extraction Process System," Bioproc. Biosyst. Eng., 6, 173-177(1990).
12 Xu, Y. Z., Guo, N. N., Zheng, Z. M. and Ou, X. J., "Metabolism in 1,3-Propanediol Fed-batch Fermentation by a D-Lactate Deficient Mutant of Klebsiella Pneumoniae," Biotechnol. Bioeng., 104, 965-972(2009).   DOI   ScienceOn
13 Kim, Y. H. and Moon, S.-H., "Lactic Acid Recovery from Fermentation Broth Using One-stage Electrodialysis," J. Chem. Technol. Biotechnol., 76, 169-178(2001).   DOI   ScienceOn
14 Deckwer, W. D., "Microbiol Conversion of Glycerol Production to 1,3-Propanediol," FEMS Microbiol. Rev., 16, 143-149(1995).
15 Hermann, B. G. and Patel, M., "Today's and Tomorrow's Biobased Bulk Chemicals from White Biotechnology: A Techno-economic Analysis," Appl. Biochem. Biotechnol., 136, 361-388(2007).   DOI   ScienceOn
16 Lee, E. G., Moon, S.-H., Chang, Y. K., Yoo, I.-K. and Chang, H. N., "Lactic Acid Recovery Using Two-stage Electrodialysis and Its Modelling," J. Membr. Sci., 145, 53-66(1998).   DOI   ScienceOn
17 Kurzrock, T. and Weuster-Botz, D., "Recovery of Succinic Acid from Fermentation Broth," Biotechol. Lett., 32, 331-339(2010).   DOI
18 Wu, R. C., Xu, Y. Z., Song, Y. Q., Luo, J. A. and Liu, D., "A Novel Strategy for Salts Recovery from 1,3-Propanediol Fermentation Broth by Bipolar Membrane Electrodialysis," Sep. Purif. Technol., 83, 9-14(2011).   DOI   ScienceOn
19 Grothe, E., "Konzeption und Wirtschaftlichkeit der Industriellen Glycerinvergarung zu 1,3-Propanediol," Ph.D. Dissertation, VDI Verlag GmbH, Dusseldorf(2000).
20 Roturier, J. M., Fouache, C. and Berghmans, E., "Process for the Purification of 1,3-Propanediol from a Fermentation Medium," U.S. Patent No. 6,428,992(2002).
21 Hilaly, A. K. and Binder, T. P., "Method of Recovering 1,3-Propanediol from Fermentation Broth," U.S. Patent No. 6,479,716 (2002).
22 Willke, T. and Vorlop, K., "Biotransformation of Glycerol into 1,3-Propanediol," Eur. J. Lipid Sci. Technol., 110, 831-840(2008).   DOI   ScienceOn
23 Muska, C. F. and Alles, C., "Biobased 1,3-Propanediol: A New Platform Chemical for the 21 Century," BioPerspectives 2005 BREW Symposium, May(2005).
24 Zeng, A. P. and Biebl, H., "Bulk Chemicals from Biotechnology: The Case of 1,3-Propanediol Production and the New Trends," Adv. Biochem. Eng. Biotechnol., 74, 239-259(2002).
25 Raynaud, C., Sarcabal, P., Meynial-Salles, I. and Croux, C., "Molecular Characterization of the 1,3-Propanediol Operon of Clostridium Butyricum," Proc. Natl. Acad. Sci. USA, 100, 5010-5015 (2003).   DOI   ScienceOn
26 Homann, T., Tag, C., Biebl, H. and Deckwer, W., "Fermentation of Glycerol to 1,3-Propanediol by Klebsiella and Citrobacter Strains," Appl. Microbiol. Biotechnol., 33, 121-126(1990).
27 Otte, B., Grunwaldt, E., Mahmoud, O. and Jennewein, S., "Genome Shuffling in Clostridium diolis for Improved 1,3-Propanediol Production," Appl. Environ. Microbiol., 75, 7610-7616(2009).   DOI   ScienceOn
28 Chen, Z., Liu, H. and Liu, D., "Regulation of 3-Hydroxypropionaldehyde Accumulation in Klebsiella Pneumoniae by Overexpression of dhaT and dhaD Genes," Enzyme Microb. Technol., 45, 305-309(2009).   DOI   ScienceOn
29 Zhu, J. G., Li, S., Ji, X. J. and Huang, H., "Enhanced 1,3-Propanediol Production in Recombinant Klebsiella Pneumoniae Carrying the Gene yqhD Encoding 1,3-Propanediol Oxidoreductase Isoenzyme," World J. Microbiol. Biotechnol., 25, 1217-1223(2009).   DOI
30 Yang, G., Tian, J. S. and Li, J. L., "Fermentation of 1,3-Propanediol by a Lactate Deficient Mutant of Klebsiella Oxytoca under Microaerobic Conditions," Appl. Microbiol. Biotechnol., 73, 1017-1024(2007).
31 Liu, H., Xu, Y., Zheng, Z. and Liu, D., "1,3-Propanediol and Its Copolymers: Research, Development and Industrialization," Biotechnol. J., 5, 1137-1148(2010).   DOI   ScienceOn
32 Hong, Y. K. and Hong, W. H., "Biodiesel Production Technology and Its Fuel Properties," Korean Chem. Eng. Res. (HWAHAK KONGHAK), 45, 424-432(2007).   과학기술학회마을
33 Behr, A., Eilting, J., Irawadi, K., Leschinski, J. and Lindner, F., "Improved Utilisation of Renewable Resources: New Important Derivatives of Glycerol," Green Chem., 10, 13-30(2008).   DOI   ScienceOn
34 Pagliaro, M., Ciriminna, R., Kimura, H., Rossi, M. and Della Pina, C., "From Glycerol to Value-Added Products," Angew. Chem. Int. Ed., 46. 4434-4440(2007).   DOI   ScienceOn
35 Li, Z., Jiang, B., Zhang, D. and Xiu, Z., "Aqueous Two-phase Extraction of 1,3-Propanediol from Glycerol-based Fermentation," Sep. Purif. Technol., 66, 472-478(2009).   DOI   ScienceOn