• Bulletin of the Korean Chemical Society
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• v.35 no.8
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• pp.2290-2294
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• 2014

For the present study, rhEGF was encapsulated into solid lipid nanoparticles (SLNs). The SLNs were prepared by the $W_1/O/W_2$ double emulsification method combined with the high pressure homogenization method and the physical properties such as particle size, zeta-potential and encapsulation efficiency were measured. The overall particle morphology of SLNs was investigated using a transmission electron microscopy (TEM). The percutaneous skin permeation and accumulation property of rhEGF was evaluated using Franz diffusion cell system along with confocal laser scanning microscopy (CLSM). The mean particle size of rhEGF-loaded SLNs was $104.00{\pm}3.99nm$ and the zeta-potential value was in the range of -$36.99{\pm}0.54mV$, providing a good colloidal stability. The TEM image revealed a spherical shape of SLNs about 100 nm and the encapsulation efficiency was $18.47{\pm}0.22%$. The skin accumulation of rhEGF was enhanced by SLNs. CLSM image analysis provided that the rhEGF rat skin accumulation is facilitated by an entry of SLNs through the pores of skin.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.8
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• pp.1207-1211
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• 2015

Various laser systems have been widely used in almost all industrial technologies because they have high energy density, directivity and coherence. Recently the clinical application is becoming wider in medical parts such as incurable disease, diagnosis and so on. Generally, ruby laser beam has the greatest efficacy for removing tattoos, freckle and other skin problem. But current medical ruby laser system has the maximum repetition rate of 2Hz and optical output beam energy of 1J. Many medical doctors really want to have a high repetition ruby laser system because that can reduce the operation time. We investigated a new ruby laser system with high repetition rate of 4Hz using double cavities. Furthermore, we develop a new power supply system adopting zero voltage switching(ZVS) to minimize switching loss by LLC resonant converter designed as 2kW class.

• KIEAE Journal
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• v.6 no.1
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• pp.25-32
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• 2006

Regarding to the Domestic housing politics to improve residing environment and effective use of country land, apartment buildings have been constructed since early of 1970s. Now apartment is taking over 50% out of entire housing in Korea. In the view point of PV application to the apartment, PV has amny advantages because of the wideness of out-walls and high floors building in APT. Therefore, if APT could use the electricity produced by BIPV, we can solve more easily environment and energy problems caused by housing. The research conclusion by analysing conditions and application method to introduce BIPV application to APT in near future is as below. -The out look of APT has been developed periodically and recently gable roof or canopy is popular which PV installation is more favorable. -For Balcony part with double skin facade sassy window, It has a preferable condition to install on the wall depending on the window direction. -In case of shorter distance between buildings due to high ratio of outside measurement, it is more desirable to install PV on the roof than on the wall of Apartment by considering low solar altitude. -Also depending on the direction of APT building, it is more effective and productive in electricity in the broad surface of side wall of APT. -In case of superhigh floor APT where facade system is mostly double skin facade of curtain wall system, PV module can replace the traditional curtain wall and will reduce architectural materials and obtain various out look design thereof.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.7
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• pp.3197-3202
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• 2013

When car builder designs the large carbody structure of railway vehicles, it is necessary to optimize the damping characteristics through the analysis of structure borne noise such as sound pressure level(SPL). This paper is a study on the structure borne noise analysis by characterizing the damping of double skin aluminum extruded panels for rolling stock carbody. The normalized SPL was calculated based on the simple source theory using measured mechanical mobility parameters from vibration tests(i.e. point, transfer and modal mobility). The reduced SPL was predicted by using finite element method by applying loss factor of damping material into laminated shell elements. It was found out that the damping material coated on the panels like underframe, which part is seriously affected by vibration during train run, took effect to reduce noise level.

• Fire Science and Engineering
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• v.30 no.5
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• pp.100-107
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• 2016

Today, high-rise buildings expected to meet various needs and improve the quality of frequency of fire and the potential risks are increasing. In particular, the fire spread risk in the vertical direction is increasing. As a result there is a problem with delays in the evacuation time of occupants. To overcome this problem, there is a need to consider the structure of the building and develop a system for the early detection of fire by applying a fire alarm system according to the risk ranking. Therefore, this paper describes the vertical fire spread characteristics of a multistory double-skin and stairs structure with risk. The data were compared with that from the national and international fire alarms as well as with. smoke density, smoke detectors, visibility, and CO concentration using FDS. A fire alarm system for each structure is proposed.

• Journal of Pharmaceutical Investigation
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• v.37 no.3
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• pp.149-158
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• 2007

To investigate the permeability of lidocaine, percutaneous absorption studies were performed using excised hairless mouse skin and the penetration of lidocaine via the skin was determined. To increase the skin permeation of lidocine, the effects of $Labrasol^{(R)}$, $Labrafil^{(R)}$, $Labrafac^{(R)}$ and $Transcutol^{(R)}$ were investigated. The skin permeation of lidocaine was increased when $Labrasol^{(R)}$ and $Transcutol^{(R)}$ were used as permeation enhancer. To evaluate the influence of ultrasound, various factors such as application modes (continuous mode and pulsed mode), frequency (1.0 and 3.0 MHz) and intensity (1.0, 1.5 and 2.0 w/$cm^2$) were investigated with lidocaine hydrogel. The pronounced effect of ultrasound on the skin permeation of lidocaine was observed at all ultrasound energy levels. The influence of frequency having an effect on skin permeation rate was higher in the case of using 1 MHz, 2.0 w/$cm^2$ and continuous treatment. As the intensity of ultrasound increased, the permeation of lidocaine was accelerated. The in vivo anesthetic effects were evaluated by two aspects as mechanical threshold and electrical threshold. Six healthy volunteers consented to the randomized, double-blind, and cross-over designed study in each group. In each subject, 3 groups were adapted such as K group (ultrasound with gel base only), L group (lidocaine gel) and B group (ultrasound with lidocaine gel). In conclusion, lidocaine was potent anesthetic which could be block pain threshold effectively. And ultrasound could accelerate the skin penetration of lidocaine. The phonophoretic delivery system could be a good candidate for lidocaine as a local anaesthetic to improve the skin permeation and in vivo anaesthetic effect.

• Journal of the Korean Applied Science and Technology
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• v.38 no.3
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• pp.662-668
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• 2021

The aim of the present study was to design ascorbyl glucoside (AG) loaded solid lipid nanoparticles (SLNs) to improve skin penetration of AG. AG loaded SLNs were prepared using double emulsion method. The prepared AG loaded SLNs investigated particle characteristics (particle size, polydispersity index, zeta potential, loading capacity). Skin penetration study was carried out using SkinEthic RHE as one of the reconstructed human epidermis models. The mean particle size and zeta potential of SLNs were 172.65 - 347.19 nm and -22.90 - -41.20 mV, respectively. The loading capacity of AG loaded SLNs demonstrated that loading efficiency and loading amount were ranged from 44.18% to 57.77% and 12.83% to 16.15%, respectively. The results of penetration showed that all SLNs enhanced the skin penetration of AG and the amount of AG from SLNs were approximately 3.7 - 7.4 times higher than that from AG solution. Therefore, AG loaded SLN might be a promising topical drug delivery system.

• 한국전산유체공학회:학술대회논문집
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• 1996.05a
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• pp.58-67
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• 1996

This paper describes some computational results of various energy and environmental systems using Patankar's SIMPLE method. The specific topics handled in this study are jet bubbling reactor for flue gas desulfurization, cyclone-type afterburner for incineration, 200m tall stack for 500 MW electric power generation, double skin and heat storage systems of building energy saving for the utilization of solar heating, finally turbulent combustion systems with liquid droplet or pulverized coal particle. A control-volume based finite-difference method with the power-law scheme is employed for discretization. The pressure-velocity coupling is resolved by the use of the revised version of SIMPLE, that is, SIMPLEC. Reynolds stresses are closed using the standard $k-{\varepsilon}$ and RNG $k-{\varepsilon}$ models. Two-phase turbulent combustion of liquid drop or pulverized coal particle is modeled using locally-homogeneous, gas-phase, eddy breakup model. However simple approximate models are incorporated for the modeling of the second phase slip and retardation of ignition without consideration of any detailed particle behavior. Some important results are presented and discussed in a brief note. Especially, in order to make uniform exit flow for the jet bubbling reactor, a well-designed structure of distributor is needed. Further, the aspect ratio in the double skin system appears to be one of important factors to give rise to the visible change of the induced air flow rate. The computational tool employed in this study, in general, appears as a viable method for the design of various engineering system of interest.

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.1
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• pp.1-11
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• 2021

Thermal protection system structures such as double-panel structures are used on the skin of the fuselage and wings to prevent the transfer of high heat into the interior of an high supersonic/hypersonic aircraft. The thin-walled double-panel skin can be exposed to acoustic loads by high power engine noise and jet flow noise, which can cause sonic fatigue damage. In order to predict the fatigue life of the skin, the octave bandwidth SPL should be calculated as narrow bandwidth PSD or acoustic load history using interpolation method. In this paper, a method of converting the octave bandwidth SPL acoustic load into a narrow bandwidth PSD and reconstructed acoustic load history was investigated. The octave bandwidth SPL was converted to the narrow bandwidth PSD using various interpolation methods such as flat, log and linear scale, and the probabilistic characteristics and fatigue damage results were compared. It was found that average error of fatigue damage index by the log scale interpolation method was relatively small among three methods.

• Proceedings of the KIEE Conference
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• 2002.11c
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• pp.407-410
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• 2002

As a part of electro-mechanical totally implantable artificial heart, a transcutaneous energy transmission system has been developed. By mutual magnetic induction between the first coil on the skin and the subcutaneously implanted second coil, the system transfers electrical power through the skin. This research aimed a minimizing the size of the implanted part as well as maximizing the transfer efficiency. When an air gap is 1$\sim$2cm, voltage gain and current gain low and it is hard to transfer energy due to large leakage flux. That is, the required input voltage and input current must be large compared with the output voltage and output current, respectively, This paper research the inverter topology and the control method in order to increase the voltage gain and the current gain. For this purpose, this inverter employs double tune to compensate the large leakage inductance of primary and secondary of the transcutaneous transformer. And the output energy of transcutaneous energy transmission system supply for Lithium-ion battery charger.