• Title/Summary/Keyword: Dose conversion

Search Result 244, Processing Time 0.027 seconds

Influence of an Anaerobic Fungal Culture (Orpinomyces sp.) Administration on Growth Rate, Ruminal Fermentation and Nutrient Digestion in Calves

  • Dey, Avijit;Sehgal, Jatinder Paul;Puniya, Anil Kumar;Singh, Kishan
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.17 no.6
    • /
    • pp.820-824
    • /
    • 2004
  • The study was to see the effect of administration of ruminal fungi on feed intake, growth rate, rumen fermentation and nutrient digestion of calves (Tharparkar$\times$Holstein-Friesian, average age: 10 months, average body weight: 130 kg). The 6 calves in first group were fed a mixture consisted of 50% wheat straw and 50% concentrate (Maize 62%, Groundnut cake 35%, Mineral mix. 2% and Common salt 1%) along with 1 kg green oats $animal^{-1}$ $day^{-1}$ while second group calves were fed the above-mentioned diet in addition to a dose of 160 ml ($10^{6}$ CFU/ml) fungal culture $calf^{-1}$ $week^{-1}$. The average dry matter intake per day was slightly lowered in fungal fed calves yet feed conversion ratio was higher. The average daily weight gain was significantly higher (15.37%) in fungal administered group as compared to control. The nutrient digestibility was increased for crude fibre, NDF and ADF with fungal administration. Digestible energy value of straw-based diet in terms of percent TDN also increased. The pH and $NH_{3}$-N were lower whereas TVFA, total-N, TCA-N and number of zoospores were higher in rumen liquor in fungal administered group.

Development of a Computer Code for Low-and Intermediate-Level Radioactive Waste Disposal Safety Assessment

  • Park, J.W.;Kim, C.L.;Lee, E.Y.;Lee, Y.M.;Kang, C.H.;Zhou, W.;Kozak, M.W.
    • Journal of Radiation Protection and Research
    • /
    • v.29 no.1
    • /
    • pp.41-48
    • /
    • 2004
  • A safety assessment code, called SAGE (Safety Assessment Groundwater Evaluation), has been developed to describe post-closure radionuclide releases and potential radiological doses for low- and intermediate-level radioactive waste (LILW) disposal in an engineered vault facility in Korea. The conceptual model implemented in the code is focused on the release of radionuclide from a gradually degrading engineered barrier system to an underlying unsaturated zone, thence to a saturated groundwater zone. The radionuclide transport equations are solved by spatially discretizing the disposal system into a series of compartments. Mass transfer between compartments is by diffusion/dispersion and advection. In all compartments, radionuclides ate decayed either as a single-member chain or as multi-member chains. The biosphere is represented as a set of steady-state, radionuclide-specific pathway dose conversion factors that are multiplied by the appropriate release rate from the far field for each pathway. The code has the capability to treat input parameters either deterministically or probabilistically. Parameter input is achieved through a user-friendly Graphical User Interface. An application is presented, which is compared against safety assessment results from the other computer codes, to benchmark the reliability of system-level conceptual modeling of the code.

Involvement of spermine in Control of Ethylene-Mediated Growth Response in Ranunculus sceleratus Petioles (Ranunculus sceleratus 엽병의 에틸렌 매개 생장반응조절에 있어서 Spermine의 관여)

  • 정미숙
    • Journal of Plant Biology
    • /
    • v.35 no.4
    • /
    • pp.425-429
    • /
    • 1992
  • Cell elongation is known to be promoted by ethylene in petioles of Ranunculus sceleratus. Treatment of petiole segments with spermine resulted in an inhibition of cell elongation and of ethylene biosynthesis in the presence of applied auxin. Dose response curve for the spermine inhibition of auxin-induced ethylene production appeared similar to that of ACC-based ethylene production suggesting that the polyamine inhibits ethylene biosynthesis by blocking the conversion of ACC to etylene. Auxin-induced ethylene production was significantly promoted by treatment of the tissue with either DFMA or DFMO. specific inhibitors of polyamine biosynthesis. Increased level of ethylene production by DFMA was found to be completely abolished by application of exogenous spermine at a high concentration. These results indicate that endogenous spermine plays a regulatory role in the growth response of Ranunculus petioles to auxin and ethylene.hylene.

  • PDF

A Historical Study of Non-standard Weight and Measuring Units (역대(歷代) 약물(藥物) 비표준(非標準) 계량단위(計量單位)의 고찰(考察))

  • Yun, Sung-Joong;Moon, Young-Choon;Kim, Ji-Hoon;Jung, Gi-Eun;Kim, Yun-Kyung
    • Herbal Formula Science
    • /
    • v.24 no.4
    • /
    • pp.335-351
    • /
    • 2016
  • Objective : This study was done to clarify ambiguous non-standard weight and measuring units in medical classics. Methods : Using medical classics and research dissertations, we studied the basic definitions of weight and measuring units and the types of non-standard weight and measuring units. We compared non-standard weight and measuring units in the reference literatures, to determine the dose of herbs in the prescriptions. Results : There are three types of units in non-standard weight and measuring units. These are 'Quantity measuring unit', 'Resembrance measuring unit', and 'Eye measuring unit'. And we found historical efforts and progresses for proper ways to convert non-standard weight and measuring units to standard weight and measuring units. Conclusions : This research will be the basic data for the standardization of prescriptions. Additional study was still required for precise weighing and measuring in Korean medicine and pharmacy.

Protective Effects of Water Extract from Cuscutae Semen on Ketoconazole-Induced Oxidative Stress in Testicular Damage Male Rats (토사자 추출물의 ketoconazole로 유도된 고환 독성 흰쥐의 산화적 스트레스 저해효과)

  • Kim, Sung-Hoon;Choi, Jong -Won
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.25 no.3
    • /
    • pp.417-424
    • /
    • 2011
  • Ketoconazole (KET) is an antifungal drug with a broad spectrum of activity that also induces reproductive toxicity in humans and animals. KET inhibits C17-20 lyase which blocks the conversion of 17 ${\alpha}$-hydroxyprogesterone to androstenedione. The effect of Cuscutae semen(CS) extract against KET-induced testicular damage was evaluated in male rats. CS extract was administered orally (100 and 200 mg/kg) for 26 days. Three weeks after CS extract administration, KET was CS-administered intraperitoneally at a dose of 100 mg/kg once a day for 5 days. KET-induced reproductive toxicity was associated with clear reductions of the weights of testes and epididymides, sperm indices and serum testosterone levels. In addition, marked oxidative damage to testicular lipids and alterations of natural antioxidant enzymes were reported in association with KET toxicity. Most of the KET-induced effects were greatly decreased with the concomitant application of CS extract. This study suggests a protective role of Cuscutae semen extract that could be attributed to its antioxidant properties.

Production of GABA (gamma amino butyric acid) by Lactic Acid Bacteria

  • Kook, Moo-Chang;Cho, Seok-Cheol
    • Food Science of Animal Resources
    • /
    • v.33 no.3
    • /
    • pp.377-389
    • /
    • 2013
  • Gamma-amino butyric acid (GABA) is a kind of pharmacological and biological component and its application is wide and useful in Korea specially, becoming aging society in the near feature. GABA is request special dose for the purposed biological effect but the production of concentrated GABA is very difficult due to low concentration of glutamic acid existed in the fermentation broth. To increase GABA concentrate using fermentation technology, high content of glutamic acid is required. For this reason, various strains which have the glutamic acid decarboxylase (GAD) and can convert glutamic acid to GABA, were isolated from various fermented foods. Most of GABA producing strains are lactic acid bacteria isolated from kimchi, especially added monosodium glutamate (MSG) as a taste enhancer. Optimizing the formulation of culture media and the culture condition, GABA conversion yield and amounts were increased. Finally GABA concentration of fermentation broth in batch or fed batch fermentation reached 660 mM or 1000 mM, respectively. Furthermore formulation of culture media for GABA production developed commercially. Many studies about GABA-rich product have been continued, so GABA-rich kimchi, cheese, yogurt, black raspberry juice and tomato juices has been also developed. In Korea many biological effects of GABA are evaluated recently and GABA will be expected to be used in multipurpose.

A Case of Dissociative amnesia with Conversion disorder -By using psychotherapy- (해리성 기억상실과 전환장애를 동반한 환자의 증례 -정신요법을 사용하여-)

  • Kwak, Sun;Lee, Seung-Gi;Choi, Woo-Jin
    • Journal of Oriental Neuropsychiatry
    • /
    • v.14 no.2
    • /
    • pp.191-198
    • /
    • 2003
  • Dissociative amnesia is a psychiatric disorder charicterized by a sudden loss of memory, but which has no organic disease or explanation, It usually occurs after severe psychosocial stress or traumatic experience. As for medical treatment, medicine, psychotherapy and hypnosis are used. This case describes a 35-years-old woman who developed amnesia and depression following severe troublesome events. So she suited without expression and appealed against headache, dizziness, chest discomfort and weakness. Psychoanalytic psychotherapy was enforced for three days with hypnosis. She expressed the felling over the incident which she dose not like, and canceled in the past. She became reconciled with the family and left the husband by the heart. Then she recovered memory completely and body condition also improved. Recovery and growth of self were helped using supportive expression in order to prevent a recurrence. The prognosis is good with complete recovery, and there was no relapse.

  • PDF

Antioxidant Activity of a Red Seaweed Polysiphonia morrowii Extract

  • Je, Jae-Young;Ahn, Chang-Bum;Oh, Myung-Joo;Kang, So-Young
    • Food Science and Biotechnology
    • /
    • v.18 no.1
    • /
    • pp.124-129
    • /
    • 2009
  • Antioxidant activities of the extract of red seaweed, Polysiphonia morrowii, were evaluated using several in vitro assay systems. Activity-guided fractionation revealed that the 90% MeOH fraction of the P. morrowii extract exhibited the highest antioxidant activity, and that this fraction had a high total phenolic content ($135.7{\pm}5.0\;mg$ gallic acid/g extract). Therefore, the antioxidant activities of the 90% MeOH fraction against 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical, reducing power, ferrous chelating, and hydrogen peroxide were investigated. The results revealed that the antioxidant activities of the 90% MeOH fraction were similar and/or superior to that of commercial antioxidants such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). In addition, the ability of the 90% MeOH fraction to inhibit oxidative damage to DNA was assessed by measuring the conversion of the supercoiled pBR322 plasmid DNA to the open circular form. The 90% MeOH fraction was found to significantly protect this hydroxyl radical-induced DNA damage in a dose-dependent manner. Taken together, these findings suggest that the 90% MeOH fraction of P. morrowii extract and/or its constituents has the potential for use as a new bioresource of antioxidants.

GalhuaHaeJungTang Inhibit Ethanol-induced Gastric Injury in Rats (갈화해정탕이 주상(酒傷)에 미치는 영향 - ethanol-유도 위점막의 산화적 손상을 중심으로 -)

  • Chae, Jong-Koo;Shin, Heung-Mook;Kim, Gil-Whon
    • The Journal of Korean Medicine
    • /
    • v.20 no.1 s.37
    • /
    • pp.113-121
    • /
    • 1999
  • This Study was carried out to investigate the protective effect of GalHwaHaJungTang(GHT) on the gastric lesions indused by ethanol in rats. Rats were pretreated with GHT extract 1.7ml/kg, 3.4ml/kg, 5ml/kg and then were given orally 1ml of absolute ethanol 30min later. The animals were killed 1hr after ethanol treatment In morphorogic change, ethanol induced prominent longitudinal hemorrhagic lesions in the stomach. But GHT-pretreatment showed a dose-depentent decrease in the mucosa lesions. GHT extract siginificantly reduced lipid peroxidation and also induced an increase of superoxide dismutase(SOD), catalase and gluthathion(GSH) levels, but showed no influence in the type conversion of xanthine oxidase. These results suggest that the proposed gastroprotective effect may involve activation of antioxidant effects, but independent of the xanthine oxidase system.

  • PDF

Determination of Derived Release Limits for a CANDU Nuclear Power Plant (CANDU형 원전에서의 유도방출한도 결정)

  • Kim, Kyo-Youn;Hwang, Hae-Ryong;Kim, Jong-Kyung
    • Journal of Radiation Protection and Research
    • /
    • v.19 no.1
    • /
    • pp.23-35
    • /
    • 1994
  • A computer code DRL was developed to calculate the derived release limits at CANDU type nuclear power plants. The derived release limits resulting from DRL code is to set guidelines for the release of radionuclides in airborne and water-borne effuents during normal operations of a CANDU type nuclear power plant. The DRL code generally follows the methodology Prescribed in the CSA standard N288.1-M87 and uses the Parameter values recommended in the same standards. The DRL code was used to calculate a set of preliminary derived release limits for the Wolsong NPP.

  • PDF