• Journal of Integrative Natural Science
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• v.16 no.2
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• pp.61-67
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• 2023

Human body ages differently due to environmental, genetic and pathological factors. DNA methylation patterns also differs depending on various factors such as aging and several other diseases. The aging clock model, which uses these differences to predict age, analyzes DNA methylation patterns, recognizes age-specific patterns, predicts age, and grasps the speed and degree of aging. Aging occurs in everyone and causes various problems such as deterioration of physical ability and complications. Alzheimer's disease is a disease associated with aging and the most common brain degenerative disease. This disease causes various cognitive functions disabilities such as dementia and impaired judgment to motor functions, making daily life impossible. It has been reported that the incidence and progression of this disease increase with aging, and that increased phosphorylation of Aβ and tau proteins, which are overexpressed in this disease and accelerates epigenetic aging. It has also been reported that DNA methylation is significantly increased in the hippocampus and entorhinal cortex of Alzheimer's disease patients. Therefore, we calculated the biological age using the Epi clock, a pan-tissue aging clock model, and confirmed that the epigenetic age of patients suffering from Alzheimer's disease is lower than their actual age. Also, it was confirmed to slow down aging.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.3
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• pp.1098-1112
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• 2018

Achievable sum rate and energy efficiency (EE) are investigated for the massive multiple-input multiple-output (Massive MIMO) downlink with channel aging in the time varying Ricean fading channel. Specifically, the expression of the achievable sum rate of the system for the maximum ratio transmission (MRT) precoder with aged channel state information (CSI) in the time varying Ricean fading channel is first presented. Based on the expression, the effect of both channel aging and the Ricean factor on the power scaling law are studied. It is found that the transmit power of base station (BS) is scaled down by $1/{\sqrt{M}}$(where M is the number of the BS antennas) when the Ricean factor K is equal to zero (i.e., time varying Rayleigh fading channel), indicating that aged CSI does not affect the power scaling law. However, the transmit power of the BS is scaled down by 1/M for the time varying Ricean fading channel (where $K{\neq}0$) indicating that the Ricean factor affects the power scaling law and sum rate, and channel aging only leads to a reduction of the sum rate. Second, the EE of the system is analyzed based on the general power consumption model. Both the theoretical analysis and the simulations show that the channel aging could degrade the sum rate and the EE of the system, and it does not affect the power scaling law.

• IEMEK Journal of Embedded Systems and Applications
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• v.13 no.3
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• pp.143-149
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• 2018

It has become ever harder to design reliable circuits with each nanometer technology node; under normal operation conditions, a transistor device can be affected by various aging effects resulting in performance degradation and eventually design failure. The reliability (aging) effect has traditionally been the area of process engineers. However, in the future, even the smallest of variations can slow down a transistor's switching speed, and an aging device may not perform adequately at a very low voltage. Therefore, circuit designers need to consider these reliability effects in the early stages of design to make sure there are enough margins for circuits to function correctly over their entire lifetime. However, such an approach excessively increases the size and power dissipation of a system. As the impact of reliability, new techniques in designing aging-resilient circuits are necessary to reduce the impact of the aging stresses on performance, power, and yield or to predict the failure of a system. Therefore, in this paper, a novel low power on-chip self-tuning circuit considering the aging effects has been proposed.

• Proceedings of the KIEE Conference
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• 2003.07b
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• pp.1285-1287
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• 2003

The aging of the insulation reduces the electrical and mechanical strength of the insulation. At same point, a voltage surge or mechanical shock from a traction motor start will fracture or break down the insulation. To achieve the expected life usually requires extensive laboratory evaluation of the insulation systems and the use of accelerated aging tests. There are several nondestructive test available for checking. the condition of motor insulation, the probable extent of aging, and the rate of which aging is taking place. So the insulation characteristics of stator coil were each analyzed by measurement of dielectric loss($tan{\delta}$), capacitance and partial discharge. The method of diagnosis is able to analyze the aging condition and predict the life of the traction motor.

• BMB Reports
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• v.52 no.1
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• pp.86-108
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• 2019

In multi-cellular organisms, the control of gene expression is key not only for development, but also for adult cellular homeostasis, and gene expression has been observed to be deregulated with aging. In this review, we discuss the current knowledge on the transcriptional alterations that have been described to occur with age in metazoans. First, we discuss age-related transcriptional changes in protein-coding genes, the expected functional impact of such changes, and how known pro-longevity interventions impact these changes. Second, we discuss the changes and impact of emerging aspects of transcription in aging, including age-related changes in splicing, lncRNAs and circRNAs. Third, we discuss the changes and potential impact of transcription of transposable elements with aging. Fourth, we highlight small ncRNAs and their potential impact on the regulation of aging phenotypes. Understanding the aging transcriptome will be key to identify important regulatory targets, and ultimately slow-down or reverse aging and extend healthy lifespan in humans.

• Women's Health Nursing
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• v.20 no.1
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• pp.48-61
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• 2014

Purpose: This study was done to explore the essence and meaning of the experience of 'aging', as a process of 40's and 50's women in Korea by applying the Parse's Human Becoming theory (2002). Methods: Data was collected from February to April, 2013, using the phenomenological research method. Data was collected through in-depth informal interview and analyzed following Colaizzi method. After IRB permission and informed consent from the participants, all interviews were recorded with MP3 recorder and transcribed for analysis. Results: Data analysis revealed 112 of meanings, 33 key subject words, 8 subject phrases, and 4 categories. The main themes were elaborated as 'going down' ('Being changed of body and mind', 'Being considered on my identity'), 'going up' ('Being expanded of productive role', 'Being transcendent multi-dimensionally'), 'pausing' ('Becoming more thoughtful about family', 'Looking back'), 'going forward again' ('Age is just a number, 'Contemplating of life and death'). Experiences in aging among women in 40's and 50's enlightened with Parse's theory of Human Becoming in terms of 'going down', 'going up', 'pausing', 'going forward again' appeared simultaneously, rather than consecutively. Conclusion: Women in 40's and 50's require holistic nursing intervention with physical, psychological, socio-economical, and spiritual aspects, rather than focusing on problematic physical symptom relief and prevention of further conditions. It is recommended to develop various nursing intervention considering on different environment, type of experience, and level of human becoming, individually.

• Genomics & Informatics
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• v.3 no.2
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• pp.66-72
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• 2005

The epidermis is a physiological barrier to protect organisms against environment. During the aging process, skin tissues undergo various changes including morphological and functional changes. The transcriptional regulation of genes is part of cellular reaction of aging process. In order to examine the changes of gene expression during the aging process, we used the primary cell culture system of human keratinocytes. Since UV radiation is the most important environmental skin aggressor, causing skin cancer and other problems including premature skin aging, we examined the changes of gene expression in human keratinocytes after UV irradiation using oligonucleotide microarray containing over 10,000 genes. We also compared the gene expression patterns of the senescent and UV treated cells. Expression of the variety of genes related to transcription factors, cell cycle regulation, immune response was altered in human keratinocytes. Some of down-regulated genes are represented in both senescent and UV treated cells. The results may provide a new view of gene expression following UVB exposure and aging process in human keratinocytes.

• Elastomers and Composites
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• v.50 no.4
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• pp.292-296
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• 2015

Biomimetic artificial basilar membrane being a core part of artificial cochlear requires performance evaluation through aging test. To evaluate the aging properties of PVDF piezoelectric membrane used for artificial basilar membrane, its mechanical properties such as tensile strength and elastic modulus and piezoelectric property such as piezoelectric constant were measured. The aging test conditions and acceleration constants were calculated based on Arrhenius model. The changes in tensile strengths and elastic moduli measured were less than 10~20% after aging test equivalent for 10 years. The piezoelectric constants were decreased drastically to 80% of its initial value in the early stage of the aging test and expected to decrease slowly down to 65% over 10 years. The experimental results show the reliability of totally implantable novel artificial cochlear and will contribute its commercialization.

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.170.1-170.1
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• 2002

• 한국정보디스플레이학회:학술대회논문집
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• 2003.07a
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• pp.710-713
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• 2003

The wall charge is major factor to determine the discharge characteristics. The minimum sustain voltage related to the wall charge decay were investigated as a function of aging time in AC plasma display panel. For the long time scale, the wall charge decay time is dependent on the aging time. The inverse time scale of the wall charge decay has the maximum value at around 3 hours aging time and then fell down.