• Genomics & Informatics
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• 제15권4호
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• pp.178-182
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• 2017

Next-generation sequencing (NGS) technology has become a trend in the genomics research area. There are many software programs and automated pipelines to analyze NGS data, which can ease the pain for traditional scientists who are not familiar with computer programming. However, downstream analyses, such as finding differentially expressed genes or visualizing linkage disequilibrium maps and genome-wide association study (GWAS) data, still remain a challenge. Here, we introduce a dockerized web application written in R using the Shiny platform to visualize pre-analyzed RNA sequencing and GWAS data. In addition, we have integrated a genome browser based on the JBrowse platform and an automated intermediate parsing process required for custom track construction, so that users can easily build and navigate their personal genome tracks with in-house datasets. This application will help scientists perform series of downstream analyses and obtain a more integrative understanding about various types of genomic data by interactively visualizing them with customizable options.

• 한국대기환경학회지
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• 제19권4호
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• pp.397-414
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• 2003

The performance of one-particle stochastic Lagrangian models for passive tracer dispersion are evaluated against measurements in horizontally-homogeneous neutrally-stratified atmospheric surface layer. State-of-the-technology models as well as classical Langevin models, all in class of well mixed models are numerically implemented for inter-model comparison study. Model results (far-downstream asymptotic behavior and vertical profiles of the time averaged concentrations, concentration fluxes, and concentration fluctuations) are compared with the reported measurements. The results are: 1) the far-downstream asymptotic trends of all models except Reynolds model agree well with Garger and Zhukov's measurements. 2) profiles of the average concentrations and vertical concentration fluxes by all models except Reynolds model show good agreement with Raupach and Legg's experimental data. Reynolds model produces horizontal concentration flux profiles most close to measurements, yet all other models fail severely. 3) With temporally correlated emissions, one-particle models seems to simulate fairly the concentration fluctuations induced by plume meandering, when the statistical random noises are removed from the calculated concentration fluctuations. Analytical expression for the statistical random noise of one-particle model is presented. This study finds no indication that recent models of most delicate theoretical background are superior to the simple Langevin model in accuracy and numerical performance at well.

• International Journal of Automotive Technology
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• 제1권2호
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• pp.95-100
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• 2000

The droplet and the turbulent characteristics of a counterflowing internal mixing pneumatic nozzle mainly focused. The measurements were made using a Phase Doppler Particle Analyzer under the different air pressures. The nozzle with tangential-drilled holes at an angle of 30 to the central axis has been designed. The spatial distributions of velocities, fluctuating velocities, droplet diameters and SMD were quantitatively and qualitatively fluctuating velocities were substantially higher than the radial and the tangential ones. This implies that the disintegration process is enhanced with the higher air pressure. The larger droplets were detected near the spray centerline at the upstream while the smaller ones were generated at the downstream. This was attributed to the lower rates of spherical particles which were not subject to instantaneous breakup. However, substantial increases in SMD from the central part tower spray periphery were predictable in downstream regions.

• International Journal of Automotive Technology
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• 제7권5호
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• pp.527-534
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• 2006

Modern passenger cars with diesel engines are equipped with DOC(diesel oxidation catalyst) for the purpose of reducing HC and CO in the exhaust stream. Cold start exhaust emissions pose troubles here as on gasoline engine vehicles. As a result, some of the diesel passenger cars roll off todays the assembly lines with WCC(warm-up catalytic converter). Oxidation characteristics of the particulates in WCC is analyzed in this study by EEPS(engine exhaust particulate size spectrometer). The maximum number of PM is found to come out of WCC in sizes near 10nm when an HSDI diesel engine is operated under the conditions of high speed and medium to heavy load. When the temperature of the WCC exceeds $300^{\circ}C$, the number of PM smaller than 30 nm in diameter sharply increases upon passing through the WCC. Total mass of emitted PM gets reduced downstream of the WCC under low speed and light load conditions due to adsorption of PM onto the catalyst. Under conditions of high speed and medium to heavy load, the relatively large PM shrink or break into fine particles during oxidation process within the WCC, which results in more mass fraction of fine particles downstream of the WCC.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2010년도 제35회 추계학술대회논문집
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• pp.363-366
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• 2010

여러 형태의 풍동장치 중에서 Ludwieg Tube(LT)는 높은 레이놀즈수 유동을 실현할 수 있는 가장 적합한 장치로 알려져 있다. 일반적으로 LT는 격막의 위치에 따라 두 종류로 구분된다. 본 연구에서는 상류막 방식과 하류막 방식 LT의 작동특성을 조사하기 위하여, 수치해석적인 방법을 적용하였다. 수치해석에서는 2차원 축대칭, 비정상, 압축성 Navier-Stokes 방정식에 유한체적법을 적용하였다. 그 결과, 본 수치해석은 시동과정의 유동 메커니즘을 파동선도를 이용하여 상세하게 설명하였으며, 시동 시간과 작동시간의 특성을 조사하였다.

• Geomechanics and Engineering
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• 제9권6호
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• pp.709-727
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• 2015

The main aim of this study is to introduce optimal design of homogeneous earth dams with oblique and horizontal drains based on particle swarm optimization (PSO) incorporating weighted least squares support vector machine (WLS-SVM). To achieve this purpose, the upstream and downstream slopes of earth dam, the length of oblique and horizontal drains and angle among the drains are considered as the design variables in the optimization problem of homogeneous earth dams. Furthermore, the seepage through dam body and the weight of dam as objective functions are minimized in the optimization process simultaneously. In the optimization procedure, the stability coefficient of the upstream and downstream slopes and the seepage through dam body as the hydraulic responses of homogeneous earth dam are required. Hence, the hydraulic responses are predicted using WLS-SVM approach. The optimal results of illustrative examples demonstrate the efficiency and computational advantages of PSO with WLS-SVM in the optimal design of homogeneous earth dams with drains.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1996년도 춘계공동학술대회논문집; 공군사관학교, 청주; 26-27 Apr. 1996
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• pp.689-692
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• 1996

The environment surrounded by industries is represented by the 3Cs : Customers, Competition, and Changes. The 3Cs drive industries to pursue external business targets such as customer's needs and marketplaces with BPR (Business Process Reengineering). BPR addresses core business process. One of these core business processes is product development. This product development process has been reengineered by the concept of CE (Concurrent Engineering). The aim of the paper is to build frameworks of CE to clarify the CE concept. This paper begins with investigating the product development process from the perspectives of three drivers: cost, quality and speed. CE frameworks are then followed. The first frmework is concerned with the CE definition and thus three keyphrases are extracted : from the outset, concurrent design and systematic approach. Concerned with the CE implementation, the second framework is composed of five components: generalist & specialist, cross-function team, enabling tools & techniques, success metrics, and total visibility. This paper concludes that the CE practice is hard to achieve because of the 'dont't-tell-them-early' attitude of upstream people, and the 'wait-and-see' attitude of downstream people. As resolution, a change management program is recommended that changes an employees mind-set. This paper also supposes computer systems which facilitate and keep automatic track of the CE process as engineered. Finally it gives a warning that computer systems alone do not guarantee success without being preceded by process re-engineering.

• Korean Chemical Engineering Research
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• 제50권5호
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• pp.759-765
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• 2012

바이오 디젤 생산량 증가에 따라 공정 중에 부산물로 발생하는 글리세린의 과잉공급 및 가격 하락이 이루어지고 있다. 이에 따라 글리세린에 기반한 다양한 화학제품생산과 관련된 연구가 활발히 진행되고 있으며 글리세린을 탄소원으로 한 1,3-프로판디올의 생물학적 생산은 그 중 하나이다. 1,3-프로판디올은 지금까지 화학적인 방법을 통해 생산되어 왔으나 생물학적인 방법을 통해 생산될 경우 공정의 친환경성 및 경제성 확보와 더불어 1,3-프로판디올을 중합원료로 하는 PTT (Poly(trimethylene terephthalate))의 바이오폴리머로서의 활용을 가능하게 한다. 그럼에도 글리세린 유래 1,3-프로판디올의 생물학적 생산의 경제성에 있어 핵심은 경제적인 분리공정의 수립에 있다. 본 총설에서는 1,3-프로판디올을 분리하기 위한 공정들에 대한 연구 동향을 소개하고 최근 에너지 절감과 더불어 1,3-프로판디올 분리와 부산물 제거를 동시에 달성할 있는 공정으로 주목받고 있는 수상이성분계 추출에 대한 연구개발 동향 및 전망을 제시하고자 한다.

• 한국지역지리학회지
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• 제15권2호
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• pp.192-203
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• 2009

본 연구에서는 남강 최상류부의 지우천 유역을 대상으로 침식분지 내 퇴적지형의 형성과정을 고찰하였다. 퇴적 지형의 형태적 특성과 퇴적상 분석을 통하여 밝혀진 형성과정을 요약하면 다음과 같다. 첫째, 사평, 응암, 내동뒷들 지점의 고위퇴적지는 최종빙기 동안의 한랭한 주빙하 환경하에서 젤리플럭션 작용으로 퇴적되었으며, 상류에서 하류방향으로 하상비고가 낮아진다. 고위퇴적지의 범위는 지우천과 남강이 합류하는 곳에서 하류방향 약 1km지점인 것으로 추정된다. 둘째, 장승불들 지점에 분포하는 완경사면의 퇴적물은 심층풍화된 기반암이 완만한 사면을 형성한 이후 최종 빙기 동안 젤리플럭션 작용으로 운반된 것이다. 셋째, 사평, 용추사, 등방들 지점의 저위퇴적지는 후빙기의 온난습윤한 환경하에서 고위퇴적지가 개석되는 동안 퇴적물의 일부가 하상에 남겨지고, 이후 고위퇴적지의 개석이 완료됨에 따라 하천의 저항(퇴적물양)보다 하천의 운반력이 초과함으로써 하상이 다시 침식되어 형성된 것으로 사료된다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.277.1-277.1
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• 2013

Molecular diagnostics consists of three processes, which are a sample pretreatment, a nucleic acid amplification, and an amplicon detection. Among three components, sample pretreatment is an important process in that it can increase the limit of detection by purifying nucleic acid in biological sample from contaminants that may interfere with the downstream genetic analysis such as nucleic acid amplification and detection. To achieve point-of-care virus detection system, the sample pretreatment process needs to be simple, rapid, and automatic. However, the commercial RNA extraction kits such as Rneasy (Qiagen) or MagnaPure (Roche) kit are highly labor-intensive and time-consuming due to numerous manual steps, and so it is not adequate for the on-site sample preparation. Herein, we have developed a rotary microfluidic system to extract and purify the RNA without necessity of external mechanical syringe pumps to allow flow control using microfluidic technology. We designed three reservoirs for sample, washing buffer, and elution buffer which were connected with different dimensional microfluidic channels. By controlling RPM, we could dispense a RNA sample solution, a washing buffer, and an elution buffer successively, so that the RNA was captured in the sol-gel solid phase, purified, and eluted in the downstream. Such a novel rotary sample preparation system eliminates some complicated hardwares and human intervention providing the opportunity to construct a fully integrated genetic analysis microsystem.