• 한국어병학회지
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• 제23권3호
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• pp.273-280
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• 2010

To determine whether rock bream Oplegnathus fasciatus can be protected from rock bream iridovirus (RBIV) infection by intramuscular injection of long double-stranded RNAs (dsRNAs), we compared protective effect of virus-specific dsRNAs corresponding to major capsid protein (MCP), ORF 084, ORF 086 genes, and virus non-specific green fluorescent protein (GFP) gene. Furthermore, to determine whether the non-specific type I interferon (IFN) response was associated with protective effect, we estimated the activation of type I IFN response in fish using expression level of IFN inducible Mx gene as a marker. As a result, mortality of fish injected with dsRNAs and challenged with RBIV was delayed for a few days when comparing with PBS injected control group. However, virus-specific dsRNA injected groups exhibited no significant differences in survival period when compared to the GFP dsRNA injected group. Semi-quantitative analysis indicated that the degree of antiviral response via type I IFN response is supposedly equal among dsRNA injected fish. These results suggest that type I IFN response rather than sequence-specific RNA interference might involve in the lengthened survival period of fish injected with virus-specific dsRNAs.

• 대한금속재료학회지
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• 제56권11호
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• pp.822-828
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• 2018

P-type Ce/Yb-filled skutterudites were synthesized, and their charge transport and thermoelectric properties were investigated with partial double filling and charge compensation. In the case of $(Ce_{1-z}Yb_z)_{0.8}Fe_4Sb_{12}$ without Co substitution, the marcasite ($FeSb_2$) phase formed alongside the skutterudite phase, but the generation of the marcasite phase was inhibited by increasing Co concentration. The electrical conductivity decreased with increasing temperature, exhibiting degenerate semiconductor behavior. The Hall and Seebeck coefficients were positive, which confirmed that the specimens were p-type semiconductors with holes as the major carriers. The carrier concentration decreased as the concentration of Ce and Co increased, which led to decreased electrical conductivity and increased Seebeck coefficient. The thermal conductivity decreased due to a reduction in electronic thermal conductivity via Co substitution, and due to decreased lattice thermal conductivity via double filling of Ce and Yb. $(Ce_{0.25}Yb_{0.75})_{0.8}Fe_{3.5}Co_{0.5}Sb_{12}$ exhibited the greatest dimensionless figure of merit (ZT = 0.66 at 823 K).

• 건축역사연구
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• 제28권1호
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• pp.7-16
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• 2019

As a part of the research on existing structures of private homes from Joseon Era. Focusing on one hundred twenty five-purlin houses, the current study investigated the features and characteristics of the house structure from style, size, proportion and roof pitch, and measurements of key parts, and developed the following conclusions. Most are single-houses (89, 83%), and among them, there are 47 single front-terrace houses (39%), which is the highest number. The sizes of lower house structure do not differ greatly depending on the vertical structure, and single rear terrace house and double-house have relatively larger side sizes. The size of upper structure is larger in double-houses compared to other vertical structures, indicating a relatively higher roof. The cross-section measurement of major parts show that double-houses are larger than single-houses by 3cm in pillar, 3-4.5cm in crossbeam length, and 4.5cm in crossbeam width. However, Janghyeo width was consistent at 7.5 to 10.5cm, maintaining uniformity regardless of vertical structure of the houses. In addition, the cross-section measurements decreased from sixteenth to nineteenth century, with the size of pillar size decreasing the most. The result that the Janghyeo width is not related to the house structure house confirmed that the Janghyeo width was kept consistent regardless of the size of the house structure.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.123-129
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• 2019

Objective : Ventriculoperitoneal (VP) shunt surgery is a common and effective treatment for hydrocephalus and cerebrospinal fluid disorders. Infection remains a major cause of morbidity and mortality after a VP shunt. There is evidence that a deep skin flora microbiome may have a role to play in post-operative infections. In this technical note, we present a skin preparation technique that addresses the issue of the skin flora beyond the initial incision. Methods : The patient is initially prepped, as standard, with. a single layer of 2% CHG+70% isopropyl alcohol. The novel stage is the 'double incision' whereby an initial superficial incision receives a further application of povidone-iodine prior to completing the full depth incision. Results : Of the 84 shunts inserted using the double-incision method (September 2015 to September 2016), only one developed a shunt infection. Conclusion : The double incision approach to skin preparation is a unique operative stage in VP shunt surgery that may have a role to play in reducing acute shunt infection.

• Geomechanics and Engineering
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• 제30권5호
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• pp.423-435
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• 2022

Ground vibration generated repeatedly in blasting tunnel excavation sites is known to be one of the major hazards induced by blasting operations. Various studies have been conducted to minimize these hazards, both theoretical and empirical methods using electronic detonator, the deck charge method, the center-cut method among others Among these various existing methods for controlling the ground vibration, in this study, we investigated the cut method. In particular, we analyzed and compared the V-cut method, which is commonly used in tunnel blasting, to the double-drilled parallel method, which has recently been introduced in tunnel excavation site. To understand the rock fragmentation efficiency as well as the ground vibration controllability of the two methods, we performed in-situ field blasting tests with both cut methods at a tunnel excavation site. Additionally, numerical analysis by FLAC3D has been executed for a better understanding of fracture propagation pattern and ground vibration generation by each cut method. Ground vibration levels, by PPVs measured in field blasting tests and PPVs estimated in numerical simulations, showed a lower value in the double-drilled parallel compared with the V-cut method, although the exact values are quite different in field measurement and numerical estimation.

• 한국작물학회지
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• 제30권4호
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• pp.352-358
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• 1985

건조분말상태의 인삼 및 유사 숙근성 식물간의 구별방법을 확립하기 위하여 단백질 추출과 분리방법을 달리하여 전기영동법에 의해 각 식물의 단백질 pattern 및 분자량을 추정하였던바 그 결과를 요약하면 다음과 같다. 1. 단백질분리는 증류수와 phosphate buffer로 추출하였을 때 가장 잘 되었으며 비교하기가 용이하였다. 2. 단백질추출방법에 따라 각 식물의 minor band는 약관의 차이가 있었으나 major band는 차이가 없었다. 3. 각 식물을 구별할 수 있는 band는 인삼이 45,000 및 66,000 Kd이며 사삼은 32,000∼39,000kd이고 도라지는 39,000Kd에서 double band가 특징적인 band로서 각 식물을 구별할 수 있는 단백질이었다.

• 한국유통학회지:유통연구
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• 제1권2호
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• pp.173-198
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• 1996

Distribution of farm produce in Korea is known to be inefficient due to the numerous stages that exist in the distribution channel. This has resulted in dissatisfaction for both farmer and consuers; farmers sell their produce at low prices to middlemen while consumers pay high prices for them because of price increases that occur in the distribution chain. We apply Spengler's theory of double marginalization to show that price increases are inevitable as the length of the farm distribution chain increases. We then show that the negative effects of double marginalization can be contained by setting up a physical distribution center. The physical distribution center effectively reduces the stages in the distribution from 5 or 6 stages to 3 or 4 stages. We also lay out the design and major characteristics of the distribution center, as well as the expected cost savings.

• 가정과삶의질연구
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• 제21권5호
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• pp.1-12
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• 2003

Determinants of consumption patterns of elderly couple and elderly single were investigated using the 1996 National Survey of Family Income and Expenditure by National Statistical Office. There were large differences in consumption patterns between the elderly couple and single in terms of monthly expenditures and average budget shares of individual consumption items. Consumption functions of individual items were estimated using double-log function. Major determinants of consumption functions were income, overspending behavior, educational level of householder, and net worth for both groups, householder's job status and city residence mainly for elderly couple, and age of householder mainly for elderly single. In addition, income elasticity of elderly households was larger than net worth elasticity for all consumption items.

• 연구논문집
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• 통권29호
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• pp.83-90
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• 1999

In naval ships, pump machineries are the major sources of airborne and structure-borne noise. Noise is critical issue in ships not only it causes annoyance to crews, but also it can increase the underwater radiated noise, which is crucial in anti-submarine warfare. In present study, it is discussed the reduction of structure-borne noise of pump machineries by showing several examples. The most typical and effective solution is to use double resilient mount system. However, in cases where double resilient system cannot be applied due to space and weight increase, rubber pad can be used to reduce the structure-borne noise. In principle, the concept of structure-borne noise reduction is the same as that of vibration isolation.

• Journal of Chest Surgery
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• 제26권2호
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• pp.158-159
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• 1993

The hemorragic episode is the major problem of mechanical prosthesis, because of the necessity for anticoagulant therapy to prevent complication of thromboembolism. Double valve replacement was performed to 42 year old male due to aortic stenoinsufficiency and mitral stenosis. For anticoagulant therapy, the patient has been given wafarin under the control of prothrombin time 0.5-2 times of normal) in the our hospital. The patient was injuried the right pelvic area by waves in the beach 4 years after double valve replacement. Pelvic MRI scan showed huge hematoma in the right pelvic cavity. The patient was operated removal of intrapelvic hematoma.