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http://dx.doi.org/10.12925/jkocs.2021.38.3.662

Design and Characterization of Ascorbyl Glucoside loaded Solid Lipid Nanoparticles to improve skin penetration  

Yeo, Sooho (College of Pharmacy, Chung-Ang University)
Publication Information
Journal of the Korean Applied Science and Technology / v.38, no.3, 2021 , pp. 662-668 More about this Journal
Abstract
The aim of the present study was to design ascorbyl glucoside (AG) loaded solid lipid nanoparticles (SLNs) to improve skin penetration of AG. AG loaded SLNs were prepared using double emulsion method. The prepared AG loaded SLNs investigated particle characteristics (particle size, polydispersity index, zeta potential, loading capacity). Skin penetration study was carried out using SkinEthic RHE as one of the reconstructed human epidermis models. The mean particle size and zeta potential of SLNs were 172.65 - 347.19 nm and -22.90 - -41.20 mV, respectively. The loading capacity of AG loaded SLNs demonstrated that loading efficiency and loading amount were ranged from 44.18% to 57.77% and 12.83% to 16.15%, respectively. The results of penetration showed that all SLNs enhanced the skin penetration of AG and the amount of AG from SLNs were approximately 3.7 - 7.4 times higher than that from AG solution. Therefore, AG loaded SLN might be a promising topical drug delivery system.
Keywords
Ascorbyl glucoside; Solid lipid nanoparticles; Skin penetration; Skin retention; SkinEthic RHE;
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